Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_K08
(797 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P18052|PTPRA_MOUSE Receptor-type tyrosine-protein phosph... 82 2e-15
sp|Q03348|PTPRA_RAT Receptor-type tyrosine-protein phosphat... 82 2e-15
sp|P18433|PTPRA_HUMAN Receptor-type tyrosine-protein phosph... 81 3e-15
sp|P49446|PTpre_MOUSE Receptor-type tyrosine-protein phosph... 79 1e-14
sp|P23469|PTpre_HUMAN Receptor-type tyrosine-protein phosph... 77 5e-14
sp|P08575|CD45_HUMAN Leukocyte common antigen precursor (L-... 72 1e-12
sp|P06800|CD45_MOUSE Leukocyte common antigen precursor (L-... 72 2e-12
sp|Q15678|PTN14_HUMAN Tyrosine-protein phosphatase, non-rec... 70 7e-12
sp|P04157|CD45_RAT Leukocyte common antigen variant 4 precu... 70 7e-12
sp|Q12913|PTPRJ_HUMAN Receptor-type tyrosine-protein phosph... 70 9e-12
>sp|P18052|PTPRA_MOUSE Receptor-type tyrosine-protein phosphatase alpha precursor
(Protein-tyrosine phosphatase alpha) (R-PTP-alpha)
(LCA-related phosphatase) (PTPTY-28)
Length = 829
Score = 81.6 bits (200), Expect = 2e-15
Identities = 43/97 (44%), Positives = 59/97 (60%), Gaps = 2/97 (2%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPKIS-DFLKFYENYQKVRRNYQ-SVVVHCSAGVGRTGTFILIDEEL 685
+TQ H +W D P LKF + + Y ++VVHCSAGVGRTGTF++ID L
Sbjct: 427 ITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAML 486
Query: 686 SRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
+ E K++++ + ++R RCQMVQTD QY FIY
Sbjct: 487 DMMHSER-KVDVYGFVSRIRAQRCQMVQTDMQYVFIY 522
Score = 53.5 bits (127), Expect = 6e-07
Identities = 33/99 (33%), Positives = 48/99 (48%), Gaps = 4/99 (4%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPK----ISDFLKFYENYQKVRRNYQSVVVHCSAGVGRTGTFILIDE 679
+ Q H W + P + + + + Q+ N+ + VHCSAG GRTGTF +
Sbjct: 716 IRQFHFHGWPEVGIPSDGKGMINIIAAVQKQQQQSGNHP-ITVHCSAGAGRTGTFCALST 774
Query: 680 ELSRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
L R+ E +++F + LR R MVQT QY F Y
Sbjct: 775 VLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCY 812
>sp|Q03348|PTPRA_RAT Receptor-type tyrosine-protein phosphatase alpha precursor
(Protein-tyrosine phosphatase alpha) (R-PTP-alpha)
Length = 796
Score = 81.6 bits (200), Expect = 2e-15
Identities = 43/97 (44%), Positives = 59/97 (60%), Gaps = 2/97 (2%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPKIS-DFLKFYENYQKVRRNYQ-SVVVHCSAGVGRTGTFILIDEEL 685
+TQ H +W D P LKF + + Y ++VVHCSAGVGRTGTF++ID L
Sbjct: 394 ITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAML 453
Query: 686 SRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
+ E K++++ + ++R RCQMVQTD QY FIY
Sbjct: 454 DMMHSER-KVDVYGFVSRIRAQRCQMVQTDMQYVFIY 489
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/99 (31%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPK----ISDFLKFYENYQKVRRNYQSVVVHCSAGVGRTGTFILIDE 679
+ Q H W + P + + + + Q+ N+ + VHCSAG GRTGTF +
Sbjct: 683 IRQFHFHGWPEVGIPSDGKGMINIIAAVQKQQQQSGNHP-ITVHCSAGAGRTGTFCALST 741
Query: 680 ELSRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
L + E +++F + LR R MVQ QY F Y
Sbjct: 742 VLECVKAE-GILDVFQTVKTLRLQRPHMVQILEQYEFCY 779
>sp|P18433|PTPRA_HUMAN Receptor-type tyrosine-protein phosphatase alpha precursor
(Protein-tyrosine phosphatase alpha) (R-PTP-alpha)
Length = 802
Score = 81.3 bits (199), Expect = 3e-15
Identities = 43/97 (44%), Positives = 59/97 (60%), Gaps = 2/97 (2%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPKIS-DFLKFYENYQKVRRNYQ-SVVVHCSAGVGRTGTFILIDEEL 685
+TQ H +W D P LKF + + Y ++VVHCSAGVGRTGTF++ID L
Sbjct: 400 ITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAML 459
Query: 686 SRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
+ E K++++ + ++R RCQMVQTD QY FIY
