Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_B17
(749 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 235 1e-61
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 233 3e-61
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 231 2e-60
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 228 1e-59
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 224 2e-58
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 219 5e-57
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 217 3e-56
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 217 3e-56
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 216 4e-56
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 214 2e-55
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 235 bits (599), Expect = 1e-61
Identities = 123/235 (52%), Positives = 150/235 (63%), Gaps = 1/235 (0%)
Frame = +2
Query: 47 LNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMT 226
L +W +K R Y + RR +WE+N+K I+ HN EY GKH++++ +N F DMT
Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84
Query: 227 NEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFS 406
+EEF+ G KP +G + P P SVDWR+KGYVTPVKNQ QCGSCW+FS
Sbjct: 85 SEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFS 142
Query: 407 ATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDY 583
ATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y++D G++SE Y
Sbjct: 143 ATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESY 202
Query: 584 PYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 748
PY AT+ +CK NP V TGF DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 203 PYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESF 256
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 233 bits (595), Expect = 3e-61
Identities = 122/247 (49%), Positives = 158/247 (63%), Gaps = 1/247 (0%)
Frame = +2
Query: 11 TAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHT 190
+AVP KF N L+ +W +K T R Y + RR +WE+N+K I+ HN EY GKH
Sbjct: 16 SAVP-KFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHG 72
Query: 191 YSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVK 370
+++ +N F DMTNEEF+ + +G + + +G + P + LP SVDWR+KGYVTPVK
Sbjct: 73 FTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVK 130
Query: 371 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 550
NQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+
Sbjct: 131 NQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYV 190
Query: 551 KDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAI 727
K+ G++SE YPY A D CK P V TGFT + E L AVATVGP+SVA+
Sbjct: 191 KENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAM 250
Query: 728 DAGHASF 748
DAGH+SF
Sbjct: 251 DAGHSSF 257
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 231 bits (589), Expect = 2e-60
Identities = 124/251 (49%), Positives = 153/251 (60%), Gaps = 2/251 (0%)
Frame = +2
Query: 2 VAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLG 181
+ I + KF + LN +W +K T R Y + RR +WE+N+K I+ HN EY G
Sbjct: 12 LGIASAAPKF--DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQG 69
Query: 182 KHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVT 361
KH +++ +N F DMTNEEF+ G K +G + P +P SVDWR+KGYVT
Sbjct: 70 KHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDWREKGYVT 127
Query: 362 PVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAF 541
PVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF
Sbjct: 128 PVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAF 187
Query: 542 RYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPV 715
RY+KD G++SE YPY D TC P TGF D+ Q E L AVAT+GP+
Sbjct: 188 RYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDL-PQREKALMKAVATLGPI 246
Query: 716 SVAIDAGHASF 748
SVAIDAGH SF
Sbjct: 247 SVAIDAGHQSF 257
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 228 bits (581), Expect = 1e-59
Identities = 123/240 (51%), Positives = 147/240 (61%), Gaps = 2/240 (0%)
Frame = +2
Query: 35 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 214
++ L+ W +K T R Y + RR +WE+N K I HN EY GKH + + +N F
Sbjct: 21 LDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHAFRMAMNAF 80
Query: 215 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 394
DMTNEEF+ G K +G + P + V P SVDW +KGYVTPVKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWTKKGYVTPVKNQGQCGSC 138
Query: 395 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIES 571
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YIKD G++S
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDS 198
Query: 572 EGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 748
E YPY ATD +C P TGF DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 199 EESYPYLATDTNSCNYKPECSAANDTGFVDI-PQREKALMKAVATVGPISVAIDAGHTSF 257
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 224 bits (571), Expect = 2e-58
Identities = 119/240 (49%), Positives = 150/240 (62%), Gaps = 2/240 (0%)
Frame = +2
Query: 35 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 214
++ L+ +W +K T GR Y + RR +WE+N+K I+ HN EY GKH +S+ +N F
Sbjct: 21 LDQNLDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAF 80
Query: 215 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 394
DMTNEEF+ G K +G + + V P SVDWR+KGYVT VKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDWREKGYVTAVKNQGQCGSC 138
Query: 395 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIES 571
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+Y+KD G+++
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDT 198
