Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_K22
(878 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O95758|ROD1_HUMAN Regulator of differentiation 1 (Rod1) 125 2e-28
sp|Q8BHD7|ROD1_MOUSE Regulator of differentiation 1 (Rod1) 120 7e-27
sp|Q00438|PTBP1_RAT Polypyrimidine tract-binding protein 1 ... 120 7e-27
sp|P17225|PTBP1_MOUSE Polypyrimidine tract-binding protein ... 119 8e-27
sp|Q9Z118|ROD1_RAT Regulator of differentiation 1 (Rod1) 119 1e-26
sp|Q29099|PTBP1_PIG Polypyrimidine tract-binding protein 1 ... 118 2e-26
sp|P26599|PTBP1_HUMAN Polypyrimidine tract-binding protein ... 117 4e-26
sp|Q8R081|HNRPL_MOUSE Heterogeneous nuclear ribonucleoprote... 67 5e-11
sp|P14866|HNRPL_HUMAN Heterogeneous nuclear ribonucleoprote... 67 5e-11
sp|Q8WVV9|HNRLL_HUMAN Heterogeneous nuclear ribonucleoprote... 62 3e-09
>sp|O95758|ROD1_HUMAN Regulator of differentiation 1 (Rod1)
Length = 521
Score = 125 bits (313), Expect = 2e-28
Identities = 73/237 (30%), Positives = 121/237 (51%), Gaps = 15/237 (6%)
Frame = +2
Query: 83 SDNEDSKKIRREIPA---SKVLHIRSLPDDVTELEIASVATPFGHISYMVLTRKTGQALL 253
++ DSKK +R+ P S+VLH+R +P DVTE EI S+ PFG ++ +++ + QA L
Sbjct: 9 ANGNDSKKFKRDRPPCSPSRVLHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFL 68
Query: 254 EMETKDIAETMFEYYQRHAPHLRNKRCFVQYXXXXXXXXXXXXXXPEAENAVTTANQICD 433
EM +++ A TM YY PHLR++ ++QY A+ A+ + +
Sbjct: 69 EMASEEAAVTMVNYYTPITPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQS 128
Query: 434 SMAKESSG------------PVLRLVVDNWNHEKITNLHLFKIFQHYGILERIVIYVSKG 577
S G PVLR++++N + +T L +IF +G + +I+ +
Sbjct: 129 GSLALSGGPSNEGTVLPGQSPVLRIIIENLFY-PVTLEVLHQIFSKFGTVLKIITFTKNN 187
Query: 578 VVQGFIQYSDPFSAKVAKALTNELCIFPRSCIMRVNFSNRQSLDISREDDLVRDFVR 748
Q +QY+DP +A AK + I+ C +R++FS SL++ +D RDF R
Sbjct: 188 QFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTR 244
>sp|Q8BHD7|ROD1_MOUSE Regulator of differentiation 1 (Rod1)
Length = 523
Score = 120 bits (300), Expect = 7e-27
Identities = 72/234 (30%), Positives = 122/234 (52%), Gaps = 12/234 (5%)
Frame = +2
Query: 83 SDNEDSKKIRREIPASKVLHIRSLPDDVTELEIASVATPFGHISYMVLTRKTGQALLEME 262
+DN+ K R S+VLH+R +P DVTE E+ S+ PFG ++ +++ + QA LEM
Sbjct: 14 NDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMA 73
Query: 263 TKDIAETMFEYYQRHAPHLRNKRCFVQYXXXXXXXXXXXXXXPEAE------NAVTTAN- 421
+++ A TM YY PHLR++ ++QY A+ +AV + N
Sbjct: 74 SEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNL 133
Query: 422 QICDSMAKESS-----GPVLRLVVDNWNHEKITNLHLFKIFQHYGILERIVIYVSKGVVQ 586
+ + A E + PVLR++++N + +T L +IF +G + +I+ + Q
Sbjct: 134 SLPGATANEGTLLPGQSPVLRIIIENLFY-PVTLEVLHQIFSKFGTVLKIITFTKNNQFQ 192
Query: 587 GFIQYSDPFSAKVAKALTNELCIFPRSCIMRVNFSNRQSLDISREDDLVRDFVR 748
+QY+DP +A+ AK + I+ C +R++FS SL++ +D RDF R
Sbjct: 193 ALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTR 246
