Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_A16
(848 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P13395|SPTCA_DROME Spectrin alpha chain 330 3e-90
sp|P07751|SPTA2_CHICK Spectrin alpha chain, brain (Spectrin... 299 6e-81
sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, ... 295 1e-79
sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin... 293 3e-79
sp|P08032|SPTA1_MOUSE Spectrin alpha chain, erythrocyte (Er... 213 5e-55
sp|P02549|SPTA1_HUMAN Spectrin alpha chain, erythrocyte (Er... 212 9e-55
sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin... 198 2e-50
sp|Q00963|SPTCB_DROME Spectrin beta chain 135 1e-31
sp|Q9QWN8|SPTN2_RAT Spectrin beta chain, brain 2 (Spectrin,... 133 5e-31
sp|O15020|SPTN2_HUMAN Spectrin beta chain, brain 2 (Spectri... 133 7e-31
>sp|P13395|SPTCA_DROME Spectrin alpha chain
Length = 2415
Score = 330 bits (846), Expect = 3e-90
Identities = 159/282 (56%), Positives = 216/282 (76%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
RY+ FK T ++R+KLED++++Q FKRDADELESWI EK+Q S+E+++D TNLQ+K QK
Sbjct: 28 RYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESYRDPTNLQAKIQK 87
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQA E E++A S + LD +G EMI H+ASE IQ RLD+LH LWE LL+ EK
Sbjct: 88 HQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLAEKGLK 147
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L+ L VQFLR+ +E++FW K+KETFV ++EFGQDLEHVEVLQ+KF+EF KD+ QE +
Sbjct: 148 LQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYR 207
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
E+ AD L+Q+ PE++++ +K+++ +A RLK LA RQ+KLF AHEIQ+F RD
Sbjct: 208 VTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDA 267
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D+T+AW+ EK + LSS+D+GRDLASVQAL+RKHE ++RDL+A
Sbjct: 268 DETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAA 309
Score = 184 bits (467), Expect = 3e-46
Identities = 98/284 (34%), Positives = 165/284 (58%), Gaps = 2/284 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R+ KE E+R +L D + Q F RDADE+E+WI EK+Q ++E++KD N+QSK+QK
Sbjct: 1480 RWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQSKHQK 1539
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYAS--EIIQTRLDQLHALWEKLLNMFKEKS 356
HQA E E+AA ++ + + G +I+ + + +Q RL Q+ WE L + EKS
Sbjct: 1540 HQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKS 1599
Query: 357 RLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQE 536
LK ++ V ++ FW E E+ + +E+ G+DL V+ L KK D+ E
Sbjct: 1600 LKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHE 1659
Query: 537 EKAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFR 716
++ ++ ++AD L++ + + K++ + + +R+ +LA RQ +L EA + +FFR
Sbjct: 1660 DRIKDMNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFR 1719
Query: 717 DTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D +W+ EK + + S+D+GRDL VQ LK+KH+ L+ +L +
Sbjct: 1720 DIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGS 1763
Score = 175 bits (443), Expect = 2e-43
Identities = 93/276 (33%), Positives = 156/276 (56%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R +A +E + +RR+ LED+ +YQ F+RD DE + WI EK++ +D+++ D TNL K QK
Sbjct: 557 RRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQK 616
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQ E E+ A + + G E+IE HYA++ I TR+ ++ LWE L+ +K
Sbjct: 617 HQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTK 676
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L QF R +++I W E E ++SE+ G+DL V+ LQKK D+ +++
Sbjct: 677 LNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDR 736
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
I A+ ++ + +++ NK+ ++ L + +R+Q L ++ ++Q+ FRD
Sbjct: 737 IESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDL 796
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEAL 830
+ AW+ EK +S + GRDL VQ L +KH+A+
Sbjct: 797 EDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAV 832
Score = 139 bits (349), Expect = 1e-32
Identities = 81/283 (28%), Positives = 145/283 (51%), Gaps = 1/283 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEK-IQTYSDENFKDLTNLQSKNQ 179
RY R+ +L +A F RD + ESWI EK + SD+ +DLT +Q+ +
Sbjct: 1693 RYERICNLAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKK 1752
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KH+ LE E+ + + + ++G ++++ + I+ RL L+ W +L N+ + +
Sbjct: 1753 KHKRLEAELGSHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAWAELKNLAATRGQ 1812
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L +L Y QFL +V+E W EK+ + E++G + V+ L KK + F D ++
Sbjct: 1813 KLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKD 1872
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
+ + I + L++ ES+ + + + LD L +LA +R+ L + +F
Sbjct: 1873 RCSLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWK 1932
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D +W+++K + S++FGRDL++VQ L K E D L+A
Sbjct: 1933 ADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNA 1975
Score = 132 bits (333), Expect = 9e-31
Identities = 74/277 (26%), Positives = 151/277 (54%), Gaps = 1/277 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQALE 197
+A++++ KL +A + Q F R +++E W+ E + Q S+++ KDLT++Q+ +KH LE
Sbjct: 668 QASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLE 727
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
++ A + + + + N+ IE+ H+ ++ I+ + L A + L E+ + L +L
Sbjct: 728 ADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSL 787
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
Q R +++ W +EKE S G+DL V+ L KK + ++ E + +
Sbjct: 788 QVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVI 847
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
S +++L++ + + + + +++ + LK + +R+Q L ++ + ++F D ++ +
Sbjct: 848 SSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAES 907
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W+ EK + D+G+D S +AL +KHEAL DL A
Sbjct: 908 WMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEA 944
Score = 131 bits (329), Expect = 3e-30
Identities = 78/276 (28%), Positives = 141/276 (51%), Gaps = 2/276 (0%)
Frame = +3
Query: 27 TEERRKKLEDAKKYQLFKRDADELESWI--LEKIQTYSDENFKDLTNLQSKNQKHQALEL 200
T E+ KL++A K + + +L+ W+ +E + T D KDL ++Q+ +KHQ +E
Sbjct: 1595 TTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSG-KDLASVQNLMKKHQLVEA 1653
Query: 201 EIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLD 380
+I A + + ++ + ++E+ + + IQ + ++ +E++ N+ + L L
Sbjct: 1654 DIVAHEDRIKDMNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALT 1713
Query: 381 YVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYS 560
QF R + + W KEK+ V S+++G+DL V+ L+KK +L E +
Sbjct: 1714 LHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQE 1773
Query: 561 KADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAW 740
+ L+ + + K + A LK+LA R QKL E+ Q+F ++ AW
Sbjct: 1774 AGEKLMDVSNLGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAW 1833
Query: 741 VNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ EK LS ED+G +A+VQ L +KH+A + D +A
Sbjct: 1834 ITEKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTA 1869
Score = 122 bits (307), Expect = 1e-27
Identities = 76/272 (27%), Positives = 144/272 (52%), Gaps = 1/272 (0%)
Frame = +3
Query: 36 RRKKLEDAKKYQLFKRDADELESWILEKIQTY-SDENFKDLTNLQSKNQKHQALELEIAA 212
R++KL D+ Q F D +L +WI + SDE D+T ++ ++HQ EI A
Sbjct: 1279 RKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQEHRTEIDA 1338
Query: 213 QSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQF 392
++ ++ GNE+++ +HYAS I+ +++ L E L + E+ L+ LD +
Sbjct: 1339 RAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLY 1398
Query: 393 LRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADH 572
+R + W +E F+ +++ +VE L KK +F K + E+K A + + AD
Sbjct: 1399 MRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQ 1458
Query: 573 LLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEK 752
L+ ++ + K+K V + LK +++ +L + +Q+F RD D+ W+ EK
Sbjct: 1459 LIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEK 1518
Query: 753 SIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ L++E+ +D A++Q+ +KH+A + +L+A
Sbjct: 1519 -LQLATEESYKDPANIQSKHQKHQAFEAELAA 1549
Score = 122 bits (306), Expect = 1e-27
Identities = 76/273 (27%), Positives = 145/273 (53%), Gaps = 1/273 (0%)
Frame = +3
Query: 33 ERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQALELEIA 209
ER++KL+++ F D +L SWI K +DE KD+ ++ ++HQ + EI
Sbjct: 355 ERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLERHQEHKGEID 414
Query: 210 AQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQ 389
A+ ++ + +SG +++E HYA+ IQ +L L LL++++++ L + +D
Sbjct: 415 AREDSFKLTTESGQKLLEREHYAAAEIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQL 474
Query: 390 FLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKAD 569
F R ++ W ++E F+ +E+ G L+ VE L KK +F K L QEEK + A
Sbjct: 475 FYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIFAT 534
Query: 570 HLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNE 749
L+ + + +++ + L+ + KR+Q L +++ Q+F RD D+T W++E
Sbjct: 535 KLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISE 594
Query: 750 KSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
K + +++D D ++ +KH+ + +L+A
Sbjct: 595 K-LKFATDDSYLDPTNLNGKMQKHQNFEHELNA 626
Score = 122 bits (305), Expect = 2e-27
Identities = 70/207 (33%), Positives = 119/207 (57%), Gaps = 2/207 (0%)
Frame = +3
Query: 234 LDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQFLRRVDEI 413
L S +++ H A R +Q+++ ++ LL + +E+ L T+ +R ++
Sbjct: 1031 LSASQQNLVDNHSIAK-----RQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADL 1085
Query: 414 LFWTKEKETFV-ISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADHLLQEDF 590
W ++KE I++ G+DLE VEVLQKKF++F DL+ E + A + A L
Sbjct: 1086 AQWIRDKENHAQIADVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLGQ 1145
Query: 591 PEQESLI-NKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLS 767
E I + +D+ + + L++L ++ +L AHE+Q+F RD D+T W+ EK+ L+
Sbjct: 1146 TEAALKIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALN 1205
Query: 768 SEDFGRDLASVQALKRKHEALDRDLSA 848
++D G+DL SVQ L+RKHE ++RDL+A
Sbjct: 1206 NDDLGKDLRSVQTLQRKHEGVERDLAA 1232
Score = 120 bits (300), Expect = 6e-27
Identities = 71/282 (25%), Positives = 142/282 (50%), Gaps = 1/282 (0%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEK-IQTYSDENFKDLTNLQSKNQK 182
+ K+ R++KL A + Q F RDADE +WI EK + SD+ +DL ++Q+ +K
Sbjct: 240 WQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRK 299
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
H+ +E ++AA + ++ L + H S+ I+ + ++ W+ L +E+ +
Sbjct: 300 HEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQK 359
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L + +FL +++ W + + ++E +D+ E L ++ E +++ +E+
Sbjct: 360 LDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLERHQEHKGEIDAREDS 419
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
LL+ + + K +E+ L SL + R+ + ++Q F+RDT
Sbjct: 420 FKLTTESGQKLLEREHYAAAEIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQLFYRDT 479
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
++ W+ ++ L++ED G L SV+AL +KHE ++ L+A
Sbjct: 480 EQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAA 521
Score = 117 bits (292), Expect = 5e-26
Identities = 65/274 (23%), Positives = 145/274 (52%), Gaps = 2/274 (0%)
Frame = +3
Query: 33 ERRKKLEDAKKYQLFKRDADELESWILEKIQTY--SDENFKDLTNLQSKNQKHQALELEI 206
E+ KL+ A F R +E+ WI +K +T+ +DE +DL +++ +K + ++
Sbjct: 143 EKGLKLQQALVLVQFLRQCEEVMFWIKDK-ETFVTADEFGQDLEHVEVLQRKFDEFQKDM 201
Query: 207 AAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYV 386
A+Q + +++ +++++ H + I R ++L+ W++L + + L +
Sbjct: 202 ASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQ 261
Query: 387 QFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKA 566
+F R DE + W EK+ + S+++G+DL V+ LQ+K +DL E+K + + ++A
Sbjct: 262 RFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEA 321
Query: 567 DHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVN 746
L + + +K+ ++ + L + A++R+QKL E++ + +F D ++W+N
Sbjct: 322 QRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWIN 381
Query: 747 EKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+S+++ +D+A +AL +H+ ++ A
Sbjct: 382 GMKAIISADELAKDVAGAEALLERHQEHKGEIDA 415
Score = 117 bits (292), Expect = 5e-26
Identities = 64/282 (22%), Positives = 144/282 (51%), Gaps = 1/282 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
+++ + T E+ +L A + Q F RD DE + WI EK ++++ KDL ++Q+ +
Sbjct: 1162 KWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQR 1221
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KH+ +E ++AA + + LD++ N ++++H +E + +++ +W++++ +
Sbjct: 1222 KHEGVERDLAALRDKIRQLDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKE 1281
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L + D +FL ++L W + V S+E D+ E L ++ E +++ +
Sbjct: 1282 KLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQEHRTEIDARAG 1341
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
+ LLQ + + K +D+ A + L+ +R+ +L + ++Q + RD
Sbjct: 1342 TFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRD 1401
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
+ +W++ + L+++D +V+AL +KHE D+ ++
Sbjct: 1402 CELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAIN 1443
Score = 115 bits (289), Expect = 1e-25
Identities = 75/274 (27%), Positives = 137/274 (50%), Gaps = 1/274 (0%)
Frame = +3
Query: 30 EERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKD-LTNLQSKNQKHQALELEI 206
E+RR E QLF RD ++ ++W+ ++ ++E+ D L ++++ +KH+ E +
Sbjct: 460 EDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSL 519
Query: 207 AAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYV 386
AAQ E + LD ++I+ HYA++ + R L A L ++ +LL+ + Y
Sbjct: 520 AAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQ 579
Query: 387 QFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKA 566
QF R DE W EK F + + D ++ +K F +L + + +I +
Sbjct: 580 QFERDCDETKGWISEKLKFATDDSY-LDPTNLNGKMQKHQNFEHELNANKSRIEDITNVG 638
Query: 567 DHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVN 746
L+++ + + + +++ + L + K+ KL EA + Q+F R + W++
Sbjct: 639 TELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLS 698
Query: 747 EKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
E L SED G+DL SVQ L++KH L+ D+ A
Sbjct: 699 EIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMA 732
Score = 111 bits (277), Expect = 3e-24
Identities = 73/291 (25%), Positives = 141/291 (48%), Gaps = 9/291 (3%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEK-----IQTYSDENFKDLTNLQ 167
+Y ER+ KL + K + R+A +L WI +K I E+ +++ LQ
Sbjct: 1054 QYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIADVVGEDLEEVEVLQ 1113
Query: 168 SK----NQKHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLL 335
K N +A E+ +A N+N + + +T A+ IQT++ L+ W L
Sbjct: 1114 KKFDDFNDDLKANEVRLA----NMNEIAVQLTSLGQTE--AALKIQTQMQDLNEKWNNLQ 1167
Query: 336 NMFKEKSRLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFM 515
+ EK+ L + +F R +DE W EK + +++ G+DL V+ LQ+K
Sbjct: 1168 TLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVE 1227
Query: 516 KDLEYQEEKAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAH 695
+DL +K ++ A+ L+Q E K+K++ + D++ + + R++KL +++
Sbjct: 1228 RDLAALRDKIRQLDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSY 1287
Query: 696 EIQKFFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
++Q+F D +AW+N ++S++ D+ +AL +H+ ++ A
Sbjct: 1288 DLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQEHRTEIDA 1338
Score = 103 bits (257), Expect = 6e-22
Identities = 71/291 (24%), Positives = 129/291 (44%), Gaps = 10/291 (3%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKD-LTNLQSKNQK 182
++ K R +KL+++ YQ F +E E+WI EK Q S E++ D + +Q +K
Sbjct: 1800 WAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKK 1859
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
H A E + A + +++ G+E++E ++ E I R QL + L + +
Sbjct: 1860 HDAFETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGA 1919
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLE-YQEE 539
L Y+QF+ + D + W +KE +V S+EFG+DL V+ L K F L +++E
Sbjct: 1920 LLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQE 1979
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
I + D L+ + +++ + DV +L+ + R+ +L E + +
Sbjct: 1980 GIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRKDRLLAMQEQFRQIEE 2039
Query: 720 TDKTIA--------WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
T A W L+ + ++AL+ H LS+
Sbjct: 2040 LYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASLSS 2090
Score = 85.5 bits (210), Expect = 2e-16
Identities = 56/198 (28%), Positives = 94/198 (47%), Gaps = 1/198 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
RY+A ER++ L D+ + Q RD ++ +WI EK + N +DL +Q+ +
Sbjct: 768 RYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIK 827
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KHQA+ EI L + SG M++ +AS+ I+ RL+ L W L ++ +
Sbjct: 828 KHQAVLAEINNHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQ 887
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L +L Q+ +E W +EKE ++G+D + E L KK + DLE
Sbjct: 888 DLDDSLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGN 947
Query: 540 KAAEIYSKADHLLQEDFP 593
+ +A + Q++ P
Sbjct: 948 TIQALQEQAKNCRQQETP 965
Score = 61.2 bits (147), Expect = 3e-09
Identities = 40/189 (21%), Positives = 90/189 (47%)
Frame = +3
Query: 282 EIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEF 461
E IQ R +Q+ + + ++K L+ + + F R DE+ W EK SEE
Sbjct: 16 EDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEK-LQAASEES 74
Query: 462 GQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADHLLQEDFPEQESLINKKKDVEDAL 641
+D +++ +K F ++ + + ++ + ES+ + ++
Sbjct: 75 YRDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLW 134
Query: 642 DRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKH 821
+ L S ++ KL +A + +F R ++ + W+ +K +++++FG+DL V+ L+RK
Sbjct: 135 ELLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKF 194
Query: 822 EALDRDLSA 848
+ +D+++
Sbjct: 195 DEFQKDMAS 203
>sp|P07751|SPTA2_CHICK Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Fodrin alpha chain)
Length = 2477
Score = 299 bits (766), Expect = 6e-81
Identities = 153/282 (54%), Positives = 197/282 (69%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
RY FKE + RR+KLED+ ++Q F+RDADEL WI EK+Q SDEN+KD +NLQ K QK
