Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_J12
(733 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 precur... 227 3e-59
sp|P38657|PDIA3_BOVIN Protein disulfide-isomerase A3 precur... 227 3e-59
sp|P27773|PDIA3_MOUSE Protein disulfide-isomerase A3 precur... 222 9e-58
sp|P11598|PDIA3_RAT Protein disulfide-isomerase A3 precurso... 220 3e-57
sp|P38658|ERP60_SCHMA Probable protein disulfide-isomerase ... 207 2e-53
sp|P13667|PDIA4_HUMAN Protein disulfide-isomerase A4 precur... 174 3e-43
sp|P38659|PDIA4_RAT Protein disulfide-isomerase A4 precurso... 171 2e-42
sp|P08003|PDIA4_MOUSE Protein disulfide-isomerase A4 precur... 170 4e-42
sp|P55059|PDI_HUMIN Protein disulfide-isomerase precursor (... 162 1e-39
sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase ... 156 6e-38
>sp|P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
(58 kDa glucose regulated protein)
Length = 505
Score = 227 bits (578), Expect = 3e-59
Identities = 109/188 (57%), Positives = 139/188 (73%), Gaps = 2/188 (1%)
Frame = +1
Query: 1 FAISNSQEQSHELSEFGIESPDSNKVYIVARDEKNQKFKMAEVFTME--AFEKFINDFLN 174
FA+++ + SHELS+FG+ES + R K +KF M E F+ + A E+F+ D+ +
Sbjct: 299 FAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFD 358
Query: 175 EQVPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEE 354
+ YLKSE IPE ND PVKVVVA+NFD +VN+ KDVLIEFYAPWCGHCK+L PKY+E
Sbjct: 359 GNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKE 418
Query: 355 LAKKLSGESDIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLK 534
L +KLS + +IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE+ D +
Sbjct: 419 LGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFIS 478
Query: 535 YIASESTS 558
Y+ E+T+
Sbjct: 479 YLQREATN 486
Score = 70.9 bits (172), Expect = 3e-12
Identities = 37/103 (35%), Positives = 63/103 (61%), Gaps = 3/103 (2%)
Frame = +1
Query: 253 NFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-DV 423
NF++ ++D +L+EF+APWCGHCK LAP+YE A +L G + +AK+D TAN +
Sbjct: 34 NFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAKVDCTANTNT 91
Query: 424 PSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 552
+ Y V+G+PT+ + +Y+G R D ++ ++ ++
Sbjct: 92 CNKYGVSGYPTLKIFRDGEEAG--AYDGPRTADGIVSHLKKQA 132
>sp|P38657|PDIA3_BOVIN Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERP60) (58 kDa microsomal protein) (P58) (ERp57)
Length = 505
Score = 227 bits (578), Expect = 3e-59
Identities = 108/188 (57%), Positives = 138/188 (73%), Gaps = 2/188 (1%)
Frame = +1
Query: 1 FAISNSQEQSHELSEFGIESPDSNKVYIVARDEKNQKFKMAEVFTME--AFEKFINDFLN 174
FA+++ + SHELS+FG+ES + R K +KF M E F+ + A E+F+ D+ +
Sbjct: 299 FAVASRKTFSHELSDFGLESTTGEIPVVAVRTAKGEKFVMQEEFSRDGKALERFLEDYFD 358
Query: 175 EQVPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEE 354
+ YLKSE IPE ND PVKVVVA+NFD +VN+ KDVLIEFYAPWCGHCK+L PKY+E
Sbjct: 359 GNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKE 418
Query: 355 LAKKLSGESDIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLK 534
