Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_E23
(806 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 85 3e-16
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 82 1e-15
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 79 1e-14
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 76 9e-14
sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precu... 74 4e-13
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 74 5e-13
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 70 9e-12
sp||P09648_1 [Segment 1 of 2] Cathepsin L [Contains: Cathep... 68 3e-11
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 68 3e-11
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 67 6e-11
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 84.7 bits (208), Expect = 3e-16
Identities = 72/221 (32%), Positives = 107/221 (48%), Gaps = 4/221 (1%)
Frame = +1
Query: 4 YLPPLNIDNLPDSVDWRTKGYVTNVENAQHDPH*P*FLTFVTCWAFSTTGSLEGQHFRKH 183
++ P ++ LP SVDWRTKG VT V++ H +CWAFS+TG+LEGQHFRK
Sbjct: 116 FISPAHV-TLPKSVDWRTKGAVTAVKDQGHCG---------SCWAFSSTGALEGQHFRKS 165
Query: 184 KVLQNISETTISRLCYKKF---WL*WWMDEYSF*IYFKPWNRIRKIIIHTKQNKEIVCLI 354
VL ++SE + C K+ + + +F Y K I + + + C
Sbjct: 166 GVLVSLSEQNLVD-CSTKYGNNGCNGGLMDNAF-RYIKDNGGIDTEKSYPYEAIDDSCHF 223
Query: 355 NQKLLQIC-KGFQNINSCNEKDLAVAVATVGPISVAIDVGYSFSTIQTRCFTMKLNVILQ 531
N+ + +GF +I +EK +A AVATVGP+SVAID + + + Q
Sbjct: 224 NKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQ 283
Query: 532 YKIMLFLVVGYGVENGT*ILG*LKTVGVHPWGMNGYIKNVK 654
LVVG+G + +K WG G+IK ++
Sbjct: 284 NLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLR 324
Score = 51.2 bits (121), Expect = 3e-06
Identities = 58/190 (30%), Positives = 80/190 (42%), Gaps = 24/190 (12%)
Frame = +2
Query: 206 KQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GIESER*LSIPSKTRKLCV**IKSCCKF 376
+Q LVDC TK N+GCNGG M+ AF YI + GI++E+ S P + I C F
Sbjct: 173 EQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEK--SYPYEA-------IDDSCHF 223
Query: 377 VKDFKI*TVVTKKI*LLLSPRLDRFQWQ*MWATV-------------FQQYKQGVLL*S* 517
K TV P+ D + ATV FQ Y +GV
Sbjct: 224 NKG----TVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGV----- 274
Query: 518 M*SYNTKSCCSL*LDTVL--------KMGHKYWAS*KQLGSIPGA*MDI*KMSKDRDNNC 673
YN C + LD + + G YW G+ G KM ++++N C
Sbjct: 275 ---YNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGD-KGFIKMLRNKENQC 330
Query: 674 GIATTAKFPL 703
GIA+ + +PL
Sbjct: 331 GIASASSYPL 340
Score = 36.2 bits (82), Expect = 0.11
Identities = 14/18 (77%), Positives = 16/18 (88%)
Frame = -1
Query: 128 VTNVKNQGQCGSCWAFST 75