Sbjct: 25 RYHRFKELSSLRRQKLEDSYRFQFFQRDADELGKWIQEKLQIASDENYKDPSNLQGKLQK 84
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQA E E+ A S + LD++GN+MI H+ASE I+TRL +LH LWE LL +EK
Sbjct: 85 HQAFEAEVQANSGAIVKLDETGNQMINEGHFASETIRTRLQELHRLWELLLEKMREKGVK 144
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L VQFLR ++++ W +KE V SEE GQDLEHVEVLQKKF EF DL EE+
Sbjct: 145 LLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEER 204
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
E+ A L+QE PE+E + +K+ +V + RLK LA++RQ KLF A E+Q+F RD
Sbjct: 205 VNEVNQFAGKLIQEQHPEEELIKSKQDEVNASWQRLKGLAQQRQGKLFGAAEVQRFNRDV 264
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D+TI+W+ EK ++S+DFGRDLASVQAL RKHE L+RDL+A
Sbjct: 265 DETISWIKEKGQLMASDDFGRDLASVQALLRKHEGLERDLAA 306
Score = 195 bits (496), Expect = 1e-49
Identities = 107/289 (37%), Positives = 167/289 (57%), Gaps = 7/289 (2%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQ----- 167
R+ K E+R KL +++ Q F RD DE+E+WI EK+QT SDE++KD TN+Q
Sbjct: 1532 RWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLL 1591
Query: 168 SKNQKHQALELEIAAQSENLNVLDKSGNEMIETHHYAS--EIIQTRLDQLHALWEKLLNM 341
SK+QKHQA E E+ A ++ + + + GN +IE A + ++ RL L WE L+
Sbjct: 1592 SKHQKHQAFEAELHANADRIRGVIEMGNPLIERGACAGSEDAVKARLAALADQWEFLVQK 1651
Query: 342 FKEKSRLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKD 521
EKS+ LK F + + FW E E + SE++G+DL V L KK D
Sbjct: 1652 SSEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEAD 1711
Query: 522 LEYQEEKAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEI 701
+ E++ ++ S+AD L+ + + +K++ + R+KS+A R+ KL E+H +
Sbjct: 1712 ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRETINGRFQRIKSMAAARRAKLNESHRL 1771
Query: 702 QKFFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+FFRD D +W+ EK + +SSED+GRDL VQ L++KH+ L+ +L+A
Sbjct: 1772 HQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
Score = 176 bits (445), Expect = 1e-43
Identities = 96/281 (34%), Positives = 163/281 (58%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R +A E +RR +L D+ Q F RD+DEL+SW+ EK++T +DE +KD +NLQ K QK
Sbjct: 554 RRNALHERAMKRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQK 613
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQA E E++A ++ L+K+G ++I+ +HYAS+ + R++++ +LW+KLL + K
Sbjct: 614 HQAFEAELSANQSRIDALEKAGQKLIDVNHYASDEVAARMNEVISLWKKLLEATELKGIK 673
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L+ QF R V++I W E E + S+++G+DL V+ LQKK D+ ++
Sbjct: 674 LREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTSVQNLQKKHALLEADVAAHQDP 733
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
I +A + +++ K++ + + LK R+QKL ++ +Q+ FRD
Sbjct: 734 IDGITIQARQFQDAGHFDADNIKKKQEALVARYEALKDPMVARKQKLADSLRLQQLFRDI 793
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
+ W+ EK +S + G+DL VQ L +KH+AL +++
Sbjct: 794 EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA 834
Score = 153 bits (387), Expect = 5e-37
Identities = 89/283 (31%), Positives = 149/283 (52%), Gaps = 1/283 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ K RR KL ++ + F RD D+ ESWI EK S E++ +DLT +Q+ +
Sbjct: 1750 RFQRIKSMAAARRAKLNESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRK 1809
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KH+ LE E+AA + + +G ++ + + E IQ RL Q W++L + + +
Sbjct: 1810 KHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVDHWKELKQLAAARGQ 1869
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ +L+Y QF+ V+E W EK T V SE++G L ++ L KK F D ++
Sbjct: 1870 RLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKD 1929
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
+ ++ + + L++++ E++ K K ++ + L+ A +R+ KL E +F
Sbjct: 1930 RVNDVCANGEDLIKKNNHHVENITAKMKGLKGKVSDLEKAAAQRKAKLDENSAFLQFNWK 1989
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D +W+ EK L ++D+GRDL+SVQ L K E D L A
Sbjct: 1990 ADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA 2032
Score = 137 bits (346), Expect = 3e-32
Identities = 80/273 (29%), Positives = 146/273 (53%), Gaps = 1/273 (0%)
Frame = +3
Query: 33 ERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQALELEIA 209
ER +L D+ + Q F D +L SW+ E K +DE D+ ++ +HQ + EI
Sbjct: 352 ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEID 411
Query: 210 AQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQ 389
A ++ D+SG ++ HYAS+ ++ +L L LL +++ + + + +D
Sbjct: 412 AHEDSFRSADESGQALLAAGHYASDEVKEKLTILSDERSALLELWELRRQQYEQCMDLQL 471
Query: 390 FLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKAD 569
F R +++ W ++E F+++E+ G L+ VE L KK +F K L QEEK + A
Sbjct: 472 FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
Query: 570 HLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNE 749
L+Q + + + ++ + + L A KR+ +L ++ +Q+FFRD+D+ +WVNE
Sbjct: 532 KLIQNNHYAMDDVATRRDALLSRRNALHERAMKRRAQLADSFHLQQFFRDSDELKSWVNE 591
Query: 750 KSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
K + E + +D +++Q +KH+A + +LSA
Sbjct: 592 KMKTATDEAY-KDPSNLQGKVQKHQAFEAELSA 623
Score = 137 bits (346), Expect = 3e-32
Identities = 82/277 (29%), Positives = 149/277 (53%), Gaps = 1/277 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQALE 197
EATE + KL +A + Q F R+ +++E W+ E + SD+ KDLT++Q+ +KH LE
Sbjct: 665 EATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTSVQNLQKKHALLE 724
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
++AA + ++ + + + H+ ++ I+ + + L A +E L + + + L +L
Sbjct: 725 ADVAAHQDPIDGITIQARQFQDAGHFDADNIKKKQEALVARYEALKDPMVARKQKLADSL 784
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
Q R +++ W +EKE S G+DL V+ L KK ++ E + +
Sbjct: 785 RLQQLFRDIEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT 844
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
K + +++E E + K ++ D LK+ A +R+Q L ++ + Q++F D ++ +
Sbjct: 845 QKGNAMVEEGHFAAEDVKIKLNELNQKWDSLKAKASQRRQDLEDSLQAQQYFADANEAQS 904
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W+ EK + S D+G+D S +AL +KHEAL DLSA
Sbjct: 905 WMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSA 941
Score = 135 bits (339), Expect = 2e-31
Identities = 88/287 (30%), Positives = 151/287 (52%), Gaps = 6/287 (2%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQK 182
+S+ + ++R++KL D+ Q F D +L SWI + SDE KD+T ++ ++
Sbjct: 1321 WSSLGKRADQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQ EI A++ ++ G +++ HYAS I+ +LD L L + ++ +
Sbjct: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLARGHYASPEIKEKLDILDQERTDLEKAWVQRRMM 1440
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L L+ F R ++ W +E F+ +E+ G L+ VE L KK +F K + QEEK
Sbjct: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
A + S AD L+ D + + N++ +V D RLK+ +++ KL E+ +Q+F RD
Sbjct: 1501 IAVLQSFADQLIAADHYAKGVIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALK-----RKHEALDRDLSA 848
D+ AW++EK S E + +D ++Q K +KH+A + +L A
Sbjct: 1561 DEIEAWISEKLQTASDESY-KDPTNIQLSKLLSKHQKHQAFEAELHA 1606
Score = 132 bits (333), Expect = 9e-31
Identities = 76/276 (27%), Positives = 145/276 (52%), Gaps = 1/276 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALE 197
+ + E+ +KL++A K Q F + + W+ E + E++ KDL ++ + +KHQ LE
Sbjct: 1650 QKSSEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLE 1709
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
+I+A + L L+ + ++ + + + ++ + + ++ ++++ +M + L +
Sbjct: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRETINGRFQRIKSMAAARRAKLNESH 1769
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
QF R +D+ W KEK+ V SE++G+DL V+ L+KK +L E +
Sbjct: 1770 RLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVL 1829
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
L ++ +E + + D LK LA R Q+L E+ E Q+F + ++ A
Sbjct: 1830 DTGKKLSDDNTIGKEEIQQRLAQFVDHWKELKQLAAARGQRLEESLEYQQFVANVEEEEA 1889
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
W+NEK ++SED+G LA++Q L +KHEA + D +
Sbjct: 1890 WINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT 1925
Score = 129 bits (323), Expect = 1e-29
Identities = 72/278 (25%), Positives = 151/278 (54%), Gaps = 2/278 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALE 197
E E+ KL A+K F R+ +++ WI +K + E +DL +++ +K + +
Sbjct: 136 EKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQ 195
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
++AA E +N +++ ++I+ H E+I+++ D+++A W++L + +++ L
Sbjct: 196 TDLAAHEERVNEVNQFAGKLIQEQHPEEELIKSKQDEVNASWQRLKGLAQQRQGKLFGAA 255
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
+ +F R VDE + W KEK + S++FG+DL V+ L +K +DL K +
Sbjct: 256 EVQRFNRDVDETISWIKEKGQLMASDDFGRDLASVQALLRKHEGLERDLAAFHHKVKALC 315
Query: 558 SKADHLLQEDFPEQESLIN-KKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTI 734
++AD LQ+ P S I K++++ +++++LA +R +L +++ +Q+F D
Sbjct: 316 AEADR-LQQSHPINASQIQVKREELIANWEQIRTLAAERHARLNDSYRLQRFLADFRDLT 374
Query: 735 AWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+WV E +++++ D+A +AL +H+ ++ A
Sbjct: 375 SWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDA 412
Score = 125 bits (315), Expect = 1e-28
Identities = 76/282 (26%), Positives = 140/282 (49%), Gaps = 1/282 (0%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQK 182
+ K ++R+ KL A + Q F RD DE SWI EK Q + ++F +DL ++Q+ +K
Sbjct: 237 WQRLKGLAQQRQGKLFGAAEVQRFNRDVDETISWIKEKGQLMASDDFGRDLASVQALLRK 296
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
H+ LE ++AA + L + + ++H + IQ + ++L A WE++ + E+
Sbjct: 297 HEGLERDLAAFHHKVKALCAEADRLQQSHPINASQIQVKREELIANWEQIRTLAAERHAR 356
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L + +FL ++ W E + + ++E D+ E L + E +++ E+
Sbjct: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDS 416
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
LL + + K + D L L + R+Q+ + ++Q F+RDT
Sbjct: 417 FRSADESGQALLAAGHYASDEVKEKLTILSDERSALLELWELRRQQYEQCMDLQLFYRDT 476
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
++ W++++ L +ED G L SV+AL +KHE ++ LSA
Sbjct: 477 EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSA 518
Score = 123 bits (308), Expect = 7e-28
Identities = 77/262 (29%), Positives = 129/262 (49%), Gaps = 44/262 (16%)
Frame = +3
Query: 195 ELEIAAQSENLNVLDKSGNEMIETHHYASEIIQT--------RLDQLHALWEKLLNMFKE 350
+L+ A + N+L++ G+ + ++ + T R+ Q+ L+ LL + ++
Sbjct: 1023 KLDPAQSASRENLLEEQGSIALRQEQIDNQTLITKEVGSVSLRMKQVEELYHSLLELGEK 1082
Query: 351 KSRLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEY 530
+ +L+ + R +E+ W EKE + +EE G DLE VEVLQKKF++F KDL+
Sbjct: 1083 RKGMLEKSCKKFMLFREANELQQWINEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKA 1142
Query: 531 QEEKAAEIYSKADHLLQEDFPEQE------------------------------------ 602
E + +I A+ L E +E
Sbjct: 1143 NESRLKDINKVANDLESEGLMAEEVQAVEHQEVYGMMPRDETDSKTVSPWKSARMMVHTV 1202
Query: 603 SLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFG 782
+ N K++ + L+ LA++R Q L A E+Q+F RD D+T W+ EK+ L+++++G
Sbjct: 1203 ATFNSIKELNERWRSLQQLAEERSQLLGSADEVQRFHRDADETKEWIEEKNQALNTDNYG 1262
Query: 783 RDLASVQALKRKHEALDRDLSA 848
DLASVQAL+R E +RDL+A
Sbjct: 1263 HDLASVQALQRNDEGFERDLAA 1284
Score = 117 bits (292), Expect = 5e-26
Identities = 74/281 (26%), Positives = 141/281 (50%), Gaps = 1/281 (0%)
Frame = +3
Query: 9 SAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKD-LTNLQSKNQKH 185
SA E E RR++ E QLF RD +++++W+ ++ +E+ D L ++++ +KH
Sbjct: 450 SALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKH 509
Query: 186 QALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLL 365
+ E ++AQ E + LD+ ++I+ +HYA + + TR D L + L ++ L
Sbjct: 510 EDFEKSLSAQEEKITALDEFATKLIQNNHYAMDDVATRRDALLSRRNALHERAMKRRAQL 569
Query: 366 KLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKA 545
+ QF R DE+ W EK E + +D +++ +K F +L + +
Sbjct: 570 ADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAFEAELSANQSRI 628
Query: 546 AEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTD 725
+ L+ + + + + +V +L + + KL EA++ Q+F R+ +
Sbjct: 629 DALEKAGQKLIDVNHYASDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVE 688
Query: 726 KTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W+ E L+S+D+G+DL SVQ L++KH L+ D++A
Sbjct: 689 DIELWLYEVEGHLASDDYGKDLTSVQNLQKKHALLEADVAA 729
Score = 113 bits (283), Expect = 6e-25
Identities = 71/282 (25%), Positives = 135/282 (47%), Gaps = 1/282 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ + ++ EER + L A + Q F RDADE + WI EK Q + +N+ DL ++Q+ +
Sbjct: 1214 RWRSLQQLAEERSQLLGSADEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+ E ++AA + +N L ++ +I++H +E +Q + +L+ W L ++
Sbjct: 1274 NDEGFERDLAALGDKVNSLGETAQRLIQSHPELAEDLQEKCTELNQAWSSLGKRADQRKE 1333
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L + D +FL +++ W V S+E +D+ E L ++ E +++ +
Sbjct: 1334 KLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAG 1393
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
LL + K ++ L+ +R+ L + E+Q F RD
Sbjct: 1394 TFQAFEQFGQQLLARGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDQCLELQLFHRD 1453
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
++ W+ + L++ED G L SV+AL +KHE D+ ++
Sbjct: 1454 CEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAIN 1495
Score = 109 bits (272), Expect = 1e-23
Identities = 62/201 (30%), Positives = 104/201 (51%), Gaps = 1/201 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
RY A K+ R++KL D+ + Q RD ++ E+WI EK + N KDL +Q+ +
Sbjct: 765 RYEALKDPMVARKQKLADSLRLQQLFRDIEDEETWIREKEPIAASTNRGKDLIGVQNLLK 824
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KHQAL+ EIA + + + GN M+E H+A+E ++ +L++L+ W+ L ++ +
Sbjct: 825 KHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKIKLNELNQKWDSLKAKASQRRQ 884
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ +L Q+ +E W +EKE V S ++G+D + E L KK M DL
Sbjct: 885 DLEDSLQAQQYFADANEAQSWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGS 944
Query: 540 KAAEIYSKADHLLQEDFPEQE 602
+ +A Q+ P +
Sbjct: 945 SIQALREQAQSCRQQVAPTDD 965
Score = 104 bits (260), Expect = 3e-22
Identities = 78/320 (24%), Positives = 144/320 (45%), Gaps = 39/320 (12%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDA-KKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
Y + E E+R+ LE + KK+ LF R+A+EL+ WI EK ++E DL ++ +
Sbjct: 1073 YHSLLELGEKRKGMLEKSCKKFMLF-REANELQQWINEKEAALTNEEVGADLEQVEVLQK 1131
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQT--------------------- 296
K + ++ A L ++K N++ E+ +E +Q
Sbjct: 1132 KFDDFQKDLKANESRLKDINKVANDL-ESEGLMAEEVQAVEHQEVYGMMPRDETDSKTVS 1190
Query: 297 ----------------RLDQLHALWEKLLNMFKEKSRLLKLTLDYVQFLRRVDEILFWTK 428
+ +L+ W L + +E+S+LL + +F R DE W +
Sbjct: 1191 PWKSARMMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSADEVQRFHRDADETKEWIE 1250
Query: 429 EKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADHLLQEDFPEQESL 608
EK + ++ +G DL V+ LQ+ F +DL +K + A L+Q E L
Sbjct: 1251 EKNQALNTDNYGHDLASVQALQRNDEGFERDLAALGDKVNSLGETAQRLIQSHPELAEDL 1310
Query: 609 INKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFGRD 788
K ++ A L A +R++KL ++H++Q+F D ++W+N +SS++ +D
Sbjct: 1311 QEKCTELNQAWSSLGKRADQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKD 1370
Query: 789 LASVQALKRKHEALDRDLSA 848
+ +AL +H+ ++ A
Sbjct: 1371 VTGAEALLERHQEHRTEIDA 1390
Score = 73.9 bits (180), Expect = 5e-13
Identities = 51/209 (24%), Positives = 103/209 (49%), Gaps = 4/209 (1%)
Frame = +3
Query: 234 LDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLD----YVQFLRR 401
+D SG +++ET E Q LD+ H FKE S L + L+ + F R
Sbjct: 1 MDPSGVKVLETAEDIQERRQQVLDRYHR--------FKELSSLRRQKLEDSYRFQFFQRD 52
Query: 402 VDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADHLLQ 581
DE+ W +EK + S+E +D +++ +K F +++ ++ + ++
Sbjct: 53 ADELGKWIQEK-LQIASDENYKDPSNLQGKLQKHQAFEAEVQANSGAIVKLDETGNQMIN 111
Query: 582 EDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIP 761
E E++ + +++ + L +++ KL +A ++ +F R+ + + W+N+K
Sbjct: 112 EGHFASETIRTRLQELHRLWELLLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAI 171
Query: 762 LSSEDFGRDLASVQALKRKHEALDRDLSA 848
++SE+ G+DL V+ L++K E DL+A
Sbjct: 172 VTSEELGQDLEHVEVLQKKFEEFQTDLAA 200
Score = 73.6 bits (179), Expect = 7e-13
Identities = 67/296 (22%), Positives = 140/296 (47%), Gaps = 14/296 (4%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
++ + K +RR+ LED+ + Q + DA+E +SW+ EK ++ KD + ++ +
Sbjct: 871 KWDSLKAKASQRRQDLEDSLQAQQYFADANEAQSWMREKEPIVGSTDYGKDEDSAEALLK 930
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KH+AL +++A ++ L + + A +T + + AL++ ++EKS
Sbjct: 931 KHEALMSDLSAYGSSIQALREQAQSCRQ--QVAPTDDETGKELVLALYD-----YQEKSP 983
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKF---NEFMKDLEY 530
++T+ K+ + + +D VEV ++ ++K L+
Sbjct: 984 R-EVTM----------------KKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDP 1026
Query: 531 QEEKAAE--IYSKADHLLQEDFPEQESLINKK--------KDVEDALDRLKSLAKKRQQK 680
+ + E + + L+++ + ++LI K+ K VE+ L L +KR+
Sbjct: 1027 AQSASRENLLEEQGSIALRQEQIDNQTLITKEVGSVSLRMKQVEELYHSLLELGEKRKGM 1086
Query: 681 LFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
L ++ + FR+ ++ W+NEK L++E+ G DL V+ L++K + +DL A
Sbjct: 1087 LEKSCKKFMLFREANELQQWINEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKA 1142
>sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 2472
Score = 295 bits (755), Expect = 1e-79
Identities = 153/282 (54%), Positives = 194/282 (68%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
RY FKE + RR+KLED+ ++Q F+RDA+ELE WI EK+Q SDEN+KD TNLQ K QK
Sbjct: 25 RYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQVASDENYKDPTNLQGKLQK 84
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQA E E+ A S + LD++GN MI H+ASE I+TRL +LH WE LL +EK
Sbjct: 85 HQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIK 144
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L VQ+LR ++++ W +KE V SEE GQDLEHVEVLQKKF EF DL EE+
Sbjct: 145 LLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEER 204
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
E+ A L+QE PE+E + K+++V A RLK LA +RQ KLF A E+Q+F RD
Sbjct: 205 VNEVNQFAAKLIQEQHPEEELIKTKQEEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDV 264
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D+TI W+ EK ++S+DFGRDLASVQAL RKHE L+RDL+A
Sbjct: 265 DETIGWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAA 306
Score = 198 bits (503), Expect = 2e-50
Identities = 105/284 (36%), Positives = 164/284 (57%), Gaps = 2/284 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R+ K E+R KL +++ Q F RD DE+E+WI EK+QT SDE++KD TN+QSK+QK
Sbjct: 1532 RWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQK 1591
