Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_F21
(698 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P11884|ALDH2_RAT Aldehyde dehydrogenase, mitochondrial p... 280 3e-75
sp|P81178|ALDH2_MESAU Aldehyde dehydrogenase, mitochondrial... 280 3e-75
sp|Q63639|AL1A2_RAT Retinal dehydrogenase 2 (RalDH2) (RALDH... 278 8e-75
sp|P05091|ALDH2_HUMAN Aldehyde dehydrogenase, mitochondrial... 278 1e-74
sp|Q62148|AL1A2_MOUSE Retinal dehydrogenase 2 (RalDH2) (RAL... 278 1e-74
sp|P12762|ALDH2_HORSE Aldehyde dehydrogenase, mitochondrial... 276 4e-74
sp|P47738|ALDH2_MOUSE Aldehyde dehydrogenase, mitochondrial... 276 5e-74
sp|O94788|AL1A2_HUMAN Retinal dehydrogenase 2 (RalDH2) (RAL... 276 5e-74
sp|P30837|AL1B1_HUMAN Aldehyde dehydrogenase X, mitochondri... 275 8e-74
sp|Q8MI17|AL1A1_RABIT Retinal dehydrogenase 1 (RalDH1) (RAL... 275 1e-73
>sp|P11884|ALDH2_RAT Aldehyde dehydrogenase, mitochondrial precursor (ALDH class 2)
(ALDH1) (ALDH-E2)
Length = 519
Score = 280 bits (716), Expect = 3e-75
Identities = 136/232 (58%), Positives = 167/232 (71%)
Frame = +2
Query: 2 TAGAALSSHHDVRKITFTGSTEIGHVIMKTIGETSLKRVTLELGGKSPLIIFXXXXXXXX 181
TAGAA++SH DV K+ FTGSTE+GH+I G ++LKRVTLELGGKSP II
Sbjct: 246 TAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWA 305
Query: 182 XXXXXXXCMTNHGQCCVAGTRTFVEASIYDTIIEKLKKLAEERIVGDPFDEKTIQGPQVD 361
N GQCC AG+RTFV+ +YD +E+ A+ R+VG+PFD +T QGPQVD
Sbjct: 306 VEQAHFALFFNQGQCCCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVD 365
Query: 362 KEQFNKILDLIESGKHEGAKLVTGGNRIGNVGYFIQPTVFGDVKDNMRIAKEEIFGPVQS 541
+ QF KIL I+SG+ EGAKL+ GG + GYFIQPTVFGDVKD M IAKEEIFGPV
Sbjct: 366 ETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQ 425
Query: 542 VFKFNTMEEVIERANNSDYGLGAGVFTSDINKAIMMTQALEAGSVWVNCYDV 697
+ KF T+EEV+ RANNS YGL A VFT D++KA ++QAL+AG+VW+NCYDV
Sbjct: 426 ILKFKTIEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDV 477
>sp|P81178|ALDH2_MESAU Aldehyde dehydrogenase, mitochondrial (ALDH class 2) (ALDH1)
(ALDH-E2)
Length = 500
Score = 280 bits (716), Expect = 3e-75
Identities = 136/232 (58%), Positives = 167/232 (71%)
Frame = +2
Query: 2 TAGAALSSHHDVRKITFTGSTEIGHVIMKTIGETSLKRVTLELGGKSPLIIFXXXXXXXX 181
TAGAA++SH DV K+ FTGSTE+GH+I G ++LKRVTLELGGKSP II
Sbjct: 227 TAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWA 286
Query: 182 XXXXXXXCMTNHGQCCVAGTRTFVEASIYDTIIEKLKKLAEERIVGDPFDEKTIQGPQVD 361
N GQCC AG+RTFV+ +YD +E+ A+ R+VG+PFD +T QGPQVD
Sbjct: 287 VEQAHFALFFNQGQCCCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVD 346
Query: 362 KEQFNKILDLIESGKHEGAKLVTGGNRIGNVGYFIQPTVFGDVKDNMRIAKEEIFGPVQS 541
+ QF KIL I+SG+ EGAKL+ GG + GYFIQPTVFGDVKD M IAKEEIFGPV
Sbjct: 347 ETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQ 406
Query: 542 VFKFNTMEEVIERANNSDYGLGAGVFTSDINKAIMMTQALEAGSVWVNCYDV 697
+ KF T+EEV+ RANNS YGL A VFT D++KA ++QAL+AG+VW+NCYDV
Sbjct: 407 ILKFKTIEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDV 458
>sp|Q63639|AL1A2_RAT Retinal dehydrogenase 2 (RalDH2) (RALDH 2) (RALDH(II))
