Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_I11
(895 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P21613|KINH_LOLPE Kinesin heavy chain 266 4e-71
sp|P17210|KINH_DROME Kinesin heavy chain 255 1e-67
sp|P35978|KINH_STRPU Kinesin heavy chain 254 3e-67
sp|O60282|KIF5C_HUMAN Kinesin heavy chain isoform 5C (Kines... 246 8e-65
sp|P28738|KIF5C_MOUSE Kinesin heavy chain isoform 5C (Kines... 244 2e-64
sp|P33176|KINH_HUMAN Kinesin heavy chain (Ubiquitous kinesi... 233 4e-61
sp|P33175|KINN_MOUSE Neuronal kinesin heavy chain (NKHC) (K... 233 4e-61
sp|Q61768|KINH_MOUSE Kinesin heavy chain (Ubiquitous kinesi... 233 7e-61
sp|Q12840|KINN_HUMAN Neuronal kinesin heavy chain (NKHC) (K... 232 1e-60
sp|P34540|KINH_CAEEL Kinesin heavy chain (Uncoordinated pro... 120 5e-27
>sp|P21613|KINH_LOLPE Kinesin heavy chain
Length = 967
Score = 266 bits (681), Expect = 4e-71
Identities = 149/298 (50%), Positives = 193/298 (64%)
Frame = +1
Query: 1 EFEVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEILAGQL 180
+ E +M +L + ++E +KR LE+ D L+ E +K KA EQ+ + A ++ E
Sbjct: 635 QHEAKMASLQEAIKDSENKKRMLEDNVDSLNEEYAKLKAQEQMHLAALSEREKETSQAS- 693
Query: 181 DIKSKLDEEFKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYEKVV 360
+ + L+++ + EQ+ +Q++ LRD++ EKQ + +KD LS EKL+ DY+K+
Sbjct: 694 ETREVLEKQMEMHREQHQKQLQSLRDEISEKQATVDNLKDDNQRLSLALEKLQADYDKLK 753
Query: 361 AEGEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVKKST 540
E KAAKL + ++REQA+QDLKGLE+TV KELQTLHNLRKLFVQDL N+VKKS
Sbjct: 754 QEEVEKAAKLADLSLQIDRREQAKQDLKGLEETVAKELQTLHNLRKLFVQDLQNKVKKSC 813
Query: 541 RGVNXXXXXXXXXXXXXXXXXXNLVQKQKIQFLEMNLEQLTKVHKQLVRDNSDXXXXXXX 720
N QKQKI FLE NLEQLTKVHKQLVRDN+D
Sbjct: 814 SKTEEEDEDTGG----------NAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPK 863
Query: 721 XXXXXXSTTERVKALESALKDAKEGAMRDRRRYQHEVDRIKEAVRQRNIARRGNAPQI 894
+T ERVK+LESALKDAKEGAMRDR+RYQHEVDRIKEAVRQ+N+ARRG+A QI
Sbjct: 864 LEKRLRATMERVKSLESALKDAKEGAMRDRKRYQHEVDRIKEAVRQKNLARRGHAAQI 921
Score = 36.6 bits (83), Expect = 0.097
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 4/106 (3%)
Frame = +1
Query: 25 LNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEILAGQLDIKSKLDE 204
L++K DE Q + +E+ +Q+ + + + N Q+ + I A K ++ E
Sbjct: 426 LDDKDDEINNQSQLIEKLKEQMMEQEDLIAQSRRDYENLQ-QDMSRIQADNESAKDEVKE 484
Query: 205 EFKRQSE---QYSQQIKELRDKLDEKQRASEEMKDKIHHL-SFQNE 330
+ E Y Q+ +E+ DK E + SEE+ K+ L S QNE
Sbjct: 485 VLQALEELAMNYDQKSQEVEDKNKENENLSEELNQKLSTLNSLQNE 530
>sp|P17210|KINH_DROME Kinesin heavy chain
Length = 975
Score = 255 bits (652), Expect = 1e-67
Identities = 149/299 (49%), Positives = 190/299 (63%), Gaps = 1/299 (0%)
Frame = +1
Query: 1 EFEVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQL-IVNANAQNRAEILAGQ 177
+ E RM +L + E E +KR LEEQ D L E +K KA E + VNA + RAE
Sbjct: 662 QHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAE----- 716