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYAS--EIIQTRLDQLHALWEKLLNMFKEKS 356
HQA E E+ A ++ + + GN +IE A + ++ RL L W+ L+ EKS
Sbjct: 1592 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKS 1651
Query: 357 RLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQE 536
+ LK F + + FW E E + SE++G+DL V L KK D+ E
Sbjct: 1652 QKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHE 1711
Query: 537 EKAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFR 716
++ ++ S+AD L+ + + K+ + ++KS+A R+ KL E+H + +FFR
Sbjct: 1712 DRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFR 1771
Query: 717 DTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D D +W+ EK + +SSED+GRDL VQ L++KH+ L+ +L+A
Sbjct: 1772 DMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAA 1815
Score = 178 bits (452), Expect = 1e-44
Identities = 97/281 (34%), Positives = 163/281 (58%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R +A E RR +L D+ Q F RD+DEL+SW+ EK++T +DE +KD +NLQ K QK
Sbjct: 554 RRNALHERAMHRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQK 613
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQA E E++A ++ L+K+G ++I+ +HYA E + R++++ +LW+KLL + K
Sbjct: 614 HQAFEAELSANQSRIDALEKAGQKLIDVNHYAKEEVAARMNEVISLWKKLLEATELKGVK 673
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L+ QF R V++I W E E + S+++G+DL +V+ LQKK D+ +++
Sbjct: 674 LREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDR 733
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
I +A + E++ K++ + + LK R+QKL ++ +Q+ FRD
Sbjct: 734 IDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDV 793
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
+ W+ EK +S + G+DL VQ L +KH+AL +++
Sbjct: 794 EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA 834
Score = 155 bits (392), Expect = 1e-37
Identities = 89/283 (31%), Positives = 149/283 (52%), Gaps = 1/283 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ K RR KL ++ + F RD D+ ESWI EK S E++ +DLT +Q+ +
Sbjct: 1745 RFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRK 1804
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KH+ LE E+AA + + +G ++ + + E IQ RL Q W++L + + +
Sbjct: 1805 KHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQ 1864
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ +L+Y QF+ V+E W EK T V SE++G L ++ L KK F D ++
Sbjct: 1865 RLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKD 1924
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
+ ++ + L++++ +E++ +K K + + L+ A +R+ KL E +F
Sbjct: 1925 RVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWK 1984
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D +W+ EK L ++D+GRDL+SVQ L K E D L A
Sbjct: 1985 ADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA 2027
Score = 140 bits (354), Expect = 3e-33
Identities = 84/277 (30%), Positives = 148/277 (53%), Gaps = 1/277 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQALE 197
EATE + KL +A + Q F R+ +++E W+ E + SD+ KDLTN+Q+ +KH LE
Sbjct: 665 EATELKGVKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLE 724
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
++AA + ++ + + + H+ +E I+ + + L A +E L + + L +L
Sbjct: 725 ADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
Q R V++ W +EKE S G+DL V+ L KK ++ E + +
Sbjct: 785 RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT 844
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
K + +++E E + K ++ + LK+ A +R+Q L ++ + Q++F D ++ +
Sbjct: 845 QKGNAMVEEGHFAAEDVKAKLSELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAES 904
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W+ EK + S D+G+D S +AL +KHEAL DLSA
Sbjct: 905 WMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSA 941
Score = 137 bits (346), Expect = 3e-32
Identities = 80/273 (29%), Positives = 146/273 (53%), Gaps = 1/273 (0%)
Frame = +3
Query: 33 ERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQALELEIA 209
ER +L+D+ + Q F D +L SW+ E K +DE D+ ++ +HQ + EI
Sbjct: 352 ERHARLDDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEID 411
Query: 210 AQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQ 389
A ++ D+SG ++ HYAS+ ++ +L L LL +++ + + + +D
Sbjct: 412 AHEDSFKSADESGQALLAAGHYASDEVREKLSILSEERAALLELWELRRQQYEQCMDLQL 471
Query: 390 FLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKAD 569
F R +++ W ++E F+++E+ G L+ VE L KK +F K L QEEK + A
Sbjct: 472 FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
Query: 570 HLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNE 749
L+Q + E + ++ + + L A R+ +L ++ +Q+FFRD+D+ +WVNE
Sbjct: 532 KLIQNNHYAMEDVATRRDALLSRRNALHERAMHRRAQLADSFHLQQFFRDSDELKSWVNE 591
Query: 750 KSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
K + E + +D +++Q +KH+A + +LSA
Sbjct: 592 KMKTATDEAY-KDPSNLQGKVQKHQAFEAELSA 623
Score = 136 bits (343), Expect = 6e-32
Identities = 85/282 (30%), Positives = 150/282 (53%), Gaps = 1/282 (0%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQK 182
+++ + ++R+ KL D+ Q F D +L SWI + SDE KD+T ++ ++
Sbjct: 1321 WTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQ EI A++ ++ G +++ HYAS I+ +LD L L + ++ +
Sbjct: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQRRMM 1440
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L L+ F R ++ W +E F+ +E+ G L+ VE L KK +F K + QEEK
Sbjct: 1441 LDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
A + + AD L+ D + + N++ +V D RLK+ +++ KL E+ +Q+F RD
Sbjct: 1501 IAALQAFADQLIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D+ AW++EK S E + +D ++Q+ +KH+A + +L A
Sbjct: 1561 DEIEAWISEKLQTASDESY-KDPTNIQSKHQKHQAFEAELHA 1601
Score = 135 bits (340), Expect = 1e-31
Identities = 78/276 (28%), Positives = 145/276 (52%), Gaps = 1/276 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALE 197
+ + E+ +KL++A K Q F + + W+ E + E++ KDL ++ + +KHQ LE
Sbjct: 1645 QKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLE 1704
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
+I+A + L L+ + ++ + + + ++ + D ++ ++K+ +M + L +
Sbjct: 1705 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESH 1764
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
QF R +D+ W KEK+ V SE++G+DL V+ L+KK +L E +
Sbjct: 1765 RLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVL 1824
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
L ++ QE + + + LK LA R Q+L E+ E Q+F + ++ A
Sbjct: 1825 DTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEA 1884
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
W+NEK ++SED+G LA++Q L +KHEA + D +
Sbjct: 1885 WINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT 1920
Score = 132 bits (333), Expect = 9e-31
Identities = 80/262 (30%), Positives = 132/262 (50%), Gaps = 44/262 (16%)
Frame = +3
Query: 195 ELEIAAQSENLNVLDKSGNEMIETHHYASEI--------IQTRLDQLHALWEKLLNMFKE 350
+L+ A + N+L++ G+ + ++ + R+ Q+ L++ LL + ++
Sbjct: 1023 KLDPAQSASRENLLEEQGSIALRQGQIDNQTRITKEAGSVSLRMKQVEELYQSLLELGEK 1082
Query: 351 KSRLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEY 530
+ +L+ + R +E+ W EKE + SEE G DLE VEVLQKKF++F KDL+
Sbjct: 1083 RKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKA 1142
Query: 531 QEEKAAEIYSKADHLLQEDFPEQE------------------------------------ 602
E + +I A+ L E +E
Sbjct: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDEADSKTASPWKSARLMVHTV 1202
Query: 603 SLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFG 782
+ N K++ + L+ LA++R Q L AHE+Q+F RD D+T W+ EK+ L+++++G
Sbjct: 1203 ATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYG 1262
Query: 783 RDLASVQALKRKHEALDRDLSA 848
DLASVQAL+RKHE +RDL+A
Sbjct: 1263 HDLASVQALQRKHEGFERDLAA 1284
Score = 131 bits (329), Expect = 3e-30
Identities = 70/277 (25%), Positives = 150/277 (54%), Gaps = 1/277 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALE 197
E E+ KL A+K + R+ +++ WI +K + E +DL +++ +K + +
Sbjct: 136 EKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQ 195
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
++AA E +N +++ ++I+ H E+I+T+ ++++A W++L + ++ L
Sbjct: 196 TDLAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQEEVNAAWQRLKGLALQRQGKLFGAA 255
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
+ +F R VDE + W KEKE + S++FG+DL V+ L +K +DL E+K +
Sbjct: 256 EVQRFNRDVDETIGWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALC 315
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
++AD L Q + K++++ +++++LA +R +L +++ +Q+F D +
Sbjct: 316 AEADRLQQSHPLSANQIQVKREELITNWEQIRTLAAERHARLDDSYRLQRFLADFRDLTS 375
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
WV E +++++ D+A +AL +H+ ++ A
Sbjct: 376 WVTEMKALINADELANDVAGAEALLDRHQEHKGEIDA 412
Score = 122 bits (305), Expect = 2e-27
Identities = 73/279 (26%), Positives = 146/279 (52%), Gaps = 7/279 (2%)
Frame = +3
Query: 33 ERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALELEIA 209
+R+ KL A + Q F RD DE WI EK Q + ++F +DL ++Q+ +KH+ LE ++A
Sbjct: 246 QRQGKLFGAAEVQRFNRDVDETIGWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 210 AQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQ 389
A + + L + + ++H ++ IQ + ++L WE++ + E+ L + +
Sbjct: 306 ALEDKVKALCAEADRLQQSHPLSANQIQVKREELITNWEQIRTLAAERHARLDDSYRLQR 365
Query: 390 FLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE------KAAE 551
FL ++ W E + + ++E D+ E L + E +++ E+ ++ +
Sbjct: 366 FLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
Query: 552 IYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKT 731
A H ++ E+ S++++++ L L + R+Q+ + ++Q F+RDT++
Sbjct: 426 ALLAAGHYASDEVREKLSILSEERAA------LLELWELRRQQYEQCMDLQLFYRDTEQV 479
Query: 732 IAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W++++ L +ED G L SV+AL +KHE ++ LSA
Sbjct: 480 DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSA 518
Score = 117 bits (293), Expect = 4e-26
Identities = 74/281 (26%), Positives = 141/281 (50%), Gaps = 1/281 (0%)
Frame = +3
Query: 9 SAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKD-LTNLQSKNQKH 185
+A E E RR++ E QLF RD +++++W+ ++ +E+ D L ++++ +KH
Sbjct: 450 AALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKH 509
Query: 186 QALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLL 365
+ E ++AQ E + LD+ ++I+ +HYA E + TR D L + L + L
Sbjct: 510 EDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMHRRAQL 569
Query: 366 KLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKA 545
+ QF R DE+ W EK E + +D +++ +K F +L + +
Sbjct: 570 ADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAFEAELSANQSRI 628
Query: 546 AEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTD 725
+ L+ + +E + + +V +L + + KL EA++ Q+F R+ +
Sbjct: 629 DALEKAGQKLIDVNHYAKEEVAARMNEVISLWKKLLEATELKGVKLREANQQQQFNRNVE 688
Query: 726 KTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W+ E L+S+D+G+DL +VQ L++KH L+ D++A
Sbjct: 689 DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA 729
Score = 116 bits (291), Expect = 7e-26
Identities = 72/282 (25%), Positives = 137/282 (48%), Gaps = 1/282 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ + ++ EER + L A + Q F RDADE + WI EK Q + +N+ DL ++Q+ +
Sbjct: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KH+ E ++AA + +N L ++ +I++H ++E ++ + +L+ W L ++
Sbjct: 1274 KHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLKEKCTELNQAWTSLGKRADQRKA 1333
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L + D +FL +++ W V S+E +D+ E L ++ E +++ +
Sbjct: 1334 KLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAG 1393
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
LL + K ++ L+ +R+ L E+Q F RD
Sbjct: 1394 TFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDHCLELQLFHRD 1453
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
++ W+ + L++ED G L SV+AL +KHE D+ ++
Sbjct: 1454 CEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAIN 1495
Score = 110 bits (276), Expect = 4e-24
Identities = 64/198 (32%), Positives = 102/198 (51%), Gaps = 1/198 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
RY A KE R++KL D+ + Q RD ++ E+WI EK + N KDL +Q+ +
Sbjct: 765 RYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLK 824
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KHQAL+ EIA + + + GN M+E H+A+E ++ +L +L+ WE L ++ +
Sbjct: 825 KHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLSELNQKWEALKAKASQRRQ 884
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ +L Q+ +E W +EKE V S ++G+D + E L KK M DL
Sbjct: 885 DLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGS 944
Query: 540 KAAEIYSKADHLLQEDFP 593
+ +A Q+ P
Sbjct: 945 SIQALREQAQSCRQQVAP 962
Score = 105 bits (261), Expect = 2e-22
Identities = 76/319 (23%), Positives = 140/319 (43%), Gaps = 38/319 (11%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDA-KKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
Y + E E+R+ LE + KK+ LF R+A+EL+ WI EK + E DL ++ +
Sbjct: 1073 YQSLLELGEKRKGMLEKSCKKFMLF-REANELQQWINEKEAALTSEEVGADLEQVEVLQK 1131
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHAL------------- 320
K + ++ A L ++K ++ A E+ + +++ +
Sbjct: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDEADSKTASP 1191
Query: 321 -----------------------WEKLLNMFKEKSRLLKLTLDYVQFLRRVDEILFWTKE 431
W L + +E+S+LL + +F R DE W +E
Sbjct: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251
Query: 432 KETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADHLLQEDFPEQESLI 611
K + ++ +G DL V+ LQ+K F +DL +K + A L+Q E L
Sbjct: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLK 1311
Query: 612 NKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFGRDL 791
K ++ A L A +R+ KL ++H++Q+F D ++W+N +SS++ +D+
Sbjct: 1312 EKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDV 1371
Query: 792 ASVQALKRKHEALDRDLSA 848
+AL +H+ ++ A
Sbjct: 1372 TGAEALLERHQEHRTEIDA 1390
Score = 75.9 bits (185), Expect = 1e-13
Identities = 72/297 (24%), Positives = 136/297 (45%), Gaps = 15/297 (5%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
++ A K +RR+ LED+ + Q + DA+E ESW+ EK ++ KD + ++ +
Sbjct: 871 KWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLK 930
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KH+AL +++A + IQ +Q + +++ M E +
Sbjct: 931 KHEALMSDLSAYGSS---------------------IQALREQAQSCRQQVAPMDDETGK 969
Query: 360 LLKLTL-DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKF---NEFMKDLE 527
L L L DY + R E+ K+ + + +D VEV ++ ++K L+
Sbjct: 970 ELVLALYDYQEKSPR--EVTM--KKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025
Query: 528 YQEEKAAE--IYSKADHLLQEDFPEQESLINKK--------KDVEDALDRLKSLAKKRQQ 677
+ + E + + L++ + ++ I K+ K VE+ L L +KR+
Sbjct: 1026 PAQSASRENLLEEQGSIALRQGQIDNQTRITKEAGSVSLRMKQVEELYQSLLELGEKRKG 1085
Query: 678 KLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
L ++ + FR+ ++ W+NEK L+SE+ G DL V+ L++K + +DL A
Sbjct: 1086 MLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKA 1142
Score = 48.5 bits (114), Expect = 2e-05
Identities = 24/83 (28%), Positives = 49/83 (59%)
Frame = +3
Query: 600 ESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDF 779
E + +++ V D R K L+ R+QKL +++ Q F RD ++ W+ EK + ++S++
Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK-LQVASDEN 71
Query: 780 GRDLASVQALKRKHEALDRDLSA 848
+D ++Q +KH+A + ++ A
Sbjct: 72 YKDPTNLQGKLQKHQAFEAEVQA 94
>sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 2472
Score = 293 bits (751), Expect = 3e-79
Identities = 152/282 (53%), Positives = 194/282 (68%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
RY FKE + RR+KLED+ ++Q F+RDA+ELE WI EK+Q SDEN+KD TNLQ K QK
Sbjct: 25 RYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQK 84
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQA E E+ A S + LD++GN MI H+ASE I+TRL +LH WE LL +EK
Sbjct: 85 HQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIK 144
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L VQ+LR ++++ W +KE V SEE GQDLEHVEVLQKKF EF D+ EE+
Sbjct: 145 LLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEER 204
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
E+ A L+QE PE+E + K+ +V A RLK LA +RQ KLF A E+Q+F RD
Sbjct: 205 VNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDV 264
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D+TI+W+ EK ++S+DFGRDLASVQAL RKHE L+RDL+A
Sbjct: 265 DETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAA 306
Score = 196 bits (499), Expect = 5e-50
Identities = 104/284 (36%), Positives = 164/284 (57%), Gaps = 2/284 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R+ K E+R KL +++ Q F RD DE+E+WI EK+QT SDE++KD TN+QSK+QK
Sbjct: 1532 RWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQK 1591
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYAS--EIIQTRLDQLHALWEKLLNMFKEKS 356
HQA E E+ A ++ + + GN +IE A + ++ RL L W+ L+ EKS
Sbjct: 1592 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKS 1651
Query: 357 RLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQE 536
+ LK F + + FW E E + SE++G+DL V L KK D+ E
Sbjct: 1652 QKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHE 1711
Query: 537 EKAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFR 716
++ ++ S+AD L+ + + +K+ + ++KS+A R+ KL E+H + +FFR
Sbjct: 1712 DRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFR 1771
Query: 717 DTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D D +W+ EK + + SED+GRDL VQ L++KH+ L+ +L+A
Sbjct: 1772 DMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1815
Score = 177 bits (449), Expect = 3e-44
Identities = 96/281 (34%), Positives = 163/281 (58%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R +A E RR +L D+ Q F RD+DEL+SW+ EK++T +DE +KD +NLQ K QK
Sbjct: 554 RRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQK 613
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQA E E++A ++ L+K+G ++I+ +HYA + + R++++ +LW+KLL + K
Sbjct: 614 HQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIK 673
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L+ QF R V++I W E E + S+++G+DL +V+ LQKK D+ +++
Sbjct: 674 LREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDR 733
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
I +A + E++ K++ + + LK R+QKL ++ +Q+ FRD
Sbjct: 734 IDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDV 793
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
+ W+ EK +S + G+DL VQ L +KH+AL +++
Sbjct: 794 EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA 834
Score = 154 bits (388), Expect = 4e-37
Identities = 88/283 (31%), Positives = 148/283 (52%), Gaps = 1/283 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ K RR KL ++ + F RD D+ ESWI EK E++ +DLT +Q+ +
