Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_B04
(850 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9V3A4|CSUP_DROME Catecholamines up protein 184 3e-46
sp|Q92504|KE4_HUMAN Zinc transporter SLC39A7 (Solute carrie... 179 7e-45
sp|Q31125|KE4_MOUSE Zinc transporter SLC39A7 (Solute carrie... 176 1e-43
sp|Q9XTQ7|KE4L_CAEEL Hypothetical Ke4-like protein H13N06.5... 160 3e-39
sp|Q9XUC4|YGJK_CAEEL Hypothetical protein T28F3.3 in chromo... 158 2e-38
sp|Q9PUB8|KE4_BRARE Zinc transporter Slc39a7 (Solute carrie... 154 4e-37
sp|Q9VAF0|Y816_DROME Hypothetical protein CG7816 92 1e-18
sp|P40544|YIC3_YEAST Hypothetical 37.4 kDa protein in IRR1-... 89 1e-17
sp|Q6P5W5|S39A4_HUMAN Zinc transporter ZIP4 precursor (Solu... 78 3e-14
sp|Q78IQ7|S39A4_MOUSE Zinc transporter ZIP4 precursor (Solu... 78 4e-14
>sp|Q9V3A4|CSUP_DROME Catecholamines up protein
Length = 449
Score = 184 bits (467), Expect = 3e-46
Identities = 108/281 (38%), Positives = 152/281 (54%), Gaps = 6/281 (2%)
Frame = +3
Query: 15 LWLYSLSATILVSAAPLLVIFLIP--DLKNHRVXXXXXXXXXXXXXXXXXXXXXIPHSID 188
+WL+S+ +T+L+SAAP +++++IP + + + IPH+
Sbjct: 131 IWLHSIGSTLLISAAPFVLLYIIPLDNSEAMKPRLKVLLAFASGGLLGDAFLHLIPHATH 190
Query: 189 PHDHQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALHDHSKNMIVGLWVVAGIMSFLIVE 368
PH H H HS +M +GLWV+ GI++FL VE
Sbjct: 191 PHSHGEHGHDHGHDHHHHHDGEEHE-----------HGHSHDMSIGLWVLGGIIAFLSVE 239
Query: 369 KFVRLVKGDXXXXXXXXXXL----IITEPPFSNKKQSSKGENTNSEMEVRSRXXXXXXXX 536
K VR++KG + + S+K+ S G+ +++S+
Sbjct: 240 KLVRILKGGHGGHGHSHGAPKPKPVPAKKKSSDKEDSGDGDKPAKPAKIKSKKPE----- 294
Query: 537 XXXXXXALAVDQVQNIKVSGYLNLVADFAHNFTDGLAIGASFLVNKNVGIVTTITILFHE 716
+ +++SGYLNL ADFAHNFTDGLAIGAS+L ++GIVTTITIL HE
Sbjct: 295 ---------AEPEGEVEISGYLNLAADFAHNFTDGLAIGASYLAGNSIGIVTTITILLHE 345
Query: 717 VPHEIGDYAILIQSGCSRRKAILLQLVTAVGAMLGTVLSLL 839
VPHEIGD+AILI+SGCSRRKA+LLQLVTA+GA+ GT L+LL
Sbjct: 346 VPHEIGDFAILIKSGCSRRKAMLLQLVTALGALAGTALALL 386
Score = 30.4 bits (67), Expect = 6.5
Identities = 13/33 (39%), Positives = 17/33 (51%)
Frame = -2
Query: 288 HDHVCVHGCARVYDCDHVHDHAYVHGNYSDDHE 190
H H HG +D DH HDH + H + DH+
Sbjct: 76 HHH---HGHDHDHDHDHGHDHGHHHHGHDHDHD 105
>sp|Q92504|KE4_HUMAN Zinc transporter SLC39A7 (Solute carrier family 39 member 7)
(Histidine-rich membrane protein Ke4)
Length = 469
Score = 179 bits (455), Expect = 7e-45
Identities = 113/292 (38%), Positives = 155/292 (53%), Gaps = 15/292 (5%)
Frame = +3
Query: 15 LWLYSLSATILVSAAPLLVIFLIPDLKN---HRVXXXXXXXXXXXXXXXXXXXXXIPHSI 185
LW Y+L AT+L+SAAP V+FLIP N HR IPH++
Sbjct: 134 LWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHAL 193
Query: 186 DPHDHQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALHDHSKN---MIVGLWVVAGIMSF 356
+PH H H HS + VGLWV++GI++F
Sbjct: 194 EPHSHHTLEQPGHG-----------------------HSHSGQGPILSVGLWVLSGIVAF 230