Query: 572 EGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 748
E YPY + +C P TGF DI Q E L AVATVGP+SVAIDAGH+SF
Sbjct: 199 EESYPYLGRETNSCTYKPECSAANDTGFVDI-PQREKALMKAVATVGPISVAIDAGHSSF 257
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 219 bits (559), Expect = 5e-57
Identities = 106/224 (47%), Positives = 140/224 (62%)
Frame = +2
Query: 59 WETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEF 238
W +K + ++Y+ D RR IWE+N+K+IQ+HNL +DLG TY+LGLNQF DMT EEF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 239 KAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGS 418
KAKYL M + N +P +DWR+ GYVT VK+Q CGSCW+FS TG+
Sbjct: 81 KAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGT 140
Query: 419 LEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQGIESEGDYPYTAT 598
+EGQY + ISFSEQQLVDCS LM+NA++Y+K G+E+E YPYTA
Sbjct: 141 MEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAV 200
Query: 599 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAID 730
+G C+ N V K TG+ + S +E +L N V P +VA+D
Sbjct: 201 EGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVD 244
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 217 bits (552), Expect = 3e-56
Identities = 121/258 (46%), Positives = 157/258 (60%), Gaps = 9/258 (3%)
Frame = +2
Query: 2 VAITAVPQKFSVNSELNEEWETYKTTFGRKY-DELTDITRRLIWEQNLKYIQKHNLEYDL 178
+A+ A+ Q S + EEW TYK + Y +E+ + R I+ +N I KHN +
Sbjct: 9 LALVALTQAISPLDLIKEEWHTYKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQLFAQ 68
Query: 179 GKHTYSLGLNQFADMTNEEFKAKYLG-------IMKTKPTLEGSTYMAPENIGVLPASVD 337
GK +Y LGLN++ADM + EFK G +M+ + L G+TY+ P ++ V P SVD
Sbjct: 69 GKVSYKLGLNKYADMLHHEFKETMNGYNHTLRQLMRERTGLVGATYIPPAHVTV-PKSVD 127
Query: 338 WRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXX 517
WR+ G VT VK+Q CGSCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS
Sbjct: 128 WREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCN 187
Query: 518 XXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANA 694
LMDNAFRYIKD GI++E YPY D +C N + I TGF DI +E + A
Sbjct: 188 GGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKA 247
Query: 695 VATVGPVSVAIDAGHASF 748
VAT+GPVSVAIDA H SF
Sbjct: 248 VATMGPVSVAIDASHESF 265
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 217 bits (552), Expect = 3e-56
Identities = 118/231 (51%), Positives = 144/231 (62%), Gaps = 1/231 (0%)
Frame = +2
Query: 56 EWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEE 235
EW +K+T R Y + RR IWE+N++ IQ HN EY G+H +S+ +N F DMTNEE
Sbjct: 28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEE 87
Query: 236 FKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATG 415
F+ G K +G + P + + P SVDWR+KG VTPVKNQ QCGSCW+FSA+G
Sbjct: 88 FRQVVNGYRHQKHK-KGRLFQEPLMLKI-PKSVDWREKGCVTPVKNQGQCGSCWAFSASG 145
Query: 416 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYT 592
LEGQ F K +LIS SEQ LVDCS LMD AF+YIK+ G++SE YPY
Sbjct: 146 CLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYE 205
Query: 593 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 745
A DG+CK V TGF DI Q E L AVATVGP+SVA+DA H S
Sbjct: 206 AKDGSCKYRAEFAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPS 255
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 216 bits (551), Expect = 4e-56
Identities = 116/233 (49%), Positives = 145/233 (62%), Gaps = 1/233 (0%)
Frame = +2
Query: 50 NEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTN 229
N +W +K+T R Y + RR +WE+N++ IQ HN EY GKH +++ +N F DMTN
Sbjct: 26 NAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTN 85
Query: 230 EEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSA 409
EEF+ G K +G + P + + P +VDWR+KG VTPVKNQ QCGSCW+FSA
Sbjct: 86 EEFRQIVNGYRHQKHK-KGRLFQEPLMLQI-PKTVDWREKGCVTPVKNQGQCGSCWAFSA 143
Query: 410 TGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYP 586
+G LEGQ F K +LIS SEQ LVDCS LMD AF+YIK+ G++SE YP
Sbjct: 144 SGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYP 203
Query: 587 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 745
Y A DG+CK V TGF DI Q E L AVATVGP+SVA+DA H S
Sbjct: 204 YEAKDGSCKYRAEYAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPS 255
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 214 bits (545), Expect = 2e-55
Identities = 115/238 (48%), Positives = 150/238 (63%), Gaps = 4/238 (1%)
Frame = +2
Query: 47 LNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADM 223
L+ +WE +K T+ ++Y+ D I+RRLIWE+NLK+I HNLE LG HTY L +N DM
Sbjct: 22 LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDM 81
Query: 224 TNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCW 397
T+EE K G+ K P+ S T P+ G P S+D+R+KGYVTPVKNQ QCGSCW
Sbjct: 82 TSEEVVQKMTGL-KVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCW 140
Query: 398 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI-KDQGIESE 574
+FS+ G+LEGQ +K +L++ S Q LVDC M NAF+Y+ +++GI+SE
Sbjct: 141 AFSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENYGCGGGYMTNAFQYVQRNRGIDSE 198
Query: 575 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 748
YPY D +C NP+ KC G+ +I NE L AVA VGPVSVAIDA SF
Sbjct: 199 DAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSF 256
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,642,162
Number of Sequences: 369166
Number of extensions: 1550180
Number of successful extensions: 4506
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4062
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4187
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6824907600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)