Sbjct: 1745 RFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRK 1804
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KH+ LE E+AA + + +G ++ + + E IQ RL Q W++L + + +
Sbjct: 1805 KHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQ 1864
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ +L+Y QF+ V+E W EK T V SE++G L ++ L KK F D ++
Sbjct: 1865 RLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKD 1924
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
+ ++ + L++++ +E++ +K K + + L+ A +R+ KL E +F
Sbjct: 1925 RVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWK 1984
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D +W+ EK L ++D+GRDL+SVQ L K E D L A
Sbjct: 1985 ADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA 2027
Score = 140 bits (352), Expect = 6e-33
Identities = 84/277 (30%), Positives = 148/277 (53%), Gaps = 1/277 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQALE 197
EATE + KL +A + Q F R+ +++E W+ E + SD+ KDLTN+Q+ +KH LE
Sbjct: 665 EATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLE 724
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
++AA + ++ + + + H+ +E I+ + + L A +E L + + L +L
Sbjct: 725 ADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
Q R V++ W +EKE S G+DL V+ L KK ++ E + +
Sbjct: 785 RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT 844
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
K + +++E E + K ++ + LK+ A +R+Q L ++ + Q++F D ++ +
Sbjct: 845 QKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAES 904
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W+ EK + S D+G+D S +AL +KHEAL DLSA
Sbjct: 905 WMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSA 941
Score = 138 bits (347), Expect = 2e-32
Identities = 80/273 (29%), Positives = 146/273 (53%), Gaps = 1/273 (0%)
Frame = +3
Query: 33 ERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQALELEIA 209
ER +L D+ + Q F D +L SW+ E K +DE D+ ++ +HQ + EI
Sbjct: 352 ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
Query: 210 AQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQ 389
A ++ D+SG ++ HYAS+ ++ +L L LL +++ + + + +D
Sbjct: 412 AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
Query: 390 FLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKAD 569
F R +++ W ++E F+++E+ G L+ VE L KK +F K L QEEK + A
Sbjct: 472 FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
Query: 570 HLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNE 749
L+Q + E + ++ + + L A +R+ +L ++ +Q+FFRD+D+ +WVNE
Sbjct: 532 KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
Query: 750 KSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
K + E + +D +++Q +KH+A + +LSA
Sbjct: 592 KMKTATDEAY-KDPSNLQGKVQKHQAFEAELSA 623
Score = 133 bits (335), Expect = 5e-31
Identities = 84/282 (29%), Positives = 149/282 (52%), Gaps = 1/282 (0%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQK 182
+S+ + ++R+ KL D+ Q F D +L SWI + SDE KD+T ++ ++
Sbjct: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQ EI A++ ++ G +++ HYAS I+ +LD L L + ++ +
Sbjct: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM 1440
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L L+ F R ++ W +E F+ +E+ G L+ VE L KK +F K + QEEK
Sbjct: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
A + + AD L+ + + +++ +V D RLK+ +++ KL E+ +Q+F RD
Sbjct: 1501 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D+ AW++EK S E + +D ++Q+ +KH+A + +L A
Sbjct: 1561 DEIEAWISEKLQTASDESY-KDPTNIQSKHQKHQAFEAELHA 1601
Score = 133 bits (334), Expect = 7e-31
Identities = 77/276 (27%), Positives = 145/276 (52%), Gaps = 1/276 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALE 197
+ + E+ +KL++A K Q F + + W+ E + E++ KDL ++ + +KHQ LE
Sbjct: 1645 QKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLE 1704
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
+I+A + L L+ + ++ + + + ++ + D ++ ++K+ +M + L +
Sbjct: 1705 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1764
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
QF R +D+ W KEK+ V SE++G+DL V+ L+KK +L E +
Sbjct: 1765 RLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVL 1824
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
L ++ +E + + + LK LA R Q+L E+ E Q+F + ++ A
Sbjct: 1825 DTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEA 1884
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
W+NEK ++SED+G LA++Q L +KHEA + D +
Sbjct: 1885 WINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT 1920
Score = 132 bits (333), Expect = 9e-31
Identities = 80/262 (30%), Positives = 131/262 (50%), Gaps = 44/262 (16%)
Frame = +3
Query: 195 ELEIAAQSENLNVLDKSGNEMIETHHYASEI--------IQTRLDQLHALWEKLLNMFKE 350
+L+ A + N+L++ G+ + ++ + R+ Q+ L+ LL + ++
Sbjct: 1023 KLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEK 1082
Query: 351 KSRLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEY 530
+ +L+ + R +E+ W EKE + SEE G DLE VEVLQKKF++F KDL+
Sbjct: 1083 RKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKA 1142
Query: 531 QEEKAAEIYSKADHLLQEDFPEQE------------------------------------ 602
E + +I A+ L E +E
Sbjct: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
Query: 603 SLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFG 782
+ N K++ + L+ LA++R Q L AHE+Q+F RD D+T W+ EK+ L+++++G
Sbjct: 1203 ATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYG 1262
Query: 783 RDLASVQALKRKHEALDRDLSA 848
DLASVQAL+RKHE +RDL+A
Sbjct: 1263 HDLASVQALQRKHEGFERDLAA 1284
Score = 132 bits (331), Expect = 2e-30
Identities = 71/277 (25%), Positives = 150/277 (54%), Gaps = 1/277 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALE 197
E E+ KL A+K + R+ +++ WI +K + E +DL +++ +K + +
Sbjct: 136 EKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQ 195
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
++AA E +N +++ ++I+ H E+I+T+ D+++A W++L + ++ L
Sbjct: 196 TDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAA 255
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
+ +F R VDE + W KEKE + S++FG+DL V+ L +K +DL E+K +
Sbjct: 256 EVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALC 315
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
++AD L Q + K++++ +++++LA +R +L +++ +Q+F D +
Sbjct: 316 AEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTS 375
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
WV E +++++ D+A +AL +H+ ++ A
Sbjct: 376 WVTEMKALINADELASDVAGAEALLDRHQEHKGEIDA 412
Score = 122 bits (307), Expect = 1e-27
Identities = 73/273 (26%), Positives = 138/273 (50%), Gaps = 1/273 (0%)
Frame = +3
Query: 33 ERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALELEIA 209
+R+ KL A + Q F RD DE SWI EK Q + ++F +DL ++Q+ +KH+ LE ++A
Sbjct: 246 QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 210 AQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQ 389
A + + L + + ++H ++ IQ + ++L WE++ + E+ L + +
Sbjct: 306 ALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQR 365
Query: 390 FLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKAD 569
FL ++ W E + + ++E D+ E L + E +++ E+
Sbjct: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
Query: 570 HLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNE 749
LL + + K + + L L + R+Q+ + ++Q F+RDT++ W+++
Sbjct: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
Query: 750 KSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ L +ED G L SV+AL +KHE ++ LSA
Sbjct: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSA 518
Score = 117 bits (292), Expect = 5e-26
Identities = 72/282 (25%), Positives = 137/282 (48%), Gaps = 1/282 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ + ++ EER + L A + Q F RDADE + WI EK Q + +N+ DL ++Q+ +
Sbjct: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KH+ E ++AA + +N L ++ + ++H ++E +Q + +L+ W L ++
Sbjct: 1274 KHEGFERDLAALGDKVNSLGETAERLTQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L + D +FL +++ W V S+E +D+ E L ++ E +++ +
Sbjct: 1334 KLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAG 1393
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
LL + K ++ L+ +R+ L + E+Q F RD
Sbjct: 1394 TFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRD 1453
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
++ W+ + L++ED G L SV+AL +KHE D+ ++
Sbjct: 1454 CEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAIN 1495
Score = 115 bits (289), Expect = 1e-25
Identities = 73/281 (25%), Positives = 141/281 (50%), Gaps = 1/281 (0%)
Frame = +3
Query: 9 SAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKD-LTNLQSKNQKH 185
+A E E RR++ E QLF RD +++++W+ ++ +E+ D L ++++ +KH
Sbjct: 450 AALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKH 509
Query: 186 QALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLL 365
+ E ++AQ E + LD+ ++I+ +HYA E + TR D L + L + L
Sbjct: 510 EDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQL 569
Query: 366 KLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKA 545
+ QF R DE+ W EK E + +D +++ +K F +L + +
Sbjct: 570 ADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAFEAELSANQSRI 628
Query: 546 AEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTD 725
+ L+ + ++ + + +V +L + + KL EA++ Q+F R+ +
Sbjct: 629 DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVE 688
Query: 726 KTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W+ E L+S+D+G+DL +VQ L++KH L+ D++A
Sbjct: 689 DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA 729
Score = 110 bits (276), Expect = 4e-24
Identities = 64/201 (31%), Positives = 103/201 (51%), Gaps = 1/201 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
RY A KE R++KL D+ + Q RD ++ E+WI EK + N KDL +Q+ +
Sbjct: 765 RYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLK 824
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KHQAL+ EIA + + + GN M+E H+A+E ++ +L +L+ WE L ++ +
Sbjct: 825 KHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQ 884
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ +L Q+ +E W +EKE V S ++G+D + E L KK M DL
Sbjct: 885 DLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGS 944
Query: 540 KAAEIYSKADHLLQEDFPEQE 602
+ +A Q+ P +
Sbjct: 945 SIQALREQAQSCRQQVAPTDD 965
Score = 104 bits (260), Expect = 3e-22
Identities = 76/319 (23%), Positives = 140/319 (43%), Gaps = 38/319 (11%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDA-KKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
Y + E E+R+ LE + KK+ LF R+A+EL+ WI EK + E DL ++ +
Sbjct: 1073 YHSLLELGEKRKGMLEKSCKKFMLF-REANELQQWINEKEAALTSEEVGADLEQVEVLQK 1131
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHAL------------- 320
K + ++ A L ++K ++ A E+ + +++ +
Sbjct: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191
Query: 321 -----------------------WEKLLNMFKEKSRLLKLTLDYVQFLRRVDEILFWTKE 431
W L + +E+S+LL + +F R DE W +E
Sbjct: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251
Query: 432 KETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADHLLQEDFPEQESLI 611
K + ++ +G DL V+ LQ+K F +DL +K + A+ L Q E L
Sbjct: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLTQSHPESAEDLQ 1311
Query: 612 NKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFGRDL 791
K ++ A L A +R+ KL ++H++Q+F D ++W+N +SS++ +D+
Sbjct: 1312 EKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDV 1371
Query: 792 ASVQALKRKHEALDRDLSA 848
+AL +H+ ++ A
Sbjct: 1372 TGAEALLERHQEHRTEIDA 1390
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/83 (28%), Positives = 49/83 (59%)
Frame = +3
Query: 600 ESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDF 779
E + +++ V D R K L+ R+QKL +++ Q F RD ++ W+ EK + ++S++
Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK-LQIASDEN 71
Query: 780 GRDLASVQALKRKHEALDRDLSA 848
+D ++Q +KH+A + ++ A
Sbjct: 72 YKDPTNLQGKLQKHQAFEAEVQA 94
>sp|P08032|SPTA1_MOUSE Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin)
Length = 2415
Score = 213 bits (542), Expect = 5e-55
Identities = 112/281 (39%), Positives = 170/281 (60%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
+Y FK+ ER +KLE++ YQ+F+RDAD+LE WI+EK++ D+ ++ TN+Q K QK
Sbjct: 33 QYQRFKDRVAERGQKLEESYHYQVFRRDADDLEKWIMEKLEIAKDKTYEP-TNIQGKYQK 91
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
H++ E+ A+S L L++ H+A E +T L QL LW+ LL + +EKS +
Sbjct: 92 HESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATKTHLKQLRLLWDLLLELTQEKSDV 151
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L L + Q+ + ++IL W KEKE V E G D E EVL KKF EF ++L ++ K
Sbjct: 152 LLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKKFEEFQEELTARKGK 211
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
+ A+ QE P+ + K+ +V A DRL SLA KR++ L A ++Q+F RD
Sbjct: 212 VDRVNQYANECAQEKHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSNAADLQRFKRDV 271
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
++ I W+ EK L+SED+G+DL S +AL H+ L+R+L+
Sbjct: 272 NEAIQWMEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLA 312
Score = 151 bits (382), Expect = 2e-36
Identities = 85/282 (30%), Positives = 151/282 (53%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R A +E RRK L D++ Q +D+D+L++WI +K + D+++KD+ NL+S+ QK
Sbjct: 561 RRDALRERAATRRKLLVDSQLLQQLYQDSDDLKTWINKKKKLADDDDYKDVQNLKSRVQK 620
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
Q E E+A LN L+K+G EMIE HYASE + RL ++ LW++LL +K
Sbjct: 621 QQDFEEELAVNEIMLNNLEKTGQEMIEDGHYASEAVAARLSEVANLWKELLEATAQKGTQ 680
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L +QF +++ W +E E V SE++G+ L V+ L +K D+ ++ +
Sbjct: 681 LYEANQLLQFENNAEDLKRWLEEVEWQVTSEDYGKVLADVQNLLRKHGLLESDVTARQNQ 740
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
+ A H + P+ + +++ + + LK R++KL + ++Q+ RD+
Sbjct: 741 MDTLTDMAAHFEEIGHPDSGDIRARQESLLSRFEALKEPLAIRKKKLIDLLKLQQICRDS 800
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ AW+ E +S G+DL + + L +HE + D+++
Sbjct: 801 EDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILADIAS 842
Score = 145 bits (365), Expect = 2e-34
Identities = 89/284 (31%), Positives = 143/284 (50%), Gaps = 2/284 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R+ A KE KL D + F RD ++LE WI E + DE++KD TN+Q K K
Sbjct: 1479 RWKALKEQLLTELGKLGDYADLKQFYRDLEDLEEWINEMLPIACDESYKDPTNIQRKYLK 1538
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETH--HYASEIIQTRLDQLHALWEKLLNMFKEKS 356
HQA E E+ ++E ++ + GN +IE E +Q +LD L W+ LL +K
Sbjct: 1539 HQAFENEVNGRAEQVDGVINLGNSLIERRVCDGDEENMQEQLDMLKENWDYLLERTTDKG 1598
Query: 357 RLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQE 536
+ L +F + + FW E E + ++ +DL L KK ++ +E
Sbjct: 1599 QKLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLARE 1658
Query: 537 EKAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFR 716
+ ++ A L+ + + K V + + ++SLA +KL E + + +FF+
Sbjct: 1659 DPLKDLNDLAQELISSGTFNIDQIEEKMNGVNERFENVQSLAAAHHEKLKETYALFQFFQ 1718
Query: 717 DTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D D AW+ EK + +SS+D+GRDL SVQ L +KH+ L+ +L A
Sbjct: 1719 DLDDEEAWIEEKLLRVSSQDYGRDLQSVQNLLKKHKRLEGELVA 1762
Score = 117 bits (293), Expect = 4e-26
Identities = 76/276 (27%), Positives = 138/276 (50%), Gaps = 1/276 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYS-DENFKDLTNLQSKNQKHQALE 197
E T ++ +KL +A + Q F + E W+ E + + +DLT+ + +KHQ LE
Sbjct: 1592 ERTTDKGQKLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQLLE 1651
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
E+ A+ + L L+ E+I + + + I+ +++ ++ +E + ++ LK T
Sbjct: 1652 AEMLAREDPLKDLNDLAQELISSGTFNIDQIEEKMNGVNERFENVQSLAAAHHEKLKETY 1711
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
QF + +D+ W +EK V S+++G+DL+ V+ L KK +L E +
Sbjct: 1712 ALFQFFQDLDDEEAWIEEKLLRVSSQDYGRDLQSVQNLLKKHKRLEGELVAHEPAVQNVL 1771
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
A+ L + +E + + ++LK LAK R L E+ E +F + ++ A
Sbjct: 1772 DTAESLRDKAAVGKEEIQERLAQFVQHWEKLKELAKTRGVNLEESLEYLQFMENAEEEEA 1831
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
W+ EK +S D G LA+ Q+L +KHEAL+ D +
Sbjct: 1832 WLGEKCALVSRGDSGDTLAATQSLLKKHEALENDFA 1867
Score = 114 bits (284), Expect = 4e-25
Identities = 66/269 (24%), Positives = 138/269 (51%), Gaps = 1/269 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYS-DENFKDLTNLQSKNQKHQALE 197
E T+E+ L A K+ + ++ +++ W+ EK + E D + ++K + +
Sbjct: 143 ELTQEKSDVLLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKKFEEFQ 202
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
E+ A+ ++ +++ NE + H I+ + D+++A W++L ++ ++ L
Sbjct: 203 EELTARKGKVDRVNQYANECAQEKHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSNAA 262
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
D +F R V+E + W +EKE + SE++G+DL E L ++L ++K E+
Sbjct: 263 DLQRFKRDVNEAIQWMEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLAVMDDKVKELC 322
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
+KAD L+ + + K D+ +R+++LA R KL ++ +F D D+
Sbjct: 323 AKADKLMISHSADALQIQQMKLDLVSNWERIRALATNRYAKLKASYGYHRFLSDYDELSG 382
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHE 824
W+ EK+ +++++ D+AS +AL +H+
Sbjct: 383 WMKEKTALINADELPTDVASGEALLARHQ 411
Score = 112 bits (279), Expect = 2e-24
Identities = 69/271 (25%), Positives = 138/271 (50%), Gaps = 1/271 (0%)
Frame = +3
Query: 36 RRKKLEDAKKYQLFKRDADELESWILEKIQTYS-DENFKDLTNLQSKNQKHQALELEIAA 212
R KL+ + Y F D DEL W+ EK + DE D+ + ++ +HQ + EI +
Sbjct: 360 RYAKLKASYGYHRFLSDYDELSGWMKEKTALINADELPTDVASGEALLARHQQHKHEIDS 419
Query: 213 QSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQF 392
+ D +G E+++ +H ASE I+ ++ L W LL ++ + + LD+ F
Sbjct: 420 YDDRFQSADATGQELLDGNHEASEEIREKMTILANDWAALLELWDKCQHQYRQCLDFHLF 479
Query: 393 LRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADH 572
R +++ W +E F+ +E+ G + VE L +K ++F + QEEK + A
Sbjct: 480 YRDSEQVDSWMSRQEAFLENEDLGNSVGSVEALLQKHDDFEEAFTAQEEKIITLDETATK 539
Query: 573 LLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEK 752
L+ D + E++ + + D L+ A R++ L ++ +Q+ ++D+D W+N+K
Sbjct: 540 LIDNDHYDSENIAAIRDGLLARRDALRERAATRRKLLVDSQLLQQLYQDSDDLKTWINKK 599
Query: 753 SIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
L+ +D +D+ ++++ +K + + +L+
Sbjct: 600 K-KLADDDDYKDVQNLKSRVQKQQDFEEELA 629
Score = 111 bits (278), Expect = 2e-24
Identities = 79/286 (27%), Positives = 136/286 (47%), Gaps = 4/286 (1%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ + +KL++ F +D D+ E+WI EK+ S +++ +DL ++Q+ +
Sbjct: 1692 RFENVQSLAAAHHEKLKETYALFQFFQDLDDEEAWIEEKLLRVSSQDYGRDLQSVQNLLK 1751
Query: 180 KHQALELEIAAQSENL-NVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKS 356
