Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_C23
(766 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00458|IFRD1_HUMAN Interferon-related developmental regu... 98 2e-20
sp|P19182|IFRD1_MOUSE Interferon-related developmental regu... 98 3e-20
sp|Q5S1U6|IFRD1_PIG Interferon-related developmental regula... 98 3e-20
sp|Q12894|IFRD2_HUMAN Interferon-related developmental regu... 96 8e-20
sp|P20695|IFRD1_RAT Interferon-related developmental regula... 95 2e-19
sp|Q8RA32|DPO3_THETN DNA polymerase III polC-type (PolIII) 39 0.020
sp|O13290|DYHC_SCHPO Dynein heavy chain, cytosolic (DYHC) 38 0.034
sp|Q92878|RAD50_HUMAN DNA repair protein RAD50 (hRAD50) 35 0.22
sp|Q97I19|MUTS_CLOAB DNA mismatch repair protein mutS 35 0.29
sp|Q9JIL8|RAD50_RAT DNA repair protein RAD50 33 0.65
>sp|O00458|IFRD1_HUMAN Interferon-related developmental regulator 1 (Nerve growth
factor-inducible protein PC4)
Length = 451
Score = 98.2 bits (243), Expect = 2e-20
Identities = 65/206 (31%), Positives = 108/206 (52%)
Frame = +1
Query: 37 LEITAIRCWSLLFTILPEHMLETIGSDILCLSLELLTRDSVDVRIRAGECLALIFGRLRD 216
L I+++ W+LL TI P + ++ LL+ D V++RI AGE LAL+F R
Sbjct: 240 LHISSLLAWTLLLTICPINEVKKKLEMHFHKLPSLLSCDDVNMRIAAGESLALLFELARG 299
Query: 217 EIDPEFVCDDYVTLLDQVRNLSVDGRKARNRNERAKQRHEFREIVQSIESYSSKFSNVNI 396
I+ +F +D +L +R L+ DG K R + ++ KQR FR++++++E F I
Sbjct: 300 -IESDFFYEDMESLTQMLRALATDGNKHRAKVDKRKQRSVFRDVLRAVEERD--FPTETI 356
Query: 397 QFGLETLMITNWSKQIQYDFLLKILQDGINKQLQLNIDIREIFDLGEPIDVNKMKLILRK 576
+FG E + I W K+ YD ++L G+ LQ N +R +F+LG P+ ++ L K
Sbjct: 357 KFGPERMYIDCWVKKHTYDTFKEVLGSGMQYHLQSNEFLRNVFELGPPVMLDAATLKTMK 416
Query: 577 FRKDEKEKLYKNKERENKIARNKERN 654
+ E+ + AR+K R+
Sbjct: 417 ISRFERHLYNSAAFKARTKARSKCRD 442
>sp|P19182|IFRD1_MOUSE Interferon-related developmental regulator 1 (Nerve growth
factor-inducible protein PC4) (TPA-induced sequence 7)
(TIS7 protein)
Length = 449
Score = 97.8 bits (242), Expect = 3e-20
Identities = 63/206 (30%), Positives = 109/206 (52%)
Frame = +1
Query: 37 LEITAIRCWSLLFTILPEHMLETIGSDILCLSLELLTRDSVDVRIRAGECLALIFGRLRD 216
L I+++ W+LL TI P + ++ LL+ D V++RI AGE LAL+F R
Sbjct: 238 LHISSLLAWTLLLTICPINEVKKKLELHFHKLPSLLSCDDVNMRIAAGESLALLFELARG 297
Query: 217 EIDPEFVCDDYVTLLDQVRNLSVDGRKARNRNERAKQRHEFREIVQSIESYSSKFSNVNI 396
++ +F +D +L +R L+ DG K R + ++ KQR FR++++++E F +