(Retinaldehyde-specific dehydrogenase type 2) (Aldehyde
dehydrogenase family 1 member A2)
Length = 499
Score = 278 bits (712), Expect = 8e-75
Identities = 135/231 (58%), Positives = 173/231 (74%)
Frame = +2
Query: 2 TAGAALSSHHDVRKITFTGSTEIGHVIMKTIGETSLKRVTLELGGKSPLIIFXXXXXXXX 181
TAGAA++SH + KI FTGSTE+G +I + G ++LKRVTLELGGKSP IIF
Sbjct: 226 TAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYA 285
Query: 182 XXXXXXXCMTNHGQCCVAGTRTFVEASIYDTIIEKLKKLAEERIVGDPFDEKTIQGPQVD 361
N GQCC AG+R FVE SIY+ +++ + A+ RIVG PFD T QGPQ+D
Sbjct: 286 VEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSVERAKRRIVGSPFDPTTEQGPQID 345
Query: 362 KEQFNKILDLIESGKHEGAKLVTGGNRIGNVGYFIQPTVFGDVKDNMRIAKEEIFGPVQS 541
K+Q+NKIL+LI+SG EGAKL GG +G G+FI+PTVF +V D+MRIAKEEIFGPVQ
Sbjct: 346 KKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQE 405
Query: 542 VFKFNTMEEVIERANNSDYGLGAGVFTSDINKAIMMTQALEAGSVWVNCYD 694
+ +F TM+EVIERANNSD+GL A VFT+DINKA+M++ A++AG+VW+NCY+
Sbjct: 406 ILRFKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTVWINCYN 456
>sp|P05091|ALDH2_HUMAN Aldehyde dehydrogenase, mitochondrial precursor (ALDH class 2)
(ALDHI) (ALDH-E2)
Length = 517
Score = 278 bits (711), Expect = 1e-74
Identities = 139/232 (59%), Positives = 165/232 (71%)
Frame = +2
Query: 2 TAGAALSSHHDVRKITFTGSTEIGHVIMKTIGETSLKRVTLELGGKSPLIIFXXXXXXXX 181
TAGAA++SH DV K+ FTGSTEIG VI G ++LKRVTLELGGKSP II
Sbjct: 244 TAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWA 303
Query: 182 XXXXXXXCMTNHGQCCVAGTRTFVEASIYDTIIEKLKKLAEERIVGDPFDEKTIQGPQVD 361
N GQCC AG+RTFV+ IYD +E+ A+ R+VG+PFD KT QGPQVD
Sbjct: 304 VEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVD 363
Query: 362 KEQFNKILDLIESGKHEGAKLVTGGNRIGNVGYFIQPTVFGDVKDNMRIAKEEIFGPVQS 541
+ QF KIL I +GK EGAKL+ GG + GYFIQPTVFGDV+D M IAKEEIFGPV
Sbjct: 364 ETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQ 423
Query: 542 VFKFNTMEEVIERANNSDYGLGAGVFTSDINKAIMMTQALEAGSVWVNCYDV 697
+ KF T+EEV+ RANNS YGL A VFT D++KA ++QAL+AG+VWVNCYDV
Sbjct: 424 ILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDV 475
>sp|Q62148|AL1A2_MOUSE Retinal dehydrogenase 2 (RalDH2) (RALDH 2) (RALDH(II))
(Retinaldehyde-specific dehydrogenase type 2) (Aldehyde
dehydrogenase family 1 member A2)
Length = 499
Score = 278 bits (711), Expect = 1e-74
Identities = 134/231 (58%), Positives = 173/231 (74%)
Frame = +2
Query: 2 TAGAALSSHHDVRKITFTGSTEIGHVIMKTIGETSLKRVTLELGGKSPLIIFXXXXXXXX 181
TAGAA++SH + KI FTGSTE+G +I + G ++LKRVTLELGGKSP IIF
Sbjct: 226 TAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYA 285
Query: 182 XXXXXXXCMTNHGQCCVAGTRTFVEASIYDTIIEKLKKLAEERIVGDPFDEKTIQGPQVD 361
N GQCC AG+R FVE SIY+ +++ + A+ RIVG PFD T QGPQ+D
Sbjct: 286 VEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSVERAKRRIVGSPFDPTTEQGPQID 345
Query: 362 KEQFNKILDLIESGKHEGAKLVTGGNRIGNVGYFIQPTVFGDVKDNMRIAKEEIFGPVQS 541
K+Q+NK+L+LI+SG EGAKL GG +G G+FI+PTVF +V D+MRIAKEEIFGPVQ
Sbjct: 346 KKQYNKVLELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQE 405