KH+ LE E+ A + NVLD + + + E IQ RL Q WEKL + K +
Sbjct: 1752 KHKRLEGELVAHEPAVQNVLD-TAESLRDKAAVGKEEIQERLAQFVQHWEKLKELAKTRG 1810
Query: 357 RLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQE 536
L+ +L+Y+QF+ +E W EK V + G L + L KK D +
Sbjct: 1811 VNLEESLEYLQFMENAEEEEAWLGEKCALVSRGDSGDTLAATQSLLKKHEALENDFAVHK 1870
Query: 537 EKAAEIYSKADHLLQEDFPEQESLINKKKDV--EDALDRLKSLAKKRQQKLFEAHEIQKF 710
+ ++ ++ + +L ++ + + I+ K V E K+LA + Q L + H Q+F
Sbjct: 1871 NRVQDVCAQGEDILNKEETQNKDKISTKIQVLNEKTASLAKALAAWKSQ-LDDVHAFQQF 1929
Query: 711 FRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D +W+ EK L ++ G DL + L KH+ LD L +
Sbjct: 1930 NWKADVVESWIGEKEASLKTKSNGADLTAFLTLLAKHDTLDASLQS 1975
Score = 107 bits (267), Expect = 4e-23
Identities = 69/274 (25%), Positives = 134/274 (48%), Gaps = 2/274 (0%)
Frame = +3
Query: 33 ERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALELEIA 209
+RR+ L +A Q FKRD +E W+ EK + E++ KDL + ++ H+ LE +A
Sbjct: 253 KRRESLSNAADLQRFKRDVNEAIQWMEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLA 312
Query: 210 AQSENLNVLDKSGNEMIETHHY-ASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYV 386
+ + L ++++ +H A +I Q +LD L + WE++ + + LK + Y
Sbjct: 313 VMDDKVKELCAKADKLMISHSADALQIQQMKLD-LVSNWERIRALATNRYAKLKASYGYH 371
Query: 387 QFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKA 566
+FL DE+ W KEK + ++E D+ E L + + +++ +++ +
Sbjct: 372 RFLSDYDELSGWMKEKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQSADATG 431
Query: 567 DHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVN 746
LL + E + K + + L L K Q + + + F+RD+++ +W++
Sbjct: 432 QELLDGNHEASEEIREKMTILANDWAALLELWDKCQHQYRQCLDFHLFYRDSEQVDSWMS 491
Query: 747 EKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ L +ED G + SV+AL +KH+ + +A
Sbjct: 492 RQEAFLENEDLGNSVGSVEALLQKHDDFEEAFTA 525
Score = 104 bits (259), Expect = 4e-22
Identities = 66/284 (23%), Positives = 140/284 (49%), Gaps = 2/284 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDEN-FKDLTNLQSKNQ 179
R+++ K +E+ + L A ++F R+AD+++ I +K + + + DL ++Q+ +
Sbjct: 1162 RWNSLKRLADEQYQLLSSAHAVEMFHREADDVKEQIDKKCRALNAADPGSDLLSVQALQR 1221
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+H+ E +I E +N L ++ + E+H A+E +Q + +L+ W+ L + ++
Sbjct: 1222 QHECFERDIIPLGEKVNTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRKE 1281
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L + FL + ++ W K + S E +DL E+L ++ E D++ ++
Sbjct: 1282 SLNEAHKFFLFLSKASDLENWIKTIGGVISSPELAEDLTGTEILLERHQEHHDDIKREDP 1341
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
+ L+ + + N +++ D L+ + R++ L + E+Q F
Sbjct: 1342 TFQALEDFGTELIDSGHRNRREIDNTLQNINSKRDNLEKSWENRKKMLDQCLELQLFRGK 1401
Query: 720 TDKTIAWVNEKSIPLSSEDFGRD-LASVQALKRKHEALDRDLSA 848
D+ +W+ + L S+D RD L S+QAL +K + LD+ ++A
Sbjct: 1402 CDQVESWMVARENSLRSDD--RDHLDSLQALMKKRDDLDKAITA 1443
Score = 100 bits (249), Expect = 5e-21
Identities = 63/282 (22%), Positives = 140/282 (49%), Gaps = 1/282 (0%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQK 182
++A E ++ + + + LF RD+++++SW+ + +E+ + ++++ QK
Sbjct: 456 WAALLELWDKCQHQYRQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSVGSVEALLQK 515
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
H E AQ E + LD++ ++I+ HY SE I D L A + L + +L
Sbjct: 516 HDDFEEAFTAQEEKIITLDETATKLIDNDHYDSENIAAIRDGLLARRDALRERAATRRKL 575
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L + Q + D++ W +K+ +++ +D+++++ +K +F ++L E
Sbjct: 576 LVDSQLLQQLYQDSDDLKTWINKKKKLADDDDY-KDVQNLKSRVQKQQDFEEELAVNEIM 634
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
+ ++++ E++ + +V + L ++ +L+EA+++ +F +
Sbjct: 635 LNNLEKTGQEMIEDGHYASEAVAARLSEVANLWKELLEATAQKGTQLYEANQLLQFENNA 694
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ W+ E ++SED+G+ LA VQ L RKH L+ D++A
Sbjct: 695 EDLKRWLEEVEWQVTSEDYGKVLADVQNLLRKHGLLESDVTA 736
Score = 98.2 bits (243), Expect = 3e-20
Identities = 67/277 (24%), Positives = 134/277 (48%), Gaps = 1/277 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQALE 197
EAT ++ +L +A + F+ +A++L+ W+ E + Q S++ K L ++Q+ +KH LE
Sbjct: 672 EATAQKGTQLYEANQLLQFENNAEDLKRWLEEVEWQVTSEDYGKVLADVQNLLRKHGLLE 731
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
++ A+ ++ L E H S I+ R + L + +E L + + L L
Sbjct: 732 SDVTARQNQMDTLTDMAAHFEEIGHPDSGDIRARQESLLSRFEALKEPLAIRKKKLIDLL 791
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
Q R ++ W +E E S G+DL + L + + D+ E + I
Sbjct: 792 KLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILADIASHEPRIQVIT 851
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
+ + +++E E + ++ + + ++ L + A +R+ L ++Q++ D + A
Sbjct: 852 ERGNKMVEEGHFAAEDIASRVESLNKNMESLHARAIRRENDLKANVQLQQYLADLHEAEA 911
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W+ EK + ++++G D + AL +KHEA DL+A
Sbjct: 912 WIKEKEPIVDNKNYGADEEAAGALLKKHEAFLVDLNA 948
Score = 95.1 bits (235), Expect = 2e-19
Identities = 59/195 (30%), Positives = 98/195 (50%), Gaps = 1/195 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ A KE R+KKL D K Q RD+++ E+WI E + + + KDL ++
Sbjct: 772 RFEALKEPLAIRKKKLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLN 831
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+H+ + +IA+ + V+ + GN+M+E H+A+E I +R++ L+ E L +
Sbjct: 832 RHEVILADIASHEPRIQVITERGNKMVEEGHFAAEDIASRVESLNKNMESLHARAIRREN 891
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
LK + Q+L + E W KEKE V ++ +G D E L KK F+ DL E
Sbjct: 892 DLKANVQLQQYLADLHEAEAWIKEKEPIVDNKNYGADEEAAGALLKKHEAFLVDLNAFEN 951
Query: 540 KAAEIYSKADHLLQE 584
+ +A+ Q+
Sbjct: 952 SIKALRDQAEVCQQQ 966
Score = 94.4 bits (233), Expect = 4e-19
Identities = 66/279 (23%), Positives = 131/279 (46%), Gaps = 2/279 (0%)
Frame = +3
Query: 18 KEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQKHQALE 197
+++ E R+K L+ + QLF+ D++ESW++ + + ++ L +LQ+ +K L+
Sbjct: 1379 EKSWENRKKMLDQCLELQLFRGKCDQVESWMVARENSLRSDDRDHLDSLQALMKKRDDLD 1438
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
I AQ ++ L+ +I+ HYA E I RL ++ W+ L + L
Sbjct: 1439 KAITAQEGKISDLENVATRLIDNDHYAKEEIAARLQRVLDRWKALKEQLLTELGKLGDYA 1498
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
D QF R ++++ W E E + +D +++ K F ++ + E+ +
Sbjct: 1499 DLKQFYRDLEDLEEWINEMLPIACDESY-KDPTNIQRKYLKHQAFENEVNGRAEQVDGVI 1557
Query: 558 SKADHLLQEDF--PEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKT 731
+ + L++ ++E++ + +++ D L + QKL EA Q+F
Sbjct: 1558 NLGNSLIERRVCDGDEENMQEQLDMLKENWDYLLERTTDKGQKLNEASRQQRFNTSIRDF 1617
Query: 732 IAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W++E L+ +D RDL S L +KH+ L+ ++ A
Sbjct: 1618 EFWLSEAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLA 1656
Score = 82.4 bits (202), Expect = 1e-15
Identities = 64/279 (22%), Positives = 117/279 (41%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQKH 185
Y + + EERR++L L +A ++ WI EK + D+ LQ K +
Sbjct: 1062 YHSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKTENTGVELDDVWELQKKFDEF 1121
Query: 186 QALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLL 365
Q ++ + L ++K +E++ E R +L+ W L + E+ +LL
Sbjct: 1122 QR---DLKSNEPRLKDINKVADELLFEELLTPEGAHIR-QELNTRWNSLKRLADEQYQLL 1177
Query: 366 KLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKA 545
F R D++ +K + + + G DL V+ LQ++ F +D+ EK
Sbjct: 1178 SSAHAVEMFHREADDVKEQIDKKCRALNAADPGSDLLSVQALQRQHECFERDIIPLGEKV 1237
Query: 546 AEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTD 725
+ A+ L + E L ++ ++ +A D L+ L R++ L EAH+ F
Sbjct: 1238 NTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRKESLNEAHKFFLFLSKAS 1297
Query: 726 KTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDL 842
W+ +SS + DL + L +H+ D+
Sbjct: 1298 DLENWIKTIGGVISSPELAEDLTGTEILLERHQEHHDDI 1336
Score = 37.7 bits (86), Expect = 0.041
Identities = 23/83 (27%), Positives = 42/83 (50%)
Frame = +3
Query: 600 ESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDF 779
E + +++ +V + R K +R QKL E++ Q F RD D W+ EK ++D
Sbjct: 21 EEIQHRRAEVLNQYQRFKDRVAERGQKLEESYHYQVFRRDADDLEKWIMEKL--EIAKDK 78
Query: 780 GRDLASVQALKRKHEALDRDLSA 848
+ ++Q +KHE+ ++ A
Sbjct: 79 TYEPTNIQGKYQKHESFVSEVQA 101
Score = 33.1 bits (74), Expect = 1.00
Identities = 47/234 (20%), Positives = 91/234 (38%), Gaps = 17/234 (7%)
Frame = +3
Query: 33 ERRKKLEDAKK-YQLFKRDADELESWILEKIQTYSDE-NFKDLTNLQSKNQKHQALELEI 206
E++ L+ A++ + F A +W + S+ + L ++ ++H+A +
Sbjct: 2029 EKQLPLQKAEELFMEFAHKASAFNNWCENAEEDMSEPVHCVSLNEIRQLQKEHEAFLASL 2088
Query: 207 AAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEK--------SRL 362
A E+ N L + ++ + +S +D L +W L ++ KE+ +R
Sbjct: 2089 AGAQEDFNYLLELDKQIKALNVPSSPYTWLTVDVLGRIWNHLPDIIKEREQELQKEEARQ 2148
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
+K +F + L W +E + + L K+ LE + K
Sbjct: 2149 IKNFEMCQEFEQNASAFLQWIQETRAYFLDGS----------LLKETGTLESQLEANKRK 2198
Query: 543 AAEIYSKADHLLQ-EDFPE--QESLINKKK----DVEDALDRLKSLAKKRQQKL 683
EI + HL + ED + +E+LI K + D+L L + Q L
Sbjct: 2199 QKEIQAMKRHLTKIEDLGDSMEEALILDIKYSTIGLAQQWDQLHQLGMRMQHNL 2252
>sp|P02549|SPTA1_HUMAN Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin)
Length = 2418
Score = 212 bits (540), Expect = 9e-55
Identities = 107/281 (38%), Positives = 170/281 (60%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
RY +FKE ER +KLED+ Q+FKRDAD+L WI+EK+ +D++++D TN+Q K QK
Sbjct: 34 RYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQK 93
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQ+LE E+ +S ++ L+K+ E H A E + +++L LW+ LL + EK
Sbjct: 94 HQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQ 153
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L L + Q+++ +IL W +KE S E G+D E EVL KKF +F +L +E +
Sbjct: 154 LLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGR 213
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
E+ A+ +E+ P+ + +K+ +V A +RL+ LA +RQ+ L A +Q+F RD
Sbjct: 214 VVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDV 273
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
+ I W+ EK L+SED+G+DL + + L H+ L+R+L+
Sbjct: 274 TEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLA 314
Score = 155 bits (393), Expect = 1e-37
Identities = 91/283 (32%), Positives = 149/283 (52%), Gaps = 1/283 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R+ A K + R KL D + F RD +ELE WI E + T DE++KD TN+Q K K
Sbjct: 1481 RWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLK 1540
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASE-IIQTRLDQLHALWEKLLNMFKEKSR 359
HQ E+ +SE ++ + GN +IE +E ++ +L+QL W+ LL +K +
Sbjct: 1541 HQTFAHEVDGRSEQVHGVINLGNSLIERSCDGNEEAMKEQLEQLKEHWDHLLERTNDKGK 1600
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L +F + + FW E ET + ++ +DL L KK +++ +E+
Sbjct: 1601 KLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLARED 1660
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
++ + A+ LL + ++ KK +V ++ LA +KL EA+ + +FF+D
Sbjct: 1661 ALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQD 1720
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D +W+ EK I +SS+D+GRDL VQ L +KH+ L+ +L A
Sbjct: 1721 LDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVA 1763
Score = 142 bits (358), Expect = 1e-33
Identities = 79/282 (28%), Positives = 148/282 (52%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R A +E RR+ L+++ Q D+D+L++WI +K + DE++KD+ NL+S+ QK
Sbjct: 563 RRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQK 622
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
Q E E+A L + K+G EMIE HYAS+ + TRL ++ +LWE+LL K+K
Sbjct: 623 QQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQ 682
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L +QF +++ W ++ E V SE++G+ L V+ +K + ++++
Sbjct: 683 LHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQ 742
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
+ A + + P+ + + +++ + + LK R++KL + +Q RDT
Sbjct: 743 VDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ AW+ E +S G+DL + + L +H + ++++
Sbjct: 803 EDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIAS 844
Score = 118 bits (295), Expect = 2e-26
Identities = 73/275 (26%), Positives = 139/275 (50%), Gaps = 5/275 (1%)
Frame = +3
Query: 36 RRKKLEDAKKYQLFKRDADELESWILEKIQTYS-DENFKDLTNLQSKNQKHQALELEIAA 212
R +KL+ Y F D DEL W+ EK + DE D+ + +HQ + EI +
Sbjct: 362 RYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDS 421
Query: 213 QSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQF 392
+ D++G +++ +H AS+ ++ +++ L W LL ++ E+ R + LD+ F
Sbjct: 422 YDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLF 481
Query: 393 LRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADH 572
R +++ W +E F+ +E+ G L E L +K +F + QEEK + A
Sbjct: 482 YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
Query: 573 LLQEDFPEQESLINKKKDVEDAL----DRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAW 740
L+ +D + E++ K + D L D L+ A R++ L E+ +QK + D+D W
Sbjct: 542 LIGDDHYDSENI----KAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNW 597
Query: 741 VNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
+N+K ED+ +D+ ++++ +K + +++L+
Sbjct: 598 INKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELA 631
Score = 113 bits (283), Expect = 6e-25
Identities = 69/270 (25%), Positives = 141/270 (52%), Gaps = 2/270 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEK--IQTYSDENFKDLTNLQSKNQKHQAL 194
E T E+ +L A K+Q + ++ ++ WI +K I T S E +D + ++K +
Sbjct: 145 ELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIAT-SVELGEDWERTEVLHKKFEDF 203
Query: 195 ELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLT 374
++E+ A+ + +++ NE E +H +IQ++ ++++A WE+L + ++ + L
Sbjct: 204 QVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNA 263
Query: 375 LDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEI 554
+ +F R V E + W KEKE + SE++G+DL E L ++L +K E+
Sbjct: 264 ANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKEL 323
Query: 555 YSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTI 734
+KA+ L + + K+D+ + + +++LA R +KL + +F D D+
Sbjct: 324 CAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELS 383
Query: 735 AWVNEKSIPLSSEDFGRDLASVQALKRKHE 824
W+NEK+ +++++ D+A + L +H+
Sbjct: 384 GWMNEKTAAINADELPTDVAGGEVLLDRHQ 413
Score = 112 bits (279), Expect = 2e-24
Identities = 75/276 (27%), Positives = 134/276 (48%), Gaps = 1/276 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYS-DENFKDLTNLQSKNQKHQALE 197
E T ++ KKL +A + Q F + E W+ E + + +DL + + +KHQ LE
Sbjct: 1593 ERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLE 1652
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
E+ A+ + L L+ +++ + + + I + D ++ + + + LK
Sbjct: 1653 REMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAY 1712
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
QF + +D+ W +EK V S+++G+DL+ V+ L KK +L E +
Sbjct: 1713 ALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVL 1772
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
A+ L + QE + + + ++LK LAK R KL E+ E +F ++ ++ A
Sbjct: 1773 DMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEA 1832
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
W+NEK+ D G LA+ Q+L KHEAL+ D +
Sbjct: 1833 WINEKNALAVRGDCGDTLAATQSLLMKHEALENDFA 1868
Score = 107 bits (267), Expect = 4e-23
Identities = 68/282 (24%), Positives = 139/282 (49%), Gaps = 1/282 (0%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQK 182
++A E +ER ++ E + LF RD+++++SW+ + +E+ L + ++ QK
Sbjct: 458 WTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQK 517
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
H+ E AQ E + +DK+ ++I HY SE I+ D L A + L + RL
Sbjct: 518 HEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRL 577
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
LK +L + D++ W +K+ E++ +D+++++ +K F K+L + +
Sbjct: 578 LKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQ 636
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
I +++ +++ + +V + L K++ +L EA++ +F +
Sbjct: 637 LENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNA 696
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ W+ + ++SED+G+ LA VQ RKH L+ ++A
Sbjct: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAA 738
Score = 106 bits (265), Expect = 7e-23
Identities = 77/287 (26%), Positives = 132/287 (45%), Gaps = 5/287 (1%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ +E +KL++A F +D D+ ESWI EK+ S +++ +DL +Q+ +
Sbjct: 1693 RFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLK 1752
Query: 180 KHQALELEIAAQSENL-NVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKS 356
KH+ LE E+ A + NVLD + ++ + E IQ RL Q WEKL + K +
Sbjct: 1753 KHKRLEGELVAHEPAIQNVLDMA-EKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARG 1811
Query: 357 RLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQE 536
L+ +L+Y+QF++ +E W EK + + G L + L K D E
Sbjct: 1812 LKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHE 1871
Query: 537 EKAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAK---KRQQKLFEAHEIQK 707
+ + ++ + +L + E+ +E ++ SLAK + +L + + Q+
Sbjct: 1872 TRVQNVCAQGEDILNKVLHEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQE 1931
Query: 708 FFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
F D AW+ +K L + G DL L K + LD L +
Sbjct: 1932 FNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQS 1978
Score = 104 bits (259), Expect = 4e-22
Identities = 65/273 (23%), Positives = 126/273 (46%), Gaps = 1/273 (0%)
Frame = +3
Query: 33 ERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALELEIA 209
+R+K L +A Q FKRD E WI EK + E++ KDL + H+ LE +A
Sbjct: 255 QRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLA 314
Query: 210 AQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQ 389
S+ + L ++ +H + IQ + L + WE + + + L+ T Y +
Sbjct: 315 VMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHR 374
Query: 390 FLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKAD 569
F DE+ W EK + ++E D+ EVL + + +++ +++
Sbjct: 375 FSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQ 434
Query: 570 HLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNE 749
L+ + + + K + +++ L L +R ++ + + F+RD+++ +W++
Sbjct: 435 DLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSR 494
Query: 750 KSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ L +ED G L S +AL +KHE + +A
Sbjct: 495 QEAFLENEDLGNSLGSAEALLQKHEDFEEAFTA 527
Score = 102 bits (254), Expect = 1e-21
Identities = 66/277 (23%), Positives = 136/277 (49%), Gaps = 1/277 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQALE 197
EAT+++ +L +A + F+ +A++L+ W+ + + Q S++ K L +Q++ +KH LE