L +KL + +IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE+ D +
Sbjct: 419 LGEKLRKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKQNPKKYEGGRELSDFIS 478
Query: 535 YIASESTS 558
Y+ E+T+
Sbjct: 479 YLKREATN 486
Score = 72.8 bits (177), Expect = 9e-13
Identities = 37/103 (35%), Positives = 63/103 (61%), Gaps = 3/103 (2%)
Frame = +1
Query: 253 NFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-DV 423
NF++ + D +L+EF+APWCGHCK LAP+YE A +L G + +AK+D TAN +
Sbjct: 34 NFESRITDTGSSGLMLVEFFAPWCGHCKKLAPEYEAAATRLKG--IVPLAKVDCTANTNT 91
Query: 424 PSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 552
+ Y V+G+PT+ ++ +Y+G R D ++ ++ ++
Sbjct: 92 CNKYGVSGYPTLKIFRDGEESG--AYDGPRTADGIVSHLKKQA 132
>sp|P27773|PDIA3_MOUSE Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
Length = 504
Score = 222 bits (565), Expect = 9e-58
Identities = 106/188 (56%), Positives = 139/188 (73%), Gaps = 2/188 (1%)
Frame = +1
Query: 1 FAISNSQEQSHELSEFGIESPDSNKVYIVARDEKNQKFKMAEVFTME--AFEKFINDFLN 174
FA+++ + SHELS+F +ES + R K +KF M E F+ + A E+F+ ++ +
Sbjct: 298 FAVASRKTFSHELSDFSLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFD 357
Query: 175 EQVPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEE 354
+ YLKSE IPE N+ PVKVVVA+NFD +VN+ KDVLIEFYAPWCGHCK+L PKY+E
Sbjct: 358 GNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKE 417
Query: 355 LAKKLSGESDIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLK 534
L +KLS + +IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE++D +
Sbjct: 418 LGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFIS 477
Query: 535 YIASESTS 558
Y+ E+T+
Sbjct: 478 YLQREATN 485
Score = 68.9 bits (167), Expect = 1e-11
Identities = 37/104 (35%), Positives = 63/104 (60%), Gaps = 3/104 (2%)
Frame = +1
Query: 250 KNFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-D 420
+NF++ V+D +L+EF+APWCGHCK LAP+YE A +L + +AK+D TAN +
Sbjct: 33 ENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRL---KIVPLAKVDCTANTN 89
Query: 421 VPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 552
+ Y V+G+PT+ + +Y+G R D ++ ++ ++
Sbjct: 90 TCNKYGVSGYPTLKIF--RAGEEAGAYDGPRTADGIVSHLKKQA 131
>sp|P11598|PDIA3_RAT Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
(HIP-70) (Q-2)
Length = 505
Score = 220 bits (561), Expect = 3e-57
Identities = 106/188 (56%), Positives = 139/188 (73%), Gaps = 2/188 (1%)
Frame = +1
Query: 1 FAISNSQEQSHELSEFGIESPDSNKVYIVARDEKNQKFKMAEVFTME--AFEKFINDFLN 174
FA+++ + SHELS+FG+ES + R K +KF M E F+ + A E+F+ ++ +
Sbjct: 299 FAVASRKTFSHELSDFGLESTTGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQEYFD 358
Query: 175 EQVPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEE 354
+ YLKSE IPE N+ PVKVVVA++FD +VN KDVLIEFYAPWCGHCK+L PKY+E
Sbjct: 359 GNLKRYLKSEPIPETNEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKE 418
Query: 355 LAKKLSGESDIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLK 534
L +KLS + +IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE++D +