Sbjct: 460 DMMHTER-KVDVYGFVSRIRAQRCQMVQTDMQYVFIY 495
Score = 53.1 bits (126), Expect = 8e-07
Identities = 33/99 (33%), Positives = 47/99 (47%), Gaps = 4/99 (4%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPK----ISDFLKFYENYQKVRRNYQSVVVHCSAGVGRTGTFILIDE 679
+ Q H W + P + + + Q+ N+ + VHCSAG GRTGTF +
Sbjct: 689 IRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHP-ITVHCSAGAGRTGTFCALST 747
Query: 680 ELSRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
L R+ E +++F + LR R MVQT QY F Y
Sbjct: 748 VLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCY 785
>sp|P49446|PTpre_MOUSE Receptor-type tyrosine-protein phosphatase epsilon precursor
(Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon)
Length = 699
Score = 79.3 bits (194), Expect = 1e-14
Identities = 44/97 (45%), Positives = 60/97 (61%), Gaps = 2/97 (2%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPKIS-DFLKFYENYQKVRRNYQS-VVVHCSAGVGRTGTFILIDEEL 685
V+QLH +W D P LKF + + + ++ +VVHCSAGVGRTGTFI+ID +
Sbjct: 292 VSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPSHAGPIVVHCSAGVGRTGTFIVIDAMM 351
Query: 686 SRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
I E K+++F + ++R R QMVQTD QY FIY
Sbjct: 352 DMIHSE-QKVDVFEFVSRIRNQRPQMVQTDVQYTFIY 387
Score = 57.0 bits (136), Expect = 6e-08
Identities = 36/99 (36%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPK----ISDFLKFYENYQKVRRNYQSVVVHCSAGVGRTGTFILIDE 679
V Q H W + P + D + + Q+ N+ + VHCSAG GRTGTFI +
Sbjct: 586 VRQFHFHGWPEVGIPAEGKGMIDLIAAVQKQQQQTGNHP-ITVHCSAGAGRTGTFIALSN 644
Query: 680 ELSRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
L R+ E +++F + LR R MVQT QY F Y
Sbjct: 645 ILERVKAE-GLLDVFQAVKSLRLQRPHMVQTLEQYEFCY 682
>sp|P23469|PTpre_HUMAN Receptor-type tyrosine-protein phosphatase epsilon precursor
(Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon)
Length = 700
Score = 77.0 bits (188), Expect = 5e-14
Identities = 43/97 (44%), Positives = 60/97 (61%), Gaps = 2/97 (2%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPKIS-DFLKFYENYQKVRRNYQS-VVVHCSAGVGRTGTFILIDEEL 685
V+QLH +W D P LKF + + + + +VVHCSAGVGRTGTFI+ID +
Sbjct: 293 VSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMM 352
Query: 686 SRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
+ + E K+++F + ++R R QMVQTD QY FIY
Sbjct: 353 AMMHAE-QKVDVFEFVSRIRNQRPQMVQTDMQYTFIY 388
Score = 57.0 bits (136), Expect = 6e-08
Identities = 36/99 (36%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPK----ISDFLKFYENYQKVRRNYQSVVVHCSAGVGRTGTFILIDE 679
V Q H W + P + D + + Q+ N+ + VHCSAG GRTGTFI +
Sbjct: 587 VRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHP-ITVHCSAGAGRTGTFIALSN 645
Query: 680 ELSRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
L R+ E +++F + LR R MVQT QY F Y
Sbjct: 646 ILERVKAE-GLLDVFQAVKSLRLQRPHMVQTLEQYEFCY 683
>sp|P08575|CD45_HUMAN Leukocyte common antigen precursor (L-CA) (CD45 antigen) (T200)
Length = 1304
Score = 72.4 bits (176), Expect = 1e-12
Identities = 39/97 (40%), Positives = 57/97 (58%), Gaps = 2/97 (2%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPKISDFLKFYENYQKVRRNYQS--VVVHCSAGVGRTGTFILIDEEL 685
VT + +W DH P+ L N+ S +VVHCSAGVGRTGT+I ID L
Sbjct: 809 VTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAML 868
Query: 686 SRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
+ E +K++++ ++KLR+ RC MVQ ++QY I+
Sbjct: 869 EGLEAE-NKVDVYGYVVKLRRQRCLMVQVEAQYILIH 904
Score = 37.0 bits (84), Expect = 0.062
Identities = 23/60 (38%), Positives = 34/60 (56%), Gaps = 1/60 (1%)
Frame = +2
Query: 620 VVVHCSAGVGRTGTFILIDEELSRISKETDKI-EIFHNLLKLRKLRCQMVQTDSQYCFIY 796
+++HC G +TG F + L S ET+++ +IF + LRK R MV T QY F+Y
Sbjct: 1163 LLIHCRDGSQQTGIFCALLNLLE--SAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220