Sbjct: 298 -MESDFFYEDMDSLTQMLRALATDGNKHRAKVDKRKQRSVFRDVLRAVEERD--FPTETV 354
Query: 397 QFGLETLMITNWSKQIQYDFLLKILQDGINKQLQLNIDIREIFDLGEPIDVNKMKLILRK 576
+FG E + I +W K+ YD ++L G+ LQ N +R +F+LG P+ ++ L K
Sbjct: 355 KFGPERMYIDSWVKKHTYDTFKEVLGSGMQYHLQTNEFLRNVFELGPPVMLDAATLKTMK 414
Query: 577 FRKDEKEKLYKNKERENKIARNKERN 654
+ E+ + AR+K R+
Sbjct: 415 ISRFERHLYNSAAFKARTKARSKCRD 440
>sp|Q5S1U6|IFRD1_PIG Interferon-related developmental regulator 1
Length = 450
Score = 97.8 bits (242), Expect = 3e-20
Identities = 65/206 (31%), Positives = 108/206 (52%)
Frame = +1
Query: 37 LEITAIRCWSLLFTILPEHMLETIGSDILCLSLELLTRDSVDVRIRAGECLALIFGRLRD 216
L I+++ W+LL TI P ++ + LL+ D V++RI AGE LAL+F R
Sbjct: 239 LHISSLLAWTLLLTICPLSEVKKKLEMHVHKLPSLLSSDDVNMRIAAGESLALLFELARG 298
Query: 217 EIDPEFVCDDYVTLLDQVRNLSVDGRKARNRNERAKQRHEFREIVQSIESYSSKFSNVNI 396
++ +F +D +L +R L+ DG K R + ++ KQR FR+I++++E F +
Sbjct: 299 -MESDFFYEDMESLTQMLRALATDGNKHRAKVDKRKQRSVFRDILRAVEERD--FPTETV 355
Query: 397 QFGLETLMITNWSKQIQYDFLLKILQDGINKQLQLNIDIREIFDLGEPIDVNKMKLILRK 576
+FG E + I W K+ YD +IL G+ LQ N +R +F+LG P+ ++ L K
Sbjct: 356 KFGPERMYIDCWVKKRTYDTFKEILGSGMQYHLQSNEFLRNVFELGPPVMLDAATLKTMK 415
Query: 577 FRKDEKEKLYKNKERENKIARNKERN 654
+ E+ + AR+K R+
Sbjct: 416 ISRFERHLYNSAAFKARTKARSKCRD 441
>sp|Q12894|IFRD2_HUMAN Interferon-related developmental regulator 2 (SKMC15 protein)
Length = 442
Score = 96.3 bits (238), Expect = 8e-20
Identities = 64/207 (30%), Positives = 108/207 (52%), Gaps = 4/207 (1%)
Frame = +1
Query: 49 AIRCWSLLFTILPEHMLETIGSDILCLSLELLTRDSVDVRIRAGECLALIFGRLRDEIDP 228
A++ W+LL TI P + I L +LL+ +SV++RI AGE +AL+F RD ++
Sbjct: 238 ALQAWALLLTICPSTQISHILDRQLPRLPQLLSSESVNLRIAAGETIALLFELARD-LEE 296
Query: 229 EFVCDDYVTLLDQVRNLSVDGRKARNRNERAKQRHEFREIVQSIESYSSKFSNVNIQFGL 408
EFV +D L +R L+ D K R + +R +QR FR ++ S+E + ++FG
Sbjct: 297 EFVYEDMEALCSVLRTLATDSNKYRAKADRRRQRSTFRAVLHSVE--GGECEEEIVRFGF 354
Query: 409 ETLMITNWSKQIQYDFLLKILQDGINKQLQLNIDIREIFDLGEPIDVNKMKLILRKFRKD 588
E L + +W++ Y ++L G++ LQ N +R+IF LG + ++ L K +
Sbjct: 355 EVLYMDSWARHRIYAAFKEVLGSGMHHHLQNNELLRDIFGLGPVLLLDATALKACKVPRF 414
Query: 589 EKE----KLYKNKERENKIARNKERNI 657
EK +K + + R+K +I
Sbjct: 415 EKHLYNAAAFKARTKARSRVRDKRADI 441
>sp|P20695|IFRD1_RAT Interferon-related developmental regulator 1 (Nerve growth
factor-inducible protein PC4) (IRPR)
Length = 449
Score = 95.1 bits (235), Expect = 2e-19