Sbjct: 674 EATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLE 733
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
+AA+ + +++L E H S+ I+ R + L +E L + + L L
Sbjct: 734 SAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLL 793
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
R ++ W +E E S G+DL + L + ++++ E + EI
Sbjct: 794 HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
+ + +++E E + ++ K + ++ L++ A +RQ L + Q++ D +
Sbjct: 854 ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W+ EK + + ++G D + AL +KHEA DL++
Sbjct: 914 WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNS 950
Score = 98.6 bits (244), Expect = 2e-20
Identities = 66/283 (23%), Positives = 138/283 (48%), Gaps = 1/283 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDEN-FKDLTNLQSKNQ 179
R+ + + +E+R+ L A ++F R+AD+ + I +K Q S + DL ++Q+ +
Sbjct: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQR 1223
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+H+ E ++ + + +L ++ + E+H A+E +Q + +L+ WE L K++
Sbjct: 1224 RHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKE 1283
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L + FL + ++ W V S+E +DL +E+L ++ E D+E +
Sbjct: 1284 SLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAP 1343
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
+ + L+ + K + V+ D L+ +KR++ L + E+Q F +
Sbjct: 1344 TFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGN 1403
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D+ + + + L S+D L S++AL +K + LD+ ++A
Sbjct: 1404 CDQVESRMVARENSLRSDD-KSSLDSLEALMKKRDDLDKAITA 1445
Score = 97.1 bits (240), Expect = 6e-20
Identities = 66/278 (23%), Positives = 135/278 (48%), Gaps = 1/278 (0%)
Frame = +3
Query: 18 KEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQKHQALE 197
++A E+R+K L+ + Q+F+ + D++ES ++ + + ++ L +L++ +K L+
Sbjct: 1381 EKAWEKRKKILDQCLELQMFQGNCDQVESRMVARENSLRSDDKSSLDSLEALMKKRDDLD 1440
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
I AQ + L+ +I HYA E I TRL ++ W+ L ++ L
Sbjct: 1441 KAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYA 1500
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
+ QF R ++E+ W E E + +D +++ K F +++ + E+ +
Sbjct: 1501 NLKQFYRDLEELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVI 1559
Query: 558 SKADHLLQEDFP-EQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTI 734
+ + L++ +E++ + + +++ D L + +KL EA Q+F
Sbjct: 1560 NLGNSLIERSCDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFE 1619
Query: 735 AWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W++E L+ +D RDLAS L +KH+ L+R++ A
Sbjct: 1620 FWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLA 1657
Score = 86.3 bits (212), Expect = 1e-16
Identities = 55/208 (26%), Positives = 98/208 (47%), Gaps = 1/208 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ A KE R+KKL D QL RD ++ E+WI E + + KDL +
Sbjct: 774 RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLN 833
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+H+ + IA+ + + + GN+M+E H+A+E + +R+ L+ E L +
Sbjct: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQN 893
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ + + Q+L + E W +EKE V + +G D E L KK F+ DL +
Sbjct: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGD 953
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKK 623
+ ++A+ Q+ E + +++
Sbjct: 954 SMKALRNQANACQQQQAAPVEGVAGEQR 981
Score = 82.0 bits (201), Expect = 2e-15
Identities = 65/282 (23%), Positives = 122/282 (43%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
+Y + + EERR++L L +A ++ WI EK + D+ LQ K +
Sbjct: 1063 QYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDE 1122
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
Q ++ L ++K ++++ E Q R +L+A W L + E+ +L
Sbjct: 1123 FQK---DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNARWGSLQRLADEQRQL 1178
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L F R D+ ++K + + + G DL V+ LQ++ F +DL +K
Sbjct: 1179 LGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
+ A+ L + E L +K ++ +A + L+ K R++ L EA + F
Sbjct: 1239 VTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKA 1298
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W++ +SS++ DL ++ L +H+ D+ A
Sbjct: 1299 RDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA 1340
Score = 50.4 bits (119), Expect = 6e-06
Identities = 43/210 (20%), Positives = 92/210 (43%), Gaps = 4/210 (1%)
Frame = +3
Query: 231 VLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQFLRRVDE 410
V++ SG +++ET +E IQ R ++ ++ E+ + L+ + F R D+
Sbjct: 9 VVESSGPKVLET----AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
Query: 411 ILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADHLLQEDF 590
+ W EK + + + E +Q K+ + + LE + + + + S+ + +E F
Sbjct: 65 LGKWIMEKVNILTDKSY----EDPTNIQGKYQKH-QSLEAEVQTKSRLMSELEKTREERF 119
Query: 591 PEQESLINKKK----DVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSI 758
S + K ++ D L L ++ +L A + Q++ ++ + W+ +K
Sbjct: 120 TMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEA 179
Query: 759 PLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+S + G D + L +K E +L A
Sbjct: 180 IATSVELGEDWERTEVLHKKFEDFQVELVA 209
Score = 50.4 bits (119), Expect = 6e-06
Identities = 54/253 (21%), Positives = 104/253 (41%), Gaps = 18/253 (7%)
Frame = +3
Query: 45 KLEDAKKYQLFKRDADELESWILEKIQTY-SDENFKDLTNLQSKNQKHQALELEIAA-QS 218
+LED +Q F AD +E+WI +K + ++ N DL + + K L+ + + Q
Sbjct: 1922 QLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQ 1981
Query: 219 ENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFK-EKSRLLKLTLD----- 380
E L + +++I H S+ I+ R L WE+LL + +LL+ L
Sbjct: 1982 ERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2041
Query: 381 --YVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEI 554
+V+F + + W ++ E + L + LQK +F+ L + +
Sbjct: 2042 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCL 2101
Query: 555 YSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKL--FEAHEI------QKF 710
+ P + +E L + ++R+Q+L EA ++ Q+F
Sbjct: 2102 LELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEF 2161
Query: 711 FRDTDKTIAWVNE 749
++ + W+ E
Sbjct: 2162 EQNASTFLQWILE 2174
>sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 1458
Score = 198 bits (503), Expect = 2e-50
Identities = 105/284 (36%), Positives = 164/284 (57%), Gaps = 2/284 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R+ K E+R KL +++ Q F RD DE+E+WI EK+QT SDE++KD TN+QSK+QK
Sbjct: 518 RWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQK 577
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYAS--EIIQTRLDQLHALWEKLLNMFKEKS 356
HQA E E+ A ++ + + GN +IE A + ++ RL L W+ L+ EKS
Sbjct: 578 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKS 637
Query: 357 RLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQE 536
+ LK F + + FW E E + SE++G+DL V L KK D+ E
Sbjct: 638 QKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHE 697
Query: 537 EKAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFR 716
++ ++ S+AD L+ + + K+ + ++KS+A R+ KL E+H + +FFR
Sbjct: 698 DRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFR 757
Query: 717 DTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D D +W+ EK + +SSED+GRDL VQ L++KH+ L+ +L+A
Sbjct: 758 DMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAA 801
Score = 155 bits (392), Expect = 1e-37
Identities = 89/283 (31%), Positives = 149/283 (52%), Gaps = 1/283 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ K RR KL ++ + F RD D+ ESWI EK S E++ +DLT +Q+ +
Sbjct: 731 RFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRK 790
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
KH+ LE E+AA + + +G ++ + + E IQ RL Q W++L + + +
Sbjct: 791 KHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQ 850
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ +L+Y QF+ V+E W EK T V SE++G L ++ L KK F D ++
Sbjct: 851 RLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKD 910
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
+ ++ + L++++ +E++ +K K + + L+ A +R+ KL E +F
Sbjct: 911 RVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWK 970
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D +W+ EK L ++D+GRDL+SVQ L K E D L A
Sbjct: 971 ADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA 1013
Score = 136 bits (343), Expect = 6e-32
Identities = 85/282 (30%), Positives = 150/282 (53%), Gaps = 1/282 (0%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQK 182
+++ + ++R+ KL D+ Q F D +L SWI + SDE KD+T ++ ++
Sbjct: 307 WTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 366
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQ EI A++ ++ G +++ HYAS I+ +LD L L + ++ +
Sbjct: 367 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQRRMM 426
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L L+ F R ++ W +E F+ +E+ G L+ VE L KK +F K + QEEK
Sbjct: 427 LDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 486
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
A + + AD L+ D + + N++ +V D RLK+ +++ KL E+ +Q+F RD
Sbjct: 487 IAALQAFADQLIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 546
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D+ AW++EK S E + +D ++Q+ +KH+A + +L A
Sbjct: 547 DEIEAWISEKLQTASDESY-KDPTNIQSKHQKHQAFEAELHA 587
Score = 135 bits (340), Expect = 1e-31
Identities = 78/276 (28%), Positives = 145/276 (52%), Gaps = 1/276 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALE 197
+ + E+ +KL++A K Q F + + W+ E + E++ KDL ++ + +KHQ LE
Sbjct: 631 QKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLE 690
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
+I+A + L L+ + ++ + + + ++ + D ++ ++K+ +M + L +
Sbjct: 691 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESH 750
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
QF R +D+ W KEK+ V SE++G+DL V+ L+KK +L E +
Sbjct: 751 RLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVL 810
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
L ++ QE + + + LK LA R Q+L E+ E Q+F + ++ A
Sbjct: 811 DTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEA 870
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
W+NEK ++SED+G LA++Q L +KHEA + D +
Sbjct: 871 WINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT 906
Score = 128 bits (321), Expect = 2e-29
Identities = 80/254 (31%), Positives = 129/254 (50%), Gaps = 36/254 (14%)
Frame = +3
Query: 195 ELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLT 374
+L+ A + N+L++ G+ I R Q+ ++ LL + +++ +L+ +
Sbjct: 29 KLDPAQSASRENLLEEQGS------------IALRQGQIDNQYQSLLELGEKRKGMLEKS 76
Query: 375 LDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEI 554
R +E+ W EKE + +EE G DLE VEVLQKKF++F KDL+ E + +I
Sbjct: 77 CKKFMLFREANELQQWITEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDI 136
Query: 555 YSKADHLLQEDFPEQESLINKKKDVEDALDR----------------------------- 647
A+ L E +E ++++V A+ R
Sbjct: 137 NKVAEDLESEGLMAEEVQAVQQQEVYGAMPRDEADSKTASPWKSARLMVHTVATFNSIKE 196
Query: 648 -------LKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQA 806
L+ LA++R Q L AHE+Q+F RD D+T W+ EK+ L+++++G DLASVQA
Sbjct: 197 LNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQA 256
Query: 807 LKRKHEALDRDLSA 848
L+RKHE +RDL+A
Sbjct: 257 LQRKHEGFERDLAA 270
Score = 106 bits (265), Expect = 7e-23
Identities = 77/320 (24%), Positives = 142/320 (44%), Gaps = 38/320 (11%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDA-KKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKN 176
+Y + E E+R+ LE + KK+ LF R+A+EL+ WI EK ++E DL ++
Sbjct: 58 QYQSLLELGEKRKGMLEKSCKKFMLF-REANELQQWITEKEAALTNEEVGADLEQVEVLQ 116
Query: 177 QKHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTR------------------- 299
+K + ++ A L ++K ++ A E+ +
Sbjct: 117 KKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGAMPRDEADSKTAS 176
Query: 300 -----------------LDQLHALWEKLLNMFKEKSRLLKLTLDYVQFLRRVDEILFWTK 428
+ +L+ W L + +E+S+LL + +F R DE W +
Sbjct: 177 PWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIE 236
Query: 429 EKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADHLLQEDFPEQESL 608
EK + ++ +G DL V+ LQ+K F +DL +K + A L+Q E L
Sbjct: 237 EKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDL 296
Query: 609 INKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFGRD 788
K ++ A L A +R+ KL ++H++Q+F D ++W+N +SS++ +D
Sbjct: 297 KEKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKD 356
Query: 789 LASVQALKRKHEALDRDLSA 848
+ +AL +H+ ++ A
Sbjct: 357 VTGAEALLERHQEHRTEIDA 376
>sp|Q00963|SPTCB_DROME Spectrin beta chain
Length = 2291
Score = 135 bits (341), Expect = 1e-31
Identities = 81/282 (28%), Positives = 148/282 (52%), Gaps = 1/282 (0%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYS-DENFKDLTNLQSKNQK 182
Y+ ERR +LE+++K F D + E+WI EK Q S DE DLT + K
Sbjct: 617 YAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSK 676
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
H+ALE EI + L + K G+E+I H+ ++ I+ RL ++ W+ LL++ K + +
Sbjct: 677 HKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQR 736
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L+ ++Y Q D++ W + V SE+ G+D +V+ L KK + +L+ E
Sbjct: 737 LENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEV 796
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
++ +A+ L + E+ ++ + + +++ L LAK R+Q+L +A + K +
Sbjct: 797 IDALHKQAESLKLNE-AEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEA 855
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D W+ EK+ L + G+D+ V+ +K + E D++++A
Sbjct: 856 DGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNA 897
Score = 123 bits (309), Expect = 6e-28
Identities = 72/278 (25%), Positives = 145/278 (52%), Gaps = 2/278 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQKHQALE 197
+ T+ RR++LE+A +Y DAD++++W+L+ ++ S E+ +D N+QS +KH+ +
Sbjct: 728 DLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVA 787
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
E+ +E ++ L K E ++ + + RL+ + +++L + K + + L L
Sbjct: 788 DELKNYAEVIDALHKQA-ESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDAL 846
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
+ + D + W KEK + + G+D+E VE+++ +F F K++ + A +
Sbjct: 847 SLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVN 906
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
A LL + P + ++ ++ + L+ A+ + L AH +Q F+ + +TI+
Sbjct: 907 QLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETIS 966
Query: 738 WVNEKSIPLSSED-FGRDLASVQALKRKHEALDRDLSA 848
W+ +K L+ D DL V L+R+ +DRDL+A
Sbjct: 967 WIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAA 1004
Score = 120 bits (300), Expect = 6e-27
Identities = 77/272 (28%), Positives = 138/272 (50%), Gaps = 2/272 (0%)
Frame = +3
Query: 33 ERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQKHQALELEIAA 212
++ +KL++ K F +D +EL W+ EK T DE+++ + SK +HQA E EIAA
Sbjct: 1266 DQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAA 1325
Query: 213 QSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQF 392
E L +KS E+ + ++I+ +L +L ++ L KEK +L V
Sbjct: 1326 NKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLV 1385
Query: 393 LRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADH 572
+ D+I + + E ++S + DL V +L +K + + + EI K
Sbjct: 1386 QQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEI-DKQTE 1444
Query: 573 LLQEDFPEQ--ESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVN 746
LQ+ PE+ E ++ KK V + +++K+ +RQ+ L + E +F RD + W++
Sbjct: 1445 YLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWID 1504
Query: 747 EKSIPLSSEDFGRDLASVQALKRKHEALDRDL 842
EK +S D+G L +V LK+K+++L ++
Sbjct: 1505 EKLPVANSPDYGNSLFNVHVLKKKNQSLATEI 1536
Score = 109 bits (273), Expect = 8e-24
Identities = 73/278 (26%), Positives = 145/278 (52%), Gaps = 7/278 (2%)
Frame = +3
Query: 36 RRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFK-DLTNLQSKNQKHQALELEIAA 212
R++KLE F R A E+W+ E + S +NF DL +++ +KH+A+E +I A
Sbjct: 412 RQEKLEQLAAR--FDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFA 469
Query: 213 QSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQF 392
E + + +E+ ++ + I R D + LW LL + + + L+++L Q
Sbjct: 470 YEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQN 529
Query: 393 LRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADH 572
+ + IL +E + ++++++G+ L VE L +K + D+ E+ + +
Sbjct: 530 FQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQK 589
Query: 573 LLQEDFPEQ------ESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTI 734
L +D PE E ++++ + +EDA L LA +R+ +L E+ ++ +F+ DT
Sbjct: 590 FLSDD-PESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEE 648
Query: 735 AWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
W+ EK +S+++ G DL +V + KH+AL+ ++++
Sbjct: 649 NWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITS 686
Score = 107 bits (266), Expect = 5e-23
Identities = 71/275 (25%), Positives = 136/275 (49%), Gaps = 3/275 (1%)
Frame = +3
Query: 27 TEERRKKLEDAKKYQLFKRDADELESWI--LEKIQTYSDENFKDLTNLQSKNQKHQALEL 200
T+E+ L DA + L ++ D+++S+I LEK Q S + DLT++ QK Q ++
Sbjct: 1369 TKEKGAMLFDANREVLVQQTCDDIDSYITDLEK-QIVSGDTANDLTSVNILMQKQQVIQT 1427
Query: 201 EIAAQSENLNVLDKSGNEMIET-HHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
++A ++ + +DK + +T E I + + +EK+ E+ + L+
Sbjct: 1428 QMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKK 1487
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
+ QF R V++ W EK S ++G L +V VL+KK +++ E + I
Sbjct: 1488 EAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAIC 1547
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIA 737
+ L+ E + + D+ LK + R++ L E+ ++Q++F D + +
Sbjct: 1548 NNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAES 1607
Query: 738 WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDL 842
W++E+ + + ED G+D S Q L +KHE L++ +
Sbjct: 1608 WMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSV 1642
Score = 102 bits (253), Expect = 2e-21
Identities = 71/280 (25%), Positives = 132/280 (47%), Gaps = 6/280 (2%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEK--IQTYSDENFKDLTNLQSKNQ 179
+S +E E + L+ A Q F + E SWI +K I T +D DLT + + +
Sbjct: 934 WSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQR 993
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+ ++ ++AA L+ L++ N + + H ++II+ R+ Q+ +WE+L M KE+
Sbjct: 994 RLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDS 1053
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ D +FLR +D W + +T V SE+ L E L + ++++ E