VT VK+QG CGSCWAFS+
Sbjct: 136 VTAVKDQGHCGSCWAFSS 153
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 82.4 bits (202), Expect = 1e-15
Identities = 70/218 (32%), Positives = 103/218 (47%), Gaps = 4/218 (1%)
Frame = +1
Query: 4 YLPPLNIDNLPDSVDWRTKGYVTNVENAQHDPH*P*FLTFVTCWAFSTTGSLEGQHFRKH 183
Y+PP ++ +P SVDWR G VT V++ H +CWAFS+TG+LEGQHFRK
Sbjct: 114 YIPPAHV-TVPKSVDWREHGAVTGVKDQGHCG---------SCWAFSSTGALEGQHFRKA 163
Query: 184 KVLQNISETTISRLCYKKF---WL*WWMDEYSF*IYFKPWNRIRKIIIHTKQNKEIVCLI 354
VL ++SE + C K+ + + +F Y K I + + + C
Sbjct: 164 GVLVSLSEQNLVD-CSTKYGNNGCNGGLMDNAF-RYIKDNGGIDTEKSYPYEGIDDSCHF 221
Query: 355 NQKLLQIC-KGFQNINSCNEKDLAVAVATVGPISVAIDVGYSFSTIQTRCFTMKLNVILQ 531
N+ + GF +I +E+ + AVAT+GP+SVAID + + + + Q
Sbjct: 222 NKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQ 281
Query: 532 YKIMLFLVVGYGVENGT*ILG*LKTVGVHPWGMNGYIK 645
LVVGYG + +K WG GYIK
Sbjct: 282 NLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIK 319
Score = 51.2 bits (121), Expect = 3e-06
Identities = 58/189 (30%), Positives = 82/189 (43%), Gaps = 24/189 (12%)
Frame = +2
Query: 206 KQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GIESER*LSIPSKTRKLCV**IKSCCKF 376
+Q LVDC TK N+GCNGG M+ AF YI + GI++E+ S P + I C F
Sbjct: 171 EQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEK--SYPYEG-------IDDSCHF 221
Query: 377 VKDFKI*TVVTKKI*LLLSPRLDRFQWQ*MWATV-------------FQQYKQGVLL*S* 517
K T+ + P D + + AT+ FQ Y +GV
Sbjct: 222 NKA----TIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGV----- 272
Query: 518 M*SYNTKSCCSL*LD-TVLKMGH-------KYWAS*KQLGSIPGA*MDI*KMSKDRDNNC 673
YN C LD VL +G+ YW G+ G KM+++++N C
Sbjct: 273 ---YNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGE-QGYIKMARNQNNQC 328
Query: 674 GIATTAKFP 700
GIAT + +P
Sbjct: 329 GIATASSYP 337
Score = 37.0 bits (84), Expect = 0.064
Identities = 14/18 (77%), Positives = 16/18 (88%)
Frame = -1
Query: 128 VTNVKNQGQCGSCWAFST 75
VT VK+QG CGSCWAFS+
Sbjct: 134 VTGVKDQGHCGSCWAFSS 151
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 79.0 bits (193), Expect = 1e-14
Identities = 69/205 (33%), Positives = 92/205 (44%), Gaps = 4/205 (1%)
Frame = +1
Query: 43 VDWRTKGYVTNVENAQHDPH*P*FLTFVTCWAFSTTGSLEGQHFRKHKVLQNISETTI-- 216
VDWRTKG VT V++ +CWAFSTTGSLEGQHF K L +++E +
Sbjct: 111 VDWRTKGAVTPVKDQGQCG---------SCWAFSTTGSLEGQHFLKTGSLISLAEQQLVD 161
Query: 217 -SRLCYKKFWL*WWMDEYSF*IYFKPWNRIRKIIIHTKQNKEIVCLI-NQKLLQICKGFQ 390
SR + WM++ Y K N I + + ++ C + + C G
Sbjct: 162 CSRPYGPQGCNGGWMNDAF--DYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHT 219