Sbjct: 419 LGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFIS 478
Query: 535 YIASESTS 558
Y+ E+T+
Sbjct: 479 YLQREATN 486
Score = 72.0 bits (175), Expect = 2e-12
Identities = 43/127 (33%), Positives = 73/127 (57%), Gaps = 3/127 (2%)
Frame = +1
Query: 181 VPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEE 354
V + L S + +D V + +NF++ V+D +L+EF+APWCGHCK LAP+YE
Sbjct: 12 VALLLASALLASASD--VLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69
Query: 355 LAKKLSGESDIVIAKMDATAN-DVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDML 531
A +L G + +AK+D TAN + + Y V+G+PT+ + +Y+G R D ++
Sbjct: 70 AATRLKG--IVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAG--AYDGPRTADGIV 125
Query: 532 KYIASES 552
++ ++
Sbjct: 126 SHLKKQA 132
>sp|P38658|ERP60_SCHMA Probable protein disulfide-isomerase ER-60 precursor (ERP60)
Length = 484
Score = 207 bits (527), Expect = 2e-53
Identities = 100/202 (49%), Positives = 144/202 (71%)
Frame = +1
Query: 1 FAISNSQEQSHELSEFGIESPDSNKVYIVARDEKNQKFKMAEVFTMEAFEKFINDFLNEQ 180
FA S + + S+E+S++GIE+ +K+ V K++K+K+ E F+++AF F+N F +
Sbjct: 287 FAYSFADDFSYEISDYGIEA---DKLPAVVIQSKDKKYKL-EKFSLDAFSDFLNKFEDGL 342
Query: 181 VPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELA 360
+ ++KSE +P + VK +VA NFD +VN+ KDV++ F+A WCGHCK+L PKYEE A
Sbjct: 343 LTPHVKSEPLPTDDSSAVKKLVALNFDEIVNNEEKDVMVVFHAGWCGHCKNLMPKYEEAA 402
Query: 361 KKLSGESDIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYI 540
K+ E ++V+A MDATANDVPSPY+V GFPTIYF PK K+SP SY GGR+ +D++KY+
Sbjct: 403 SKVKNEPNLVLAAMDATANDVPSPYQVRGFPTIYFVPKGKKSSPVSYEGGRDTNDIIKYL 462
Query: 541 ASESTSSLKSYDRQGRVRKSDL 606
A E+T L YDR G +KS+L
Sbjct: 463 AREATEELIGYDRSGNPKKSEL 484
Score = 67.4 bits (163), Expect = 4e-11
Identities = 32/89 (35%), Positives = 54/89 (60%), Gaps = 2/89 (2%)
Frame = +1
Query: 292 LIEFYAPWCGHCKSLAPKYEELAKKLSGE-SDIVIAKMDATAND-VPSPYEVTGFPTIYF 465
L++FYAPWCGHCK LAP++ A+ +SG+ +D+ + K+D T + + S + V+G+PT+
Sbjct: 38 LVKFYAPWCGHCKKLAPEFTSAAQIISGKTNDVKLVKVDCTTQESICSEFGVSGYPTLKI 97
Query: 466 APKNSKNSPKSYNGGREVDDMLKYIASES 552
+ YNG R + + Y+ S +
Sbjct: 98 FRNGDLDG--EYNGPRNANGIANYMISRA 124
>sp|P13667|PDIA4_HUMAN Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
Length = 645
Score = 174 bits (440), Expect = 3e-43
Identities = 89/188 (47%), Positives = 120/188 (63%), Gaps = 3/188 (1%)
Frame = +1
Query: 1 FAISNSQEQSHELSEFGIESPDSNKVYIVARDEKNQKFKMA-EVFTMEAFEKFINDFLNE 177
FAI++ ++ + E+ + G+ S V DE +KF M E F + +F+ F
Sbjct: 450 FAIADEEDYAGEVKDLGL-SESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKG 508
Query: 178 QVPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEEL 357
++ +KS+ +P+ N PVKVVV K FD++V DP KDVLIEFYAPWCGHCK L P Y L
Sbjct: 509 KLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSL 568
Query: 358 AKKLSGESDIVIAKMDATANDVPSP-YEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDML 531
AKK G+ +VIAKMDATANDVPS Y+V GFPTIYFAP K +P + GG R+++ +
Sbjct: 569 AKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLS 628
Query: 532 KYIASEST 555
K+I +T
