Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_O11
(845 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X compo... 174 4e-43
sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X compo... 165 2e-40
sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltran... 138 2e-32
sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltran... 135 1e-31
sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltran... 135 1e-31
sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransf... 134 2e-31
sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltran... 133 7e-31
sp|P20285|ODP2_NEUCR Dihydrolipoyllysine-residue acetyltran... 132 2e-30
sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltran... 130 3e-30
sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltran... 127 4e-29
>sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (Lipoyl-containing
pyruvate dehydrogenase complex component X)
Length = 501
Score = 174 bits (440), Expect = 4e-43
Identities = 100/310 (32%), Positives = 167/310 (53%), Gaps = 33/310 (10%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G IV+W +KEG+ +SAGD +C+++TDKAVV ++A+++GILAKI+ + ++ IQ+G IAL
Sbjct: 71 GNIVKWLRKEGEAVSAGDSLCEIETDKAVVTLDANDDGILAKIVVEEGAKNIQLGSLIAL 130
Query: 183 LAGEDEDWKTVEIPAGGATVGVXXXXXXXXXXXXXXXXXXXXRKSNKATS--KLGPAVRR 356
+ E EDWK VEIP + RK +K T+ +L PA R
Sbjct: 131 MVEEGEDWKQVEIPKDVSAPPPVSKPPAPTQPSPQPQIPCPARKEHKGTARFRLSPAARN 190
Query: 357 LLDTYGINENQVDHSGPHDVLTKSDVLQHIDRSRLS------------------------ 464
+L+ + ++ +Q +GP + TK D L+ ++ ++
Sbjct: 191 ILEKHSLDASQGTATGPRGIFTKEDALKLVELKQMGKITESRPASAPPPSLSASVPPQAT 250
Query: 465 -------PVCPPTTRPAAQPEQQQHVDVPLTNMRQTIARRMAASKSSIPHRYSTAEASXX 623
P+ PP + P ++P +N+R+ IA+R+ SKS++PH Y+TA+
Sbjct: 251 AGPSYPRPMTPPVSIPGQPNAAGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLG 310
Query: 624 XXXXXXXXXXDQRGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNVDISVAVA 803
+ + +SVNDFI++AA++ L+ +P +N + +G ++ +VDISVAVA
Sbjct: 311 AVLKVRRDLV-KDDIKVSVNDFIIRAAAVTLKQMPGVNVTWDGEGPKQL-PSVDISVAVA 368
Query: 804 SESGLITPIV 833
++ GLITPI+
Sbjct: 369 TDKGLITPII 378
>sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (Lipoyl-containing
pyruvate dehydrogenase complex component X) (E3-binding
protein) (E3BP) (proX)
Length = 501
Score = 165 bits (417), Expect = 2e-40
Identities = 97/310 (31%), Positives = 159/310 (51%), Gaps = 33/310 (10%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G IV+W KKEG+ +SAGD +C+++TDKAVV ++A ++GILAKI+ + S+ I++G I L
Sbjct: 71 GNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGL 130
Query: 183 LAGEDEDWKTVEIPAGGATVGVXXXXXXXXXXXXXXXXXXXXRKSNKAT--SKLGPAVRR 356
+ E EDWK VEIP ++ T +L PA R
Sbjct: 131 IVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTLRFRLSPAARN 190
Query: 357 LLDTYGINENQVDHSGPHDVLTKSDVLQHIDRSRLS------------------------ 464
+L+ + ++ +Q +GP + TK D L+ + +
Sbjct: 191 ILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQAT 250