Query: 391 NINSCNEKDLAVAVATVGPISVAIDVGYSFSTIQTRCFTMKLNVILQYKIMLFLVVGYGV 570
NI S +E L AV +GPISV ID +S + + + Y L VGYG
Sbjct: 220 NIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGS 279
Query: 571 ENGT*ILG*LKTVGVHPWGMNGYIK 645
E G +K WG GYIK
Sbjct: 280 EGGQ-DFWLVKNSWATSWGDAGYIK 303
Score = 39.7 bits (91), Expect = 0.010
Identities = 16/18 (88%), Positives = 17/18 (94%)
Frame = -1
Query: 128 VTNVKNQGQCGSCWAFST 75
VT VK+QGQCGSCWAFST
Sbjct: 119 VTPVKDQGQCGSCWAFST 136
Score = 35.8 bits (81), Expect = 0.14
Identities = 14/20 (70%), Positives = 18/20 (90%)
Frame = +2
Query: 644 KMSKDRDNNCGIATTAKFPL 703
KMS++R+NNCGIAT A +PL
Sbjct: 303 KMSRNRNNNCGIATVASYPL 322
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 76.3 bits (186), Expect = 9e-14
Identities = 76/234 (32%), Positives = 103/234 (44%), Gaps = 20/234 (8%)
Frame = +1
Query: 13 PLNIDNLPDSVDWRTKGYVTNVENAQHDPH*P*FLTFVTCWAFSTTGSLEGQHFRKHKVL 192
PL +D LP SVDWR KGYVT V+N + +CWAFS TG+LEGQ FRK L
Sbjct: 109 PLFLD-LPKSVDWRKKGYVTPVKNQKQCG---------SCWAFSATGALEGQMFRKTGKL 158
Query: 193 QNISETTI--------SRLCYKKFWL*WWM---------DEYSF*IYFKPWNRIRKIIIH 321
++SE + ++ C F + E S+ P+ + +I +
Sbjct: 159 VSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESY-----PYVAVDEICKY 213
Query: 322 TKQNKEIVCLINQKLLQICKGFQNINSCNEKDLAVAVATVGPISVAIDVGYSFSTIQTRC 501
+N + N GF + EK L AVATVGPISVA+D G+S
Sbjct: 214 RPENS----VAND------TGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSG 263
Query: 502 FTMKLNVILQYKIMLFLVVGYGVE---NGT*ILG*LKTVGVHPWGMNGYIKNVK 654
+ + + LVVGYG E + +K WG NGY+K K
Sbjct: 264 IYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAK 317
Score = 46.2 bits (108), Expect = 1e-04
Identities = 56/192 (29%), Positives = 85/192 (44%), Gaps = 27/192 (14%)
Frame = +2
Query: 206 KQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GIESER*LSIPSKTRKLCV**IKSCCKF 376
+Q LVDC N GCNGG+M AF+Y+ + G++SE S P + CK+
Sbjct: 163 EQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEE--SYPYVA-------VDEICKY 213
Query: 377 VKDFKI*TVVTKKI*LLLSPRLDRFQWQ*MWATV-------------FQQYKQGVLL*S* 517
+ +V +++P ++ + + ATV FQ YK G+
Sbjct: 214 RPEN---SVANDTGFTVVAPGKEKALMKAV-ATVGPISVAMDAGHSSFQFYKSGI----- 264
Query: 518 M*SYNTKSCCSL*LD-TVLKMGH----------KYWAS*KQLGSIPGA*MDI*KMSKDRD 664
Y C S LD VL +G+ KYW G G+ + K++KD++
Sbjct: 265 ---YFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYV-KIAKDKN 320
Query: 665 NNCGIATTAKFP 700
N+CGIAT A +P
Sbjct: 321 NHCGIATAASYP 332
Score = 37.4 bits (85), Expect = 0.049
Identities = 15/18 (83%), Positives = 16/18 (88%)
Frame = -1
Query: 131 HVTNVKNQGQCGSCWAFS 78
+VT VKNQ QCGSCWAFS