>sp|Q00438|PTBP1_RAT Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I) (Pyrimidine-binding
protein) (PYBP)
Length = 555
Score = 120 bits (300), Expect = 7e-27
Identities = 73/250 (29%), Positives = 123/250 (49%), Gaps = 19/250 (7%)
Frame = +2
Query: 56 FDAKEEETRSDNEDSKKIRRE-----IPASKVLHIRSLPDDVTELEIASVATPFGHISYM 220
F + ++ DSKK + + +P S+V+H+R LP DVTE E+ S+ PFG ++ +
Sbjct: 29 FIMSSSASAANGNDSKKFKGDNRSTGVP-SRVIHVRKLPSDVTEGEVISLGLPFGKVTNL 87
Query: 221 VLTRKTGQALLEMETKDIAETMFEYYQRHAPHLRNKRCFVQYXXXXXXXXXXXXXXPEAE 400
++ + QA +EM T++ A TM YY AP LR + ++Q+ A+
Sbjct: 88 LMLKGKNQAFIEMSTEEAANTMVNYYTSVAPVLRGQPIYIQFSNHKELKTDSSPNQARAQ 147
Query: 401 NAVTTANQICD--------------SMAKESSGPVLRLVVDNWNHEKITNLHLFKIFQHY 538
A+ N + MA PVLR++V+N + +T L +IF +
Sbjct: 148 AALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFY-PVTLDVLHQIFSKF 206
Query: 539 GILERIVIYVSKGVVQGFIQYSDPFSAKVAKALTNELCIFPRSCIMRVNFSNRQSLDISR 718
G + +I+ + Q +QY+DP SA+ AK + I+ C +R++FS SL++
Sbjct: 207 GTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKY 266
Query: 719 EDDLVRDFVR 748
+D RD+ R
Sbjct: 267 NNDKSRDYTR 276
>sp|P17225|PTBP1_MOUSE Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I)
Length = 527
Score = 119 bits (299), Expect = 8e-27
Identities = 73/250 (29%), Positives = 123/250 (49%), Gaps = 19/250 (7%)
Frame = +2
Query: 56 FDAKEEETRSDNEDSKKIRRE-----IPASKVLHIRSLPDDVTELEIASVATPFGHISYM 220
F + ++ DSKK + + +P S+V+H+R LP DVTE E+ S+ PFG ++ +
Sbjct: 29 FIMSSSASAANGNDSKKFKGDNRSAGVP-SRVIHVRKLPSDVTEGEVISLGLPFGKVTNL 87
Query: 221 VLTRKTGQALLEMETKDIAETMFEYYQRHAPHLRNKRCFVQYXXXXXXXXXXXXXXPEAE 400
++ + QA +EM T++ A TM YY AP LR + ++Q+ A+
Sbjct: 88 LMLKGKNQAFIEMNTEEAANTMVNYYTSVAPVLRGQPIYIQFSNHKELKTDSSPNQVRAQ 147
Query: 401 NAVTTANQICD--------------SMAKESSGPVLRLVVDNWNHEKITNLHLFKIFQHY 538
A+ N + MA PVLR++V+N + +T L +IF +
Sbjct: 148 AALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFY-PVTLDVLHQIFSKF 206
Query: 539 GILERIVIYVSKGVVQGFIQYSDPFSAKVAKALTNELCIFPRSCIMRVNFSNRQSLDISR 718
G + +I+ + Q +QY+DP SA+ AK + I+ C +R++FS SL++
Sbjct: 207 GTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKY 266
Query: 719 EDDLVRDFVR 748
+D RD+ R
Sbjct: 267 NNDKSRDYTR 276
>sp|Q9Z118|ROD1_RAT Regulator of differentiation 1 (Rod1)
Length = 523
Score = 119 bits (298), Expect = 1e-26
Identities = 68/234 (29%), Positives = 117/234 (50%), Gaps = 12/234 (5%)
Frame = +2
Query: 83 SDNEDSKKIRREIPASKVLHIRSLPDDVTELEIASVATPFGHISYMVLTRKTGQALLEME 262
+DN+ K R S+VLH+R +P DVTE E+ S+ PFG ++ +++ + QA LEM
Sbjct: 14 NDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMA 73
Query: 263 TKDIAETMFEYYQRHAPHLRNKRCFVQYXXXXXXXXXXXXXXPEAENAVTTANQI----- 427
+++ A TM YY PHLR++ ++QY A+ A+ + +
Sbjct: 74 SEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNL 133
Query: 428 -------CDSMAKESSGPVLRLVVDNWNHEKITNLHLFKIFQHYGILERIVIYVSKGVVQ 586
