Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_L19
(849 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q16563|SYPL_HUMAN Synaptophysin-like protein (Pantophysin) 79 2e-14
sp|P07825|SYPH_RAT Synaptophysin (Major synaptic vesicle pr... 77 6e-14
sp|Q62277|SYPH_MOUSE Synaptophysin (Major synaptic vesicle ... 77 6e-14
sp|P08247|SYPH_HUMAN Synaptophysin (Major synaptic vesicle ... 76 1e-13
sp|P20488|SYPH_BOVIN Synaptophysin (Major synaptic vesicle ... 76 1e-13
sp|O09117|SYPL_MOUSE Synaptophysin-like protein (Pantophysin) 74 7e-13
sp|Q8BGN8|SYNPR_MOUSE Synaptoporin 70 1e-11
sp|P22831|SYNPR_RAT Synaptoporin 69 2e-11
sp|Q8TBG9|SYNPR_HUMAN Synaptoporin 68 4e-11
sp|Q5VXT5|SYPL2_HUMAN Synaptophysin-like protein 2 62 2e-09
>sp|Q16563|SYPL_HUMAN Synaptophysin-like protein (Pantophysin)
Length = 259
Score = 79.0 bits (193), Expect = 2e-14
Identities = 64/234 (27%), Positives = 87/234 (37%), Gaps = 12/234 (5%)
Frame = +1
Query: 25 NLEVFKEPKGXXXXXXXXXXXXXXXXXXXXGGKVSLFFNCTDLPAITINVDVY----YPF 192
NL KEP G G+ + NC PA+T N V YPF
Sbjct: 25 NLNPLKEPLGFIKVLEWIASIFAFATCGGFKGQTEIQVNCP--PAVTENKTVTATFGYPF 82
Query: 193 NLVNQ--------NITVWNATNIAAKINYESSAQFSVFISSVSLIYCLCALAVYILLNDF 348
L NI N + +Y SSAQF V + +YC+ AL +Y+
Sbjct: 83 RLNEASFQPPPGVNICDVNWKDYVLIGDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTSL 142
Query: 349 LYQDPKIRKADFVIEAVLTFLWFVVGIAWSDVSVKLKSDISTSLCGQLTPSLKSHSNVTC 528
K+ DFV+ V TFLW V AW+ +K ++ +L P K V C
Sbjct: 143 YLDSRKLPMIDFVVTLVATFLWLVSTSAWAKALTDIKIATGHNIIDELPPCKK--KAVLC 200
Query: 529 SVAKDIPFGSAYIGIIASFTTFCLMLSGLWFLWKETAWFKSPPQSNPYVDNESP 690
GS + +I F L WF++KET+ S P+ P
Sbjct: 201 YFGSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKETSLHSPSNTSAPHSQGGIP 254
>sp|P07825|SYPH_RAT Synaptophysin (Major synaptic vesicle protein p38)
Length = 307
Score = 77.0 bits (188), Expect = 6e-14
Identities = 62/249 (24%), Positives = 98/249 (39%), Gaps = 9/249 (3%)
Frame = +1
Query: 4 NYYMINYNLEVFKEPKGXXXXXXXXXXXXXXXXXXXXGGKVSLFFNCTDLP--AITINVD 177
N + V KEP G G++ L C + A+ I V+
Sbjct: 5 NQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVE 64
Query: 178 VYYPFNLVN-----QNITVWNATNIAAKINYESSAQFSVFISSVSLIYCLCALAVYILLN 342
YPF L + T I +Y SSA+F V ++ + +Y + ALA YI L
Sbjct: 65 FEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQ 124
Query: 343 DFLYQDPKIRKADFVIEAVLTFLWFVVGIAWSD--VSVKLKSDISTSLCGQLTPSLKSHS 516
+ ++ K DF+ AV F+W V AW+ VK+ +D + + P +
Sbjct: 125 NKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENII--KEMPMCRQTG 182
Query: 517 NVTCSVAKDIPFGSAYIGIIASFTTFCLMLSGLWFLWKETAWFKSPPQSNPYVDNESPRG 696
N TC +D ++ F L + LWF++KET W ++ P + P
