Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_F07
(662 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase)... 50 7e-06
sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contai... 47 4e-05
sp|Q9Y5Q5|CORIN_HUMAN Atrial natriuteric peptide-converting... 45 1e-04
sp|Q9Z319|CORIN_MOUSE Atrial natriuteric peptide-converting... 45 2e-04
sp|P98158|LRP2_RAT Low-density lipoprotein receptor-related... 45 2e-04
sp|P98162|RSVR_COTJA Subgroup A Rous sarcoma virus receptor... 43 6e-04
sp|Q04833|LRP_CAEEL Low-density lipoprotein receptor-relate... 43 6e-04
sp|P01130|LDLR_HUMAN Low-density lipoprotein receptor precu... 43 6e-04
sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinas... 43 6e-04
sp|Q07954|LRP1_HUMAN Low-density lipoprotein receptor-relat... 42 0.001
>sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic mini chain; Enteropeptidase non-catalytic
heavy chain; Enteropeptidase catalytic light chain]
Length = 1034
Score = 49.7 bits (117), Expect = 7e-06
Identities = 28/66 (42%), Positives = 33/66 (50%), Gaps = 7/66 (10%)
Frame = +3
Query: 42 YLTIAAFATEDKTGTSS-----GNGCPESQPW--PCKTPGKCLSFDFICDGEPDCPDKYD 200
Y T + T DK TSS GN E P PC KC++ D CDGE +CPD D
Sbjct: 171 YSTTSPSTTSDKLTTSSPPATPGNVSIECLPGSRPCADALKCIAVDLFCDGELNCPDGSD 230
Query: 201 EDQSLC 218
ED +C
Sbjct: 231 EDSKIC 236
>sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1069
Score = 47.0 bits (110), Expect = 4e-05
Identities = 27/63 (42%), Positives = 33/63 (52%), Gaps = 2/63 (3%)
Frame = +3
Query: 36 LLYLTIAAFATEDKTGTSSGNGCPESQPW--PCKTPGKCLSFDFICDGEPDCPDKYDEDQ 209
L L+ A FAT +SG+ E QP PC C++ D CDGE +CPD DED
Sbjct: 210 LCNLSTATFAT------TSGHVSIECQPGSRPCAHAWNCVATDLFCDGEVNCPDGSDEDT 263
Query: 210 SLC 218
LC
Sbjct: 264 GLC 266
>sp|Q9Y5Q5|CORIN_HUMAN Atrial natriuteric peptide-converting enzyme (pro-ANP-converting
enzyme) (Corin) (Heart-specific serine proteinase ATC2)
(Transmembrane protease, serine 10)
Length = 1042
Score = 45.4 bits (106), Expect = 1e-04
Identities = 18/35 (51%), Positives = 20/35 (57%)
Frame = +3
Query: 99 GCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
GC E W C + +CL ICDG PDCPD DE
Sbjct: 615 GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDE 649
Score = 36.6 bits (83), Expect = 0.060
Identities = 12/27 (44%), Positives = 19/27 (70%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDEDQSLC 218
G+C++ +++CDG+ DC DK DE C
Sbjct: 353 GRCIAMEWVCDGDHDCVDKSDEVNCSC 379
Score = 35.4 bits (80), Expect = 0.13
Identities = 15/31 (48%), Positives = 18/31 (58%)
Frame = +3
Query: 126 CKTPGKCLSFDFICDGEPDCPDKYDEDQSLC 218
C T GKCL++ +CDG DC D DE C
Sbjct: 313 CHT-GKCLNYSLVCDGYDDCGDLSDEQNCDC 342
Score = 31.6 bits (70), Expect = 1.9
Identities = 24/83 (28%), Positives = 33/83 (39%), Gaps = 12/83 (14%)
Frame = +3
Query: 144 CLSFDFICDGEPDCPDKYDE------------DQSLCTAKNRPPYEVLEGFLQKYVSWLI 287
C+S D CDGE DC D DE L + + V Q+ +S L