Sbjct: 629 KFIEEHAT 636
Score = 92.8 bits (229), Expect = 8e-19
Identities = 51/111 (45%), Positives = 71/111 (63%), Gaps = 2/111 (1%)
Frame = +1
Query: 226 EPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKM 402
E V+ +NFD +VND +L+EFYAPWCGHCK LAP+YE+ AK+LS S I +AK+
Sbjct: 177 EVTLVLTKENFDEVVND-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 235
Query: 403 DATA-NDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 552
DATA D+ ++V+G+PT+ K P YNG RE ++ Y+ +S
Sbjct: 236 DATAETDLAKRFDVSGYPTLKIF---RKGRPYDYNGpreKYGIVDYMIEQS 283
Score = 76.6 bits (187), Expect = 6e-14
Identities = 47/122 (38%), Positives = 70/122 (57%), Gaps = 3/122 (2%)
Frame = +1
Query: 196 KSETIPEKNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKLS 372
+ + + K + V V+ NFD V D KD VL+EFYAPWCGHCK AP+YE++A L
Sbjct: 52 EEDDLEVKEENGVLVLNDANFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIANILK 109
Query: 373 G-ESDIVIAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIAS 546
+ I +AK+DAT A+ + S ++V+G+PTI K Y G R ++++ +
Sbjct: 110 DKDPPIPVAKIDATSASVLASRFDVSGYPTIKIL---KKGQAVDYEGSRTQEEIVAKVRE 166
Query: 547 ES 552
S
Sbjct: 167 VS 168
>sp|P38659|PDIA4_RAT Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
(Calcium-binding protein 2) (CaBP2)
Length = 643
Score = 171 bits (432), Expect = 2e-42
Identities = 87/188 (46%), Positives = 121/188 (64%), Gaps = 3/188 (1%)
Frame = +1
Query: 1 FAISNSQEQSHELSEFGIESPDSNKVYIVARDEKNQKFKMA-EVFTMEAFEKFINDFLNE 177
FAI++ ++ + E+ + G+ S V DE +KF M E F +A ++F+ F
Sbjct: 448 FAIADEEDYATEVKDLGL-SESGEDVNAAILDESGKKFAMEPEEFDSDALQEFVMAFKKG 506
Query: 178 QVPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEEL 357
++ +KS+ +P+ N PV+VVV K FDA+V DP KDVLIEFYAPWCGHCK L P Y L
Sbjct: 507 KLKPVIKSQPVPKNNKGPVRVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPVYTSL 566
Query: 358 AKKLSGESDIVIAKMDATANDVPSP-YEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDML 531
KK G+ D+VIAKMDATAND+ + Y+V GFPTIYFAP K +P + GG R+++ +
Sbjct: 567 GKKYKGQKDLVIAKMDATANDITNDRYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLS 626
Query: 532 KYIASEST 555
K+I +T
Sbjct: 627 KFIDEHAT 634
Score = 87.0 bits (214), Expect = 5e-17
Identities = 48/111 (43%), Positives = 69/111 (62%), Gaps = 2/111 (1%)
Frame = +1
Query: 226 EPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKM 402
E + +NFD +VN+ +L+EFYAPWCGHCK LAP+YE+ AK+LS S I +AK+
Sbjct: 175 EVTLTLTKENFDDVVNN-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 233
Query: 403 DAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 552
DAT D+ ++V+G+PT+ K P YNG RE ++ Y+ +S
Sbjct: 234 DATEQTDLAKRFDVSGYPTLKIF---RKGRPFDYNGpreKYGIVDYMVEQS 281
Score = 79.3 bits (194), Expect = 1e-14
Identities = 47/115 (40%), Positives = 69/115 (60%), Gaps = 3/115 (2%)
Frame = +1
Query: 217 KNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKL-SGESDIV 390
K + V V+ +NFD V D KD VL+EFYAPWCGHCK AP+YE++A L + I
Sbjct: 57 KEENGVWVLNDENFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIA 114