Query: 465 -------PVCPPTTRPAAQPEQQQHVDVPLTNMRQTIARRMAASKSSIPHRYSTAEASXX 623
PV PP + P ++P +N+R+ IA+R+ SKS++PH Y+TA+
Sbjct: 251 AGPSYPRPVIPPVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLG 310
Query: 624 XXXXXXXXXXDQRGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNVDISVAVA 803
+ + +SVNDFI+KAA++ L+ +P++N + +G ++ +DISVAVA
Sbjct: 311 AVLKVRQDLV-KDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPF-IDISVAVA 368
Query: 804 SESGLITPIV 833
++ GL+TPI+
Sbjct: 369 TDKGLLTPII 378
>sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 440
Score = 138 bits (348), Expect = 2e-32
Identities = 93/309 (30%), Positives = 143/309 (46%), Gaps = 28/309 (9%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G + +W KEGD + AGD++ +++TDKA++ E + GI+AKIL + S+ I VG+ IA+
Sbjct: 17 GTLAKWLVKEGDAVKAGDILAEIETDKAIMEFETVDAGIIAKILVPEGSENIAVGQVIAV 76
Query: 183 LAGEDEDWKTVEIPAGGATVGVXXXXXXXXXXXXXXXXXXXXRKSNKATSKLG------- 341
+A ED V A +KA S G
Sbjct: 77 MAEAGEDVSQVAASASSQISEPSEKADVAQKETADSETISIDASLDKAISNAGYGNKTEN 136
Query: 342 ---------------PAVRRLLDTYGINENQVDHSGPHDVLTKSDVLQHIDRSRLSPVCP 476
P +RL ++ QV+ SGPH + K+D+ I + + P
Sbjct: 137 MTASYQEKAGRIKASPLAKRLAKKNHVDLKQVNGSGPHGRIIKADIEAFIAEANQASSNP 196
Query: 477 PTTRPAAQPE---QQQHVDVPLTNMRQTIARRMAASKSSIPHRYSTAEASXXXXXXXXXX 647
+ P A + H + L+NMR+ IARR+ SK +IPH Y T +
Sbjct: 197 SVSTPEASGKITHDTPHNSIKLSNMRRVIARRLTESKQNIPHIYLTVDVQMDALLKLRSE 256
Query: 648 XXDQ---RGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNVDISVAVASESGL 818
+ + + +SVND ++KA +LAL+ P +N + D ++ + DISVAV+ E GL
Sbjct: 257 LNESLAVQNIKISVNDMLIKAQALALKATPNVNVAFDGDQMLQFS-QADISVAVSVEGGL 315
Query: 819 ITPIVFGAD 845
ITPI+ AD
Sbjct: 316 ITPILKQAD 324
>sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (Pyruvate
dehydrogenase complex E2 subunit) (PDCE2) (E2)
(Dihydrolipoamide S-acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2) (70 kDa
mitochondrial autoantigen of primary biliary cirrhosis)
(PBC) (M2 antigen complex 70 kDa subunit)
Length = 614
Score = 135 bits (341), Expect = 1e-31
Identities = 92/299 (30%), Positives = 145/299 (48%), Gaps = 19/299 (6%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G + W KK G+K+S GDL+ +++TDKA +G E EEG LAKIL + ++ + +G + +
Sbjct: 200 GTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCI 259
Query: 183 LAGEDEDWKTV-------------EIPAGGATVGVXXXXXXXXXXXXXXXXXXXXRKSNK 323
+ ++ D ++P K
Sbjct: 260 IVEKEADISAFADYRPTEVTDLKPQVPPPTPPPVAAVPPTPQPLAPTPSTPCPATPAGPK 319
Query: 324 ATSKLGPAVRRLLDTYGINENQVDHSGPHDVLTKSDVLQHIDRSRLSP----VCPPTTRP 491
+ P ++L GI+ QV +GP +TK D+ + S+++P V PPT
Sbjct: 320 GRVFVDPLAKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVP-SKVAPAPAAVVPPTGPG 378
Query: 492 AAQPEQQQHVDVPLTNMRQTIARRMAASKSSIPHRYSTAEASXXXXXXXXXXXXD--QRG 665
A D+P++N+R+ IA+R+ SK +IPH Y + + + +
Sbjct: 379 MAPVPTGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEGR 438
