Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_J07
(774 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P52296|IMB1_RAT Importin beta-1 subunit (Karyopherin bet... 286 3e-77
sp|P70168|IMB1_MOUSE Importin beta-1 subunit (Karyopherin b... 285 1e-76
sp|Q14974|IMB1_HUMAN Importin beta-1 subunit (Karyopherin b... 285 1e-76
sp|O18388|IMB_DROME Importin beta subunit (Karyopherin beta... 252 9e-67
sp|O13864|IMB1_SCHPO Importin beta-1 subunit (Karyopherin b... 150 3e-36
sp|Q06142|IMB1_YEAST Importin beta-1 subunit (Karyopherin b... 143 5e-34
sp|O14089|IMB2_SCHPO Putative importin beta-2 subunit (Kary... 68 3e-11
sp|Q92973|TNPO1_HUMAN Transportin-1 (Importin beta-)2 (Kary... 67 5e-11
sp|Q8BFY9|TNPO1_MOUSE Transportin-1 (Importin beta-2) (Kary... 67 5e-11
sp|Q99LG2|TNPO2_MOUSE Transportin-2 (Karyopherin beta-2b) 63 8e-10
>sp|P52296|IMB1_RAT Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor
P97)
Length = 875
Score = 286 bits (733), Expect = 3e-77
Identities = 142/252 (56%), Positives = 184/252 (73%)
Frame = +1
Query: 19 PPANSSKYYARGAVKFLVPLLLDILEKQDEGDDEDEWNPHKAAGVCMALLSQACEGDIVE 198
PP ++SK+YA+GA+++LVP+L L KQDE DD+D+WNP KAAGVC+ LLS CE DIV
Sbjct: 305 PPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLSTCCEDDIVP 364
Query: 199 LVLPYVQANIRHEDWKRRDAAVMAFGSILEGPSPRSLEGLVTQAMPVITELLADPISVVR 378
VLP+++ +I++ DW+ RDAAVMAFGSILEGP P L+ LV QAMP + EL+ DP VVR
Sbjct: 365 HVLPFIKEHIKNPDWRYRDAAVMAFGSILEGPEPNQLKPLVIQAMPTLIELMKDPSVVVR 424
Query: 379 DTAAWTVGRVCEVLPEVPLGDACLPGLLAAMVAALSSEPKVATNVCWAFSSLAEGAYTVE 558
DT AWTVGR+CE+LPE + D L LL ++ LS+EP+VA+NVCWAFSSLAE AY E
Sbjct: 425 DTTAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAY--E 482
Query: 559 MRSAANPDGGDASYAEPLTYKLSPYFSNIVEQLLRTTNRADCGQSNLRNAAYSALMEMVK 738
A+ EP TY LS F IV++LL TT+R D Q+NLR++AY +LME+VK
Sbjct: 483 AADVAD------DQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVK 536
Query: 739 SAPKDCYACIQQ 774
++ KDCY +Q+
Sbjct: 537 NSAKDCYPAVQK 548
>sp|P70168|IMB1_MOUSE Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor
P97) (Pore targeting complex 97 kDa subunit) (PTAC97)
(SCG)
Length = 876
Score = 285 bits (729), Expect = 1e-76
Identities = 141/252 (55%), Positives = 184/252 (73%)
Frame = +1
Query: 19 PPANSSKYYARGAVKFLVPLLLDILEKQDEGDDEDEWNPHKAAGVCMALLSQACEGDIVE 198
PP ++SK+YA+GA+++LVP+L L KQDE DD+D+WNP KAAGVC+ LLS CE DIV
Sbjct: 306 PPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLSTCCEDDIVP 365
Query: 199 LVLPYVQANIRHEDWKRRDAAVMAFGSILEGPSPRSLEGLVTQAMPVITELLADPISVVR 378
VLP+++ +I++ DW+ RDAAV+AFGSILEGP P L+ LV QAMP + EL+ DP VVR
Sbjct: 366 HVLPFIKEHIKNPDWRYRDAAVVAFGSILEGPEPNQLKPLVIQAMPTLIELMKDPSVVVR 425
Query: 379 DTAAWTVGRVCEVLPEVPLGDACLPGLLAAMVAALSSEPKVATNVCWAFSSLAEGAYTVE 558