Sbjct: 125 YVTPVKNQKQCGSCWAFS 142
>sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precursor
Length = 322
Score = 74.3 bits (181), Expect = 4e-13
Identities = 68/221 (30%), Positives = 98/221 (44%), Gaps = 14/221 (6%)
Frame = +1
Query: 25 DNLPDS--VDWRTKGYVTNVENAQHDPH*P*FLTFVTCWAFSTTGSLEGQHFRKHKVLQN 198
D P+S VDWRTKG VT V++ +CWAFSTTG +EGQHF K L +
Sbjct: 101 DAAPESTEVDWRTKGAVTPVKDQGQCG---------SCWAFSTTGGIEGQHFLKTGRLVS 151
Query: 199 ISETTISRLC----YKKFWL*WWMDEYSF*IYFKPWNRIRKIIIHTKQNKEIVCLINQKL 366
+SE + Y + W++ +Y + + + + ++ C N
Sbjct: 152 LSEQQLVDCAGGSYYNQGCNGGWVERAI--MYVRDNGGVDTESSYPYEARDNTCRFNSNT 209
Query: 367 L-QICKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFSTIQT------RCFTMKLNV 522
+ C G+ I +E L A +GPISVAID + SF + T C + +L+
Sbjct: 210 IGATCTGYVGIAQGSESALKTATRDIGPISVAIDASHRSFQSYYTGVYYEPSCSSSQLDH 269
Query: 523 ILQYKIMLFLVVGYGVENGT*ILG*LKTVGVHPWGMNGYIK 645
+ L VGYG E G +K WG +GYIK
Sbjct: 270 AV-------LAVGYGSEGGQ-DFWLVKNSWATSWGESGYIK 302
Score = 42.0 bits (97), Expect = 0.002
Identities = 55/192 (28%), Positives = 79/192 (41%), Gaps = 27/192 (14%)
Frame = +2
Query: 206 KQQLVDCVTK---NSGCNGGWMNIAFEYISSHG-IESER*LSIPSKTRKLCV**IKSCCK 373
+QQLVDC N GCNGGW+ A Y+ +G +++E S P + R + C+
Sbjct: 154 EQQLVDCAGGSYYNQGCNGGWVERAIMYVRDNGGVDTES--SYPYEARD-------NTCR 204
Query: 374 FVKDFKI*TVVTKKI*LL----------------LSPRLDRFQWQ*MWATVFQQYKQGVL 505
F + I T + + +S +D FQ Y GV
Sbjct: 205 FNSN-TIGATCTGYVGIAQGSESALKTATRDIGPISVAIDASHRS------FQSYYTGV- 256
Query: 506 L*S*M*SYNTKSCCSL*LD-TVLKMGH------KYWAS*KQLGSIPGA*MDI*KMSKDRD 664
Y SC S LD VL +G+ +W + G I KM+++R+
Sbjct: 257 -------YYEPSCSSSQLDHAVLAVGYGSEGGQDFWLVKNSWATSWGESGYI-KMARNRN 308
Query: 665 NNCGIATTAKFP 700
NNCGIAT A +P
Sbjct: 309 NNCGIATDACYP 320
Score = 39.7 bits (91), Expect = 0.010
Identities = 16/18 (88%), Positives = 17/18 (94%)
Frame = -1
Query: 128 VTNVKNQGQCGSCWAFST 75
VT VK+QGQCGSCWAFST
Sbjct: 117 VTPVKDQGQCGSCWAFST 134
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 73.9 bits (180), Expect = 5e-13
Identities = 72/213 (33%), Positives = 94/213 (44%), Gaps = 6/213 (2%)
Frame = +1
Query: 34 PDSVDWRTKGYVTNVENAQHDPH*P*FLTFVTCWAFSTTGSLEGQHFRKHKVLQNISETT 213
P SVDWR KGYVT V+N +CWAFS TG+LEGQ FRK L ++SE
Sbjct: 115 PRSVDWREKGYVTPVKNQGQCG---------SCWAFSATGALEGQMFRKTGRLISLSEQN 165
Query: 214 ISRLC--YKKFWL*WWMDEYSF*IYFKPWNRIRKIIIHTKQNKEIVCLINQKL-LQICKG 384
+ + +Y+F Y + + + + E C N K + G
Sbjct: 166 LVDCSGPQGNEGCNGGLMDYAF-QYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTG 224
Query: 385 FQNINSCNEKDLAVAVATVGPISVAIDVGYSFSTIQTRCFTMKLNVILQYKIMLFLVVGY 564