Sbjct: 183 N-TCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFMRAPPGAPEKQPAP 241
Query: 697 DESQNDRTY 723
++ D Y
Sbjct: 242 GDAYGDAGY 250
>sp|Q62277|SYPH_MOUSE Synaptophysin (Major synaptic vesicle protein p38) (BM89 antigen)
Length = 314
Score = 77.0 bits (188), Expect = 6e-14
Identities = 62/249 (24%), Positives = 98/249 (39%), Gaps = 9/249 (3%)
Frame = +1
Query: 4 NYYMINYNLEVFKEPKGXXXXXXXXXXXXXXXXXXXXGGKVSLFFNCTDLP--AITINVD 177
N + V KEP G G++ L C + A+ I V+
Sbjct: 11 NQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVE 70
Query: 178 VYYPFNLVN-----QNITVWNATNIAAKINYESSAQFSVFISSVSLIYCLCALAVYILLN 342
YPF L + T I +Y SSA+F V ++ + +Y + ALA YI L
Sbjct: 71 FEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQ 130
Query: 343 DFLYQDPKIRKADFVIEAVLTFLWFVVGIAWSD--VSVKLKSDISTSLCGQLTPSLKSHS 516
+ ++ K DF+ AV F+W V AW+ VK+ +D + + P +
Sbjct: 131 NKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENII--KEMPMCRQTG 188
Query: 517 NVTCSVAKDIPFGSAYIGIIASFTTFCLMLSGLWFLWKETAWFKSPPQSNPYVDNESPRG 696
N TC +D ++ F L + LWF++KET W ++ P + P
Sbjct: 189 N-TCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFMRAPPGAPEKQPAP 247
Query: 697 DESQNDRTY 723
++ D Y
Sbjct: 248 GDAYGDAGY 256
>sp|P08247|SYPH_HUMAN Synaptophysin (Major synaptic vesicle protein p38)
Length = 313
Score = 76.3 bits (186), Expect = 1e-13
Identities = 60/248 (24%), Positives = 98/248 (39%), Gaps = 8/248 (3%)
Frame = +1
Query: 4 NYYMINYNLEVFKEPKGXXXXXXXXXXXXXXXXXXXXGGKVSLFFNCTDLPA--ITINVD 177
N + V KEP G G++ L +C + ++I V+
Sbjct: 11 NQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTESDLSIEVE 70
Query: 178 VYYPFNLVNQNITVWNATNIAAKI----NYESSAQFSVFISSVSLIYCLCALAVYILLND 345
YPF L K+ +Y SSA+F V ++ + +Y + ALA YI L +
Sbjct: 71 FEYPFRLHQVYFDAPTCRGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQN 130
Query: 346 FLYQDPKIRKADFVIEAVLTFLWFVVGIAWSD--VSVKLKSDISTSLCGQLTPSLKSHSN 519
++ K DF+ AV F+W V AW+ VK+ +D + + P + N
Sbjct: 131 KYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENII--KEMPVCRQTGN 188
Query: 520 VTCSVAKDIPFGSAYIGIIASFTTFCLMLSGLWFLWKETAWFKSPPQSNPYVDNESPRGD 699
TC +D ++ F L + LWF++KET W ++ P + P
Sbjct: 189 -TCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAPEKQPAPG 247
Query: 700 ESQNDRTY 723
++ D Y
Sbjct: 248 DAYGDAGY 255
>sp|P20488|SYPH_BOVIN Synaptophysin (Major synaptic vesicle protein p38)
Length = 313
Score = 76.3 bits (186), Expect = 1e-13
Identities = 59/230 (25%), Positives = 91/230 (39%), Gaps = 12/230 (5%)
Frame = +1
Query: 4 NYYMINYNLEVFKEPKGXXXXXXXXXXXXXXXXXXXXGGKVSLFFNCTDLPAITINVDVY 183
N + V KEP G G++ L +C + +N++V