+ PVLR++++N + +T L +IF +G + +I+ + Q
Sbjct: 134 SLPGATSNEGTLLPGQSPVLRIIIENLFY-PVTLEVLHQIFSKFGTVLKIITFTKNNQFQ 192
Query: 587 GFIQYSDPFSAKVAKALTNELCIFPRSCIMRVNFSNRQSLDISREDDLVRDFVR 748
+QY+DP +A+ AK + I+ C +R++FS SL++ +D RDF R
Sbjct: 193 ALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTR 246
>sp|Q29099|PTBP1_PIG Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I)
Length = 557
Score = 118 bits (296), Expect = 2e-26
Identities = 72/241 (29%), Positives = 120/241 (49%), Gaps = 19/241 (7%)
Frame = +2
Query: 83 SDNEDSKKIRRE-----IPASKVLHIRSLPDDVTELEIASVATPFGHISYMVLTRKTGQA 247
++ DSKK + + +P S+V+HIR LP DVTE E+ S+ PFG ++ +++ + QA
Sbjct: 39 ANGNDSKKFKGDNRSAGVP-SRVIHIRKLPSDVTEGEVISLGLPFGKVTNLLMLKGKNQA 97
Query: 248 LLEMETKDIAETMFEYYQRHAPHLRNKRCFVQYXXXXXXXXXXXXXXPEAENAVTTANQI 427
+EM T++ A TM YY P LR + ++Q+ A+ A+ N +
Sbjct: 98 FIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSV 157
Query: 428 CD--------------SMAKESSGPVLRLVVDNWNHEKITNLHLFKIFQHYGILERIVIY 565
MA PVLR++V+N + +T L +IF +G + +I+ +
Sbjct: 158 QSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFY-PVTLDVLHQIFSKFGTVLKIITF 216
Query: 566 VSKGVVQGFIQYSDPFSAKVAKALTNELCIFPRSCIMRVNFSNRQSLDISREDDLVRDFV 745
Q +QY+DP SA+ AK + I+ C +R++FS SL++ +D RD+
Sbjct: 217 TKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYT 276
Query: 746 R 748
R
Sbjct: 277 R 277
>sp|P26599|PTBP1_HUMAN Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I) (57 kDa RNA-binding
protein PPTB-1)
Length = 531
Score = 117 bits (293), Expect = 4e-26
Identities = 71/240 (29%), Positives = 119/240 (49%), Gaps = 18/240 (7%)
Frame = +2
Query: 83 SDNEDSKKIRREIPA----SKVLHIRSLPDDVTELEIASVATPFGHISYMVLTRKTGQAL 250
++ DSKK + + + S+V+HIR LP DVTE E+ S+ PFG ++ +++ + QA
Sbjct: 39 ANGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAF 98
Query: 251 LEMETKDIAETMFEYYQRHAPHLRNKRCFVQYXXXXXXXXXXXXXXPEAENAVTTANQIC 430
+EM T++ A TM YY P LR + ++Q+ A+ A+ N +
Sbjct: 99 IEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQ 158
Query: 431 D--------------SMAKESSGPVLRLVVDNWNHEKITNLHLFKIFQHYGILERIVIYV 568
MA PVLR++V+N + +T L +IF +G + +I+ +
Sbjct: 159 SGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFY-PVTLDVLHQIFSKFGTVLKIITFT 217
Query: 569 SKGVVQGFIQYSDPFSAKVAKALTNELCIFPRSCIMRVNFSNRQSLDISREDDLVRDFVR 748
Q +QY+DP SA+ AK + I+ C +R++FS SL++ +D RD+ R
Sbjct: 218 KNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTR 277
>sp|Q8R081|HNRPL_MOUSE Heterogeneous nuclear ribonucleoprotein L (hnRNP L)
Length = 555
Score = 67.4 bits (163), Expect = 5e-11
Identities = 60/218 (27%), Positives = 95/218 (43%), Gaps = 3/218 (1%)
Frame = +2
Query: 122 PASKVLHIRSLPDDVTELEIASVATPFGHISYMVLTRKTGQALLEMETKDIAETMFEYYQ 301
PAS V+HIR L D V E ++ FG ISY+V+ K QAL+E E A Y
Sbjct: 65 PASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAA 124