Sbjct: 1054 KLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTE 1113
Query: 540 KAAEIYSKADHLLQE----DFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQK 707
+ + L E D P+ L + ++D + L + + RQ L ++ + Q
Sbjct: 1114 DYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQL 1173
Query: 708 FFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEA 827
F RD +T ++++ LS +D +L + ++HEA
Sbjct: 1174 FNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEA 1213
Score = 100 bits (248), Expect = 7e-21
Identities = 64/283 (22%), Positives = 128/283 (45%), Gaps = 1/283 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
R+ K ER+K LE K+ F RD ++ + WI EK+ + ++ L N+ +
Sbjct: 1468 RFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKK 1527
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
K+Q+L EI +N + +G ++I+ H ++ + + L W++L + + + +
Sbjct: 1528 KNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRK 1587
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L + Q+ E W E+E +++ E+ G+D + L KK + +E
Sbjct: 1588 HLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYAN 1647
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
++ A +D +++ K+ ++ LK LA +R+ +L EA ++ R+
Sbjct: 1648 TIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSRE 1707
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
D W+ ++ + S++ G+D V L + RD A
Sbjct: 1708 VDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEA 1750
Score = 98.2 bits (243), Expect = 3e-20
Identities = 64/283 (22%), Positives = 134/283 (47%), Gaps = 3/283 (1%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDEN-FKDLTNLQSKNQ 179
RY E + R+++L DA +AD +E WI EK + KD+ +++
Sbjct: 827 RYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKH 886
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+ + + E+ A + + V+++ +++ H S+ I R + L+ W L + K
Sbjct: 887 RFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMD 946
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVI-SEEFGQDLEHVEVLQKKFNEFMKDLEYQE 536
LK F E + W ++K+ + ++ DL V LQ++ + +DL +
Sbjct: 947 DLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQ 1006
Query: 537 EKAAEIYSKADHLLQEDFPEQESLINKK-KDVEDALDRLKSLAKKRQQKLFEAHEIQKFF 713
K + + +A+ + +++ PE+ +I ++ +E ++L + K+R KL EA ++ +F
Sbjct: 1007 AKLSSLEREANSI-EDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFL 1065
Query: 714 RDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDL 842
RD D W+ + ++SED L + L +H+++ ++
Sbjct: 1066 RDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEI 1108
Score = 98.2 bits (243), Expect = 3e-20
Identities = 65/289 (22%), Positives = 142/289 (49%), Gaps = 10/289 (3%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEK-IQTYSDENFKDLTNLQSKNQK 182
Y+ K+ ERR +L +A + + R+ D+LE WI ++ + S E +D ++ +++
Sbjct: 1681 YAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSER 1740
Query: 183 HQALELEI-AAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+ A E + ++ + +I+ H S I D L+ W+ LL + + +++
Sbjct: 1741 FNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQ 1800
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
+L + + +F ++L EK+ +S+E G+D V LQ+K F++DL
Sbjct: 1801 MLAASRELHKFFHDCKDVLGRILEKQ-HGVSDELGRDAGSVSTLQRKHYNFLQDL----- 1854
Query: 540 KAAEIYSKADHLLQEDFPEQES--------LINKKKDVEDALDRLKSLAKKRQQKLFEAH 695
+YS+ + +E Q++ + N++++V A D L+++ R+QKL +
Sbjct: 1855 --ITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTG 1912
Query: 696 EIQKFFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDL 842
++ +FF + W+ + +++ + RD++ V+ L H++L ++
Sbjct: 1913 DLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEI 1961
Score = 90.9 bits (224), Expect = 4e-18
Identities = 72/280 (25%), Positives = 130/280 (46%), Gaps = 6/280 (2%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQL-FKRDADELESWILEKIQTYSDENFKDLTNLQSKNQKHQALE 197
E RR +LE + + Q F+ L++ K +D+ K L ++ QKH +E
Sbjct: 511 ELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVE 570
Query: 198 LEIAAQSENLNVLDKSGNEMIETHHYA-----SEIIQTRLDQLHALWEKLLNMFKEKSRL 362
+I E + V+ ++ + + + EII +R+ QL + +L+ + E+
Sbjct: 571 ADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSR 630
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L+ + QF + W KEKE V ++E G DL V ++ K ++ + +
Sbjct: 631 LEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQ 690
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
+ L+ E + + ++ K++ + D L L K R+Q+L A E + F D
Sbjct: 691 LQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADA 750
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDL 842
D W+ + +SSED GRD A+VQ+L +KH+ + +L
Sbjct: 751 DDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADEL 790
Score = 75.9 bits (185), Expect = 1e-13
Identities = 58/227 (25%), Positives = 105/227 (46%), Gaps = 1/227 (0%)
Frame = +3
Query: 30 EERRKKLEDAKKYQLFKRDADELESWILEKI-QTYSDENFKDLTNLQSKNQKHQALELEI 206
+ R++KL D F L W+ + + Q + E +D++ ++ HQ+L+ EI
Sbjct: 1902 DARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEI 1961
Query: 207 AAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYV 386
+ +N G E++ +HYAS I+ RL L LL ++E+ L+L L+
Sbjct: 1962 DTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVY 2021
Query: 387 QFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKA 566
QF R W +E +++S E G ++ VE L KK F K QEE+ +S
Sbjct: 2022 QFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEER----FSAL 2077
Query: 567 DHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQK 707
+ L + E + +++++ + +R + ++ + EA E K
Sbjct: 2078 ERLTTFELKE----MKRRQELAEEAERQRIKEEQEAKAASEAAEQAK 2120
Score = 73.6 bits (179), Expect = 7e-13
Identities = 59/278 (21%), Positives = 120/278 (43%), Gaps = 2/278 (0%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQKHQALEL 200
E E R + L +++ F D ++ ILEK SDE +D ++ + +KH
Sbjct: 1793 ELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFLQ 1852
Query: 201 EIAAQSENLNVLDKSGNEMIETH--HYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLT 374
++ + + + ++ + + A EI + LHA W+ L M + + L T
Sbjct: 1853 DLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHA-WDNLQAMCDARKQKLADT 1911
Query: 375 LDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEI 554
D +F V ++ W ++ + + E +D+ VE+L +++ +E+
Sbjct: 1912 GDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGAC 1971
Query: 555 YSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTI 734
S LL + + ++ + ++ + L ++R + L E+ +F RD
Sbjct: 1972 ISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAE 2031
Query: 735 AWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
AW+ + L S + G + V+ L +KHEA ++ +A
Sbjct: 2032 AWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAA 2069
Score = 62.0 bits (149), Expect = 2e-09
Identities = 45/190 (23%), Positives = 87/190 (45%), Gaps = 8/190 (4%)
Frame = +3
Query: 300 LDQLHALWEKL--------LNMFKEKSRLLKLTLDYVQFLRRVDEILFWTKEKETFVISE 455
+ ++ WE+L L + +E R KL +F R+ W E + V +
Sbjct: 385 ISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQD 444
Query: 456 EFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADHLLQEDFPEQESLINKKKDVED 635
FG DL VE KK D+ EE+ + + D L E + + + ++ +K +V
Sbjct: 445 NFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMR 504
Query: 636 ALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKR 815
L L + R+ +L + ++Q+ F++ + + E L ++D+G+ L V+ L +
Sbjct: 505 LWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQ 564
Query: 816 KHEALDRDLS 845
KH ++ D++
Sbjct: 565 KHSLVEADIN 574
>sp|Q9QWN8|SPTN2_RAT Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2)
(Beta-III spectrin) (SPNB-3) (Beta SpIII sigma 1)
(Spectrin-like protein GTRAP41)
Length = 2388
Score = 133 bits (335), Expect = 5e-31
Identities = 83/280 (29%), Positives = 145/280 (51%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R+ +EA ++ +L D ++ Q F +D EL+ WI EK+ T D ++ + NL +K QK
Sbjct: 1259 RHRKNQEAVQQLLGRLRDNREQQHFLQDCQELKLWIDEKMLTAQDVSYDEARNLHTKWQK 1318
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQA E+AA + L+ +DK G E+ ++ +L+ LH W++L + K+R
Sbjct: 1319 HQAFMAELAANKDWLDKVDKEGRELTLEKPELKVLVSEKLEDLHRRWDELETTTQAKARS 1378
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L F + + W + + + S+++G+DL V +L KK +++ +E++
Sbjct: 1379 LFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKE 1438
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
I ++A L QED E + + VE+ L K R ++L + E +F RD
Sbjct: 1439 VEAIQAQAKALAQEDQSAGE-VERTSRAVEEKFRALCQPMKDRCRRLQASREQHQFHRDV 1497
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDL 842
+ I WV E+ SS + G+DL SVQ L +K++ L +++
Sbjct: 1498 EDEILWVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEI 1537
Score = 130 bits (326), Expect = 6e-30
Identities = 87/275 (31%), Positives = 140/275 (50%), Gaps = 2/275 (0%)
Frame = +3
Query: 30 EERRKKLEDAKKYQLFKRDADELESWILEK-IQTYSDENFKDLTNLQSKNQKHQALELEI 206
E R K+LE+A + Q F RDA E E+W+ E+ + E KD + Q++ +KHQ LE +
Sbjct: 1578 ELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQAL 1637
Query: 207 AAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYV 386
A ++ + L S +MI+ H S + R Q+ L+ L + E+ L+ L
Sbjct: 1638 ADYAQTIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYAGLKELAGERRERLQEHLRLC 1697
Query: 387 QFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLE-YQEEKAAEIYSK 563
Q R +D++ W +E+E S E GQD EHV +L+ KF EF +D +E+ +
Sbjct: 1698 QLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANAL 1757
Query: 564 ADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWV 743
A+ L+ + ++ K + +A L L R Q L A+E+Q+F + +A V
Sbjct: 1758 ANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARV 1817
Query: 744 NEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
K L + GRDL + +AL+R+H A + D+ A
Sbjct: 1818 QHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQA 1851
Score = 114 bits (285), Expect = 3e-25
Identities = 76/284 (26%), Positives = 142/284 (50%), Gaps = 2/284 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSD-ENFKDLTNLQSKNQ 179
++ + EER ++L A F+ DA+++E+W+++ ++ S E D + Q+ +
Sbjct: 728 QWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQALAR 787
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+H+ALE EI A L+ L + + + E+ Q R+ L +E+L E++R
Sbjct: 788 QHRALEEEIRAHRPTLDALREQAAALPPALSHTPEV-QGRVPTLEQHYEELQARAGERAR 846
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ L + L W +EKE ++ + LE +EV+Q++F ++
Sbjct: 847 ALEAALAFYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAA 906
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
+ + A+ LL+ P ++ +I ++ + + +SLA ++ L A IQ + +
Sbjct: 907 RVTAVSDIAEQLLKASPPGKDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLE 966
Query: 720 TDKTIAWVNEKS-IPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+T AW+ EK+ + S++D G DLA V AL+RK +RDL A
Sbjct: 967 CTETQAWMREKTKVIESTQDLGNDLAGVLALQRKLAGTERDLEA 1010
Score = 97.4 bits (241), Expect = 4e-20
Identities = 73/275 (26%), Positives = 133/275 (48%), Gaps = 5/275 (1%)
Frame = +3
Query: 36 RRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFK-DLTNLQSKNQKHQALELEIAA 212
R++KLE F R A E+W+ E + S +NF +L +++ +KH+A+E +I A
Sbjct: 419 RQEKLEQLAAR--FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVA 476
Query: 213 QSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQF 392
S + +D E+ H++ + I R + + LW+ L M + L L L+ +
Sbjct: 477 YSGRVQAVDAVAAELAAEHYHDIKRIAARQNNVARLWDFLREMVAARRERLLLNLELQKV 536
Query: 393 LRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADH 572
+ + ++ W E + + S++ G+ L VE L + D+ Q E+ + + A
Sbjct: 537 FQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASALR 596
Query: 573 LL---QEDFPEQESLINKK-KDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAW 740
+E P L++++ +E + + L LA R+ +L E+ + +F + + AW
Sbjct: 597 FCDPGKEYRPCDPQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEAW 656
Query: 741 VNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
V E+ L+S + GRDL V L KH AL ++S
Sbjct: 657 VREQQHLLASAETGRDLTGVLRLLNKHTALRGEMS 691
Score = 91.3 bits (225), Expect = 3e-18
Identities = 65/282 (23%), Positives = 130/282 (46%), Gaps = 1/282 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSD-ENFKDLTNLQSKNQ 179
++ A + ++R ++L+ +++ F RD ++ W+ E++ S E+ KDL ++Q +
Sbjct: 1469 KFRALCQPMKDRCRRLQASREQHQFHRDVEDEILWVTERLPMASSLEHGKDLPSVQLLMK 1528
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
K+Q L+ EI + L K + T E L +L +W++L + + + +
Sbjct: 1529 KNQTLQKEIQGHEPRIADL-KERQRTLGTAAAGPE-----LAELQEMWKRLSHELELRGK 1582
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ L QF R E W E+E ++ +E +D + KK + L +
Sbjct: 1583 RLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQ 1642
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
++ + + ++ + PE L ++ V+ LK LA +R+++L E + + R+
Sbjct: 1643 TIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
D W+ E+ + +S + G+D V L+ K RD S
Sbjct: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTS 1744
Score = 86.7 bits (213), Expect = 8e-17
Identities = 69/282 (24%), Positives = 127/282 (45%), Gaps = 5/282 (1%)
Frame = +3
Query: 18 KEATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQAL 194
+E RR++L + Q +D L W+ E K + S + K L ++ Q H+ +
Sbjct: 517 REMVAARRERLLLNLELQKVFQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLHELV 576
Query: 195 ELEIAAQSENLNVLDKSGNEMI----ETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
E +IA Q+E + + S E +++ R+ L +E L + +
Sbjct: 577 EADIAVQAERVRAVSASALRFCDPGKEYRPCDPQLVSERVATLEQSYEALCELAATRRAR 636
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L+ + +FL V E W +E++ + S E G+DL V L K ++ +
Sbjct: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGP 696
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
+ L+ E P + +++ +RL++LA++R Q+L +A + +F D
Sbjct: 697 LKLTLEQGQQLVAEGHPGANQASTRAAELQAQWERLEALAEERAQRLAQAASLYQFQADA 756
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ AW+ + +SS + G D S QAL R+H AL+ ++ A
Sbjct: 757 NDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRALEEEIRA 798
Score = 85.5 bits (210), Expect = 2e-16
Identities = 67/278 (24%), Positives = 121/278 (43%), Gaps = 3/278 (1%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKD-LTNLQSKNQK 182
Y + ER + LE A + +A W+ EK Q + + L +L+ Q+
Sbjct: 834 YEELQARAGERARALEAALAFYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQR 893
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
+ LE E+ A + + + ++++ + I +QL+ W++ ++ K
Sbjct: 894 FETLEPEMNALAARVTAVSDIAEQLLKASPPGKDRIIGTQEQLNQRWQQFRSLADGKKAA 953
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVIS-EEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L L + E W +EK + S ++ G DL V LQ+K +DLE
Sbjct: 954 LTSALSIQNYHLECTETQAWMREKTKVIESTQDLGNDLAGVLALQRKLAGTERDLEAISA 1013
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKK-DVEDALDRLKSLAKKRQQKLFEAHEIQKFFR 716
+ E+ +A+ L P Q IN + +V+ + L++ ++R++ L EA +Q F R
Sbjct: 1014 RVGELTQEAN-ALAAGHPAQAPAINTRLGEVQTGWEDLRATMRRREESLGEARRLQDFLR 1072
Query: 717 DTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEAL 830
D AW+ ++SE+ L +AL +H AL
Sbjct: 1073 SLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAAL 1110
Score = 75.5 bits (184), Expect = 2e-13
Identities = 63/277 (22%), Positives = 129/277 (46%), Gaps = 5/277 (1%)
Frame = +3
Query: 30 EERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQKHQALE---L 200
E R+ +L A +Q F RDA + E + Q Y + + LQ+ + + LE
Sbjct: 1162 ESRQGRLAQAHGFQGFLRDARQAEGVLSS--QEYFLSHTEMPGTLQAADAAIKKLEDFMS 1219
Query: 201 EIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLD 380
+ A E + L ++G +++ + +E IQ + D + K ++ L+ +
Sbjct: 1220 TMDANGERIRGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNRE 1279
Query: 381 YVQFLRRVDEILFWTKEKETFVISEEFGQD-LEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
FL+ E+ W EK + +++ D ++ +K FM +L ++ ++
Sbjct: 1280 QQHFLQDCQELKLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVD 1337
Query: 558 SKADHLLQEDFPEQESLINKK-KDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTI 734
+ L E PE + L+++K +D+ D L++ + + + LF+A+ + F +
Sbjct: 1338 KEGRELTLEK-PELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALE 1396
Query: 735 AWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
+W+ L S+D+G+DL SV L +K + L+R+++
Sbjct: 1397 SWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMA 1433
Score = 72.4 bits (176), Expect = 1e-12
Identities = 57/277 (20%), Positives = 115/277 (41%), Gaps = 3/277 (1%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTY--SDENFKDLTNLQSKN 176
R+ F+ + ++ L A Q + + E ++W+ EK + + + DL + +
Sbjct: 939 RWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQDLGNDLAGVLALQ 998
Query: 177 QKHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKS 356
+K E ++ A S + L + N + H + I TRL ++ WE L + +
Sbjct: 999 RKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEVQTGWEDLRATMRRRE 1058
Query: 357 RLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQE 536
L FLR +D+ W +T V SEE L E L + ++E +
Sbjct: 1059 ESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQ 1118
Query: 537 EKAAEIYSKADHLLQEDFPEQESLINKKKD-VEDALDRLKSLAKKRQQKLFEAHEIQKFF 713
+ + + + + + ++ Q + ++ + + + L + + RQ +L +AH Q F
Sbjct: 1119 SEYSRLRTLGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFL 1178
Query: 714 RDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHE 824
RD + ++ + LS + L + A +K E
Sbjct: 1179 RDARQAEGVLSSQEYFLSHTEMPGTLQAADAAIKKLE 1215
Score = 68.9 bits (167), Expect = 2e-11
Identities = 65/273 (23%), Positives = 113/273 (41%), Gaps = 20/273 (7%)
Frame = +3
Query: 87 ADELESWILEKIQTYSDENFKDLTN-----LQSKNQKHQALELEIAAQSENLNVLD---- 239
A EL WI + I T +D + + LQS N + + NL VL
Sbjct: 314 ASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQ 373
Query: 240 ---KSGNEMIETHHYASEIIQTRLDQLHALWEKL--------LNMFKEKSRLLKLTLDYV 386
++ N+ + T I ++ WE+L L + E R KL
Sbjct: 374 SKLRANNQKVYTpreGRLI-----SDINKAWERLEKAEHERELALRTELIRQEKLEQLAA 428
Query: 387 QFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKA 566
+F R+ W E + V + FG +L VE +K D+ + + + A
Sbjct: 429 RFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVA 488
Query: 567 DHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWVN 746
L E + + + + ++ +V D L+ + R+++L E+QK F+D + W+
Sbjct: 489 AELAAEHYHDIKRIAARQNNVARLWDFLREMVAARRERLLLNLELQKVFQDLLYLMDWMA 548
Query: 747 EKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
E L S+D G+ LA V+ L + HE ++ D++
Sbjct: 549 EMKGRLQSQDLGKHLAGVEDLLQLHELVEADIA 581
Score = 67.8 bits (164), Expect = 4e-11