DT AWTVGR+CE+LPE + D L LL ++ LS+EP+VA+NVCWAFSSLAE AY E
Sbjct: 426 DTTAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAY--E 483
Query: 559 MRSAANPDGGDASYAEPLTYKLSPYFSNIVEQLLRTTNRADCGQSNLRNAAYSALMEMVK 738
A+ EP TY LS F IV++LL TT+R D Q+NLR++AY +LME+VK
Sbjct: 484 AADVAD------DQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVK 537
Query: 739 SAPKDCYACIQQ 774
++ KDCY +Q+
Sbjct: 538 NSAKDCYPAVQK 549
>sp|Q14974|IMB1_HUMAN Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor
P97) (Importin 90)
Length = 876
Score = 285 bits (728), Expect = 1e-76
Identities = 141/252 (55%), Positives = 184/252 (73%)
Frame = +1
Query: 19 PPANSSKYYARGAVKFLVPLLLDILEKQDEGDDEDEWNPHKAAGVCMALLSQACEGDIVE 198
PP ++SK+YA+GA+++LVP+L L KQDE DD+D+WNP KAAGVC+ LL+ CE DIV
Sbjct: 306 PPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVP 365
Query: 199 LVLPYVQANIRHEDWKRRDAAVMAFGSILEGPSPRSLEGLVTQAMPVITELLADPISVVR 378
VLP+++ +I++ DW+ RDAAVMAFG ILEGP P L+ LV QAMP + EL+ DP VVR
Sbjct: 366 HVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVR 425
Query: 379 DTAAWTVGRVCEVLPEVPLGDACLPGLLAAMVAALSSEPKVATNVCWAFSSLAEGAYTVE 558
DTAAWTVGR+CE+LPE + D L LL ++ LS+EP+VA+NVCWAFSSLAE AY E
Sbjct: 426 DTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAY--E 483
Query: 559 MRSAANPDGGDASYAEPLTYKLSPYFSNIVEQLLRTTNRADCGQSNLRNAAYSALMEMVK 738
A+ EP TY LS F IV++LL TT+R D Q+NLR++AY +LME+VK
Sbjct: 484 AADVAD------DQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVK 537
Query: 739 SAPKDCYACIQQ 774
++ KDCY +Q+
Sbjct: 538 NSAKDCYPAVQK 549
>sp|O18388|IMB_DROME Importin beta subunit (Karyopherin beta-4 subunit) (Protein ketel)
Length = 884
Score = 252 bits (643), Expect = 9e-67
Identities = 125/251 (49%), Positives = 169/251 (67%)
Frame = +1
Query: 22 PANSSKYYARGAVKFLVPLLLDILEKQDEGDDEDEWNPHKAAGVCMALLSQACEGDIVEL 201
P SK+YARGA++FL P+L++ L KQDE DDED W+P KAA VC+ +L+ CE +IV
Sbjct: 313 PQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPH 372
Query: 202 VLPYVQANIRHEDWKRRDAAVMAFGSILEGPSPRSLEGLVTQAMPVITELLADPISVVRD 381
VLP+++ NI +W+ RDAAVM FGS+L G +L+ LV QAMP + L+ D +VRD
Sbjct: 373 VLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRD 432
Query: 382 TAAWTVGRVCEVLPEVPLGDACLPGLLAAMVAALSSEPKVATNVCWAFSSLAEGAYTVEM 561
T AWT GR+C+++PE + + L LL V +L SEP+VA NVCWAF L++ A+
Sbjct: 433 TIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAW---- 488
Query: 562 RSAANPDGGDASYAEPLTYKLSPYFSNIVEQLLRTTNRADCGQSNLRNAAYSALMEMVKS 741
+A DG P TY LSPYF I+ QLL TT+R+D Q+NLR AAY ALM+M+K+
Sbjct: 489 EAAVTNDG-----ETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKN 543
Query: 742 APKDCYACIQQ 774
+P DCY +Q+
Sbjct: 544 SPLDCYLVVQR 554
>sp|O13864|IMB1_SCHPO Importin beta-1 subunit (Karyopherin beta-1 subunit) (Importin 95)
Length = 863
Score = 150 bits (380), Expect = 3e-36
