Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_A04
(865 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9WUB0|UB7I3_MOUSE Ubiquitin-conjugating enzyme 7-intera... 99 1e-20
sp|Q9BYM8|UB7I3_HUMAN Ubiquitin-conjugating enzyme 7-intera... 99 2e-20
sp|Q62921|UB7I3_RAT Ubiquitin-conjugating enzyme 7-interact... 99 2e-20
sp|Q924T7|RNF31_MOUSE RING finger protein 31 56 1e-07
sp|Q96EP0|RNF31_HUMAN RING finger protein 31 (Zinc in-betwe... 55 2e-07
sp|P58283|UB7I1_MOUSE E3 ubiquitin ligase TRIAD3 (Ubiquitin... 50 8e-06
sp|Q9NWF9|UB7I1_HUMAN E3 ubiquitin ligase TRIAD3 (Ubiquitin... 50 1e-05
sp|Q22431|ARI2_CAEEL Probable ariadne-2 protein (Ari-2) 44 6e-04
sp|Q80TT8|PARC_MOUSE p53-associated parkin-like cytoplasmic... 43 0.001
sp|P36113|YKZ7_YEAST Hypothetical 63.6 kDa protein in YPT52... 43 0.001
>sp|Q9WUB0|UB7I3_MOUSE Ubiquitin-conjugating enzyme 7-interacting protein 3
(UbcM4-interacting protein 28)
Length = 498
Score = 99.4 bits (246), Expect = 1e-20
Identities = 59/214 (27%), Positives = 101/214 (47%), Gaps = 23/214 (10%)
Frame = +3
Query: 285 QMKNNAYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCFEETLKNVN--------F 440
Q++ + + N+E EC +C S + P E +++R C H +C+ C + T++N
Sbjct: 255 QLEQRSLVLNTEPTECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVACPFI 314
Query: 441 TSNFKCPKCGIEINNQEIIKAVGVEKLIGMACKEAAPK---MFCCKYPDCDG--MWDNDV 605
S + CP +E + ++ ++ + + A + + CK PDC G +++DV
Sbjct: 315 DSTYSCPGKLLEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDV 374
Query: 606 IRKGSFICPVCKHSNCLDCEDVHEDKSCEEFR-----LTERYIDAQKA----KKKLQGES 758
F CPVC NCL C+ +HE +C E++ + + A++ K LQ
Sbjct: 375 ---NEFTCPVCTRVNCLLCKAIHEHMNCREYQDDLALRAQNDVAARQTTEMLKVMLQQGE 431
Query: 759 GIKCICGRFLVQ-KGGCGALHCDSCGRQICVFTK 857
+ C R +VQ K GC + C C +IC TK
Sbjct: 432 AMHCPQCRIVVQKKDGCDWIRCTVCHTEICWVTK 465
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/112 (24%), Positives = 45/112 (40%)
Frame = +3
Query: 78 CLTSNCSAIMFIEDNKAIFQCQFCDQPNCLKCEKRHYPNQCGDLNHNEDAIEAAAKVAMS 257
C T +C F ED+ F C C + NCL C+ H C + + +D A +
Sbjct: 359 CKTPDCRGWCFFEDDVNEFTCPVCTRVNCLLCKAIHEHMNCRE--YQDDLALRAQNDVAA 416
Query: 258 RHRREALEEQMKNNAYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCF 413
R E L+ ++ E+ C C + ++G C C+ + C+
Sbjct: 417 RQTTEMLKVMLQ------QGEAMHCPQCRIVVQKKDGCDWIRCTVCHTEICW 462
>sp|Q9BYM8|UB7I3_HUMAN Ubiquitin-conjugating enzyme 7-interacting protein 3 (Hepatitis B
virus X-associated protein 4) (HBV-associated factor 4)
(RING finger protein 54)
Length = 500
Score = 98.6 bits (244), Expect = 2e-20
Identities = 71/280 (25%), Positives = 124/280 (44%), Gaps = 40/280 (14%)
Frame = +3
Query: 138 CQFCDQPN------CLKCEKRHYPNQCGDLNHNEDAIEAAAKVAMSRHRREALEEQMKNN 299
C F ++P C + Y E+ A + R ++ ++Q + N