Identities = 67/282 (23%), Positives = 124/282 (43%), Gaps = 7/282 (2%)
Frame = +3
Query: 24 ATEERRKK-LEDAKKYQLFKRDADELESWILEKIQTY--SDENFKDLTNLQSKNQKHQAL 194
AT RR++ L +A++ Q F R D+ ++W L + QT S+E L ++ +H AL
Sbjct: 1052 ATMRRREESLGEARRLQDFLRSLDDFQAW-LGRTQTAVASEEGPATLPEAEALLAQHAAL 1110
Query: 195 ELEIAAQSENLNVLDKSGNEMIETHHYASE---IIQTRLDQLHALWEKLLNMFKEKSRLL 365
E+ + L G E+ T A ++ RL+ L WE+L M++ + L
Sbjct: 1111 RGEVERAQSEYSRLRTLGEEV--TRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
Query: 366 KLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKA 545
+ FLR + +E F+ E L+ + KK +FM ++ E+
Sbjct: 1169 AQAHGFQGFLRDARQAEGVLSSQEYFLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERI 1228
Query: 546 AEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTD 725
+ L+ + E + K +E + + ++ +L + E Q F +D
Sbjct: 1229 RGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQ 1288
Query: 726 KTIAWVNEKSIPLSSEDFGRDLA-SVQALKRKHEALDRDLSA 848
+ W++EK L+++D D A ++ +KH+A +L+A
Sbjct: 1289 ELKLWIDEKM--LTAQDVSYDEARNLHTKWQKHQAFMAELAA 1328
Score = 63.2 bits (152), Expect = 9e-10
Identities = 59/280 (21%), Positives = 118/280 (42%), Gaps = 4/280 (1%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQKHQALEL 200
E + R + L A + Q F A + + + K Q D +DL ++ ++H A E
Sbjct: 1788 ELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEH 1847
Query: 201 EIAAQSENLNVLDKSGNEMIETHHY-ASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
+I A S + + G + + + +E I + + W +L + +LL T
Sbjct: 1848 DIQALSTQVQQVQDDGLRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTT 1907
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
D +F + V E++ W + ++E +D+ +++ K ++E + ++ +
Sbjct: 1908 DKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSACI 1967
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQK---LFEAHEIQKFFRDTDK 728
LL + E + K ++ R + A+K Q+K L E+ F RD
Sbjct: 1968 DMGQELLARNHYAAEEISEKLSQLQ---SRRQETAEKWQEKMDWLQLVLEVLVFGRDAGM 2024
Query: 729 TIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
AW+ + + S + G + V++L ++HEA + A
Sbjct: 2025 AEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVA 2064
Score = 44.7 bits (104), Expect = 3e-04
Identities = 41/164 (25%), Positives = 78/164 (47%), Gaps = 17/164 (10%)
Frame = +3
Query: 408 EILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFM---KDLEYQEEKAAE-----IYSK 563
E+L W ++ + + L V+ + FN + K ++ E+ E I SK
Sbjct: 316 ELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSK 375
Query: 564 ADHLLQEDF-PEQESLINKKKDVEDALDRLKSLAKKRQ----QKLFEAHEIQKFFRDTDK 728
Q+ + P + LI+ D+ A +RL+ +R+ +L ++++ D+
Sbjct: 376 LRANNQKVYTpreGRLIS---DINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDR 432
Query: 729 TIA----WVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
A W++E +S ++FG +LA+V+A RKHEA++ D+ A
Sbjct: 433 KAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVA 476
>sp|O15020|SPTN2_HUMAN Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2)
(Beta-III spectrin)
Length = 2390
Score = 133 bits (334), Expect = 7e-31
Identities = 89/275 (32%), Positives = 141/275 (51%), Gaps = 2/275 (0%)
Frame = +3
Query: 30 EERRKKLEDAKKYQLFKRDADELESWILEK-IQTYSDENFKDLTNLQSKNQKHQALELEI 206
E R K+LEDA + Q F RDA E E+W+ E+ + E KD + Q++ +KHQ LE +
Sbjct: 1578 ELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQAL 1637
Query: 207 AAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYV 386
A ++ ++ L S +MI+ H S I R Q+ L+ L + E+ L+ L
Sbjct: 1638 ADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC 1697
Query: 387 QFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLE-YQEEKAAEIYSK 563
Q R +D++ W +E+E S E GQD EHV +L+ KF EF +D +E+ +
Sbjct: 1698 QLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANAL 1757
Query: 564 ADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAWV 743
A+ L+ + ++ K + +A L L R Q L A+E+Q+F + +A V
Sbjct: 1758 ANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARV 1817
Query: 744 NEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
K L + GRDL + +AL+R+H A + D+ A
Sbjct: 1818 QHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQA 1851
Score = 127 bits (319), Expect = 4e-29
Identities = 81/280 (28%), Positives = 144/280 (51%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQK 182
R+ ++A ++ +L D ++ Q F +D EL+ WI EK+ T D ++ + NL +K QK
Sbjct: 1259 RHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQK 1318
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
HQA E+AA + L+ +DK G E+ ++ +L LH W++L + K+R
Sbjct: 1319 HQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARS 1378
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L F + + W + + + S+++G+DL V +L KK ++ +E++
Sbjct: 1379 LFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKE 1438
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
I ++A L QED E + + VE+ L ++R ++L + E +F RD
Sbjct: 1439 VEAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDV 1497
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDL 842
+ I WV E+ SS + G+DL SVQ L +K++ L +++
Sbjct: 1498 EDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEI 1537
Score = 108 bits (270), Expect = 2e-23
Identities = 73/284 (25%), Positives = 140/284 (49%), Gaps = 2/284 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF-KDLTNLQSKNQ 179
++ + EER ++L A F+ DA+++E+W+++ ++ S D + Q+ +
Sbjct: 728 QWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALAR 787
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+H+ALE EI + L+ L + + T E+ Q R+ L +E+L E++R
Sbjct: 788 QHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEV-QGRVPTLERHYEELQARAGERAR 846
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ L L W +EKE ++ + LE +EV+Q++F ++
Sbjct: 847 ALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAA 906
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
+ + A+ LL+ + P ++ ++N ++ + + + LA ++ L A IQ + +
Sbjct: 907 QITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLE 966
Query: 720 TDKTIAWVNEKS-IPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+T AW+ EK+ + S++ G DLA V AL+RK +RDL A
Sbjct: 967 CTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEA 1010
Score = 94.4 bits (233), Expect = 4e-19
Identities = 72/275 (26%), Positives = 131/275 (47%), Gaps = 5/275 (1%)
Frame = +3
Query: 36 RRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFK-DLTNLQSKNQKHQALELEIAA 212
R++KLE F R A E+W+ E + S +NF +L +++ +KH+A+E +I A
Sbjct: 419 RQEKLEQLAAR--FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVA 476
Query: 213 QSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLDYVQF 392
S + +D E+ ++ + I R + LW+ L M + L L L+ +
Sbjct: 477 YSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKV 536
Query: 393 LRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIYSKADH 572
+ + ++ W +E + + S++ G+ L VE L + D+ Q E+ + + A
Sbjct: 537 FQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALR 596
Query: 573 LL---QEDFPEQESLINKK-KDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTIAW 740
+E P L++++ +E + + L LA R+ +L E+ + +F + + AW
Sbjct: 597 FCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAW 656
Query: 741 VNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
V E+ L+S D GRDL L KH AL ++S
Sbjct: 657 VREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691
Score = 88.6 bits (218), Expect = 2e-17
Identities = 62/282 (21%), Positives = 128/282 (45%), Gaps = 1/282 (0%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSD-ENFKDLTNLQSKNQ 179
++ A + ER ++L+ +++ F RD ++ W+ E++ S E+ KDL ++Q +
Sbjct: 1469 KFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMK 1528
Query: 180 KHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
K+Q L+ EI + L + + + L +L +W++L + + + +
Sbjct: 1529 KNQTLQKEIQGHEPRIADLRERQRAL------GAAAAGPELAELQEMWKRLGHELELRGK 1582
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L+ L QF R E W E+E ++ +E +D + KK + L +
Sbjct: 1583 RLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQ 1642
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRD 719
++ + + ++ + PE + ++ V+ LK LA +R+++L E + + R+
Sbjct: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
Query: 720 TDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
D W+ E+ + +S + G+D V L+ K RD S
Sbjct: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTS 1744
Score = 83.6 bits (205), Expect = 6e-16
Identities = 66/278 (23%), Positives = 120/278 (43%), Gaps = 3/278 (1%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKD-LTNLQSKNQK 182
Y + ER + LE A +A W+ EK Q + + L +L+ Q+
Sbjct: 834 YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQR 893
Query: 183 HQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
+ LE E+ + + ++ ++++ + + I +QL+ W++ + K
Sbjct: 894 FETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAA 953
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEE-FGQDLEHVEVLQKKFNEFMKDLEYQEE 539
L L + E W +EK + S + G DL V LQ+K +DLE
Sbjct: 954 LTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAA 1013
Query: 540 KAAEIYSKADHLLQEDFPEQESLINKK-KDVEDALDRLKSLAKKRQQKLFEAHEIQKFFR 716
+ E+ +A+ L P Q IN + ++V+ + L++ ++R++ L EA +Q F R
Sbjct: 1014 RVGELTREAN-ALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLR 1072
Query: 717 DTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEAL 830
D AW+ ++SE+ L +AL +H AL
Sbjct: 1073 SLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAAL 1110
Score = 82.0 bits (201), Expect = 2e-15
Identities = 58/285 (20%), Positives = 133/285 (46%), Gaps = 4/285 (1%)
Frame = +3
Query: 6 YSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEK-IQTYSDENFKDLTNLQSKNQK 182
Y+ KE ERR++L++ + +R+ D+LE WI E+ + S E +D ++ K
Sbjct: 1676 YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDK 1735
Query: 183 HQALELEIAA-QSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSR 359
+ + + E ++ + N +I H A + D L+ W LL + + +
Sbjct: 1736 FREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQ 1795
Query: 360 LLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEE 539
+L + +FL + L + K+ + + G+DL E LQ++ + D++
Sbjct: 1796 VLAAAYELQRFLHGARQALARVQHKQQ-QLPDGTGRDLNAAEALQRRHCAYEHDIQALSP 1854
Query: 540 KAAEIYSKADHLLQEDFP--EQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFF 713
+ ++ H LQ+ + + E + + V +A +L+ + R+Q L + + +FF
Sbjct: 1855 QVQQVQDDG-HRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFF 1913
Query: 714 RDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
+ + + W++E ++ + +++ RD++S + + + + ++ A
Sbjct: 1914 KAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEA 1958
Score = 81.3 bits (199), Expect = 3e-15
Identities = 65/280 (23%), Positives = 127/280 (45%), Gaps = 5/280 (1%)
Frame = +3
Query: 18 KEATEERRKKLEDAKKYQLFKRDADELESWILE-KIQTYSDENFKDLTNLQSKNQKHQAL 194
++ RR++L + Q +D L W+ E K + S + + L ++ Q H+ +
Sbjct: 517 RQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELV 576
Query: 195 ELEIAAQSENLNVLDKSG----NEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRL 362
E +IA Q+E + + S N E +++ R+ +L +E L + +
Sbjct: 577 EADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
Query: 363 LKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEK 542
L+ + +FL V E W +E++ + S + G+DL L K ++ +
Sbjct: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGP 696
Query: 543 AAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDT 722
+ L+ E P + +++ +RL++LA++R Q+L +A + +F D
Sbjct: 697 LKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADA 756
Query: 723 DKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDL 842
+ AW+ + +SS + G D S QAL R+H AL+ ++
Sbjct: 757 NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796
Score = 70.9 bits (172), Expect = 4e-12
Identities = 67/286 (23%), Positives = 119/286 (41%), Gaps = 20/286 (6%)
Frame = +3
Query: 48 LEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTN-----LQSKNQKHQALELEIAA 212
+E + + ++ A EL WI + I T +D + + LQS N +
Sbjct: 301 MEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFT 360
Query: 213 QSENLNVLD-------KSGNEMIETHHYASEIIQTRLDQLHALWEKL--------LNMFK 347
+ NL VL ++ N+ + T I ++ WE+L L +
Sbjct: 361 EKGNLEVLLFTIQSKLRANNQKVYTpreGRLI-----SDINKAWERLEKAEHERELALRT 415
Query: 348 EKSRLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLE 527
E R KL +F R+ W E + V + FG +L VE +K D+
Sbjct: 416 ELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIV 475
Query: 528 YQEEKAAEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQK 707
+ + + A L E + + + + ++ +V D L+ + R+++L E+QK
Sbjct: 476 AYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQK 535
Query: 708 FFRDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
F+D + W+ E L S+D GR LA V+ L + HE ++ D++
Sbjct: 536 VFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIA 581
Score = 70.1 bits (170), Expect = 7e-12
Identities = 60/277 (21%), Positives = 132/277 (47%), Gaps = 5/277 (1%)
Frame = +3
Query: 30 EERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQKHQALE---L 200
E R+ +L A +Q F RDA + E + Q Y + + LQ+ + + LE
Sbjct: 1162 ESRQGRLAQAHGFQGFLRDARQAEGVLSS--QEYVLSHTEMPGTLQAADAAIKKLEDFMS 1219
Query: 201 EIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTLD 380
+ A E ++ L ++G +++ + ++ I+ + D + +K + ++ L+ +
Sbjct: 1220 TMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNRE 1279
Query: 381 YVQFLRRVDEILFWTKEKETFVISEEFGQD-LEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
FL+ E+ W EK + +++ D ++ +K FM +L ++ ++
Sbjct: 1280 QQHFLQDCHELKLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVD 1337
Query: 558 SKADHLLQEDFPEQESLINKK-KDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTDKTI 734
+ L E PE ++L+++K +D+ D L++ + + + LF+A+ + F +
Sbjct: 1338 KEGRELTLEK-PELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALE 1396
Query: 735 AWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLS 845
+W+ L S+D+G+DL SV L +K + L+ +++
Sbjct: 1397 SWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMA 1433
Score = 69.3 bits (168), Expect = 1e-11
Identities = 55/277 (19%), Positives = 112/277 (40%), Gaps = 3/277 (1%)
Frame = +3
Query: 3 RYSAFKEATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENF--KDLTNLQSKN 176
R+ F+ + ++ L A Q + + E ++W+ EK + DL + +
Sbjct: 939 RWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQ 998
Query: 177 QKHQALELEIAAQSENLNVLDKSGNEMIETHHYASEIIQTRLDQLHALWEKLLNMFKEKS 356
+K E ++ A + + L + N + H + I RL ++ WE L + +
Sbjct: 999 RKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRRE 1058
Query: 357 RLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQE 536
L FLR +D+ W +T V SEE L E L + ++E +
Sbjct: 1059 ESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQ 1118
Query: 537 EKAAEIYSKADHLLQEDFPEQESLINKKKD-VEDALDRLKSLAKKRQQKLFEAHEIQKFF 713
+ + + + + + ++ Q + ++ + + + L + + RQ +L +AH Q F
Sbjct: 1119 SEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFL 1178
Query: 714 RDTDKTIAWVNEKSIPLSSEDFGRDLASVQALKRKHE 824
RD + ++ + LS + L + A +K E
Sbjct: 1179 RDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLE 1215
Score = 66.6 bits (161), Expect = 8e-11
Identities = 59/280 (21%), Positives = 119/280 (42%), Gaps = 4/280 (1%)
Frame = +3
Query: 21 EATEERRKKLEDAKKYQLFKRDADELESWILEKIQTYSDENFKDLTNLQSKNQKHQALEL 200
E + R + L A + Q F A + + + K Q D +DL ++ ++H A E
Sbjct: 1788 ELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEH 1847
Query: 201 EIAAQSENLNVLDKSGNEMIETHHY-ASEIIQTRLDQLHALWEKLLNMFKEKSRLLKLTL 377
+I A S + + G+ + + + +E I + + W +L + +LL T
Sbjct: 1848 DIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTT 1907
Query: 378 DYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKAAEIY 557
D +F + V E++ W E + ++E +D+ +++ K ++E + ++ +
Sbjct: 1908 DKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCI 1967
Query: 558 SKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAH---EIQKFFRDTDK 728
LL E + K ++ R + A+K Q+K+ E+ F RD
Sbjct: 1968 DMGKELLARSHYAAEEISEKLSQLQA---RRQETAEKWQEKMDWLQLVLEVLVFGRDAGM 2024
Query: 729 TIAWVNEKSIPLSSEDFGRDLASVQALKRKHEALDRDLSA 848
AW+ + + S + G + V++L ++HEA + A
Sbjct: 2025 AEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVA 2064
Score = 65.9 bits (159), Expect = 1e-10
Identities = 67/282 (23%), Positives = 124/282 (43%), Gaps = 7/282 (2%)
Frame = +3
Query: 24 ATEERRKK-LEDAKKYQLFKRDADELESWILEKIQTY--SDENFKDLTNLQSKNQKHQAL 194
AT RR++ L +A++ Q F R D+ ++W L + QT S+E L ++ +H AL
Sbjct: 1052 ATMRRREESLGEARRLQDFLRSLDDFQAW-LGRTQTAVASEEGPATLPEAEALLAQHAAL 1110
Query: 195 ELEIAAQSENLNVLDKSGNEMIETHHYASE---IIQTRLDQLHALWEKLLNMFKEKSRLL 365
E+ + L G E+ T A ++ RL+ L WE+L M++ + L
Sbjct: 1111 RGEVERAQSEYSRLRALGEEV--TRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
Query: 366 KLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKKFNEFMKDLEYQEEKA 545
+ FLR + +E + E L+ + KK +FM ++ E+
Sbjct: 1169 AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERI 1228
Query: 546 AEIYSKADHLLQEDFPEQESLINKKKDVEDALDRLKSLAKKRQQKLFEAHEIQKFFRDTD 725
+ L+ E + + K +E + + A++ +L + E Q F +D
Sbjct: 1229 HGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCH 1288
Query: 726 KTIAWVNEKSIPLSSEDFGRDLA-SVQALKRKHEALDRDLSA 848
+ W++EK L+++D D A ++ +KH+A +L+A
Sbjct: 1289 ELKLWIDEKM--LTAQDVSYDEARNLHTKWQKHQAFMAELAA 1328
Score = 46.6 bits (109), Expect = 9e-05
Identities = 61/253 (24%), Positives = 115/253 (45%), Gaps = 23/253 (9%)
Frame = +3
Query: 159 NLQSK-NQKHQALELEIAAQSENLNVLDKSGNEMIETH-----HYASEIIQTRLDQLHAL 320
NLQ+ N + L L E++NV D+ + I T+ HY S++ ++
Sbjct: 236 NLQNAFNLAEKELGLTKLLDPEDVNV-DQPDEKSIITYVATYYHYFSKMKALAVEGKRI- 293
Query: 321 WEKLLNMFKEKSRLLKLTLDYVQFLRRVDEILFWTKEKETFVISEEFGQDLEHVEVLQKK 500
K+L+ E RL++ ++ E+L W ++ + + L V+ +
Sbjct: 294 -GKVLDHAMEAERLVE------KYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQS 346
Query: 501 FNEFM---KDLEYQEEKAAE-----IYSKADHLLQEDF-PEQESLINKKKDVEDALDRLK 653
FN + K ++ E+ E I SK Q+ + P + LI+ D+ A +RL+
Sbjct: 347 FNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTpreGRLIS---DINKAWERLE 403
Query: 654 SLAKKRQ----QKLFEAHEIQKFFRDTDKTIA----WVNEKSIPLSSEDFGRDLASVQAL 809
+R+ +L ++++ D+ A W++E +S ++FG +LA+V+A
Sbjct: 404 KAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAA 463
Query: 810 KRKHEALDRDLSA 848
RKHEA++ D+ A
Sbjct: 464 VRKHEAIETDIVA 476
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,961,921
Number of Sequences: 369166
Number of extensions: 1502379
Number of successful extensions: 8139
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6834
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7739
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)