Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_J23
(961 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8VCM3|ZFY21_MOUSE Zinc finger FYVE domain-containing pr... 64 5e-10
sp|Q96T51|RUFY1_HUMAN RUN and FYVE domain containing protei... 64 6e-10
sp|Q9HCC9|ZFY28_HUMAN Zinc finger FYVE domain-containing pr... 63 1e-09
sp|Q9BQ24|ZFY21_HUMAN Zinc finger FYVE domain-containing pr... 62 2e-09
sp|P34756|FAB1_YEAST 1-phosphatidylinositol-3-phosphate 5-k... 61 4e-09
sp|Q7Z3T8|ZFY16_HUMAN Zinc finger FYVE domain-containing pr... 59 3e-08
sp|O95405|ZFYV9_HUMAN Zinc finger FYVE domain-containing pr... 58 3e-08
sp|Q80U44|ZFY16_MOUSE Zinc finger FYVE domain-containing pr... 58 3e-08
sp|O14964|HGS_HUMAN Hepatocyte growth factor-regulated tyro... 57 8e-08
sp|Q9Y2I7|FYV1_HUMAN FYVE finger-containing phosphoinositid... 57 8e-08
>sp|Q8VCM3|ZFY21_MOUSE Zinc finger FYVE domain-containing protein 21
Length = 234
Score = 64.3 bits (155), Expect = 5e-10
Identities = 26/61 (42%), Positives = 32/61 (52%)
Frame = +1
Query: 739 PQWRSDSFFPRCCHCDRNFNLFRRRHHCRRCGYLFCNSCWGTKLALPMLGIHSKVSICIE 918
PQW D PRC CD F+ R+HHCRRCG FC+ C K+ L + V C +
Sbjct: 39 PQWVPDKECPRCMQCDAKFDFITRKHHCRRCGKCFCDRCCSQKVPLRRMCFVDPVRQCAD 98
Query: 919 C 921
C
Sbjct: 99 C 99
>sp|Q96T51|RUFY1_HUMAN RUN and FYVE domain containing protein 1 (FYVE-finger protein EIP1)
(Zinc finger FYVE domain containing protein 12)
Length = 600
Score = 63.9 bits (154), Expect = 6e-10
Identities = 29/72 (40%), Positives = 40/72 (55%)
Frame = +1
Query: 745 WRSDSFFPRCCHCDRNFNLFRRRHHCRRCGYLFCNSCWGTKLALPMLGIHSKVSICIECE 924
W D C C++ F++ RR+HHCR CG++FCN+C +LALP V +C C
Sbjct: 531 WLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALP--SYPKPVRVCDSCH 588
Query: 925 EFLRGKALSSTA 960
L + SSTA
Sbjct: 589 TLLLQRC-SSTA 599
>sp|Q9HCC9|ZFY28_HUMAN Zinc finger FYVE domain-containing protein 28
Length = 887
Score = 62.8 bits (151), Expect = 1e-09
Identities = 50/212 (23%), Positives = 74/212 (34%), Gaps = 4/212 (1%)
Frame = +1
Query: 307 MHALFKLISSVSDRMQSRHASDYRFFMETVFKLF----KDEDDGDINSIYTNSKSISESD 474
+H LF IS V+D++Q+ +ASD R ++T+F++ + +D + + +S + D
Sbjct: 727 IHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALED 786
Query: 475 IFESQYKNVLSLYINIDEAVDALSYSMSEQCTYDGDCPDLSILAQMDSKAYQQSLICVXX 654
Q + LS S T DGD D
Sbjct: 787 CALCQ---------------ETLSSSELAAKTRDGDFED--------------------- 810
Query: 655 XXXXXXXXXXXXRQNSSQVIDTSIQFGRPQWRSDSFFPRCCHCDRNFNLFRRRHHCRRCG 834
P+W D C C F + RR+HHCR CG
Sbjct: 811 ---------------------------PPEWVPDEACGFCTACKAPFTVIRRKHHCRSCG 843
Query: 835 YLFCNSCWGTKLALPMLGIHSKVSICIECEEF 930
+FC+ C LP G V +C C F
Sbjct: 844 KIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMF 875
>sp|Q9BQ24|ZFY21_HUMAN Zinc finger FYVE domain-containing protein 21
Length = 234
Score = 62.0 bits (149), Expect = 2e-09
Identities = 26/61 (42%), Positives = 31/61 (50%)
Frame = +1
Query: 739 PQWRSDSFFPRCCHCDRNFNLFRRRHHCRRCGYLFCNSCWGTKLALPMLGIHSKVSICIE 918
PQW D RC CD F+ R+HHCRRCG FC+ C K+ L + V C E
Sbjct: 39 PQWVPDKECRRCMQCDAKFDFLTRKHHCRRCGKCFCDRCCSQKVPLRRMCFVDPVRQCAE 98
Query: 919 C 921
C
Sbjct: 99 C 99
>sp|P34756|FAB1_YEAST 1-phosphatidylinositol-3-phosphate 5-kinase FAB1
(Phosphatidylinositol-3-phosphate 5-kinase) (Type III
PIP kinase)
Length = 2278
Score = 61.2 bits (147), Expect = 4e-09
Identities = 25/61 (40%), Positives = 33/61 (54%)