Query: 357 LIVEKFVRLVKGDXXXXXXXXXXLIITEPPFSNKKQ--SSKGENTNSEME-----VRSRX 515
L+VEKFVR VKG T + +Q S+K + ++ E E V+ R
Sbjct: 231 LVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRR 290
Query: 516 XXXXXXXXXXXXXALAVDQVQ--NIKVSGYLNLVADFAHNFTDGLAIGASFLVNKNVGIV 689
A ++ + +++VSGYLNL AD AHNFTDGLAIGASF + +GI+
Sbjct: 291 GGSTVPKDGPVRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGIL 350
Query: 690 TTITILFHEVPHEIGDYAILIQSGCSRRKAILLQLVTAVGAMLGTVLSLLAQ 845
TT+T+L HEVPHE+GD+AIL+QSGCS+++A+ LQL+TAVGA+ GT +LL +
Sbjct: 351 TTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTE 402
>sp|Q31125|KE4_MOUSE Zinc transporter SLC39A7 (Solute carrier family 39 member 7)
(Histidine-rich membrane protein Ke4)
Length = 476
Score = 176 bits (445), Expect = 1e-43
Identities = 110/291 (37%), Positives = 151/291 (51%), Gaps = 14/291 (4%)
Frame = +3
Query: 15 LWLYSLSATILVSAAPLLVIFLIPDLKN---HRVXXXXXXXXXXXXXXXXXXXXXIPHSI 185
LW Y+L AT+L+SAAP V+FLIP N HR IPH++
Sbjct: 142 LWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHAL 201
Query: 186 DPHDHQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALHDHSKN---MIVGLWVVAGIMSF 356
+PH H H HS + VGLWV++GI++F
Sbjct: 202 EPHSHHAPEQPGHG-----------------------HSHSGQGPILSVGLWVLSGIVAF 238
Query: 357 LIVEKFVRLVKGDXXXXXXXXXXLIITEP-PFSNKKQSSKGENTNSEME-----VRSRXX 518
L+VEKFVR VKG + ++ + S E ++E E +R R
Sbjct: 239 LVVEKFVRHVKGGHGHSHGHGDRHAHGDSHTHGDRHECSSKEKPSTEEEKEVGGLRKRRG 298
Query: 519 XXXXXXXXXXXXALAVDQV--QNIKVSGYLNLVADFAHNFTDGLAIGASFLVNKNVGIVT 692
++ +++VSGYLNL AD AHNFTDGLAIGASF + +GI+T
Sbjct: 299 GNTGPRDGPVKPQSPEEEKAGSDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILT 358
Query: 693 TITILFHEVPHEIGDYAILIQSGCSRRKAILLQLVTAVGAMLGTVLSLLAQ 845
T+T+L HEVPHE+GD+AIL+QSGCS+++A+ LQLVTA+GA+ GT +LL +
Sbjct: 359 TMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLVTAIGALAGTACALLTE 409
>sp|Q9XTQ7|KE4L_CAEEL Hypothetical Ke4-like protein H13N06.5 in chromosome X
Length = 515
Score = 160 bits (406), Expect = 3e-39
Identities = 105/287 (36%), Positives = 144/287 (50%), Gaps = 7/287 (2%)
Frame = +3
Query: 9 TRLWLYSLSATILVSAAPLLVIFLIPDLKNHRVXXXXXXXXXXXXXXXXXXXXX---IPH 179
TRLW+Y++SAT+L+SAAP ++ IP N IPH
Sbjct: 208 TRLWVYAISATLLISAAPCFILMFIPIQANTSESGPLLKVLLAFGSGGLLGDAFLHLIPH 267
Query: 180 SI---DPHDHQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALHDH-SKNMIVGLWVVAGI 347
+ D H H H H + +M VG WV+ GI
Sbjct: 268 ATPAGDGHGHSHSHGHSHGGGG--------------------HSHGAHDMSVGGWVLGGI 307
Query: 348 MSFLIVEKFVRLVKGDXXXXXXXXXXLIITEPPFSNKKQSSKGENTNSEMEVRSRXXXXX 527
++FL VEK VR+++G+ +K+ +K +++ ++ +
Sbjct: 308 IAFLTVEKLVRILRGEDGHGHSHGHS-------HGGEKKETKEKDSKDKVAKKEEKPEKD 360
Query: 528 XXXXXXXXXALAVDQVQNIKVSGYLNLVADFAHNFTDGLAIGASFLVNKNVGIVTTITIL 707
Q+IKV+ YLNL ADF HNFTDGLAIGASF+ VGIVT IT+L