Query: 178 LDIKSKLDEEFKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYEKV 357
+++S D + E +++Q+ ELRD++ KQ +EMKD L ++++ DYEKV
Sbjct: 717 -ELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKV 775
Query: 358 VAEGEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVKKS 537
E K+++L+ I E+REQAR+DLKGLEDTV KELQTLHNLRKLFVQDL R++K+
Sbjct: 776 RQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKN 835
Query: 538 TRGVNXXXXXXXXXXXXXXXXXXNLVQKQKIQFLEMNLEQLTKVHKQLVRDNSDXXXXXX 717
VN +L QKQKI FLE NL+QLTKVHKQLVRDN+D
Sbjct: 836 V--VNEESEEDGG----------SLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELP 883
Query: 718 XXXXXXXSTTERVKALESALKDAKEGAMRDRRRYQHEVDRIKEAVRQRNIARRGNAPQI 894
T ERVKALE+ALK+AKEGAMRDR+RYQ+EVDRIKEAVRQ+++ RRG QI
Sbjct: 884 KLEKRLRCTMERVKALETALKEAKEGAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQI 942
Score = 40.4 bits (93), Expect = 0.007
Identities = 43/182 (23%), Positives = 80/182 (43%), Gaps = 6/182 (3%)
Frame = +1
Query: 7 EVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEILAGQLDI 186
E L + +T + L Q L + NEQ A E L QLD
Sbjct: 395 EASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQ----ARLATECERLYQQLDD 450
Query: 187 KSKLDEEFKRQS---EQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYEKV 357
K DEE +QS EQ +Q+ E + + +R E ++ ++ + +NE KE+ ++V
Sbjct: 451 K---DEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEV 507
Query: 358 VAEGEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQ---DLSNRV 528
+ E A ++ +++ + +D+ L + +++ Q++ N +Q D+S+
Sbjct: 508 LQALEELAV---NYDQKSQEIDNKNKDIDALNEE-LQQKQSVFNAASTELQQLKDMSSHQ 563
Query: 529 KK 534
KK
Sbjct: 564 KK 565
>sp|P35978|KINH_STRPU Kinesin heavy chain
Length = 1031
Score = 254 bits (648), Expect = 3e-67
Identities = 139/301 (46%), Positives = 194/301 (64%), Gaps = 3/301 (0%)
Frame = +1
Query: 1 EFEVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEI---LA 171
+ E +M +L+ + ETE +KR LE+ D L+ E+ K +A E++ + + E +
Sbjct: 628 QHEAKMKSLSENIRETEGKKRHLEDSLDMLNEEIVKLRAAEEIRLTDQEDKKREEEDKMQ 687
Query: 172 GQLDIKSKLDEEFKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYE 351
++++ + E+ + + + +Q+ LR +++EK+ EE+KD ++ Q+EKL+ DYE
Sbjct: 688 SATEMQASMSEQMESHRDAHQKQLANLRTEINEKEHQMEELKDVNQRMTLQHEKLQLDYE 747
Query: 352 KVVAEGEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVK 531
K+ E KAAKL + + ++REQA+QDLKGLE+TV KELQTLHNLRKLFV DL NRVK
Sbjct: 748 KLKIEEAEKAAKLRELSQQFDRREQAKQDLKGLEETVAKELQTLHNLRKLFVSDLQNRVK 807
Query: 532 KSTRGVNXXXXXXXXXXXXXXXXXXNLVQKQKIQFLEMNLEQLTKVHKQLVRDNSDXXXX 711
K+ G + + QKQKI FLE NLEQLTKVHKQLVRDN+D
Sbjct: 808 KALEGGDRDDDSGG-----------SQAQKQKISFLENNLEQLTKVHKQLVRDNADLRCE 856
Query: 712 XXXXXXXXXSTTERVKALESALKDAKEGAMRDRRRYQHEVDRIKEAVRQRNIARRGNAPQ 891
+T+ERVKALE +LK+ KEGAMRDR+RYQ EVDRI+EAVRQRN A+RG++ Q
Sbjct: 857 LPKLERRLRATSERVKALEMSLKETKEGAMRDRKRYQQEVDRIREAVRQRNFAKRGSSAQ 916
Query: 892 I 894
I
Sbjct: 917 I 917
Score = 40.4 bits (93), Expect = 0.007