Sbjct: 192 CTFINKPTRPGCEMCCRARPEAYQVPASYQPDEEERARLAGEEEALRQYQQRKQQQQEGN 251
Query: 300 ----------AYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCFEETLKNVNFTSN 449
+ + N+E EC +C S + P E +++R C H +C+ C + T++N + +
Sbjct: 252 YLQHVQLDQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRN-SQEAE 310
Query: 450 FKCP------KCGIEINNQEIIKAVGVEKL-----IGMACKE-AAPKMFCCKYPDCDG-- 587
CP C ++ +EI + E +G++ E + + CK PDC G
Sbjct: 311 VSCPFIDNTYSCSGKLLEREIKALLTPEDYQRFLDLGISIAENRSAFSYHCKTPDCKGWC 370
Query: 588 MWDNDVIRKGSFICPVCKHSNCLDCEDVHEDKSCEEFR-----LTERYIDAQKA----KK 740
+++DV F CPVC H NCL C+ +HE +C+E++ + + A++ K
Sbjct: 371 FFEDDV---NEFTCPVCFHVNCLLCKAIHEQMNCKEYQEDLALRAQNDVAARQTTEMLKV 427
Query: 741 KLQGESGIKCICGRFLVQ-KGGCGALHCDSCGRQICVFTK 857
LQ ++C + +VQ K GC + C C +IC TK
Sbjct: 428 MLQQGEAMRCPQCQIVVQKKDGCDWIRCTVCHTEICWVTK 467
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/112 (25%), Positives = 44/112 (39%)
Frame = +3
Query: 78 CLTSNCSAIMFIEDNKAIFQCQFCDQPNCLKCEKRHYPNQCGDLNHNEDAIEAAAKVAMS 257
C T +C F ED+ F C C NCL C+ H C + + ED A +
Sbjct: 361 CKTPDCKGWCFFEDDVNEFTCPVCFHVNCLLCKAIHEQMNCKE--YQEDLALRAQNDVAA 418
Query: 258 RHRREALEEQMKNNAYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCF 413
R E L+ ++ E+ C C + ++G C C+ + C+
Sbjct: 419 RQTTEMLKVMLQ------QGEAMRCPQCQIVVQKKDGCDWIRCTVCHTEICW 464
>sp|Q62921|UB7I3_RAT Ubiquitin-conjugating enzyme 7-interacting protein 3 (RBCC protein
interacting with PKC) (Protein kinase C-binding protein
beta-15)
Length = 498
Score = 98.6 bits (244), Expect = 2e-20
Identities = 59/214 (27%), Positives = 102/214 (47%), Gaps = 23/214 (10%)
Frame = +3
Query: 285 QMKNNAYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCFEETLKNVN--------F 440
Q++ + + N+E EC +C S + P E +++R C H +C+ C + T++N
Sbjct: 255 QLEQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFI 314
Query: 441 TSNFKCPKCGIEINNQEIIKAVGVEKLIGMACKEAAPK---MFCCKYPDCDG--MWDNDV 605
+ + CP +E + ++ ++ + + A + + CK PDC G +++DV
Sbjct: 315 DNTYSCPGKLLEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDV 374
Query: 606 IRKGSFICPVCKHSNCLDCEDVHEDKSCEEFR--LTERY---IDAQKAKKKL-----QGE 755
F CPVC NCL C+ +HE +C E++ L R + AQ+ + L QGE
Sbjct: 375 ---NEFTCPVCTRVNCLLCKAIHERMNCREYQDDLAHRARNDVAAQQTTEMLRVMLQQGE 431
Query: 756 SGIKCICGRFLVQKGGCGALHCDSCGRQICVFTK 857
+ C + +K GC + C C +IC TK
Sbjct: 432 AMYCPQCRIVVQKKDGCDWIRCTVCHTEICWVTK 465
Score = 43.9 bits (102), Expect = 6e-04
Identities = 26/112 (23%), Positives = 44/112 (39%)
Frame = +3
Query: 78 CLTSNCSAIMFIEDNKAIFQCQFCDQPNCLKCEKRHYPNQCGDLNHNEDAIEAAAKVAMS 257
C T +C F ED+ F C C + NCL C+ H C + + +D A +
Sbjct: 359 CKTPDCRGWCFFEDDVNEFTCPVCTRVNCLLCKAIHERMNCRE--YQDDLAHRARNDVAA 416
Query: 258 RHRREALEEQMKNNAYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCF 413