Query: 666 LVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNVDISVAVASESGLITPIVFGA 842
+SVNDFI+KA++LA VPE N+ D I+ NH VD+SVAV++ +GLITPIVF A
Sbjct: 439 SKISVNDFIIKASALACLKVPEANSSW-MDTVIRQNHVVDVSVAVSTPAGLITPIVFNA 496
Score = 70.9 bits (172), Expect = 4e-12
Identities = 34/67 (50%), Positives = 46/67 (68%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G I W KKEGDKI+ GDLI +V+TDKA VG E+ EE +AKIL A+ ++ + +G I +
Sbjct: 73 GTIARWEKKEGDKINEGDLIAEVETDKATVGFESLEECYMAKILVAEGTRDVPIGAIICI 132
Query: 183 LAGEDED 203
G+ ED
Sbjct: 133 TVGKPED 139
>sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 408
Score = 135 bits (340), Expect = 1e-31
Identities = 91/286 (31%), Positives = 145/286 (50%), Gaps = 5/286 (1%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G + W KKEGDK++ G++I +++TDKA + +E+ +EGILAKI+ ++SQ + V IA+
Sbjct: 17 GNLARWLKKEGDKVNPGEVIAEIETDKATMEVESVDEGILAKIIIPQNSQNVPVNSLIAV 76
Query: 183 LAGEDEDWKTVE-IPAGGATVGVXXXXXXXXXXXXXXXXXXXXRKSNKATSKLGPAVRRL 359
L+ E ED ++ A +V + K + P +RL
Sbjct: 77 LSEEGEDKADIDSFIAQNNSVSLSLKTDATLKKSNDSITNVEGIKHDSNKIFASPLAKRL 136
Query: 360 LDTYGINENQVDHSGPHDVLTKSDVLQHIDRSRLSPVCPPTTRPAAQPEQQQHVDVPLTN 539
I V SGPH + K D+L + D S ++ + +++ VP N
Sbjct: 137 AKIGDIRLENVQGSGPHGRIVKQDILSY-DSS-------TSSNKIVYRDTEEYRSVPNNN 188
Query: 540 MRQTIARRMAASKSSIPHRYSTAEAS----XXXXXXXXXXXXDQRGLVLSVNDFIVKAAS 707
+R+ IA+R+ SK ++PH Y + E + + + +SVNDFI+ A +
Sbjct: 189 IRKIIAKRLLESKQTVPHFYLSIECNVDKLLDVREDINKSFSEDKVTKISVNDFIILAVA 248
Query: 708 LALRLVPEINNGLNADGTIKINHNVDISVAVASESGLITPIVFGAD 845
AL+ VP N + D I+ +NVDISVAVA E+G++TPIV A+
Sbjct: 249 KALQEVPNANASWSED-AIRYYNNVDISVAVAIENGIVTPIVKDAN 293
>sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex) (PDC-E2) (70 kDa mitochondrial autoantigen of
primary biliary cirrhosis) (PBC)
Length = 555
Score = 134 bits (338), Expect = 2e-31
Identities = 93/295 (31%), Positives = 148/295 (50%), Gaps = 15/295 (5%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G + W KK G+K+S GDL+ +++TDKA +G E EEG LAKIL + ++ + +G + +
Sbjct: 146 GTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCI 205
Query: 183 LAGEDED------WKTVEIPA--GGATVGVXXXXXXXXXXXXXXXXXXXXRKSN-KATSK 335
+ + ED ++ E+ + A V + K
Sbjct: 206 IVEKQEDIAAFADYRPTEVTSLKPQAPPPVPPPVAAVPPIPQPLAPTPSAAPAGPKGRVF 265
Query: 336 LGPAVRRLLDTYGINENQVDHSGPHDVLTKSDVLQHIDRSRL---SPVCPPTTRPAAQPE 506
+ P ++L GI+ QV +GP + K D+ + + PP R A P
Sbjct: 266 VSPLAKKLAAEKGIDLTQVKGTGPEGRIIKKDIDSFVPTKAAPAAAAAAPPGPRVAPTPA 325
Query: 507 QQQHVDVPLTNMRQTIARRMAASKSSIPHRYSTAEASXXXXXXXXXXXX---DQRGLVLS 677
+D+P++N+R+ IA+R+ SK +IPH Y + + + + +G + S
Sbjct: 326 GV-FIDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRKELNKMLEGKGKI-S 383
Query: 678 VNDFIVKAASLALRLVPEINNGLNADGTIKINHNVDISVAVASESGLITPIVFGA 842
VNDFI+KA++LA VPE N+ D I+ NH VD+SVAV++ +GLITPIVF A
Sbjct: 384 VNDFIIKASALACLKVPEANSSW-MDTVIRQNHVVDVSVAVSTPAGLITPIVFNA 437
Score = 63.2 bits (152), Expect = 9e-10