Query: 391 IAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 552
+AK+DAT A+ + S ++V+G+PTI K Y+G R ++++ + S
Sbjct: 115 VAKIDATSASMLASKFDVSGYPTIKIL---KKGQAVDYDGSRTQEEIVAKVREVS 166
>sp|P08003|PDIA4_MOUSE Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
Length = 638
Score = 170 bits (430), Expect = 4e-42
Identities = 87/188 (46%), Positives = 119/188 (63%), Gaps = 3/188 (1%)
Frame = +1
Query: 1 FAISNSQEQSHELSEFGIESPDSNKVYIVARDEKNQKFKMA-EVFTMEAFEKFINDFLNE 177
FAI++ ++ + E+ + G+ S V DE +KF M E F + +F+ F
Sbjct: 443 FAIADEEDYATEVKDLGL-SESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKG 501
Query: 178 QVPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEEL 357
++ +KS+ +P+ N PVKVVV K FDA+V DP KDVLIEFYAPWCGHCK L P Y L
Sbjct: 502 KLKPVIKSQPVPKNNKGPVKVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSL 561
Query: 358 AKKLSGESDIVIAKMDATANDVPS-PYEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDML 531
KK G+ D+VIAKMDATAND+ + Y+V GFPTIYFAP K +P + GG R+++ +
Sbjct: 562 GKKYKGQKDLVIAKMDATANDITNDQYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLS 621
Query: 532 KYIASEST 555
K+I +T
Sbjct: 622 KFIDEHAT 629
Score = 85.9 bits (211), Expect = 1e-16
Identities = 47/102 (46%), Positives = 66/102 (64%), Gaps = 2/102 (1%)
Frame = +1
Query: 253 NFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKMDAT-ANDVP 426
NFD +VN+ +L+EFYAPWCGHCK LAP+YE+ AK+LS S I +AK+DAT D+
Sbjct: 179 NFDDVVNN-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLA 237
Query: 427 SPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 552
++V+G+PT+ K P YNG RE ++ Y+ +S
Sbjct: 238 KRFDVSGYPTLKIF---RKGRPFDYNGpreKYGIVDYMIEQS 276
Score = 78.2 bits (191), Expect = 2e-14
Identities = 47/115 (40%), Positives = 68/115 (59%), Gaps = 3/115 (2%)
Frame = +1
Query: 217 KNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKL-SGESDIV 390
K + V V+ NFD V D KD VL+EFYAPWCGHCK AP+YE++A L + I
Sbjct: 52 KEENGVWVLNDGNFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIA 109
Query: 391 IAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 552
+AK+DAT A+ + S ++V+G+PTI K Y+G R ++++ + S
Sbjct: 110 VAKIDATSASMLASKFDVSGYPTIKIL---KKGQAVDYDGSRTQEEIVAKVREVS 161
>sp|P55059|PDI_HUMIN Protein disulfide-isomerase precursor (PDI)
Length = 505
Score = 162 bits (409), Expect = 1e-39
Identities = 84/165 (50%), Positives = 110/165 (66%), Gaps = 5/165 (3%)
Frame = +1
Query: 64 DSNKVYIVARDEKNQKFKMAEV--FTMEAFEKFINDFLNEQVPVYLKSETIPEKNDEPVK 237
D + + KNQKF + T EA + F++DF+ ++ +KSE IPEK + PV
Sbjct: 299 DKFPAFAIQEVAKNQKFPFDQEKEITFEAIKAFVDDFVAGKIEPSIKSEPIPEKQEGPVT 358
Query: 238 VVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELA---KKLSGESDIVIAKMDA 408
VVVAKN++ +V D TKDVLIEFYAPWCGHCK+LAPKYEEL K + +VIAK+DA
Sbjct: 359 VVVAKNYNEIVLDDTKDVLIEFYAPWCGHCKALAPKYEELGALYAKSEFKDRVVIAKVDA 418
Query: 409 TANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIA 543
TANDVP E+ GFPTI P +K P +Y+G R V+D++K+IA
Sbjct: 419 TANDVPD--EIQGFPTIKLYPAGAKGQPVTYSGSRTVEDLIKFIA 461