Sbjct: 667 CVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLA 726
Query: 288 PKYLGQGSTAEITTRLIESTNAE 356
K +G G + T+LI+ E
Sbjct: 727 CKQMGLGEPS--VTKLIQEQEKE 747
Score = 30.8 bits (68), Expect = 3.3
Identities = 11/23 (47%), Positives = 15/23 (65%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDED 206
G+C+ F CDG+ DC D DE+
Sbjct: 390 GQCIPSTFQCDGDEDCKDGSDEE 412
Score = 30.4 bits (67), Expect = 4.3
Identities = 14/36 (38%), Positives = 19/36 (52%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRPPYE 245
G+C+ CDG+ DC D D D+ C K R +E
Sbjct: 590 GQCVLASRRCDGQADCDD--DSDEENCGCKERDLWE 623
>sp|Q9Z319|CORIN_MOUSE Atrial natriuteric peptide-converting enzyme (pro-ANP-converting
enzyme) (Corin) (Low density lipoprotein
receptor-related protein 4)
Length = 1113
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/35 (51%), Positives = 19/35 (54%)
Frame = +3
Query: 99 GCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
GC E W C +CL ICDG PDCPD DE
Sbjct: 683 GCKERALWECPFNKQCLKHTLICDGFPDCPDSMDE 717
Score = 35.8 bits (81), Expect = 0.10
Identities = 12/27 (44%), Positives = 19/27 (70%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDEDQSLC 218
G+C++ +++CDG+ DC DK DE C
Sbjct: 421 GRCIAAEWVCDGDHDCVDKSDEVNCSC 447
Score = 34.3 bits (77), Expect = 0.30
Identities = 13/27 (48%), Positives = 15/27 (55%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDEDQSLC 218
GKCL + +CDG DC D DE C
Sbjct: 384 GKCLHYSLLCDGYDDCGDPSDEQNCDC 410
Score = 33.1 bits (74), Expect = 0.67
Identities = 16/42 (38%), Positives = 22/42 (52%)
Frame = +3
Query: 132 TPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRPPYEVLEG 257
T G+C+ F CDG+ DC D DE+ C+ P E +G
Sbjct: 456 TSGQCIPSTFQCDGDEDCKDGSDEEN--CSDSQTPCPEGEQG 495
Score = 30.4 bits (67), Expect = 4.3
Identities = 14/36 (38%), Positives = 19/36 (52%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRPPYE 245
G+C+ CDG+ DC D D D+ C K R +E
Sbjct: 658 GRCVLGSRRCDGQADCDD--DSDEENCGCKERALWE 691
>sp|P98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 precursor
(Megalin) (Glycoprotein 330) (gp330)
Length = 4660
Score = 44.7 bits (104), Expect = 2e-04
Identities = 19/54 (35%), Positives = 28/54 (51%), Gaps = 8/54 (14%)
Frame = +3
Query: 69 EDKTGTSSGNGCPESQP--------WPCKTPGKCLSFDFICDGEPDCPDKYDED 206
+D + +GC +Q W C G+C+S D +CDG PDCP+ DE+
Sbjct: 245 DDCQDSGDEDGCESNQSHHRCYpreWACPGSGRCISIDKVCDGVPDCPEGDDEN 298
Score = 39.3 bits (90), Expect = 0.009
Identities = 21/47 (44%), Positives = 28/47 (59%)
Frame = +3
Query: 69 EDKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQ 209
E T S N C SQ + C G+C+S +++CDG+ DC D DEDQ
Sbjct: 2897 EPDTCGHSVNTCRASQ-FQCDN-GRCISGNWVCDGDNDCGDMSDEDQ 2941
Score = 36.2 bits (82), Expect = 0.079
Identities = 18/51 (35%), Positives = 24/51 (47%), Gaps = 4/51 (7%)
Frame = +3
Query: 84 TSSGNGCPESQPWP----CKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTA 224
TS CP P C+T C+ F+CDG+ DC D DE+ C +