+ E L ++ E+ C C + ++G C C+ + C+
Sbjct: 417 QQTTEMLRVMLQ------QGEAMYCPQCRIVVQKKDGCDWIRCTVCHTEICW 462
>sp|Q924T7|RNF31_MOUSE RING finger protein 31
Length = 1066
Score = 55.8 bits (133), Expect = 1e-07
Identities = 55/219 (25%), Positives = 89/219 (40%), Gaps = 34/219 (15%)
Frame = +3
Query: 291 KNNAYIPNSESFECGICNSFILpreGL-IIRNCFHCYCKSCFEE----TLKNVNFTSNFK 455
++ A++ + EC +C + LPR + + +C C CF + LK + T +
Sbjct: 680 QDRAFLRRLLAQECAVCG-WALPRNRMQALISCECTICPECFRQHFTIALKEKHIT-DMV 737
Query: 456 CPKCG----------------IEINNQEIIKAVGV---EKLIGMACKEAAPKMFCCKYPD 578
CP CG ++I +E + K + A PK C
Sbjct: 738 CPACGRPDLTDDAQLLSYFSTLDIQLRESLDPDAYALFHKKLTEAVLMRDPKFLWCAQCS 797
Query: 579 CDGMWDNDVIRKGSFICPVCKHSNCLDC----EDVHEDKSCEEFRLTERYID----AQKA 734
+++ + + CP C + C+ C E+ H +SCE+F+ +R D AQ
Sbjct: 798 FGFIYEREQLEA---TCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRTNDPEYQAQGL 854
Query: 735 KKKLQGESGIKCICGRF--LVQKGGCGALHCDSCGRQIC 845
LQ E+GI C +F + +GGC HC C Q C
Sbjct: 855 AMYLQ-ENGIDCPKCKFSYALARGGCMHFHCTQCRHQFC 892
Score = 32.0 bits (71), Expect = 2.3
Identities = 30/133 (22%), Positives = 46/133 (34%), Gaps = 8/133 (6%)
Frame = +3
Query: 87 SNCSAIMFIEDNKAIFQCQFCDQPNCLKC----EKRHYPNQCGDLNHNEDAIEAAAKVAM 254
+ CS E + C C Q C++C E++H C D + +
Sbjct: 794 AQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWK----------- 842
Query: 255 SRHRREALEEQMKNNAYIPNSESFECGICN-SFILpreGLIIRNCFHC---YCKSCFEET 422
R E Q + A +C C S+ L R G + +C C +C C+
Sbjct: 843 ---RTNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNA- 898
Query: 423 LKNVNFTSNFKCP 461
F + KCP
Sbjct: 899 -----FYAKNKCP 906
>sp|Q96EP0|RNF31_HUMAN RING finger protein 31 (Zinc in-between-RING-finger
ubiquitin-associated domain protein)
Length = 1072
Score = 55.5 bits (132), Expect = 2e-07
Identities = 54/220 (24%), Positives = 92/220 (41%), Gaps = 35/220 (15%)
Frame = +3
Query: 291 KNNAYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCFEE----TLKNVNFTSNFKC 458
++ A++ + EC +C + + +C C CF + LK + T + C
Sbjct: 686 QDRAFLRRLLAQECAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHIT-DMVC 744
Query: 459 PKCG----------------IEINNQEIIK----AVGVEKLI-GMACKEAAPKMFCCKYP 575
P CG ++I +E ++ A+ +KL G+ ++ PK C
Sbjct: 745 PACGRPDLTDDTQLLSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRD--PKFLWCAQC 802
Query: 576 DCDGMWDNDVIRKGSFICPVCKHSNCLDC----EDVHEDKSCEEFRLTERYID----AQK 731
+++ + + CP C + C+ C E+ H +SCE+F+ +R D AQ
Sbjct: 803 SFGFIYEREQLEA---TCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRMNDPEYQAQG 859
Query: 732 AKKKLQGESGIKCICGRF--LVQKGGCGALHCDSCGRQIC 845
LQ E+GI C +F + +GGC HC C Q C
Sbjct: 860 LAMYLQ-ENGIDCPKCKFSYALARGGCMHFHCTQCRHQFC 898
Score = 32.3 bits (72), Expect = 1.8