F +I EK L AVATVGPISVAID G+ + + + LVVGY
Sbjct: 225 FVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGY 283
Query: 565 G---VENGT*ILG*LKTVGVHPWGMNGYIKNVK 654
G E+ +K WGM GY+K K
Sbjct: 284 GFESTESDNNKYWLVKNSWGEEWGMGGYVKMAK 316
Score = 44.3 bits (103), Expect = 4e-04
Identities = 55/192 (28%), Positives = 82/192 (42%), Gaps = 27/192 (14%)
Frame = +2
Query: 206 KQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GIESER*LSIPSKTRKLCV**IKSCCKF 376
+Q LVDC N GCNGG M+ AF+Y+ + G++SE S P + + CK+
Sbjct: 163 EQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEE--SYPYEA-------TEESCKY 213
Query: 377 VKDFKI*TVVTKKI*LLLSPRLDRFQWQ*MWATV-------------FQQYKQGVLL*S* 517
+ V + P+ ++ + + ATV F YK+G+
Sbjct: 214 NPKYS----VANDTGFVDIPKQEKALMKAV-ATVGPISVAIDAGHESFLFYKEGI----- 263
Query: 518 M*SYNTKSCCSL*LD-TVLKMGH----------KYWAS*KQLGSIPGA*MDI*KMSKDRD 664
Y C S +D VL +G+ KYW G G + KM+KDR
Sbjct: 264 ---YFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYV-KMAKDRR 319
Query: 665 NNCGIATTAKFP 700
N+CGIA+ A +P
Sbjct: 320 NHCGIASAASYP 331
Score = 40.4 bits (93), Expect = 0.006
Identities = 16/18 (88%), Positives = 17/18 (94%)
Frame = -1
Query: 131 HVTNVKNQGQCGSCWAFS 78
+VT VKNQGQCGSCWAFS
Sbjct: 125 YVTPVKNQGQCGSCWAFS 142
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 69.7 bits (169), Expect = 9e-12
Identities = 71/212 (33%), Positives = 90/212 (42%), Gaps = 4/212 (1%)
Frame = +1
Query: 31 LPDSVDWRTKGYVTNVENAQHDPH*P*FLTFVTCWAFSTTGSLEGQHFRKHKVLQNISET 210
+P SVDW KGYVT V+N +CWAFS TG+LEGQ FRK L ++SE
Sbjct: 1 VPKSVDWTKKGYVTPVKNQGQCG---------SCWAFSATGALEGQMFRKTGKLVSLSEQ 51
Query: 211 TI---SRLCYKKFWL*WWMDEYSF*IYFKPWNRIRKIIIHTKQNKEIVCLINQKLLQI-C 378
+ SR + MD Y K + + + + C +
Sbjct: 52 NLVDSSRPQGNQGCNGGLMDNAF--QYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKD 109
Query: 379 KGFQNINSCNEKDLAVAVATVGPISVAIDVGYSFSTIQTRCFTMKLNVILQYKIMLFLVV 558
GF +I EK L AVATVGPISVAID G+S + + LVV
Sbjct: 110 TGFVDIPQ-REKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVV 168
Query: 559 GYGVENGT*ILG*LKTVGVHPWGMNGYIKNVK 654
GYG E +K WG GY+K K
Sbjct: 169 GYGFEGTNNKFWIVKNSWGPEWGNKGYVKMAK 200
Score = 43.1 bits (100), Expect = 9e-04
Identities = 55/189 (29%), Positives = 82/189 (43%), Gaps = 24/189 (12%)
Frame = +2
Query: 206 KQQLVDCVTK--NSGCNGGWMNIAFEYISSHG-IESER*LSIPSKTRKLCV**IKSCCKF 376
+Q LVD N GCNGG M+ AF+YI +G ++SE S P + + C +
Sbjct: 50 EQNLVDSSRPQGNQGCNGGLMDNAFQYIKENGGLDSEE--SYPYEATD-------TSCNY 100
Query: 377 VKDFKI*TVVTKKI*LLLSPRLDRFQWQ*MWATV-------------FQQYKQGVLL*S* 517
++ K + P+ ++ + + ATV FQ YK G+
Sbjct: 101 KPEYS----AAKDTGFVDIPQREKALMKAV-ATVGPISVAIDAGHSSFQFYKSGI----- 150