Sbjct: 2812 TSDEKNCPPHTCPPDFTKCQTTNICVPRAFLCDGDNDCGDGSDENPIYCAS 2862
Score = 35.8 bits (81), Expect = 0.10
Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 4/53 (7%)
Frame = +3
Query: 66 TEDKTGTSSGNGCP----ESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQS 212
T D + GCP ES + C G C+ ++CD + DC D DE Q+
Sbjct: 50 TRDCLDDTDEIGCPPRSCESGLFLCPAEGTCIPSSWVCDEDKDCSDGADEQQN 102
Score = 35.0 bits (79), Expect = 0.18
Identities = 14/34 (41%), Positives = 19/34 (55%)
Frame = +3
Query: 102 CPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
CP +Q W C C++ +CDG DCP+ DE
Sbjct: 1313 CPSTQ-WQCPGYSTCINLSALCDGVFDCPNGTDE 1345
Score = 34.7 bits (78), Expect = 0.23
Identities = 16/44 (36%), Positives = 21/44 (47%)
Frame = +3
Query: 108 ESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRPP 239
ES W C +C+ + CD DC D DED S C ++ P
Sbjct: 3597 ESNEWQCANK-RCIPQSWQCDSVNDCLDNSDEDTSHCASRTCRP 3639
Score = 34.7 bits (78), Expect = 0.23
Identities = 18/43 (41%), Positives = 24/43 (55%)
Frame = +3
Query: 90 SGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLC 218
+G CP + + CK C+ +ICDGE DC D DE+ LC
Sbjct: 3840 NGTYCPAAM-FECKNH-VCIQSFWICDGENDCVDGSDEEIHLC 3880
Score = 34.3 bits (77), Expect = 0.30
Identities = 11/23 (47%), Positives = 18/23 (78%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDED 206
G+C++ +++CDG+ DC D DED
Sbjct: 232 GQCINQNWVCDGDDDCQDSGDED 254
Score = 33.9 bits (76), Expect = 0.39
Identities = 13/31 (41%), Positives = 18/31 (58%)
Frame = +3
Query: 111 SQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
S + C +P +C+ + CDGE DC D DE
Sbjct: 2867 SNEFQCLSPQRCIPSYWFCDGEADCADGSDE 2897
Score = 33.1 bits (74), Expect = 0.67
Identities = 16/33 (48%), Positives = 18/33 (54%)
Frame = +3
Query: 111 SQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQ 209
S +PC GKC+ F CDG DC D DE Q
Sbjct: 1027 SLSFPCNN-GKCVPSFFRCDGVDDCHDNSDEHQ 1058
Score = 33.1 bits (74), Expect = 0.67
Identities = 21/67 (31%), Positives = 25/67 (37%), Gaps = 7/67 (10%)
Frame = +3
Query: 72 DKTGTSSGNGCPESQP-------WPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKN 230
D S GCP P + C+ G C+ + CDG PDC DE C K
Sbjct: 1213 DCRDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTG-CVPKT 1271
Query: 231 RPPYEVL 251
P L
Sbjct: 1272 CSPTHFL 1278
Score = 33.1 bits (74), Expect = 0.67
Identities = 12/27 (44%), Positives = 17/27 (62%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDEDQSLC 218
G+C+ F+CD + DC D DE + LC
Sbjct: 3044 GRCIPRFFVCDEDNDCGDGSDEQEHLC 3070
Score = 31.6 bits (70), Expect = 1.9
Identities = 12/46 (26%), Positives = 21/46 (45%)
Frame = +3
Query: 102 CPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRPP 239
C + + C G+C+ ++C+G +C D D+ C PP
Sbjct: 2781 CNSTTEFTCSN-GRCIPLSYVCNGINNCHDNDTSDEKNCPPHTCPP 2825
Score = 31.6 bits (70), Expect = 1.9
Identities = 13/40 (32%), Positives = 20/40 (50%)
Frame = +3