Identities = 34/182 (18%), Positives = 84/182 (46%), Gaps = 8/182 (4%)
Frame = +1
Query: 7 EVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEILAGQLDI 186
E+ N+ ++ + + +L+ Q L E+ +++A E + V EIL +
Sbjct: 334 ELTAEEWRNRYEKEKEKNGRLKAQLLILENELQRWRAGESVPVKEQGNKNDEILKEMMKP 393
Query: 187 KSKLDEEFKRQSEQYSQQIKELRDKLDEK-------QRASEEMKDKIHHLSFQNEKLKED 345
K + + ++ ++ +L ++LDEK R +E++K ++ ++ D
Sbjct: 394 KQMTVHVSEEEKNKWEEEKVKLYEQLDEKDSEIDNQSRLTEKLKQQMLEQEELLSSMQRD 453
Query: 346 YEKVVAE-GEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSN 522
YE + ++ G ++A E+A E QA +++ D KE++ + + + ++++
Sbjct: 454 YELLQSQMGRLEAENAAAKEEAKEVL-QALEEMAVNYDEKSKEVEDKNRMNETLSEEVNE 512
Query: 523 RV 528
++
Sbjct: 513 KM 514
>sp|O60282|KIF5C_HUMAN Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific
2)
Length = 957
Score = 246 bits (627), Expect = 8e-65
Identities = 139/301 (46%), Positives = 188/301 (62%), Gaps = 3/301 (0%)
Frame = +1
Query: 1 EFEVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEILAGQL 180
+ E ++ +L + + E ++R+LEE D L E++K +A E++ + E L
Sbjct: 635 QHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQ 694
Query: 181 D---IKSKLDEEFKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYE 351
D +K L+++ + E + +Q+ LRD+++EKQ+ +E++D L + EKL DY
Sbjct: 695 DAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYN 754
Query: 352 KVVAEGEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVK 531
K+ E + + KLE + +KREQAR+DLKGLE+TV +ELQTLHNLRKLFVQDL+ RVK
Sbjct: 755 KLKIEDQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVK 814
Query: 532 KSTRGVNXXXXXXXXXXXXXXXXXXNLVQKQKIQFLEMNLEQLTKVHKQLVRDNSDXXXX 711
KS N + QKQKI FLE NLEQLTKVHKQLVRDN+D
Sbjct: 815 KSVELDNDDGGG-------------SAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCE 861
Query: 712 XXXXXXXXXSTTERVKALESALKDAKEGAMRDRRRYQHEVDRIKEAVRQRNIARRGNAPQ 891
+T ERVKALESALK+AKE AMRDR+RYQ EVDRIKEAVR +N+ARR ++ Q
Sbjct: 862 LPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQ 921
Query: 892 I 894
I
Sbjct: 922 I 922
>sp|P28738|KIF5C_MOUSE Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific
2)
Length = 956
Score = 244 bits (623), Expect = 2e-64
Identities = 138/301 (45%), Positives = 186/301 (61%), Gaps = 3/301 (0%)
Frame = +1
Query: 1 EFEVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEILAGQL 180
+ E ++ +L + + E ++R+LEE D L E++K +A E++ + E L
Sbjct: 634 QHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQ 693
Query: 181 D---IKSKLDEEFKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYE 351
D +K L+++ + E + +Q+ LRD+++EKQR +E++D L + E+L DY
Sbjct: 694 DAEEVKKALEQQMESHREAHQKQLSRLRDEIEEKQRIIDEIRDLNQKLQLEQERLSSDYN 753
Query: 352 KVVAEGEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVK 531
K+ E + + KLE + +KREQAR+DLKGLE+TV ELQTLHNLRKLFVQDL+ RVK
Sbjct: 754 KLKIEDQEREVKLEKLLLLNDKREQAREDLKGLEETVSIELQTLHNLRKLFVQDLTTRVK 813
Query: 532 KSTRGVNXXXXXXXXXXXXXXXXXXNLVQKQKIQFLEMNLEQLTKVHKQLVRDNSDXXXX 711