Identities = 63/206 (30%), Positives = 107/206 (51%)
Frame = +1
Query: 37 LEITAIRCWSLLFTILPEHMLETIGSDILCLSLELLTRDSVDVRIRAGECLALIFGRLRD 216
L I+++ W+LL TI P ++ LL+ D V++RI AGE LAL+F R
Sbjct: 238 LHISSLLAWTLLLTICPISEVKKKLELHFHKLPSLLSCDDVNMRIAAGESLALLFELARG 297
Query: 217 EIDPEFVCDDYVTLLDQVRNLSVDGRKARNRNERAKQRHEFREIVQSIESYSSKFSNVNI 396
++ +F +D +L +R L+ DG K R + ++ KQR FR++++++E F +
Sbjct: 298 -MESDFFYEDMDSLTQMLRALATDGNKHRAKVDKRKQRSVFRDVLRAVEERD--FPTETV 354
Query: 397 QFGLETLMITNWSKQIQYDFLLKILQDGINKQLQLNIDIREIFDLGEPIDVNKMKLILRK 576
+FG E + I +W K+ YD + L G+ LQ N +R +F+LG P+ ++ L K
Sbjct: 355 KFGPERMYIDSWVKKHTYDTFKEALGSGMQYHLQTNEFLRNVFELGPPVMLDAATLKTMK 414
Query: 577 FRKDEKEKLYKNKERENKIARNKERN 654
+ E+ + AR+K R+
Sbjct: 415 IPRFERHLYNSAAFKARTKARSKCRD 440
>sp|Q8RA32|DPO3_THETN DNA polymerase III polC-type (PolIII)
Length = 1401
Score = 38.5 bits (88), Expect = 0.020
Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Frame = +1
Query: 412 TLMITNWSKQIQYDFLLKILQDGINKQLQLNIDIREIF-----DLGEPIDVNKMKLILRK 576
T I +K + DF ++ + + + +LN+D+ IF ++ E I +K I
Sbjct: 111 TYAIYEMAKSSKLDFAIR---EFLRNRYELNLDVELIFSEEGEEIAEKIIEEDIKAIEEV 167
Query: 577 FRKDEKEKLYKNKERENKIARNKE 648
+KDEK K K++ EN++ KE
Sbjct: 168 IQKDEKSKKEKSRSEENRVLLGKE 191
>sp|O13290|DYHC_SCHPO Dynein heavy chain, cytosolic (DYHC)
Length = 4196
Score = 37.7 bits (86), Expect = 0.034
Identities = 33/142 (23%), Positives = 62/142 (43%), Gaps = 25/142 (17%)
Frame = +1
Query: 163 VRIRAGECLALIFGRLRDEID------PEFVCDDYVTLLDQVRNLSVDGRKARNRNERAK 324
VR +CL L+ R++ E+D E V D + ++++RNL + +
Sbjct: 587 VRTSISDCLHLLVNRIKQELDLLKTRFTEDVSDTELIAMNELRNLPMASSAIIWATQLKN 646
Query: 325 QRHEFREIVQSI---------ESYSSKFSNVNIQFGLET-LMITNW-----SKQIQYDFL 459
+ HE+ + + I + + K + +Q L+T L+ TNW S+ + +DF
Sbjct: 647 RLHEYTKNINIIFGEDWNNFPDGFELKVECITLQKRLDTNLIFTNWINDVSSRNLNFDFD 706
Query: 460 LKIL----QDGINKQLQLNIDI 513
KI + L+L++ I
Sbjct: 707 SKIFYLTQSESAESPLRLSVSI 728
>sp|Q92878|RAD50_HUMAN DNA repair protein RAD50 (hRAD50)
Length = 1312
Score = 35.0 bits (79), Expect = 0.22
Identities = 46/204 (22%), Positives = 88/204 (43%), Gaps = 23/204 (11%)
Frame = +1
Query: 196 IFGRLRDEIDPEFVCDDYVTLLDQVRNLSVDGRKARNRNERAKQRHEFREIVQSI----E 363
+ G + E + VC VT++++ + D + + Q + VQ + +
Sbjct: 774 LLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQ 833
Query: 364 SYSSKFSNVNIQFGLETLMITNWSKQIQY------DFLLKILQDGINKQ---------LQ 498