Query: 84 TSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
T++ C + CKT +C+ +C+G DC D DE
Sbjct: 3674 TTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDCRDNSDE 3713
Score = 30.8 bits (68), Expect = 3.3
Identities = 12/27 (44%), Positives = 15/27 (55%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDEDQSLC 218
G C S +C+ DC D DED+ LC
Sbjct: 3565 GNCTSPQALCNARQDCADGSDEDRVLC 3591
Score = 30.4 bits (67), Expect = 4.3
Identities = 15/44 (34%), Positives = 22/44 (50%)
Frame = +3
Query: 72 DKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
D+ +G C +Q C G+C+ ++ CD DCPD DE
Sbjct: 98 DEQQNCAGTTC-SAQQMTCSN-GQCIPSEYRCDHVSDCPDGSDE 139
Score = 30.4 bits (67), Expect = 4.3
Identities = 16/47 (34%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +3
Query: 66 TEDKTGTSSGNGCPESQPWPCKTPG-KCLSFDFICDGEPDCPDKYDE 203
+++K +SG QP + P +C+S ++CDG+ DC D DE
Sbjct: 1139 SDEKNCQASGT----CQPTQFRCPDHRCISPLYVCDGDKDCADGSDE 1181
Score = 30.0 bits (66), Expect = 5.6
Identities = 12/29 (41%), Positives = 19/29 (65%)
Frame = +3
Query: 141 KCLSFDFICDGEPDCPDKYDEDQSLCTAK 227
+C+ ++CDG+ DC D DE Q+ CT +
Sbjct: 2966 RCIPQYWVCDGDADCSDALDELQN-CTMR 2993
Score = 29.6 bits (65), Expect = 7.4
Identities = 11/27 (40%), Positives = 17/27 (62%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDEDQSLC 218
G C++ D+ CD + DC D DE ++C
Sbjct: 2711 GHCINQDWKCDNDNDCGDGSDELPTVC 2737
>sp|P98162|RSVR_COTJA Subgroup A Rous sarcoma virus receptors PG800 and PG900 precursor
(Low density lipoprotein receptor-related protein)
Length = 157
Score = 43.1 bits (100), Expect = 6e-04
Identities = 23/50 (46%), Positives = 27/50 (54%), Gaps = 8/50 (16%)
Frame = +3
Query: 78 TGTSSGNG----CPESQPWPCKTP----GKCLSFDFICDGEPDCPDKYDE 203
TG SGNG CP Q + C P G+C D++CDG PDC D DE
Sbjct: 18 TGNGSGNGSLSRCPPGQ-FRCSEPPGAHGECYPQDWLCDGHPDCDDGRDE 66
>sp|Q04833|LRP_CAEEL Low-density lipoprotein receptor-related protein precursor (LRP)
Length = 4753
Score = 43.1 bits (100), Expect = 6e-04
Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 3/58 (5%)
Frame = +3
Query: 69 EDKTGTSSGNGCPES-QPW--PCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNR 233
+D +S C ++ PW C G+C+ F CDG+ DC D+ DE +LC + R
Sbjct: 3694 DDCGDSSDEQNCDKACDPWMFKCAATGRCIPRRFTCDGDDDCGDRSDEADTLCMSAER 3751
Score = 39.7 bits (91), Expect = 0.007
Identities = 17/45 (37%), Positives = 23/45 (51%)
Frame = +3
Query: 102 CPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRP 236
C + + C T GKC+ ++CD E DC D DE + C RP
Sbjct: 3833 CDDVGEFRCATSGKCIPRRWMCDTENDCGDNSDELDASCGGTTRP 3877
Score = 37.4 bits (85), Expect = 0.035
Identities = 19/45 (42%), Positives = 26/45 (57%)
Frame = +3
Query: 69 EDKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
E K G +SG C Q + C G+C+ +++CDGE DC D DE
Sbjct: 1302 EPKFGCTSGRQCSSDQ-FKCGN-GRCILNNWLCDGENDCGDGSDE 1344
Score = 36.6 bits (83), Expect = 0.060
Identities = 14/37 (37%), Positives = 19/37 (51%)
Frame = +3