Score = 68.2 bits (165), Expect = 2e-11
Identities = 44/117 (37%), Positives = 64/117 (54%), Gaps = 3/117 (2%)
Frame = +1
Query: 289 VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDAT-ANDVPSPYEVTGFPTIYF 465
VL EF+APWCGHCK+LAP+YEE A L E +I +AK+D T D+ + V G+PT+
Sbjct: 41 VLAEFFAPWCGHCKALAPEYEEAATTLK-EKNIKLAKVDCTEETDLCQQHGVEGYPTLKV 99
Query: 466 APKNSKNSPKSYNGGREVDDMLKYIASESTSSLK--SYDRQGRVRKSDL*KIKIVEY 630
SP Y G R+ + Y+ +S ++ + D +K+D K +V Y
Sbjct: 100 FRGLDNVSP--YKGQRKAAAITSYMIKQSLPAVSEVTKDNLEEFKKAD--KAVLVAY 152
>sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase A4 precursor (ERp-72 homolog)
Length = 618
Score = 156 bits (394), Expect = 6e-38
Identities = 82/196 (41%), Positives = 115/196 (58%), Gaps = 4/196 (2%)
Frame = +1
Query: 1 FAISNSQEQSHELSEFGI-ESPDSNKVYIVARDEKNQKFKMAEVFTM--EAFEKFINDFL 171
FA+++ +E + EL E G+ +S + V + D K E E E F+
Sbjct: 421 FAVADEEEFAKELEELGLGDSGLEHNVVVFGYDGKKYPMNPDEFDGELDENLEAFMKQIS 480
Query: 172 NEQVPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYE 351
+ + ++KS P+ + PVK VV NFD +VND +KDVLIEFYAPWCGHCKS KY
Sbjct: 481 SGKAKAHVKSAPAPKDDKGPVKTVVGSNFDKIVNDESKDVLIEFYAPWCGHCKSFESKYV 540
Query: 352 ELAKKL-SGESDIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDM 528
ELA+ L + ++V+AKMDAT ND PS + V GFPTIYFAP K+ P Y+G R+++D+
Sbjct: 541 ELAQALKKTQPNVVLAKMDATINDAPSQFAVEGFPTIYFAPAGKKSEPIKYSGNRDLEDL 600
Query: 529 LKYIASESTSSLKSYD 576
K++ S + D
Sbjct: 601 KKFMTKHGVKSFQKKD 616
Score = 88.2 bits (217), Expect = 2e-17
Identities = 51/131 (38%), Positives = 80/131 (61%), Gaps = 5/131 (3%)
Frame = +1
Query: 190 YLKSETIPEKNDEPVKVVV--AKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAK 363
+++S P P +VV +NFD +++ + VL+EFYAPWCGHCK LAP+YE+ A+
Sbjct: 133 WVESRVDPNYKPPPEEVVTLTTENFDDFISN-NELVLVEFYAPWCGHCKKLAPEYEKAAQ 191
Query: 364 KLSGE-SDIVIAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPK-SYNGGREVDDMLK 534
KL + S + + K+DAT D+ + Y V+G+PT+ K +N + YNG RE ++K
Sbjct: 192 KLKAQGSKVKLGKVDATIEKDLGTKYGVSGYPTM----KIIRNGRRFDYNGpreAAGIIK 247
Query: 535 YIASESTSSLK 567
Y+ +S + K
Sbjct: 248 YMTDQSKPAAK 258
Score = 86.7 bits (213), Expect = 6e-17
Identities = 48/116 (41%), Positives = 73/116 (62%), Gaps = 1/116 (0%)
Frame = +1
Query: 223 DEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKM 402
DE V V+ KNFDA + VL++FYAPWCGHCK LAP+YE+ + K+S I +AK+
Sbjct: 35 DEGVVVLTDKNFDAFLKK-NPSVLVKFYAPWCGHCKHLAPEYEKASSKVS----IPLAKV 89
Query: 403 DATA-NDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTSSLK 567
DAT ++ +E+ G+PT+ F K+ K P Y+GGR+ +++++ S + K
Sbjct: 90 DATVETELGKRFEIQGYPTLKFW-KDGK-GPNDYDGGRDEAGIVEWVESRVDPNYK 143
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,327,857
Number of Sequences: 369166
Number of extensions: 1608872
Number of successful extensions: 5177
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4871
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5081
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6534486000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)