Identities = 80/238 (33%), Positives = 131/238 (55%)
Frame = +1
Query: 22 PANSSKYYARGAVKFLVPLLLDILEKQDEGDDEDEWNPHKAAGVCMALLSQACEGDIVEL 201
PA + +AR A ++P+LL +L QDE DED+WN AA C+ L +Q IV
Sbjct: 307 PARQNHGFARAAAADILPVLLKLLCNQDEDADEDDWNISMAAATCLQLFAQVVGDLIVNP 366
Query: 202 VLPYVQANIRHEDWKRRDAAVMAFGSILEGPSPRSLEGLVTQAMPVITELLADPISVVRD 381
VL +V+ NI++ DW +R+AAVMAFGS+LEGP+ L LV QA+PV+ ++ DP+ V+D
Sbjct: 367 VLAFVEQNIQNPDWHQREAAVMAFGSVLEGPNVAMLTPLVNQALPVLINMMVDPVIFVKD 426
Query: 382 TAAWTVGRVCEVLPEVPLGDACLPGLLAAMVAALSSEPKVATNVCWAFSSLAEGAYTVEM 561
T AW +G++ + + + L +++A++ L+ P++ N CWAF +L V+
Sbjct: 427 TTAWALGQISSFVADAINPEIHLSPMVSALLQGLTDNPRIVANCCWAFMNLVCHFAPVDN 486
Query: 562 RSAANPDGGDASYAEPLTYKLSPYFSNIVEQLLRTTNRADCGQSNLRNAAYSALMEMV 735
T ++P++ I+ LL T++ ++N R + Y L ++
Sbjct: 487 HQ---------------TSVMTPFYEAIIGSLLHVTDQKG-NENNSRTSGYETLGTLI 528
>sp|Q06142|IMB1_YEAST Importin beta-1 subunit (Karyopherin beta-1 subunit) (Importin 95)
Length = 861
Score = 143 bits (361), Expect = 5e-34
Identities = 82/234 (35%), Positives = 127/234 (54%)
Frame = +1
Query: 43 YARGAVKFLVPLLLDILEKQDEGDDEDEWNPHKAAGVCMALLSQACEGDIVELVLPYVQA 222
+A ++K +VP LL++L +Q+E ++D+WN +AG C+ L +Q C I+E VL +V+
Sbjct: 317 FALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQ 376
Query: 223 NIRHEDWKRRDAAVMAFGSILEGPSPRSLEGLVTQAMPVITELLADPISVVRDTAAWTVG 402
NI ++W+ R+AAVMAFGSI++GP V QA+P I L+ D V++T AW +G
Sbjct: 377 NITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIG 436
Query: 403 RVCEVLPEVPLGDACLPGLLAAMVAALSSEPKVATNVCWAFSSLAEGAYTVEMRSAANPD 582
R+ + + E LPG++ A + L PKVATN W +L E
Sbjct: 437 RIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVE-------------- 482
Query: 583 GGDASYAEPLTYKLSPYFSNIVEQLLRTTNRADCGQSNLRNAAYSALMEMVKSA 744
AE + ++ +V+ L+ NR D + N R +A+SAL MV+ A
Sbjct: 483 ----QLAEATPSPIYNFYPALVDGLIGAANRID-NEFNARASAFSALTTMVEYA 531
>sp|O14089|IMB2_SCHPO Putative importin beta-2 subunit (Karyopherin beta-2 subunit)
(Importin 104) (Transportin) (TRN)
Length = 910
Score = 67.8 bits (164), Expect = 3e-11
Identities = 51/169 (30%), Positives = 82/169 (48%), Gaps = 15/169 (8%)
Frame = +1
Query: 85 DILEKQDEGDDE-DE-------WNPHKAAGVCMALLSQACEGDIVELVLPYVQANIRHED 240
D LE +DE DDE DE WN K + + +LS + ++E++LP+++ ++ ED
Sbjct: 368 DELEDEDEDDDEFDEDDDAFMDWNLRKCSAAALDVLSSFWKQRLLEIILPHLKQSLTSED 427
Query: 241 WKRRDAAVMAFGSILEGPSPRSLEGLV---TQAMPVITELLADPISVVRDTAAWTVGRVC 411
WK ++A V+A G+I EG ++G+V + P LL +VR WT+GR
Sbjct: 428 WKVQEAGVLAVGAIAEG----CMDGMVQYLPELYPYFLSLLDSKKPLVRTITCWTLGRYS 483
Query: 412 E----VLPEVPLGDACLPGLLAAMVAALSSEPKVATNVCWAFSSLAEGA 546
+ + E +P L + + + KV C AF+ L E A
Sbjct: 484 KWASCLESEEDRQKYFVPLLQGLLRMVVDNNKKVQEAGCSAFAILEEQA 532
>sp|Q92973|TNPO1_HUMAN Transportin-1 (Importin beta-)2 (Karyopherin beta-2) (M9 region