Query: 542 VFKFNTMEEVIERANNSDYGLGAGVFTSDINKAIMMTQALEAGSVWVNCYD 694
+ +F TM+EVIERANNSD+GL A VFT+DINKA+M++ A++AG+VW+NCY+
Sbjct: 406 ILRFKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTVWINCYN 456
>sp|P12762|ALDH2_HORSE Aldehyde dehydrogenase, mitochondrial (ALDH class 2) (ALDHI)
(ALDH-E2)
Length = 500
Score = 276 bits (706), Expect = 4e-74
Identities = 134/232 (57%), Positives = 167/232 (71%)
Frame = +2
Query: 2 TAGAALSSHHDVRKITFTGSTEIGHVIMKTIGETSLKRVTLELGGKSPLIIFXXXXXXXX 181
TAGAA++SH DV K+ FTGSTE+GH+I G ++LK+VTLELGGKSP II
Sbjct: 227 TAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGRSNLKKVTLELGGKSPNIIVSDADMDWA 286
Query: 182 XXXXXXXCMTNHGQCCVAGTRTFVEASIYDTIIEKLKKLAEERIVGDPFDEKTIQGPQVD 361
N GQCC AG+RTFV+ +Y +E+ A+ R+VG+PFD +T QGPQVD
Sbjct: 287 VEQAHFALFFNQGQCCGAGSRTFVQEDVYAEFVERSVARAKSRVVGNPFDSQTEQGPQVD 346
Query: 362 KEQFNKILDLIESGKHEGAKLVTGGNRIGNVGYFIQPTVFGDVKDNMRIAKEEIFGPVQS 541
+ QFNK+L I+SGK EGAKL+ GG + GYFIQPTVFGDV+D M IAKEEIFGPV
Sbjct: 347 ETQFNKVLGYIKSGKEEGAKLLCGGGAAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQ 406
Query: 542 VFKFNTMEEVIERANNSDYGLGAGVFTSDINKAIMMTQALEAGSVWVNCYDV 697
+ KF T+EEV+ RANNS YGL A VFT D++KA ++QAL+AG+VW+NCYDV
Sbjct: 407 ILKFKTIEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDV 458
>sp|P47738|ALDH2_MOUSE Aldehyde dehydrogenase, mitochondrial precursor (ALDH class 2)
(AHD-M1) (ALDHI) (ALDH-E2)
Length = 519
Score = 276 bits (705), Expect = 5e-74
Identities = 134/232 (57%), Positives = 167/232 (71%)
Frame = +2
Query: 2 TAGAALSSHHDVRKITFTGSTEIGHVIMKTIGETSLKRVTLELGGKSPLIIFXXXXXXXX 181
TAGAA++SH V K+ FTGSTE+GH+I G ++LKRVTLELGGKSP II
Sbjct: 246 TAGAAIASHEGVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWA 305
Query: 182 XXXXXXXCMTNHGQCCVAGTRTFVEASIYDTIIEKLKKLAEERIVGDPFDEKTIQGPQVD 361
N GQCC AG+RTFV+ ++YD +E+ A+ R+VG+PFD +T QGPQVD
Sbjct: 306 VEQAHFALFFNQGQCCCAGSRTFVQENVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVD 365
Query: 362 KEQFNKILDLIESGKHEGAKLVTGGNRIGNVGYFIQPTVFGDVKDNMRIAKEEIFGPVQS 541
+ QF KIL I+SG+ EGAKL+ GG + GYFIQPTVFGDVKD M IAKEEIFGPV
Sbjct: 366 ETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQ 425
Query: 542 VFKFNTMEEVIERANNSDYGLGAGVFTSDINKAIMMTQALEAGSVWVNCYDV 697
+ KF T+EEV+ RAN+S YGL A VFT D++KA ++QAL+AG+VW+NCYDV
Sbjct: 426 ILKFKTIEEVVGRANDSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDV 477
>sp|O94788|AL1A2_HUMAN Retinal dehydrogenase 2 (RalDH2) (RALDH 2) (RALDH(II))
(Retinaldehyde-specific dehydrogenase type 2) (Aldehyde
dehydrogenase family 1 member A2)
Length = 499
Score = 276 bits (705), Expect = 5e-74
Identities = 134/231 (58%), Positives = 171/231 (74%)
Frame = +2
Query: 2 TAGAALSSHHDVRKITFTGSTEIGHVIMKTIGETSLKRVTLELGGKSPLIIFXXXXXXXX 181
TAGAA++SH + KI FTGSTE+G +I + G ++LKRVTLELGGKSP IIF
Sbjct: 226 TAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYA 285
Query: 182 XXXXXXXCMTNHGQCCVAGTRTFVEASIYDTIIEKLKKLAEERIVGDPFDEKTIQGPQVD 361
N GQCC AG+R FVE SIY+ + + + A+ RIVG PFD T QGPQ+D
