Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_F01
(709 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 268 1e-71
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 268 1e-71
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 265 7e-71
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 265 1e-70
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 263 3e-70
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 262 8e-70
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 261 1e-69
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 259 5e-69
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 255 7e-68
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 255 9e-68
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 268 bits (684), Expect = 1e-71
Identities = 133/218 (61%), Positives = 153/218 (70%), Gaps = 5/218 (2%)
Frame = +2
Query: 2 SVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXX 181
SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ LVDCS
Sbjct: 117 SVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNE 176
Query: 182 XXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 358
LMD AF+Y++D G++SE YPY AT+ +CK NP V TGF DI Q E L
Sbjct: 177 GCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKAL 235
Query: 359 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GKKY 526
AVATVGP+SVAIDAGH SF YK GIY E CS+ +DHGVL VGYG + KY
Sbjct: 236 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY 295
Query: 527 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 640
W+VKNSW WG GY+KM+KD++N CGIA+ ASYP V
Sbjct: 296 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 268 bits (684), Expect = 1e-71
Identities = 133/215 (61%), Positives = 152/215 (70%), Gaps = 2/215 (0%)
Frame = +2
Query: 2 SVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXX 181
SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVD S
Sbjct: 4 SVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQGNQ 63
Query: 182 XXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 358
LMDNAF+YIK+ G++SE YPY ATD +C P K TGF DI Q E L
Sbjct: 64 GCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDI-PQREKAL 122
Query: 359 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKYWIV 535
AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+WIV
Sbjct: 123 MKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIV 182
Query: 536 KNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 640
KNSW WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 183 KNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 265 bits (678), Expect = 7e-71
Identities = 129/218 (59%), Positives = 150/218 (68%), Gaps = 5/218 (2%)
Frame = +2
Query: 2 SVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXX 181
SVDWR+KGYVTPVKNQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 117 SVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQ 176
Query: 182 XXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 358
M AF+Y+K+ G ++SE YPY A D CK P V TGFT + E L
Sbjct: 177 GCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKAL 236
Query: 359 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG----TQIGKKY 526
AVATVGP+SVA+DAGH+SFQ YKSGIY E CS+ LDHGVL VGYG KY
Sbjct: 237 MKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKY 296
Query: 527 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 640
W+VKNSW WG +GY+K++KDK N CGIAT ASYP V
Sbjct: 297 WLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 265 bits (676), Expect = 1e-70
Identities = 133/218 (61%), Positives = 151/218 (69%), Gaps = 5/218 (2%)
Frame = +2
Query: 2 SVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXX 181
SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 117 SVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNE 176
Query: 182 XXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETD 355
LMDNAFRY+KD G++SE YPY D TC P TGF D+ Q E
Sbjct: 177 GCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDL-PQREKA 235
Query: 356 LANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIGKKY 526
L AVAT+GP+SVAIDAGH SFQ YKSGIY + CS+ LDHGVL VGY GT K+
Sbjct: 236 LMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKF 295
Query: 527 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 640
WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 296 WIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 263 bits (672), Expect = 3e-70
Identities = 134/219 (61%), Positives = 151/219 (68%), Gaps = 6/219 (2%)
Frame = +2
Query: 2 SVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXX 181
SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 117 SVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQ 176
Query: 182 XXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETD 355
LMDNAF+YIKD G++SE YPY ATD +C P TGF DI Q E
Sbjct: 177 GCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDI-PQREKA 235
Query: 356 LANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKK 523
L AVATVGP+SVAIDAGH SFQ YKSGIY + CS LDHGVL VGYG + K
Sbjct: 236 LMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNK 295