Query: 518 M*SYNTKSCCSL*LDT-VLKMGH-------KYWAS*KQLGSIPGA*MDI*KMSKDRDNNC 673
Y C S LD VL +G+ K+W G G + KM+KD++N+C
Sbjct: 151 ---YYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYV-KMAKDQNNHC 206
Query: 674 GIATTAKFP 700
GIAT A +P
Sbjct: 207 GIATAASYP 215
Score = 40.4 bits (93), Expect = 0.006
Identities = 16/18 (88%), Positives = 17/18 (94%)
Frame = -1
Query: 131 HVTNVKNQGQCGSCWAFS 78
+VT VKNQGQCGSCWAFS
Sbjct: 12 YVTPVKNQGQCGSCWAFS 29
>sp||P09648_1 [Segment 1 of 2] Cathepsin L [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 176
Score = 68.2 bits (165), Expect = 3e-11
Identities = 61/183 (33%), Positives = 85/183 (46%), Gaps = 3/183 (1%)
Frame = +1
Query: 34 PDSVDWRTKGYVTNVENAQHDPH*P*FLTFVTCWAFSTTGSLEGQHFRKHKVLQNISETT 213
P SVDWR KGYVT V++ +CWAFSTTG+LEGQHFR L ++SE
Sbjct: 2 PRSVDWREKGYVTPVKDQGQCG---------SCWAFSTTGALEGQHFRTKGKLVSLSEQN 52
Query: 214 I---SRLCYKKFWL*WWMDEYSF*IYFKPWNRIRKIIIHTKQNKEIVCLINQKLLQICKG 384
+ SR + MD+ + + +T ++ E + G
Sbjct: 53 LVDCSRPEGNQGCNGGLMDQAFQYVQDNGGIDSEESYPYTAKDDEDCRYKAEYNAANDTG 112
Query: 385 FQNINSCNEKDLAVAVATVGPISVAIDVGYSFSTIQTRCFTMKLNVILQYKIMLFLVVGY 564
F +I +E+ L AVA+VGP+SVAID G+S + + + LVVGY
Sbjct: 113 FVDIPQGHERALMKAVASVGPVSVAIDAGHSSFQFYQSGIYYEPDCSSEDLDHGVLVVGY 172
Query: 565 GVE 573
G E
Sbjct: 173 GFE 175
Score = 40.4 bits (93), Expect = 0.006
Identities = 16/19 (84%), Positives = 18/19 (94%)
Frame = -1
Query: 131 HVTNVKNQGQCGSCWAFST 75
+VT VK+QGQCGSCWAFST
Sbjct: 12 YVTPVKDQGQCGSCWAFST 30
Score = 37.4 bits (85), Expect = 0.049
Identities = 21/50 (42%), Positives = 29/50 (58%), Gaps = 3/50 (6%)
Frame = +2
Query: 206 KQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GIESER*LSIPSKTRKLC 346
+Q LVDC N GCNGG M+ AF+Y+ + GI+SE +K + C
Sbjct: 50 EQNLVDCSRPEGNQGCNGGLMDQAFQYVQDNGGIDSEESYPYTAKDDEDC 99
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 67.8 bits (164), Expect = 3e-11
Identities = 70/223 (31%), Positives = 92/223 (41%), Gaps = 15/223 (6%)
Frame = +1
Query: 31 LPDSVDWRTKGYVTNVENAQHDPH*P*FLTFVTCWAFSTTGSLEGQHFRKHKVLQNISET 210
+P SVDWR KGYVT V+N +CWAFS TG+LEGQ FRK L ++SE
Sbjct: 114 IPKSVDWREKGYVTPVKNQGQCG---------SCWAFSATGALEGQMFRKTGKLVSLSEQ 164
Query: 211 TI---SRLCYKKFWL*WWMDEYSF*IYFKPWNRIRKIIIHTKQNKEIVCLINQKLLQICK 381
+ SR + MD N R + + + E + + C
Sbjct: 165 NLVDCSRAQGNEGCNGGLMD-----------NAFRYVKDNGGLDSEESYPYLGRDTETCN 213
Query: 382 GFQNINSCN----------EKDLAVAVATVGPISVAIDVGYSFSTIQTRCFTMKLNVILQ 531
++ N EK L AVAT+GPISVAID G+ + +
Sbjct: 214 YKPECSAANDTGFVDLPQREKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSK 273