Query: 302 RHAPHLRNKRCFVQYXXXXXXXXXXXXXXPEAENAVTTANQIC---DSMAKESSGPVLRL 472
+ ++ FV Y +T+ +I DS S VL
Sbjct: 125 DNQIYIAGHPAFVNY---------------------STSQKISRPGDSDDSRSVNSVLLF 163
Query: 473 VVDNWNHEKITNLHLFKIFQHYGILERIVIYVSKGVVQGFIQYSDPFSAKVAKALTNELC 652
+ N + T++ L+ I G ++RIVI+ G VQ +++ SA+ AKA N
Sbjct: 164 TILNPIYSITTDV-LYTICNPCGPVQRIVIFRKNG-VQAMVEFDSVQSAQRAKASLNGAD 221
Query: 653 IFPRSCIMRVNFSNRQSLDISREDDLVRDFVRHPVSPQ 766
I+ C +++ ++ L++ + D D+ +S Q
Sbjct: 222 IYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQ 259
>sp|P14866|HNRPL_HUMAN Heterogeneous nuclear ribonucleoprotein L (hnRNP L)
Length = 558
Score = 67.4 bits (163), Expect = 5e-11
Identities = 60/218 (27%), Positives = 95/218 (43%), Gaps = 3/218 (1%)
Frame = +2
Query: 122 PASKVLHIRSLPDDVTELEIASVATPFGHISYMVLTRKTGQALLEMETKDIAETMFEYYQ 301
PAS V+HIR L D V E ++ FG ISY+V+ K QAL+E E A Y
Sbjct: 68 PASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAA 127
Query: 302 RHAPHLRNKRCFVQYXXXXXXXXXXXXXXPEAENAVTTANQIC---DSMAKESSGPVLRL 472
+ ++ FV Y +T+ +I DS S VL
Sbjct: 128 DNQIYIAGHPAFVNY---------------------STSQKISRPGDSDDSRSVNSVLLF 166
Query: 473 VVDNWNHEKITNLHLFKIFQHYGILERIVIYVSKGVVQGFIQYSDPFSAKVAKALTNELC 652
+ N + T++ L+ I G ++RIVI+ G VQ +++ SA+ AKA N
Sbjct: 167 TILNPIYSITTDV-LYTICNPCGPVQRIVIFRKNG-VQAMVEFDSVQSAQRAKASLNGAD 224
Query: 653 IFPRSCIMRVNFSNRQSLDISREDDLVRDFVRHPVSPQ 766
I+ C +++ ++ L++ + D D+ +S Q
Sbjct: 225 IYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQ 262
>sp|Q8WVV9|HNRLL_HUMAN Heterogeneous nuclear ribonucleoprotein L-like (Stromal
RNA-regulating factor) (BLOCK24 protein)
Length = 542
Score = 61.6 bits (148), Expect = 3e-09
Identities = 45/211 (21%), Positives = 86/211 (40%)
Frame = +2
Query: 116 EIPASKVLHIRSLPDDVTELEIASVATPFGHISYMVLTRKTGQALLEMETKDIAETMFEY 295
++ S V+H+R L + V E ++ FG I Y+++ QAL+E E D A+ +
Sbjct: 71 KVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTF 130
Query: 296 YQRHAPHLRNKRCFVQYXXXXXXXXXXXXXXPEAENAVTTANQICDSMAKESSGPVLRLV 475
++ ++ F Y P N V + P+ +
Sbjct: 131 AADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKV---------LLLSIQNPLYPIT 181
Query: 476 VDNWNHEKITNLHLFKIFQHYGILERIVIYVSKGVVQGFIQYSDPFSAKVAKALTNELCI 655
VD L+ + G ++RIVI+ G +Q +++ A+ AKA N I
Sbjct: 182 VD----------VLYTVCNPVGKVQRIVIFKRNG-IQAMVEFESVLCAQKAKAALNGADI 230
Query: 656 FPRSCIMRVNFSNRQSLDISREDDLVRDFVR 748
+ C +++ ++ L++ R D+ D+ +
Sbjct: 231 YAGCCTLKIEYARPTRLNVIRNDNDSWDYTK 261
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,353,398
Number of Sequences: 369166
Number of extensions: 1655278
Number of successful extensions: 4510
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4378
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4499
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8742211660
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)