Identities = 30/134 (22%), Positives = 47/134 (35%), Gaps = 8/134 (5%)
Frame = +3
Query: 87 SNCSAIMFIEDNKAIFQCQFCDQPNCLKC----EKRHYPNQCGDLNHNEDAIEAAAKVAM 254
+ CS E + C C Q C++C E++H C D + +
Sbjct: 800 AQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWK----------- 848
Query: 255 SRHRREALEEQMKNNAYIPNSESFECGICN-SFILpreGLIIRNCFHC---YCKSCFEET 422
R E Q + A +C C S+ L R G + +C C +C C+
Sbjct: 849 ---RMNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNA- 904
Query: 423 LKNVNFTSNFKCPK 464
F + KCP+
Sbjct: 905 -----FYAKNKCPE 913
>sp|P58283|UB7I1_MOUSE E3 ubiquitin ligase TRIAD3 (Ubiquitin-conjugating enzyme
7-interacting protein 1) (UbcM4-interacting protein 83)
Length = 853
Score = 50.1 bits (118), Expect = 8e-06
Identities = 53/220 (24%), Positives = 80/220 (36%), Gaps = 22/220 (10%)
Frame = +3
Query: 252 MSRHRREALEEQMKNNAYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCFEETLKN 431
M+ H L QM Y + + EC C P E L H +CK C +
Sbjct: 477 MAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEF-PFEELTQCADAHLFCKECLIRYAQE 535
Query: 432 VNF---TSNFKCPK--CGIEINNQEIIKAVG-----------VEKLIGMACKEAAPKMFC 563
F S C + C E+ K + E+ + A + +
Sbjct: 536 AVFGSGKSELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPS 595
Query: 564 CKYPDCDGMWDNDVIRKGSFICPV--CKHSNCLDCEDV---HEDKSCEEFRLTERYIDAQ 728
C +P + D+DV R F CP C+ C C+ + H +CEE +
Sbjct: 596 CSFP---ALLDSDVKR---FSCPNPRCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRT 649
Query: 729 KAKKKLQGESGIKCI-CGRFLVQKGGCGALHCDSCGRQIC 845
++K+ KC CG L++ GC + C CG Q+C
Sbjct: 650 SIEEKMTAARIRKCHKCGTGLIKSEGCNRMSC-RCGAQMC 688
>sp|Q9NWF9|UB7I1_HUMAN E3 ubiquitin ligase TRIAD3 (Ubiquitin conjugating enzyme 7
interacting protein 1) (Zinc finger protein inhibiting
NF-kappa-B)
Length = 866
Score = 49.7 bits (117), Expect = 1e-05
Identities = 53/220 (24%), Positives = 80/220 (36%), Gaps = 22/220 (10%)
Frame = +3
Query: 252 MSRHRREALEEQMKNNAYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCFEETLKN 431
M+ H L QM Y + + EC C P E L H +CK C +
Sbjct: 489 MAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEF-PFEELTQCADAHLFCKECLIRYAQE 547
Query: 432 VNFTSN---FKCPK--CGIEINNQEIIKAVG-----------VEKLIGMACKEAAPKMFC 563
F S C + C E+ K + E+ + A + +
Sbjct: 548 AVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPS 607
Query: 564 CKYPDCDGMWDNDVIRKGSFICPV--CKHSNCLDCEDV---HEDKSCEEFRLTERYIDAQ 728
C +P + D+DV R F CP C+ C C+ + H +CEE +
Sbjct: 608 CSFP---ALLDSDVKR---FSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRT 661
Query: 729 KAKKKLQGESGIKCI-CGRFLVQKGGCGALHCDSCGRQIC 845
++K+ KC CG L++ GC + C CG Q+C
Sbjct: 662 SIEEKMTAARIRKCHKCGTGLIKSEGCNRMSC-RCGAQMC 700
>sp|Q22431|ARI2_CAEEL Probable ariadne-2 protein (Ari-2)
Length = 482
Score = 43.9 bits (102), Expect = 6e-04