KS + QKQKI FLE NLEQLTKVHKQLVRDN+D
Sbjct: 814 KSVE-------------LDSDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCE 860
Query: 712 XXXXXXXXXSTTERVKALESALKDAKEGAMRDRRRYQHEVDRIKEAVRQRNIARRGNAPQ 891
+T ERVKALESALK+AKE AMRDR+RYQ EVDRIKEAVR +N+ARR ++ Q
Sbjct: 861 LPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQ 920
Query: 892 I 894
I
Sbjct: 921 I 921
>sp|P33176|KINH_HUMAN Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC)
Length = 963
Score = 233 bits (595), Expect = 4e-61
Identities = 131/298 (43%), Positives = 185/298 (62%)
Frame = +1
Query: 1 EFEVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEILAGQL 180
+ E ++ +L + E +KR+LEE D L E+ + +A E+ V+ + +
Sbjct: 638 QHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEK--VHEMEKEHLNKVQTAN 695
Query: 181 DIKSKLDEEFKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYEKVV 360
++K ++++ + E + +QI LRD+++ K + +++D+ + + E+L+ ++EK+
Sbjct: 696 EVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLK 755
Query: 361 AEGEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVKKST 540
A + K+ KL + ++REQARQDLKGLE+TV KELQTLHNLRKLFVQDL+ RVKKS
Sbjct: 756 ATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSA 815
Query: 541 RGVNXXXXXXXXXXXXXXXXXXNLVQKQKIQFLEMNLEQLTKVHKQLVRDNSDXXXXXXX 720
+ QKQKI FLE NLEQLTKVHKQLVRDN+D
Sbjct: 816 E-------------IDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPK 862
Query: 721 XXXXXXSTTERVKALESALKDAKEGAMRDRRRYQHEVDRIKEAVRQRNIARRGNAPQI 894
+T ERVKALESALK+AKE A RDR+RYQ EVDRIKEAVR +N+ARRG++ QI
Sbjct: 863 LEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQI 920
Score = 33.9 bits (76), Expect = 0.63
Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 6/169 (3%)
Frame = +1
Query: 46 TELQKRKLEEQNDQLHAEVS----KFKANEQLIVNANAQ--NRAEILAGQLDIKSKLDEE 207
T+ ++RK EE+ +L+ ++ + QL+ Q ++ E+LA + + E
Sbjct: 414 TDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAE 473
Query: 208 FKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYEKVVAEGEIKAAK 387
R + +E+++ L +A EE+ S + E ++YE + E K+A
Sbjct: 474 LNRLQAENDASKEEVKEVL----QALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSAT 529
Query: 388 LEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVKK 534
L I+ +K ++ K +M L L +L ++ + +N VK+
Sbjct: 530 LASIDAELQKLKEMTNHQKKRAAEMMASL--LKDLAEIGIAVGNNDVKQ 576
>sp|P33175|KINN_MOUSE Neuronal kinesin heavy chain (NKHC) (Kinesin heavy chain isoform 5A)
(Kinesin heavy chain neuron-specific 1)
Length = 1027
Score = 233 bits (595), Expect = 4e-61
Identities = 133/298 (44%), Positives = 185/298 (62%)
Frame = +1
Query: 1 EFEVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEILAGQL 180
+ E ++ +L + EL+KR LEE D L E+++ +A+E + A + +
Sbjct: 635 QHEAKIRSLTEYMQTVELKKRHLEESYDSLSDELARLQAHETVHEVALKDKEPDTQDAE- 693
Query: 181 DIKSKLDEEFKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYEKVV 360
++K L+ + + E + +Q+ LRD+++EKQ+ +E+KD L + EKL+ DYE++