Identities = 31/67 (46%), Positives = 44/67 (65%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G I W KKEG+KIS GDLI +V+TDKA VG E+ EE +AKIL + ++ + +G I +
Sbjct: 20 GTIARWEKKEGEKISEGDLIAEVETDKATVGFESLEECYMAKILVPEGTRDVPIGCIICI 79
Query: 183 LAGEDED 203
+ +D
Sbjct: 80 TVEKPQD 86
>sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (E2)
(Dihydrolipoamide acetyltransferase component of pyruvate
dehydrogenase complex) (PDC-E2)
Length = 592
Score = 133 bits (334), Expect = 7e-31
Identities = 95/299 (31%), Positives = 141/299 (47%), Gaps = 18/299 (6%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGME-ADEEGILAKILKAKDSQGIQVGEAIA 179
GGI W KKEGD+I AGD I +V+TDKA + + D G LAKIL + GIQ+ + +
Sbjct: 178 GGIASWTKKEGDQIKAGDAIAEVETDKATMDFQYEDGNGYLAKILVPGGTSGIQINQPVC 237
Query: 180 LLAGEDEDWK-----TVEIPAGGATVGVXXXXXXXXXXXXXXXXXXXXRKSNKATSKLG- 341
++ ED +VE + ++ S + T K G
Sbjct: 238 IIVKNKEDCDKFADYSVEEQSSSSSSS-SQESTPSSSSSSSQESTPSQSSSQQTTRKSGE 296
Query: 342 -----PAVRRLLDTYGINENQVDHSGPHDVLTKSDVL------QHIDRSRLSPVCPPTTR 488
PA R + G + + ++ +GP++ + K+DVL Q + + + T +
Sbjct: 297 RIFATPAARFEASSKGYDLSAINGTGPNNRILKADVLEFVPQKQEVAQQQQQQTTTTTKK 356
Query: 489 PAAQPEQQQHVDVPLTNMRQTIARRMAASKSSIPHRYSTAEASXXXXXXXXXXXXDQRGL 668
P + D+P +N+R+ A R+ SK +IPH Y T E +
Sbjct: 357 PTTPTSSGEFTDIPHSNIRKVTAARLTESKQTIPHYYLTMECRVDKLLKLRSELNAMNTV 416
Query: 669 VLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNVDISVAVASESGLITPIVFGAD 845
+SVNDFIVKA+ ALR P +N+ D I+ HN+DI+VAV + GL TPIV G D
Sbjct: 417 KISVNDFIVKASLPALRDNPVVNSTW-TDQFIRRYHNIDINVAVNTPQGLFTPIVRGVD 474
Score = 68.2 bits (165), Expect = 3e-11
Identities = 32/67 (47%), Positives = 47/67 (70%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G IV+W KKEGD+I AGD+I +V+TDKA + D G LAKIL + ++GI++ + IA+
Sbjct: 56 GNIVQWKKKEGDQIKAGDVIREVETDKATMDSYEDGNGYLAKILIPEGTKGIEINKPIAI 115
Query: 183 LAGEDED 203
+ + ED
Sbjct: 116 IVSKKED 122
>sp|P20285|ODP2_NEUCR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (E2)
(Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2) (MRP3)
Length = 458
Score = 132 bits (331), Expect = 2e-30
Identities = 97/301 (32%), Positives = 138/301 (45%), Gaps = 20/301 (6%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
GGI W KK GDKI G+++ +++TDKA + E EEG+LAKILK + + VG IA+
Sbjct: 49 GGIGAWQKKPGDKIEPGEVLVEIETDKAQMDFEFQEEGVLAKILKDSGEKDVAVGNPIAI 108
Query: 183 LAGEDEDWK-----TVEIPAGGATVGVXXXXXXXXXXXXXXXXXXXXRKSNKATSKLG-- 341
L E D T++ G + V + TS G
Sbjct: 109 LVEEGTDVNAFKDFTLKDAGGETSPAVPKDEPKNESTASAPTPAPTPAPEPENTSFTGRF 168
Query: 342 -----------PAVRRLLDTYGINENQVDHSGPHDVLTKSDVLQHIDRSRLSPVCPPTTR 488
PA +RL GI+ V SGP +T+ DV + + +
Sbjct: 169 QTALEREPNALPAAKRLAREKGIDLRNVKGSGPGGKITEEDVKKAL-----------ASA 217
Query: 489 PAAQPEQQQHVDVPLTNMRQTIARRMAASKSSIPHRYSTAEASXXXXXXXXXXXXDQRG- 665
PAA + DVP++ MR+TIA R+ S + PH + + S
Sbjct: 218 PAAGAAAAAYTDVPISGMRKTIAARLKESVTENPHFFVSTNLSVSKLLKLRQALNSSADG 277