Frame = +1
Query: 745 WRSDSFFPRCCHCDRNFNLFRRRHHCRRCGYLFCNSCWGTKLALPMLGIHSKVSICIECE 924
W D C C + FN FRR+HHCR CG +FC+SC + G H+K+ +C C
Sbjct: 237 WMKDESSKECFSCGKTFNTFRRKHHCRICGQIFCSSC-TLLIDGDRFGCHAKMRVCYNCY 295
Query: 925 E 927
E
Sbjct: 296 E 296
>sp|Q7Z3T8|ZFY16_HUMAN Zinc finger FYVE domain-containing protein 16 (Endofin)
(Endosome-associated FYVE domain protein)
Length = 1539
Score = 58.5 bits (140), Expect = 3e-08
Identities = 25/64 (39%), Positives = 32/64 (50%)
Frame = +1
Query: 736 RPQWRSDSFFPRCCHCDRNFNLFRRRHHCRRCGYLFCNSCWGTKLALPMLGIHSKVSICI 915
+P W DS P C +C F +RRHHCR CG +FC C K L L + +C+
Sbjct: 741 QPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYL--EKEARVCV 798
Query: 916 ECEE 927
C E
Sbjct: 799 VCYE 802
>sp|O95405|ZFYV9_HUMAN Zinc finger FYVE domain-containing protein 9 (Mothers against
decapentaplegic homolog interacting protein)
(Madh-interacting protein) (Smad anchor for receptor
activation) (Receptor activation anchor) (hSARA) (Novel
serine protease) (NSP)
Length = 1425
Score = 58.2 bits (139), Expect = 3e-08
Identities = 25/65 (38%), Positives = 32/65 (49%)
Frame = +1
Query: 739 PQWRSDSFFPRCCHCDRNFNLFRRRHHCRRCGYLFCNSCWGTKLALPMLGIHSKVSICIE 918
P W DS P C C+ F +RRHHCR CG +FC SC K L + + +C+
Sbjct: 694 PVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMD-RKEARVCVI 752
Query: 919 CEEFL 933
C L
Sbjct: 753 CHSVL 757
>sp|Q80U44|ZFY16_MOUSE Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal
associated FYVE domain protein)
Length = 1528
Score = 58.2 bits (139), Expect = 3e-08
Identities = 25/64 (39%), Positives = 32/64 (50%)
Frame = +1
Query: 736 RPQWRSDSFFPRCCHCDRNFNLFRRRHHCRRCGYLFCNSCWGTKLALPMLGIHSKVSICI 915
+P W DS P C +C F +RRHHCR CG +FC C K L L + +C+
Sbjct: 729 QPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYL--EKEARVCV 786
Query: 916 ECEE 927
C E
Sbjct: 787 ICYE 790
>sp|O14964|HGS_HUMAN Hepatocyte growth factor-regulated tyrosine kinase substrate
(Protein pp110) (Hrs)
Length = 777
Score = 57.0 bits (136), Expect = 8e-08
Identities = 26/66 (39%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Frame = +1
Query: 772 CCHCDRNFNLFRRRHHCRRCGYLFCNSCWGTKLALPMLGIHSKVSICIECEEFL----RG 939
C C F + R+HHCR CG +FC C +P GI +V +C C E L G
Sbjct: 166 CHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEG 225
Query: 940 KALSST 957
KA S+T
Sbjct: 226 KATSTT 231
>sp|Q9Y2I7|FYV1_HUMAN FYVE finger-containing phosphoinositide kinase
(1-phosphatidylinositol-4-phosphate 5-kinase) (PIP5K)
(PtdIns(4)P-5-kinase) (PIKfyve) (p235)
Length = 2098
Score = 57.0 bits (136), Expect = 8e-08
Identities = 24/70 (34%), Positives = 32/70 (45%)
Frame = +1
Query: 745 WRSDSFFPRCCHCDRNFNLFRRRHHCRRCGYLFCNSCWGTKLALPMLGIHSKVSICIECE 924
W DS C C F FRRRHHCR CG +FC+ C ++ +G + C C
Sbjct: 155 WMPDSQCKECYDCSEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCR 214
Query: 925 EFLRGKALSS 954
+ A S+
Sbjct: 215 KIALSYAHST 224
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,939,786
Number of Sequences: 369166
Number of extensions: 2133062
Number of successful extensions: 5834
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5581
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5828
length of database: 68,354,980
effective HSP length: 111
effective length of database: 47,849,395
effective search space used: 9952674160
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)