Sbjct: 11 NQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTKSDLNIEVE 70
Query: 184 --YPFNLVNQNITVWNATNIAAKI----NYESSAQFSVFISSVSLIYCLCALAVYILLND 345
YPF L KI NY SSA+F V ++ + +Y + ALA YI L +
Sbjct: 71 FEYPFRLHEVYFEAPTCQGDPKKIFLVGNYSSSAEFFVTVAVFAFLYSMGALATYIFLQN 130
Query: 346 FLYQDPKIRKADFVIEAVLTFLWFVVGIAWSD--VSVKLKSDISTSLCGQLTPSLKSHSN 519
++ K DF+ AV F+W V AW+ VK+ +D + G +
Sbjct: 131 KYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKGM---HVCHQPG 187
Query: 520 VTCSVAKDIPFGSAYIGIIASFTTFCLMLSGLWFLWKETAW----FKSPP 657
TC +D ++ F L + LWF++KET W ++PP
Sbjct: 188 NTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPP 237
>sp|O09117|SYPL_MOUSE Synaptophysin-like protein (Pantophysin)
Length = 261
Score = 73.6 bits (179), Expect = 7e-13
Identities = 60/222 (27%), Positives = 88/222 (39%), Gaps = 17/222 (7%)
Frame = +1
Query: 25 NLEVFKEPKGXXXXXXXXXXXXXXXXXXXXGGKVSLFFNCTDLPAI---TINVDVYYPFN 195
NL KEP G GK + NC + T+ YPF
Sbjct: 25 NLNPLKEPLGFIKILEWFASIFAFATCGGFKGKTEIQVNCPKVGVNKNQTVTATFGYPFR 84
Query: 196 LVNQ-------NITV----WNATNIAAKINYESSAQFSVFISSVSLIYCLCALAVYILLN 342
L NQ N++V W + +Y SSAQF V + +YC+ AL +Y+
Sbjct: 85 L-NQASFHTPPNVSVCDVNWEKHVLIG--DYSSSAQFYVTFAVFVFLYCIAALLLYVGYT 141
Query: 343 DFLYQDPKIRKADFVIEAVLTFLWFVVGIAWSDVSVKLKSDISTSLCGQLTPSLK---SH 513
+ K+ DF++ V TFLW V AW+ K +DI + ++ L+
Sbjct: 142 NLYRDSRKLPMIDFIVTLVATFLWLVSSSAWA----KALTDIKVATGHRIVEELEICNPE 197
Query: 514 SNVTCSVAKDIPFGSAYIGIIASFTTFCLMLSGLWFLWKETA 639
S V+C GS + +I F L WF++KET+
Sbjct: 198 SGVSCYFVSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKETS 239
>sp|Q8BGN8|SYNPR_MOUSE Synaptoporin
Length = 265
Score = 69.7 bits (169), Expect = 1e-11
Identities = 57/215 (26%), Positives = 92/215 (42%), Gaps = 13/215 (6%)
Frame = +1
Query: 118 GKVSLFFNCTDLPAITINVDVY--YPFNLVNQNITVWNAT-------NIAAKINYESSAQ 270
G + L +C + +++D+ YPF L Q +T T +A + SSA+
Sbjct: 23 GGLRLSVDCVNKTESNLSIDIAFAYPFRL--QQVTFEVPTCEGKEQQKLALVGDSSSSAE 80
Query: 271 FSVFISSVSLIYCLCALAVYILLNDFLYQDPKIRKADFVIEAVLTFLWFVVGIAWSD--V 444
F V ++ + +Y L A VYI + ++ + DF++ V +FLW V AW+
Sbjct: 81 FFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLS 140
Query: 445 SVKLKSDISTSLCGQLTPSLKSHSNVTCSVAKDIPFGSAYIGIIASFTTFCLMLSGLWFL 624
VK+ +D L L + K SN C S ++ F F L +WF+
Sbjct: 141 DVKVATDPKEVLL--LMSACKQPSN-KCMAVHSPVMSSLNTSVVFGFLNFILWAGNIWFV 197
Query: 625 WKETAWFKSPPQ--SNPYVDNESPRGDESQNDRTY 723
+KET W S + S+P + S N +Y
Sbjct: 198 FKETGWHSSGQRYLSDPMEKHSSSYNQGRYNQESY 232
>sp|P22831|SYNPR_RAT Synaptoporin
Length = 265
Score = 68.6 bits (166), Expect = 2e-11
Identities = 55/213 (25%), Positives = 89/213 (41%), Gaps = 11/213 (5%)
Frame = +1