Query: 126 CKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRP 236
C+ KC+ + CDG+ DC D DED C +P
Sbjct: 1108 CRNTKKCIPAQYGCDGDNDCGDYSDEDVKYCKDGQKP 1144
Score = 36.2 bits (82), Expect = 0.079
Identities = 19/55 (34%), Positives = 26/55 (47%)
Frame = +3
Query: 72 DKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRP 236
D+ S C E +PC G C++ +CDG DC D+ D+SL T P
Sbjct: 2864 DELDCPSAVACAEGT-FPCSN-GHCINQTKVCDGHNDCHDEQVSDESLATCPGLP 2916
Score = 35.8 bits (81), Expect = 0.10
Identities = 15/42 (35%), Positives = 23/42 (54%)
Frame = +3
Query: 93 GNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLC 218
GN + + C G+C+ ++CDG+ DC D DED+ C
Sbjct: 1183 GNATCAANQFSCAN-GRCIPIYWLCDGDNDCYDGTDEDKERC 1223
Score = 34.7 bits (78), Expect = 0.23
Identities = 15/36 (41%), Positives = 18/36 (50%)
Frame = +3
Query: 102 CPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQ 209
CP + W C G C+ +CDG DC D DE Q
Sbjct: 262 CPPGK-WNCPGTGHCIDQLKLCDGSKDCADGADEQQ 296
Score = 34.7 bits (78), Expect = 0.23
Identities = 16/52 (30%), Positives = 27/52 (51%)
Frame = +3
Query: 69 EDKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTA 224
ED ++ + P+ + C + G C+ + CDG+ DC D DE + CT+
Sbjct: 1260 EDSCAVTAESCTPDQ--FKCVSSGLCIPASWKCDGQQDCDDGSDEPKFGCTS 1309
Score = 34.7 bits (78), Expect = 0.23
Identities = 12/33 (36%), Positives = 18/33 (54%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRP 236
G C+ CD +PDC D DE+ + C ++ P
Sbjct: 2803 GSCILLGATCDSKPDCADASDENPNYCNTRSCP 2835
Score = 33.9 bits (76), Expect = 0.39
Identities = 14/21 (66%), Positives = 15/21 (71%)
Frame = +3
Query: 141 KCLSFDFICDGEPDCPDKYDE 203
KC+S FICDGE DC D DE
Sbjct: 3018 KCISRAFICDGEDDCGDGSDE 3038
Score = 33.5 bits (75), Expect = 0.51
Identities = 12/28 (42%), Positives = 18/28 (64%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDEDQSLCT 221
G+C+ + CDG+ DC D +DE + CT
Sbjct: 2971 GRCIPETWQCDGDNDCSDGWDETHTNCT 2998
Score = 33.1 bits (74), Expect = 0.67
Identities = 15/33 (45%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Frame = +3
Query: 144 CLSFDFICDGEPDCPDKYDEDQSLC-TAKNRPP 239
C+ F+CDG+ DC D DE S C +A+ PP
Sbjct: 3971 CIPRKFMCDGDNDCGDNSDETSSECRSAQCDPP 4003
Score = 32.7 bits (73), Expect = 0.87
Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 4/50 (8%)
Frame = +3
Query: 102 CPESQ----PWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRPP 239
CP Q + C +C+ CDG+ DC D DED TA++ P
Sbjct: 1223 CPPVQCSALQFRCANGRQCVPLRNHCDGQSDCEDGSDEDSCAVTAESCTP 1272
Score = 32.3 bits (72), Expect = 1.1
Identities = 13/31 (41%), Positives = 16/31 (51%)
Frame = +3
Query: 126 CKTPGKCLSFDFICDGEPDCPDKYDEDQSLC 218
C C+ +CDG DC DK DE+Q C
Sbjct: 2926 CPNTNICIQPADLCDGYDDCGDKADENQLFC 2956
Score = 32.0 bits (71), Expect = 1.5
Identities = 14/31 (45%), Positives = 20/31 (64%)
Frame = +3
Query: 111 SQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
S + CK G+C+ ++ CDGE DC D+ DE
Sbjct: 1058 STQFQCKN-GRCIPKEWKCDGENDCLDESDE 1087