Sbjct: 286 VEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRIVGSPFDPTTEQGPQID 345
Query: 362 KEQFNKILDLIESGKHEGAKLVTGGNRIGNVGYFIQPTVFGDVKDNMRIAKEEIFGPVQS 541
K+Q+NKIL+LI+SG EGAKL GG +G G+FI+PTVF +V D+MRIAKEEIFGPVQ
Sbjct: 346 KKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQE 405
Query: 542 VFKFNTMEEVIERANNSDYGLGAGVFTSDINKAIMMTQALEAGSVWVNCYD 694
+ +F TM+EVIERANNSD+GL A VFT+DINKA+ ++ A++AG+VW+NCY+
Sbjct: 406 ILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYN 456
>sp|P30837|AL1B1_HUMAN Aldehyde dehydrogenase X, mitochondrial precursor (ALDH class 2)
Length = 517
Score = 275 bits (703), Expect = 8e-74
Identities = 134/232 (57%), Positives = 172/232 (74%)
Frame = +2
Query: 2 TAGAALSSHHDVRKITFTGSTEIGHVIMKTIGETSLKRVTLELGGKSPLIIFXXXXXXXX 181
TAGAA++ H DV K+ FTGSTE+GH+I K G+++LKRVTLELGGKSP I+
Sbjct: 244 TAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHA 303
Query: 182 XXXXXXXCMTNHGQCCVAGTRTFVEASIYDTIIEKLKKLAEERIVGDPFDEKTIQGPQVD 361
N GQCC AG+RTFVE SIY+ +E+ + A++R VG+PF+ T QGPQVD
Sbjct: 304 VEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVD 363
Query: 362 KEQFNKILDLIESGKHEGAKLVTGGNRIGNVGYFIQPTVFGDVKDNMRIAKEEIFGPVQS 541
KEQF ++L I+ G+ EGAKL+ GG R G G+FI+PTVFG V+D+MRIAKEEIFGPVQ
Sbjct: 364 KEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQP 423
Query: 542 VFKFNTMEEVIERANNSDYGLGAGVFTSDINKAIMMTQALEAGSVWVNCYDV 697
+FKF +EEV+ERANN+ YGL A VFT D++KA+ TQAL+AG+VWVN Y++
Sbjct: 424 LFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNI 475
>sp|Q8MI17|AL1A1_RABIT Retinal dehydrogenase 1 (RalDH1) (RALDH 1) (Aldehyde dehydrogenase
family 1 member A1) (Aldehyde dehydrogenase, cytosolic)
(ALHDII) (ALDH-E1)
Length = 496
Score = 275 bits (702), Expect = 1e-73
Identities = 131/232 (56%), Positives = 171/232 (73%)
Frame = +2
Query: 2 TAGAALSSHHDVRKITFTGSTEIGHVIMKTIGETSLKRVTLELGGKSPLIIFXXXXXXXX 181
TAGAA+SSH D+ K+ FTGSTE+G +I + G+++LKRVTLELGGKSP I+F
Sbjct: 223 TAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDNA 282
Query: 182 XXXXXXXCMTNHGQCCVAGTRTFVEASIYDTIIEKLKKLAEERIVGDPFDEKTIQGPQVD 361
+ GQCC+A +R FVE SIYD + + + A++ ++G+P + QGPQ+D
Sbjct: 283 VEFAHQGVFYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLAPEVNQGPQID 342
Query: 362 KEQFNKILDLIESGKHEGAKLVTGGNRIGNVGYFIQPTVFGDVKDNMRIAKEEIFGPVQS 541
KEQ+NKILDLIESGK EGAKL GG GN GYFIQPTVF +V D MRIAKEEIFGPVQ
Sbjct: 343 KEQYNKILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDEMRIAKEEIFGPVQQ 402
Query: 542 VFKFNTMEEVIERANNSDYGLGAGVFTSDINKAIMMTQALEAGSVWVNCYDV 697
+ KF ++++VI+RANN+ YGL AG+FT D++KA+ ++ AL+AG+VWVNCY V
Sbjct: 403 IMKFKSLDDVIKRANNTTYGLSAGIFTKDLDKAVTVSSALQAGTVWVNCYSV 454
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,672,347
Number of Sequences: 369166
Number of extensions: 1578990
Number of successful extensions: 4464
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4010
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4135
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6073541875
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)