>sp|P06800|CD45_MOUSE Leukocyte common antigen precursor (L-CA) (Lymphocyte common antigen
Ly-5) (CD45) (T200)
Length = 1291
Score = 71.6 bits (174), Expect = 2e-12
Identities = 39/97 (40%), Positives = 56/97 (57%), Gaps = 2/97 (2%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPKISDFLKFYENYQKVRRNYQS--VVVHCSAGVGRTGTFILIDEEL 685
VT + +W DH P+ L N+ S +VVHCSAGVGRTGT+I ID L
Sbjct: 798 VTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAML 857
Query: 686 SRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
+ E K++++ ++KLR+ RC MVQ ++QY I+
Sbjct: 858 EGLEAE-GKVDVYGYVVKLRRQRCLMVQVEAQYILIH 893
Score = 37.4 bits (85), Expect = 0.048
Identities = 21/62 (33%), Positives = 33/62 (53%)
Frame = +2
Query: 611 YQSVVVHCSAGVGRTGTFILIDEELSRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCF 790
+ S++VHC G +TG F + L E D +++F + LRK R +V + QY F
Sbjct: 1148 HASILVHCRDGSQQTGLFCALFNLLESAETE-DVVDVFQVVKSLRKARPGVVCSYEQYQF 1206
Query: 791 IY 796
+Y
Sbjct: 1207 LY 1208
>sp|Q15678|PTN14_HUMAN Tyrosine-protein phosphatase, non-receptor type 14 (Protein-tyrosine
phosphatase pez)
Length = 1187
Score = 70.1 bits (170), Expect = 7e-12
Identities = 43/108 (39%), Positives = 58/108 (53%), Gaps = 12/108 (11%)
Frame = +2
Query: 509 SVTQLHMLAWLDHSCPK-ISDFLKFYENYQKVRRNYQS-----------VVVHCSAGVGR 652
+V L W DH CP+ + FL + E Q VRR+ S +VVHCSAGVGR
Sbjct: 1068 TVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGR 1127
Query: 653 TGTFILIDEELSRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
TG IL E + + +K+E+ L LR+ R M+QT +QY F+Y
Sbjct: 1128 TGVLIL-SELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVY 1174
>sp|P04157|CD45_RAT Leukocyte common antigen variant 4 precursor (L-CA) (CD45) (T200)
Length = 1255
Score = 70.1 bits (170), Expect = 7e-12
Identities = 38/97 (39%), Positives = 55/97 (56%), Gaps = 2/97 (2%)
Frame = +2
Query: 512 VTQLHMLAWLDHSCPKISDFLKFYENYQKVRRNYQS--VVVHCSAGVGRTGTFILIDEEL 685
VT + +W DH P+ L N+ S +VVHCSAGVGRTGT+I ID L
Sbjct: 762 VTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAML 821
Query: 686 SRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFIY 796
+ E K++++ ++ LR+ RC MVQ ++QY I+
Sbjct: 822 ESLEAE-GKVDVYGYVVNLRRQRCLMVQVEAQYILIH 857
Score = 39.3 bits (90), Expect = 0.013
Identities = 22/62 (35%), Positives = 33/62 (53%)
Frame = +2
Query: 611 YQSVVVHCSAGVGRTGTFILIDEELSRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCF 790
+ S++VHC G +TG F + L E D +++F + LRK R MV + QY F
Sbjct: 1112 HASILVHCRDGSQQTGLFCALFNLLESAETE-DVVDVFQVVKSLRKARPGMVGSFEQYQF 1170
Query: 791 IY 796
+Y
Sbjct: 1171 LY 1172
>sp|Q12913|PTPRJ_HUMAN Receptor-type tyrosine-protein phosphatase eta precursor
(Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta)
(Protein-tyrosine phosphatase receptor type J)
(Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen)
Length = 1337
Score = 69.7 bits (169), Expect = 9e-12
Identities = 38/96 (39%), Positives = 54/96 (56%), Gaps = 4/96 (4%)
Frame = +2
Query: 518 QLHMLAWLDHSCPKISDFLKFYE----NYQKVRRNYQSVVVHCSAGVGRTGTFILIDEEL 685
Q H +W DH P +D L + +Y K ++VHCSAGVGRTGTFI ID +
Sbjct: 1197 QFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLI 1256
Query: 686 SRISKETDKIEIFHNLLKLRKLRCQMVQTDSQYCFI 793
+I E + ++++ + LR R MVQT+ QY F+
Sbjct: 1257 YQIENE-NTVDVYGIVYDLRMHRPLMVQTEDQYVFL 1291
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,476,174
Number of Sequences: 369166
Number of extensions: 1185815
Number of successful extensions: 2825
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2612
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2700
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7522142940
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)