interaction protein) (MIP)
Length = 890
Score = 67.0 bits (162), Expect = 5e-11
Identities = 39/166 (23%), Positives = 80/166 (48%), Gaps = 10/166 (6%)
Frame = +1
Query: 85 DILEKQDEGDDE-------DEWNPHKAAGVCMALLSQACEGDIVELVLPYVQANIRHEDW 243
D +E++D+ DDE +WN K + + +L+ +++ +LP ++ + H +W
Sbjct: 352 DGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEW 411
Query: 244 KRRDAAVMAFGSILEGPSPRSLEGLV---TQAMPVITELLADPISVVRDTAAWTVGRVCE 414
+++ ++ G+I EG ++G++ + +P + + L+D ++VR WT+ R
Sbjct: 412 VVKESGILVLGAIAEG----CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAH 467
Query: 415 VLPEVPLGDACLPGLLAAMVAALSSEPKVATNVCWAFSSLAEGAYT 552
+ P P + + L S +V C AF++L E A T
Sbjct: 468 WVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACT 513
>sp|Q8BFY9|TNPO1_MOUSE Transportin-1 (Importin beta-2) (Karyopherin beta-2)
Length = 890
Score = 67.0 bits (162), Expect = 5e-11
Identities = 39/166 (23%), Positives = 80/166 (48%), Gaps = 10/166 (6%)
Frame = +1
Query: 85 DILEKQDEGDDE-------DEWNPHKAAGVCMALLSQACEGDIVELVLPYVQANIRHEDW 243
D +E++D+ DDE +WN K + + +L+ +++ +LP ++ + H +W
Sbjct: 352 DGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEW 411
Query: 244 KRRDAAVMAFGSILEGPSPRSLEGLV---TQAMPVITELLADPISVVRDTAAWTVGRVCE 414
+++ ++ G+I EG ++G++ + +P + + L+D ++VR WT+ R
Sbjct: 412 VVKESGILVLGAIAEG----CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAH 467
Query: 415 VLPEVPLGDACLPGLLAAMVAALSSEPKVATNVCWAFSSLAEGAYT 552
+ P P + + L S +V C AF++L E A T
Sbjct: 468 WVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACT 513
>sp|Q99LG2|TNPO2_MOUSE Transportin-2 (Karyopherin beta-2b)
Length = 887
Score = 63.2 bits (152), Expect = 8e-10
Identities = 37/156 (23%), Positives = 74/156 (47%), Gaps = 3/156 (1%)
Frame = +1
Query: 94 EKQDEGDDEDEWNPHKAAGVCMALLSQACEGDIVELVLPYVQANIRHEDWKRRDAAVMAF 273
E D+ D +WN K + + +L+ +++ +LP ++ + H +W +++ ++
Sbjct: 359 EDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVL 418
Query: 274 GSILEGPSPRSLEGLV---TQAMPVITELLADPISVVRDTAAWTVGRVCEVLPEVPLGDA 444
G+I EG ++G+V + +P + + L+D ++VR A WT+ R + P
Sbjct: 419 GAIAEG----CMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMH 474
Query: 445 CLPGLLAAMVAALSSEPKVATNVCWAFSSLAEGAYT 552
P + + L +V C AF++L E A T
Sbjct: 475 LKPLMTELLKRILDGNKRVQEAACSAFATLEEEACT 510
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.317 0.132 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,375,154
Number of Sequences: 369166
Number of extensions: 1312444
Number of successful extensions: 6445
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5953
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6380
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7212136400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)