Identities = 35/170 (20%), Positives = 63/170 (37%), Gaps = 16/170 (9%)
Frame = +3
Query: 384 CFHCYCKSCFE---ETLKNVNFTSNFKCPKCGIE-----------INNQEIIKAVGVEKL 521
C HC+C+ C++ E+ + S +C + E I N +IK + E+
Sbjct: 145 CGHCFCEHCWKSHVESRLSEGVASRIECMESECEVYAPSEFVLSIIKNSPVIK-LKYERF 203
Query: 522 IGMACKEAAPKMFCCKYPDCDGMWDNDVIRKGSFICPVCKHSNCLDC-EDVHEDKSCEEF 698
+ + P + C +C + + ++ C C S C+ C D H SCE
Sbjct: 204 LLRDMVNSHPHLKFCVGNECPVIIRSTEVKPKRVTCMQCHTSFCVKCGADYHAPTSCETI 263
Query: 699 R-LTERYIDAQKAKKKLQGESGIKCICGRFLVQKGGCGALHCDSCGRQIC 845
+ + D + + + C + + GGC + C C C
Sbjct: 264 KQWMTKCADDSETANYISAHTKDCPQCHSCIEKAGGCNHIQCTRCRHHFC 313
>sp|Q80TT8|PARC_MOUSE p53-associated parkin-like cytoplasmic protein
Length = 1865
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/200 (22%), Positives = 73/200 (36%), Gaps = 27/200 (13%)
Frame = +3
Query: 327 ECGICNSFILpreGLIIRNCFHCYCKSCFEETLK---NVNFTSNFKCP--KCGIE----- 476
+C +C + + P + C HC CKSC+ E L NF N CP C +
Sbjct: 1408 QCPVCVTPLGPHDDSPSLCCLHCCCKSCWNEYLTTRIEQNFVLNCTCPIADCPAQPTGAF 1467
Query: 477 ----INNQEIIKAVGVEKLIGMACKEAAPKMFCCKYPD-CDGMWDNDVIRKGSFICPVCK 641
+++ E+I EK + E+ + C P CD + + G+ C C
Sbjct: 1468 IRNIVSSPEVISK--YEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGSGT-TCSKCG 1524
Query: 642 HSNCLDCE--DVHEDKSCEEFRLTERYID---------AQKAKKKLQGESGIKC-ICGRF 785
++C C + H SC +++D + K L +C C
Sbjct: 1525 WASCFSCSFPEAHYPASCGHM---SQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAP 1581
Query: 786 LVQKGGCGALHCDSCGRQIC 845
+ + GC + C C C
Sbjct: 1582 IEKNEGCLHMTCARCNHGFC 1601
>sp|P36113|YKZ7_YEAST Hypothetical 63.6 kDa protein in YPT52-GCN3 intergenic region
Length = 551
Score = 42.7 bits (99), Expect = 0.001
Identities = 40/178 (22%), Positives = 73/178 (41%), Gaps = 24/178 (13%)
Frame = +3
Query: 384 CFHCYCKSCFEETLKNVNFTSNF-KCPKCGIEINNQEIIKAVG---VEKLIGMACKEAAP 551
C H YC +C+ +K+ N C C + + N++I K +G KL+ + K
Sbjct: 195 CGHEYCINCYRHYIKDKLHEGNIITCMDCSLALKNEDIDKVMGHPSSSKLMDSSIKSFVQ 254
Query: 552 K----MFCCKYPDC---------DGMWDNDVIRKGSFICPVCKHSNCLDCE-DVHEDKSC 689
K C + DC + + + F+ H C +C +VH C
Sbjct: 255 KHNRNYKWCPFADCKSIVHLRDTSSLPEYTRLHYSPFVKCNSFHRFCFNCGFEVHSPADC 314
Query: 690 EEFRLTERYIDAQKAKKKLQGESGI-----KCI-CGRFLVQKGGCGALHCDSCGRQIC 845
++T ++ +KA+K+ + + + +C C + + GGC + C SC + C
Sbjct: 315 ---KITTAWV--KKARKESEILNWVLSHTKECPKCSVNIEKNGGCNHMVCSSCKYEFC 367
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,777,336
Number of Sequences: 369166
Number of extensions: 1926222
Number of successful extensions: 6426
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5960
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6395
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8582957970
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)