Sbjct: 361 E---------------QSIKVTAYLNLAADFTHNFTDGLAIGASFIAGTTVGIVTMITVL 405
Query: 708 FHEVPHEIGDYAILIQSGCSRRKAILLQLVTAVGAMLGTVLSLLAQD 848
HEVPHEIGD+AILIQSG S++KA+L+QLVTA+GA+ G V+SL + D
Sbjct: 406 VHEVPHEIGDFAILIQSGYSKKKAMLIQLVTALGALSGCVISLFSAD 452
Score = 32.7 bits (73), Expect = 1.3
Identities = 16/52 (30%), Positives = 25/52 (48%)
Frame = -2
Query: 270 HGCARVYDCDHVHDHAYVHGNYSDDHEDQ*NEESNVEMHLPIDHRQQRQEEY 115
HG A +D H HDH + H ++ H++ EE + H DH E++
Sbjct: 131 HGHAHDHDHGHAHDHGHAHDHHGHSHDE---EEDHHHGHAH-DHHGHSHEDH 178
>sp|Q9XUC4|YGJK_CAEEL Hypothetical protein T28F3.3 in chromosome IV
Length = 393
Score = 158 bits (400), Expect = 2e-38
Identities = 95/279 (34%), Positives = 136/279 (48%)
Frame = +3
Query: 12 RLWLYSLSATILVSAAPLLVIFLIPDLKNHRVXXXXXXXXXXXXXXXXXXXXXIPHSIDP 191
++W++SLSA + +S AP ++F IP + IPHS+ P
Sbjct: 82 KVWVFSLSAVVGISLAPCTLLFFIPAQHANGPFLKILLAFGAGGLLGDALLHIIPHSLSP 141
Query: 192 HDHQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALHDHSKNMIVGLWVVAGIMSFLIVEK 371
HDH HDHS + VG +V+AGI+ F++VE+
Sbjct: 142 HDHSHDHHDHNHSHKEHDHS---------------HDHSNQLRVGTFVIAGILVFMMVEQ 186
Query: 372 FVRLVKGDXXXXXXXXXXLIITEPPFSNKKQSSKGENTNSEMEVRSRXXXXXXXXXXXXX 551
VR++KG ++ E N+ E ++E
Sbjct: 187 LVRIIKGGHCHSHENGH-IVADEHRHLNEHDHEHSEEKKQQVE----------------- 228
Query: 552 XALAVDQVQNIKVSGYLNLVADFAHNFTDGLAIGASFLVNKNVGIVTTITILFHEVPHEI 731
++++K S YLNLVADF HN TDGLAIGASF +G +TT+T+L HE+PHE+
Sbjct: 229 ------GLKDVKASAYLNLVADFVHNVTDGLAIGASFSAGNTLGWITTLTVLLHELPHEV 282
Query: 732 GDYAILIQSGCSRRKAILLQLVTAVGAMLGTVLSLLAQD 848
GD+AIL+QSG S+ +AI LQ VTA+GA+ G V SLL +
Sbjct: 283 GDFAILVQSGFSKYQAIRLQAVTALGAITGCVFSLLVSN 321
>sp|Q9PUB8|KE4_BRARE Zinc transporter Slc39a7 (Solute carrier family 39 member 7)
(Histidine-rich membrane protein Ke4)
Length = 352
Score = 154 bits (388), Expect = 4e-37
Identities = 98/249 (39%), Positives = 127/249 (51%), Gaps = 3/249 (1%)
Frame = +3
Query: 15 LWLYSLSATILVSAAPLLVIFLIPDLKN---HRVXXXXXXXXXXXXXXXXXXXXXIPHSI 185
LW+ ++ AT+L+SAAP L++FLIP N H+ IPH++
Sbjct: 124 LWMQAIGATLLISAAPFLILFLIPVQSNTDQHQNLLKVLLSFASGGLLGDAFLHLIPHAL 183
Query: 186 DPHDHQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALHDHSKNMIVGLWVVAGIMSFLIV 365
+PH H A H H M VGLWV+ GI++FL+V
Sbjct: 184 EPHSHHSQPHSEESHGQSHGEESHGHSHG------AAHGHM--MSVGLWVLGGIVAFLVV 235
Query: 366 EKFVRLVKGDXXXXXXXXXXLIITEPPFSNKKQSSKGENTNSEMEVRSRXXXXXXXXXXX 545
EKFVRL+KG ++ S+++ KG+ + +V S+
Sbjct: 236 EKFVRLLKGGHSHSHSHSPSAPKSKD--SDEEDDKKGQKKGEKDKVVSQQKPTKK----- 288
Query: 546 XXXALAVDQVQNIKVSGYLNLVADFAHNFTDGLAIGASFLVNKNVGIVTTITILFHEVPH 725
V+ +IKVSGYLNL ADF HNFTDGLAIGASFLV VG VTTITIL HEVPH
Sbjct: 289 -----TVETSSDIKVSGYLNLAADFTHNFTDGLAIGASFLVGPAVGAVTTITILLHEVPH 343
Query: 726 EIGDYAILI 752
EIGD+AIL+
Sbjct: 344 EIGDFAILV 352
Score = 30.0 bits (66), Expect = 8.4