Score = 32.0 bits (71), Expect = 1.5
Identities = 14/27 (51%), Positives = 18/27 (66%), Gaps = 1/27 (3%)
Frame = +3
Query: 141 KCLSFDFICDGEPDCPDKYDE-DQSLC 218
KC+ + CDGEPDC D DE +S+C
Sbjct: 3640 KCIPKLWYCDGEPDCRDGSDEPGESIC 3666
Score = 30.8 bits (68), Expect = 3.3
Identities = 16/56 (28%), Positives = 24/56 (42%)
Frame = +3
Query: 45 LTIAAFATEDKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQS 212
+T A +++K +S C + C +C CDG+ DC D DE S
Sbjct: 119 ITDCADGSDEKDCPASTVDCSSQNVFMCADGRQCFDVSKKCDGKYDCRDLSDEKDS 174
Score = 30.8 bits (68), Expect = 3.3
Identities = 11/31 (35%), Positives = 17/31 (54%)
Frame = +3
Query: 126 CKTPGKCLSFDFICDGEPDCPDKYDEDQSLC 218
C + +C+ C+G+ DC D DED+ C
Sbjct: 3800 CSSSYRCIPNWAFCNGQDDCRDNSDEDKQRC 3830
Score = 30.4 bits (67), Expect = 4.3
Identities = 15/57 (26%), Positives = 25/57 (43%), Gaps = 4/57 (7%)
Frame = +3
Query: 66 TEDKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSL----CTA 224
+++K S + + C +C+ ++CDG DC D DE + CTA
Sbjct: 169 SDEKDSCSRNHTACFQYQFRCADKTQCIQKSWVCDGSKDCADGSDEPDTCEFKKCTA 225
Score = 30.4 bits (67), Expect = 4.3
Identities = 18/46 (39%), Positives = 23/46 (50%)
Frame = +3
Query: 102 CPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRPP 239
C ES+ + C GKC+ +CDG C D DE Q CT + P
Sbjct: 3878 CSESE-FRCND-GKCIPGSKVCDGTIQCSDGLDESQ--CTLRRCLP 3919
Score = 29.6 bits (65), Expect = 7.4
Identities = 11/22 (50%), Positives = 14/22 (63%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDE 203
GKC+ ++ CDG DC D DE
Sbjct: 63 GKCIRTEWKCDGSGDCSDGEDE 84
>sp|P01130|LDLR_HUMAN Low-density lipoprotein receptor precursor (LDL receptor)
Length = 860
Score = 43.1 bits (100), Expect = 6e-04
Identities = 19/46 (41%), Positives = 28/46 (60%)
Frame = +3
Query: 81 GTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLC 218
GT+ G+ C E + C+ GKC+S+ ++CDG +C D DE Q C
Sbjct: 20 GTAVGDRC-ERNEFQCQD-GKCISYKWVCDGSAECQDGSDESQETC 63
Score = 33.5 bits (75), Expect = 0.51
Identities = 18/45 (40%), Positives = 21/45 (46%), Gaps = 6/45 (13%)
Frame = +3
Query: 87 SSGNGCPESQPWPCKTP------GKCLSFDFICDGEPDCPDKYDE 203
S GCP P C GKC+S F+CD + DC D DE
Sbjct: 99 SDEQGCP---PKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE 140
Score = 33.5 bits (75), Expect = 0.51
Identities = 12/23 (52%), Positives = 16/23 (69%)
Frame = +3
Query: 138 GKCLSFDFICDGEPDCPDKYDED 206
G+C+ + CDG PDC DK DE+
Sbjct: 207 GECIHSSWRCDGGPDCKDKSDEE 229
>sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1035
Score = 43.1 bits (100), Expect = 6e-04
Identities = 30/78 (38%), Positives = 36/78 (46%), Gaps = 9/78 (11%)
Frame = +3
Query: 12 LNSFFIGVLL--YLTIAAFATEDKTGTS-----SGNGCPESQPWP--CKTPGKCLSFDFI 164
LNS I L + TI+ T +K TS GN E P C KC++ D
Sbjct: 159 LNSIDITASLENFSTISPATTSEKLTTSIPLATPGNVSIECPPDSRLCADALKCIAIDLF 218
Query: 165 CDGEPDCPDKYDEDQSLC 218
CDGE +CPD DED C
Sbjct: 219 CDGELNCPDGSDEDNKTC 236
Score = 30.8 bits (68), Expect = 3.3