Query: 524 YWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 640
+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 296 FWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 262 bits (669), Expect = 8e-70
Identities = 127/215 (59%), Positives = 152/215 (70%), Gaps = 2/215 (0%)
Frame = +2
Query: 2 SVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXX 181
SVDWR KG VT VK+Q CGSCW+FS+TG+LEGQ+FRK+ L+S SEQ LVDCS
Sbjct: 127 SVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNN 186
Query: 182 XXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 358
LMDNAFRYIKD G I++E YPY A D +C N + GFTDI +E +
Sbjct: 187 GCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKM 246
Query: 359 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIV 535
A AVATVGPVSVAIDA H SFQ Y G+YNE C LDHGVL VG+GT + G+ YW+V
Sbjct: 247 AEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLV 306
Query: 536 KNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 640
KNSW TWG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 307 KNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 261 bits (667), Expect = 1e-69
Identities = 122/213 (57%), Positives = 156/213 (73%), Gaps = 1/213 (0%)
Frame = +2
Query: 5 VDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXX 184
VDWR KG VTPVK+Q QCGSCW+FS TGSLEGQ+F K LIS +EQQLVDCS
Sbjct: 111 VDWRTKGAVTPVKDQGQCGSCWAFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQG 170
Query: 185 XXXXLMDNAFRYIK-DQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLA 361
M++AF YIK + GI++E YPY A DG+C+ + + + C+G T+I S +ET L
Sbjct: 171 CNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQ 230
Query: 362 NAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKN 541
AV +GP+SV IDA H+SFQ Y SG+Y E SCS + LDH VLAVGYG++ G+ +W+VKN
Sbjct: 231 QAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKN 290
Query: 542 SWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 640
SW +WG++GYIKMS+++ N CGIAT+ASYPLV
Sbjct: 291 SWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 259 bits (662), Expect = 5e-69
Identities = 127/215 (59%), Positives = 149/215 (69%), Gaps = 2/215 (0%)
Frame = +2
Query: 2 SVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXX 181
SVDWR+ G VT VK+Q CGSCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS
Sbjct: 125 SVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNN 184
Query: 182 XXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 358
LMDNAFRYIKD G I++E YPY D +C N + I TGF DI +E +
Sbjct: 185 GCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKM 244
Query: 359 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIV 535
AVAT+GPVSVAIDA H SFQLY G+YNE C LDHGVL VGYGT + G YW+V
Sbjct: 245 KKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLV 304
Query: 536 KNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 640
KNSW TWGE GYIKM++++ NQCGIAT +SYP V
Sbjct: 305 KNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 255 bits (652), Expect = 7e-68
Identities = 128/219 (58%), Positives = 151/219 (68%), Gaps = 6/219 (2%)
Frame = +2
Query: 2 SVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXX 181
SVDWR+KGYVT VKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 117 SVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQ 176
Query: 182 XXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETD 355
LMDNAF+Y+KD G+++E YPY + +C P TGF DI Q E
Sbjct: 177 GCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDI-PQREKA 235
Query: 356 LANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKK 523
L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K
Sbjct: 236 LMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSK 295
Query: 524 YWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 640
+WIVKNSW WG +GY+KM+KD+ N CGI+T ASYP V
Sbjct: 296 FWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 255 bits (651), Expect = 9e-68
Identities = 123/213 (57%), Positives = 153/213 (71%), Gaps = 1/213 (0%)
Frame = +2
Query: 5 VDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXX 184
VDWR K VTPVK+Q+QCGSCW+FSATG+LEGQ+F KN+ L+S SEQQLVDCS
Sbjct: 110 VDWRTKALVTPVKDQEQCGSCWAFSATGALEGQHFLKNDELVSLSEQQLVDCSTDYGNDG 169
Query: 185 XXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLA 361
M +AF YIKD G I++E YPY A D +C+ + + I CTG ++Q E L
Sbjct: 170 CGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEEA-LQ 228
Query: 362 NAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKN 541
AV+ VGP+SVAIDA H SFQ Y SG+Y E++CS T LDHGVLAVGYGT+ K YW+VKN
Sbjct: 229 EAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKN 288
Query: 542 SWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 640
SW +WG++GYIKMS+++ N CGIA+ SYP V
Sbjct: 289 SWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,027,040
Number of Sequences: 369166
Number of extensions: 1468601
Number of successful extensions: 4737
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4122
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4266
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6219306880
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)