Identities = 13/30 (43%), Positives = 16/30 (53%)
Frame = -2
Query: 288 HDHVCVHGCARVYDCDHVHDHAYVHGNYSD 199
HDH HG A + H H HA+ HG+ D
Sbjct: 75 HDHAHDHGHAHSHGDIHDHGHAHKHGHAHD 104
>sp|Q9VAF0|Y816_DROME Hypothetical protein CG7816
Length = 355
Score = 92.4 bits (228), Expect = 1e-18
Identities = 61/171 (35%), Positives = 85/171 (49%)
Frame = +3
Query: 324 GLWVVAGIMSFLIVEKFVRLVKGDXXXXXXXXXXLIITEPPFSNKKQSSKGENTNSEMEV 503
GLWV++GI+ F IVEK I + Q +GE + S
Sbjct: 117 GLWVLSGILIFTIVEKIFSGYASADEENPQPKCVEIANCLLRRHGGQLPEGETSESCGGA 176
Query: 504 RSRXXXXXXXXXXXXXXALAVDQVQNIKVSGYLNLVADFAHNFTDGLAIGASFLVNKNVG 683
+ Q KV+GYLNL+A+ NFT GLA+ SFLV+ G
Sbjct: 177 CDIEDVGKVCFLREQEQKSKERKEQPKKVAGYLNLLANSIDNFTHGLAVAGSFLVSFRHG 236
Query: 684 IVTTITILFHEVPHEIGDYAILIQSGCSRRKAILLQLVTAVGAMLGTVLSL 836
I+ T IL HE+PHE+GD+AIL++SG SR A QL+TA +LG ++++
Sbjct: 237 ILATFAILLHEIPHEVGDFAILLRSGFSRWDAARAQLLTAGAGLLGALVAI 287
>sp|P40544|YIC3_YEAST Hypothetical 37.4 kDa protein in IRR1-TIM44 intergenic region
Length = 346
Score = 89.4 bits (220), Expect = 1e-17
Identities = 40/79 (50%), Positives = 59/79 (74%)
Frame = +3
Query: 588 VSGYLNLVADFAHNFTDGLAIGASFLVNKNVGIVTTITILFHEVPHEIGDYAILIQSGCS 767
+S YLN+++ AH+ TDG+A+ SF + VGI+T+I + FHE+PHE+GD+AIL+ SG +
Sbjct: 185 MSAYLNVISGIAHHITDGIALATSFYSSTQVGIMTSIAVTFHEIPHELGDFAILLSSGFT 244
Query: 768 RRKAILLQLVTAVGAMLGT 824
+AI Q VTA GA++GT
Sbjct: 245 FPQAIRAQAVTAFGAVVGT 263
>sp|Q6P5W5|S39A4_HUMAN Zinc transporter ZIP4 precursor (Solute carrier family 39 member 4)
Length = 647
Score = 78.2 bits (191), Expect = 3e-14
Identities = 34/85 (40%), Positives = 57/85 (67%)
Frame = +3
Query: 582 IKVSGYLNLVADFAHNFTDGLAIGASFLVNKNVGIVTTITILFHEVPHEIGDYAILIQSG 761
+++ Y+ + D HNF DGLA+GA+F + G+ T++ + HE+PHE+GD+A L+ +G
Sbjct: 493 LRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAG 552
Query: 762 CSRRKAILLQLVTAVGAMLGTVLSL 836
S R+A+LL L +A+ A G ++L
Sbjct: 553 LSVRQALLLNLASALTAFAGLYVAL 577
>sp|Q78IQ7|S39A4_MOUSE Zinc transporter ZIP4 precursor (Solute carrier family 39 member 4)
(Activated in W/Wv mouse stomach 2) (mAWMS2)
Length = 660
Score = 77.8 bits (190), Expect = 4e-14
Identities = 34/85 (40%), Positives = 57/85 (67%)
Frame = +3
Query: 582 IKVSGYLNLVADFAHNFTDGLAIGASFLVNKNVGIVTTITILFHEVPHEIGDYAILIQSG 761
+++ YL + D HNF DGLA+GA+F + G+ T++ + HE+PHE+GD+A L+ +G
Sbjct: 506 LRLLPYLITLGDAVHNFADGLAVGAAFSSSWKTGLATSLAVFCHELPHELGDFAALLHAG 565
Query: 762 CSRRKAILLQLVTAVGAMLGTVLSL 836
S ++A+LL L +A+ A G ++L
Sbjct: 566 LSVKRALLLNLASALTAFAGLYVAL 590
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,711,454
Number of Sequences: 369166
Number of extensions: 1401582
Number of successful extensions: 3730
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3474
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3671
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)