Query: 532 YKIMLFLVVGYGVE--NGT*ILG*LKTVGVHPWGMNGYIKNVK 654
LVVGYG E + +K WG NGY+K K
Sbjct: 274 DLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAK 316
Score = 47.0 bits (110), Expect = 6e-05
Identities = 54/186 (29%), Positives = 78/186 (41%), Gaps = 21/186 (11%)
Frame = +2
Query: 206 KQQLVDC--VTKNSGCNGGWMNIAFEYISSH-GIESER*LSIPSKTRKLCV**IKSCCKF 376
+Q LVDC N GCNGG M+ AF Y+ + G++SE + + C K C
Sbjct: 163 EQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCN--YKPECSA 220
Query: 377 VKDFKI*TVVTKKI*LL--------LSPRLDRFQWQ*MWATVFQQYKQGVLL*S*M*SYN 532
D + ++ L+ +S +D FQ YK G+ Y
Sbjct: 221 ANDTGFVDLPQREKALMKAVATLGPISVAIDAGHQS------FQFYKSGI--------YF 266
Query: 533 TKSCCSL*LD-TVLKMGH---------KYWAS*KQLGSIPGA*MDI*KMSKDRDNNCGIA 682
C S LD VL +G+ K+W G G + KM+KD++N+CGIA
Sbjct: 267 DPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYV-KMAKDQNNHCGIA 325
Query: 683 TTAKFP 700
T A +P
Sbjct: 326 TAASYP 331
Score = 40.4 bits (93), Expect = 0.006
Identities = 16/18 (88%), Positives = 17/18 (94%)
Frame = -1
Query: 131 HVTNVKNQGQCGSCWAFS 78
+VT VKNQGQCGSCWAFS
Sbjct: 125 YVTPVKNQGQCGSCWAFS 142
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 67.0 bits (162), Expect = 6e-11
Identities = 55/211 (26%), Positives = 96/211 (45%), Gaps = 6/211 (2%)
Frame = +1
Query: 31 LPDSVDWRTKGYVTNVENAQHDPH*P*FLTFVTCWAFSTTGSLEGQHFRKHKVLQNISET 210
+PD +DWR GYVT V++ + +CWAFSTTG++EGQ+ + + + SE
Sbjct: 108 VPDKIDWRESGYVTEVKDQGNCG---------SCWAFSTTGTMEGQYMKNERTSISFSEQ 158
Query: 211 TISRLCYKKFWL*WWMDEYSF*IYFKPWNRIRKIIIHTKQNKEIVCLINQ----KLLQIC 378
+ W + S + + +++ + T+ + + Q K L +
Sbjct: 159 QLVDCSGP-----WGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVA 213
Query: 379 K--GFQNINSCNEKDLAVAVATVGPISVAIDVGYSFSTIQTRCFTMKLNVILQYKIMLFL 552
K G+ ++S +E +L V P +VA+DV F ++ + + L+ + L
Sbjct: 214 KVTGYYTVHSGSEVELKNLVGARRPAAVAVDVESDFMMYRSGIYQSQTCSPLRVNHAV-L 272
Query: 553 VVGYGVENGT*ILG*LKTVGVHPWGMNGYIK 645
VGYG + GT + G + WG GYI+
Sbjct: 273 AVGYGTQGGTDYWIVKNSWGTY-WGERGYIR 302
Score = 39.3 bits (90), Expect = 0.013
Identities = 15/19 (78%), Positives = 17/19 (89%)
Frame = -1
Query: 131 HVTNVKNQGQCGSCWAFST 75
+VT VK+QG CGSCWAFST
Sbjct: 119 YVTEVKDQGNCGSCWAFST 137
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,936,417
Number of Sequences: 369166
Number of extensions: 2077509
Number of successful extensions: 6027
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5099
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5828
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7666799535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)