Query: 666 -LVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNVDISVAVASESGLITPIVFGA 842
LSVNDF++KA +A + VP +N+ DG I+ VD+SVAVA+ +GLITPIV G
Sbjct: 278 RYKLSVNDFLIKAMGIASKRVPTVNSSWR-DGVIRQFETVDVSVAVATPNGLITPIVKGV 336
Query: 843 D 845
+
Sbjct: 337 E 337
>sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 412
Score = 130 bits (328), Expect = 3e-30
Identities = 92/290 (31%), Positives = 145/290 (50%), Gaps = 9/290 (3%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G + W KKEGDK++ G++I +++TDKA + +EA +EGILAKI+ ++SQ + V IA+
Sbjct: 17 GNLARWLKKEGDKVNPGEVIAEIETDKATMEVEAVDEGILAKIVIPQNSQNVPVNSLIAV 76
Query: 183 LAGEDEDWKTVE-IPAGGATVGVXXXXXXXXXXXXXXXXXXXXR----KSNKATSKLGPA 347
L+ E E+ ++ A +V + K + + P
Sbjct: 77 LSEEGEEKTDIDAFIAKNNSVSPSPKTDANLPKPHENIANVEEQVTVIKHDVSRIFASPL 136
Query: 348 VRRLLDTYGINENQVDHSGPHDVLTKSDVLQHIDRSRLSPVCPPTTRPAAQPEQQQHVDV 527
+RL I V SGPH + K D+L + + + + + PE+ + V
Sbjct: 137 AKRLAKMRNIRFESVKGSGPHGRIVKQDILSYTPSTAHNKIV------SRNPEEYRLV-- 188
Query: 528 PLTNMRQTIARRMAASKSSIPHRYSTAEASXXXXXXXXXXXX----DQRGLVLSVNDFIV 695
P N+R+ IA+R+ SK ++PH Y + E + + + +SVNDFI+
Sbjct: 189 PNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKFFSEDKSTRISVNDFII 248
Query: 696 KAASLALRLVPEINNGLNADGTIKINHNVDISVAVASESGLITPIVFGAD 845
A + AL+ VP N D I+ +NVDISVAVA E+GL+TPIV A+
Sbjct: 249 LAVAKALQEVPNANASWGEDA-IRYYNNVDISVAVAIENGLVTPIVKNAN 297
>sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 447
Score = 127 bits (319), Expect = 4e-29
Identities = 98/317 (30%), Positives = 141/317 (44%), Gaps = 36/317 (11%)
Frame = +3
Query: 3 GGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQGIQVGEAIAL 182
G + +W KEGDK+ +GD+I +++TDKA + +EA +EG +AKI+ ++G++V IA+
Sbjct: 17 GNLAKWLVKEGDKVKSGDVIAEIETDKATMEVEAVDEGTVAKIVVPAGTEGVKVNALIAV 76
Query: 183 LAGEDEDWKTVEIPAGGATVGVXXXXXXXXXXXXXXXXXXXXRK-SNKATSKLGPA---- 347
LA E ED T GA V + +A + PA
Sbjct: 77 LAAEGEDVATAAKGGNGAAGAVPAPKPKETAETAPAAAPAPAAAPAPQAAAPASPAPADG 136
Query: 348 ----------VRRLLDTYGINENQVDHSGPHDVLTKSDVLQHIDRSRLSPVCPPTTRPAA 497
RRL GI+ + + SGPH + K DV + P P PA
Sbjct: 137 EGKRIFSSPLARRLAKEAGIDLSAIAGSGPHGRVVKKDVETAVSGGAAKPAGAPAAAPAP 196
Query: 498 QP--------------EQQQHVDVPLTNMRQTIARRMAASKSSIPHRYSTAE----ASXX 623
E + VP MR+TIA+R+ SK +IPH Y + + A
Sbjct: 197 ATLAKGMSEDAVLKLFEPGSYELVPHDGMRKTIAKRLVESKQTIPHFYVSVDCELDALMA 256
Query: 624 XXXXXXXXXXDQRG---LVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNVDISV 794
++ G LSVND ++KA +LALR VP+ N +K H D+ V
Sbjct: 257 LRAQLNAAAPEKDGKPVYKLSVNDMVIKALALALRDVPDANVSWTDQNMVKHKH-ADVGV 315
Query: 795 AVASESGLITPIVFGAD 845
AV+ GLITPIV A+
Sbjct: 316 AVSIPGGLITPIVRQAE 332
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,955,765
Number of Sequences: 369166
Number of extensions: 1812507
Number of successful extensions: 6618
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6197
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6545
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)