Identities = 18/46 (39%), Positives = 21/46 (45%), Gaps = 6/46 (13%)
Frame = +3
Query: 84 TSSGNGCPESQPWPCKTP------GKCLSFDFICDGEPDCPDKYDE 203
T G G PE PCK G+C+ +CDG P C D DE
Sbjct: 649 TGYGLGIPE----PCKEDNFQCKDGECIPLVNLCDGFPHCKDGSDE 690
>sp|Q07954|LRP1_HUMAN Low-density lipoprotein receptor-related protein 1 precursor (LRP)
(Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E
receptor) (APOER) (CD91)
Length = 4544
Score = 42.4 bits (98), Expect = 0.001
Identities = 18/53 (33%), Positives = 27/53 (50%)
Frame = +3
Query: 69 EDKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAK 227
+D T + + C + C G+C++F CDG P C DK DE S C ++
Sbjct: 2513 DDLTCRAVNSSCRAQDEFECAN-GECINFSLTCDGVPHCKDKSDEKPSYCNSR 2564
Score = 40.4 bits (93), Expect = 0.004
Identities = 16/40 (40%), Positives = 22/40 (55%)
Frame = +3
Query: 126 CKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRPPYE 245
CK G+C+ + CDGE DC D DE + C + PY+
Sbjct: 3501 CKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQ 3540
Score = 39.7 bits (91), Expect = 0.007
Identities = 19/59 (32%), Positives = 32/59 (54%)
Frame = +3
Query: 63 ATEDKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRPP 239
++++K+ + C S + CK +C+S ++CDG+ DC D DE+ A RPP
Sbjct: 1091 SSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLA-CRPP 1148
Score = 37.4 bits (85), Expect = 0.035
Identities = 16/46 (34%), Positives = 27/46 (58%)
Frame = +3
Query: 102 CPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRPP 239
CP S + C+ +C+ ++CDG+ DC + DE + C+A+ PP
Sbjct: 895 CP-SDRFKCEN-NRCIPNRWLCDGDNDCGNSEDESNATCSARTCPP 938
Score = 36.6 bits (83), Expect = 0.060
Identities = 28/72 (38%), Positives = 31/72 (43%), Gaps = 16/72 (22%)
Frame = +3
Query: 66 TEDKTGTSSGN--GCPESQPWP----CKTPGKCLSFDFICDGEPDCPDKYDE-------- 203
TED G S CPE + P C T G C + FICDG+ DC D DE
Sbjct: 3355 TEDDCGDHSDEPPDCPEFKCRPGQFQCST-GICTNPAFICDGDNDCQDNSDEANCDIHVC 3413
Query: 204 --DQSLCTAKNR 233
Q CT NR
Sbjct: 3414 LPSQFKCTNTNR 3425
Score = 36.2 bits (82), Expect = 0.079
Identities = 21/57 (36%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Frame = +3
Query: 72 DKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAK-NRPP 239
D+ G S + C +Q + C + G+C+ + CDG+ DC D DE + CT + RPP
Sbjct: 1007 DEAGCS--HSCSSTQ-FKCNS-GRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPP 1059
Score = 35.8 bits (81), Expect = 0.10
Identities = 22/61 (36%), Positives = 28/61 (45%)
Frame = +3
Query: 36 LLYLTIAAFATEDKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSL 215
LL +AA KT C Q + C+ C+S + CDGE DCPD DE +
Sbjct: 12 LLSALVAAAIDAPKT-------CSPKQ-FACRDQITCISKGWRCDGERDCPDGSDEAPEI 63
Query: 216 C 218
C
Sbjct: 64 C 64
Score = 35.0 bits (79), Expect = 0.18
Identities = 16/48 (33%), Positives = 26/48 (54%)
Frame = +3
Query: 69 EDKTGTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQS 212
++ T S CP +Q + C + G+C+ + CD + DC D+ DE S