K V+ + L +I + +QIQ+ + + LQ N Q ++
Sbjct: 834 EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVE 893
Query: 499 LNIDI----REIFDLGEPIDVNKMKLILRKFRKDEKEKLYKNKERENKIARNKERNINRR 666
L+ ++ REI D E V+ ++ L KF++ EKE+L K NKIA++K +I +
Sbjct: 894 LSTEVQSLYREIKDAKE--QVSPLETTLEKFQQ-EKEELINKKNTSNKIAQDKLNDIKEK 950
Query: 667 DEYLYE*TNDNLNLYFINFVNYLR 738
+ N++ Y + NY++
Sbjct: 951 VK--------NIHGYMKDIENYIQ 966
>sp|Q97I19|MUTS_CLOAB DNA mismatch repair protein mutS
Length = 869
Score = 34.7 bits (78), Expect = 0.29
Identities = 35/156 (22%), Positives = 66/156 (42%)
Frame = +1
Query: 241 DDYVTLLDQVRNLSVDGRKARNRNERAKQRHEFREIVQSIESYSSKFSNVNIQFGLETLM 420
+D LL QV ++ K +++ AK+ R ++ + + N N + L+
Sbjct: 333 EDLKELLKQVYDIERLAGKISSKSVNAKEMISLRGSIEKLPAIKKLIKNFNSE-----LL 387
Query: 421 ITNWSKQIQYDFLLKILQDGINKQLQLNIDIREIFDLGEPIDVNKMKLILRKFRKDEKEK 600
+ + + K+L + IN L+I I G D+++++L K +
Sbjct: 388 VNMENALDDLGDIYKLLYESINDNPSLSIKEGNIIKEGYNKDIDELRLA--KSHGKQWIA 445
Query: 601 LYKNKERENKIARNKERNINRRDEYLYE*TNDNLNL 708
+N ERE ++ + + N+ Y E T NLNL
Sbjct: 446 SLENTEREVTGIKSLKVSYNKVFGYYIEITKSNLNL 481
>sp|Q9JIL8|RAD50_RAT DNA repair protein RAD50
Length = 1312
Score = 33.5 bits (75), Expect = 0.65
Identities = 45/204 (22%), Positives = 88/204 (43%), Gaps = 23/204 (11%)
Frame = +1
Query: 196 IFGRLRDEIDPEFVCDDYVTLLDQVRNLSVDGRKARNRNERAKQRHEFREIVQSI----E 363
+ G + E + VC VT++++ + D + + Q + VQ + +
Sbjct: 774 LLGTVMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGVDLDRTVQQVNQEKQ 833
Query: 364 SYSSKFSNVNIQFGLETLMITNWSKQIQY------DFLLKILQDGINKQ---------LQ 498
K V+ + L +I + +QIQ+ + + LQ N Q ++
Sbjct: 834 EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQTVE 893
Query: 499 LNIDI----REIFDLGEPIDVNKMKLILRKFRKDEKEKLYKNKERENKIARNKERNINRR 666
L+ ++ REI D E I N +++ L K ++ EKE+L K NK+A++K +I +
Sbjct: 894 LSTEVQSLNREIKDAKEQI--NPLEIALEKLQQ-EKEELIHRKNTSNKMAQDKINDIKEK 950
Query: 667 DEYLYE*TNDNLNLYFINFVNYLR 738
+ N++ Y + NY++
Sbjct: 951 VK--------NIHGYMKDIENYIQ 966
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,963,407
Number of Sequences: 369166
Number of extensions: 1157221
Number of successful extensions: 3804
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3564
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3758
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7066925600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)