Query: 118 GKVSLFFNCTDLPAITINVDVY--YPFNLVNQNITVWNATN-----IAAKINYESSAQFS 276
G + L +C + +++D+ YPF L V +A + SSA+F
Sbjct: 23 GGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALVGDSSSSAEFF 82
Query: 277 VFISSVSLIYCLCALAVYILLNDFLYQDPKIRKADFVIEAVLTFLWFVVGIAWSD--VSV 450
V ++ + +Y L A VYI + ++ + DF++ V +FLW V AW+ V
Sbjct: 83 VTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDV 142
Query: 451 KLKSDISTSLCGQLTPSLKSHSNVTCSVAKDIPFGSAYIGIIASFTTFCLMLSGLWFLWK 630
K+ +D L L + K SN C S ++ F F L +WF++K
Sbjct: 143 KVATDPKEVLL--LMSACKQPSN-KCMAVHSPVMSSLNTSVVFGFLNFILWAGNIWFVFK 199
Query: 631 ETAWFKSPPQ--SNPYVDNESPRGDESQNDRTY 723
ET W S + S+P + S N +Y
Sbjct: 200 ETGWHSSGQRYLSDPMEKHSSSYNQGGYNQDSY 232
>sp|Q8TBG9|SYNPR_HUMAN Synaptoporin
Length = 265
Score = 67.8 bits (164), Expect = 4e-11
Identities = 55/213 (25%), Positives = 89/213 (41%), Gaps = 11/213 (5%)
Frame = +1
Query: 118 GKVSLFFNCTDLPAITINVDVY--YPFNLVNQNITVWNATN-----IAAKINYESSAQFS 276
G + L +C + +++D+ YPF L V +A + SSA+F
Sbjct: 23 GGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALIGDSSSSAEFF 82
Query: 277 VFISSVSLIYCLCALAVYILLNDFLYQDPKIRKADFVIEAVLTFLWFVVGIAWSD--VSV 450
V ++ + +Y L A VYI + ++ + DF++ V +FLW V AW+ V
Sbjct: 83 VTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDV 142
Query: 451 KLKSDISTSLCGQLTPSLKSHSNVTCSVAKDIPFGSAYIGIIASFTTFCLMLSGLWFLWK 630
K+ +D L L + K SN C S ++ F F L +WF++K
Sbjct: 143 KVATDPKEVLL--LMSACKQPSN-KCMAIHSPVMSSLNTSVVFGFLNFILWAGNIWFVFK 199
Query: 631 ETAWFKSPPQ--SNPYVDNESPRGDESQNDRTY 723
ET W S + S+P + S N +Y
Sbjct: 200 ETGWHSSGQRYLSDPMEKHSSSYNQGGYNQDSY 232
>sp|Q5VXT5|SYPL2_HUMAN Synaptophysin-like protein 2
Length = 272
Score = 62.4 bits (150), Expect = 2e-09
Identities = 36/156 (23%), Positives = 62/156 (39%), Gaps = 2/156 (1%)
Frame = +1
Query: 250 NYESSAQFSVFISSVSLIYCLCALAVYILLNDFLYQDPKIRKADFVIEAVLTFLWFVVGI 429
++ + A+F V + S Y + AL +Y+ ++ ++ + DF + TF W V
Sbjct: 110 DFSAPAEFFVTLGIFSFFYTMAALVIYLRFHNLYTENKRFPLVDFCVTVSFTFFWLVAAA 169
Query: 430 AWSDVSVKLKSDISTSLCGQLTPSLK--SHSNVTCSVAKDIPFGSAYIGIIASFTTFCLM 603
AW +K S LT ++ CS G A I ++ F F L
Sbjct: 170 AWGKGLTDVKGATRPS---SLTAAMSVCHGEEAVCSAGATPSMGLANISVLFGFINFFLW 226
Query: 604 LSGLWFLWKETAWFKSPPQSNPYVDNESPRGDESQN 711
WF++KET W + D + +G ++
Sbjct: 227 AGNCWFVFKETPWHGQGQGQDQDQDQDQGQGPSQES 262
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,454,309
Number of Sequences: 369166
Number of extensions: 1764173
Number of successful extensions: 4891
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4649
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4872
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)