Sbjct: 925 DESNATCSARTCPPNQ-FSCAS-GRCIPISWTCDLDDDCGDRSDESAS 970
Score = 34.3 bits (77), Expect = 0.30
Identities = 14/35 (40%), Positives = 19/35 (54%)
Frame = +3
Query: 102 CPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDED 206
CP ++P+ CK CL CDG +C D DE+
Sbjct: 3695 CPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEE 3729
Score = 32.7 bits (73), Expect = 0.87
Identities = 14/40 (35%), Positives = 20/40 (50%)
Frame = +3
Query: 84 TSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
T GC + + C+ G C+ + CDG+ DC D DE
Sbjct: 1056 TRPPGGC-HTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDE 1094
Score = 32.0 bits (71), Expect = 1.5
Identities = 14/40 (35%), Positives = 23/40 (57%)
Frame = +3
Query: 84 TSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
TS + C S + C + G+C++ +C+G+ DC D DE
Sbjct: 2898 TSPEHKCNASSQFLCSS-GRCVAEALLCNGQDDCGDSSDE 2936
Score = 32.0 bits (71), Expect = 1.5
Identities = 20/52 (38%), Positives = 25/52 (48%)
Frame = +3
Query: 81 GTSSGNGCPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRP 236
G + + C SQ + CK KC+ F + CD E DC D DE K RP
Sbjct: 3327 GRTCVSNCTASQ-FVCKND-KCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRP 3376
Score = 31.6 bits (70), Expect = 1.9
Identities = 20/60 (33%), Positives = 27/60 (45%), Gaps = 10/60 (16%)
Frame = +3
Query: 69 EDKTGTSSGNGC---PESQPWPCKTPG-------KCLSFDFICDGEPDCPDKYDEDQSLC 218
ED+ + G C P P P PG +C+ + CDG+ DC D DE +LC
Sbjct: 831 EDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALC 890
Score = 31.2 bits (69), Expect = 2.5
Identities = 14/38 (36%), Positives = 18/38 (47%)
Frame = +3
Query: 123 PCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAKNRP 236
PC+ C + ++CDG DC D DE C RP
Sbjct: 2659 PCERTSLCYAPSWVCDGANDCGDYSDERD--CPGVKRP 2694
Score = 30.0 bits (66), Expect = 5.6
Identities = 14/34 (41%), Positives = 21/34 (61%)
Frame = +3
Query: 102 CPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDE 203
C E+Q + C+ +C+S ++CDG DC D DE
Sbjct: 2734 CSEAQ-FECQNH-RCISKQWLCDGSDDCGDGSDE 2765
Score = 29.6 bits (65), Expect = 7.4
Identities = 16/42 (38%), Positives = 24/42 (57%)
Frame = +3
Query: 102 CPESQPWPCKTPGKCLSFDFICDGEPDCPDKYDEDQSLCTAK 227
C ES+ + C G+C++ + CDG+ DC D DE CT +
Sbjct: 3575 CSESE-FSCAN-GRCIAGRWKCDGDHDCADGSDEKD--CTPR 3612
Score = 29.6 bits (65), Expect = 7.4
Identities = 13/32 (40%), Positives = 15/32 (46%)
Frame = +3
Query: 144 CLSFDFICDGEPDCPDKYDEDQSLCTAKNRPP 239
C + CDGE DC D DE+ C PP
Sbjct: 3666 CKPLAWKCDGEDDCGDNSDENPEECARFVCPP 3697
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,054,592
Number of Sequences: 369166
Number of extensions: 1465440
Number of successful extensions: 5016
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4395
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5012
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5560129980
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)