Sbjct: 694 EVKKALELQMENHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYERLK 753
Query: 361 AEGEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVKKST 540
E K+AKL+ + E+ EQ++QDLKGLE+TV +ELQTLHNLRKLFVQD++ RVKKS
Sbjct: 754 NEENEKSAKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSA 813
Query: 541 RGVNXXXXXXXXXXXXXXXXXXNLVQKQKIQFLEMNLEQLTKVHKQLVRDNSDXXXXXXX 720
QKQKI FLE NLEQLTKVHKQLVRDN+D
Sbjct: 814 EMEPEDSGGIHS-------------QKQKISFLENNLEQLTKVHKQLVRDNADLRCELPK 860
Query: 721 XXXXXXSTTERVKALESALKDAKEGAMRDRRRYQHEVDRIKEAVRQRNIARRGNAPQI 894
+T ERVKALE ALK+AKEGAM+D+RRYQ EVDRIKEAVR ++ +RG++ QI
Sbjct: 861 LEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRGHSAQI 918
>sp|Q61768|KINH_MOUSE Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC)
Length = 963
Score = 233 bits (593), Expect = 7e-61
Identities = 130/298 (43%), Positives = 186/298 (62%)
Frame = +1
Query: 1 EFEVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEILAGQL 180
+ E ++ +L + E +KR+LEE D L E+ + +A E+ V+ + +
Sbjct: 638 QHEAKIKSLTEYLQNDEQKKRQLEESLDSLGEELVQLRAQEK--VHEMEKEHLNKVQTAN 695
Query: 181 DIKSKLDEEFKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYEKVV 360
++K ++++ + E + +QI LRD+++ K++ +++D+ + + E+L+ ++E++
Sbjct: 696 EVKQAVEQQIQSHRETHQKQISSLRDEVEAKEKLITDLQDQNQKMVLETERLRVEHERLK 755
Query: 361 AEGEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVKKST 540
A + K+ KL + ++REQARQDLKGLE+TV KELQTLHNLRKLFVQDL+ RVKKS
Sbjct: 756 ATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSA 815
Query: 541 RGVNXXXXXXXXXXXXXXXXXXNLVQKQKIQFLEMNLEQLTKVHKQLVRDNSDXXXXXXX 720
+ QKQKI FLE NLEQLTKVHKQLVRDN+D
Sbjct: 816 E-------------VDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPK 862
Query: 721 XXXXXXSTTERVKALESALKDAKEGAMRDRRRYQHEVDRIKEAVRQRNIARRGNAPQI 894
+T ERVKALESALK+AKE A RDR+RYQ EVDRIKEAVR +N+ARRG++ QI
Sbjct: 863 LEFRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQI 920
Score = 35.0 bits (79), Expect = 0.28
Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 6/169 (3%)
Frame = +1
Query: 46 TELQKRKLEEQNDQLHAEVS----KFKANEQLIVNANAQ--NRAEILAGQLDIKSKLDEE 207
T+ ++RK EE+ +L+ ++ + QL+ Q ++ E+LA + + E
Sbjct: 414 TDAERRKCEEELAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAE 473
Query: 208 FKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYEKVVAEGEIKAAK 387
R + +E+++ L +A EE+ S + E ++YE + E K+A
Sbjct: 474 LNRLQAENDASKEEVKEVL----QALEELAVNYDQKSQEVEDKTKEYELLTDEFNQKSAT 529
Query: 388 LEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVKK 534
L I+ +K ++ K +M L L +L ++ + +N VK+
Sbjct: 530 LASIDAELQKLKEMTNHQKKRAAEMMASL--LKDLAEIGIAVGNNDVKQ 576
>sp|Q12840|KINN_HUMAN Neuronal kinesin heavy chain (NKHC) (Kinesin heavy chain isoform 5A)
(Kinesin heavy chain neuron-specific 1)
Length = 1032
Score = 232 bits (591), Expect = 1e-60
Identities = 133/298 (44%), Positives = 182/298 (61%)
Frame = +1
Query: 1 EFEVRMNTLNNKVDETELQKRKLEEQNDQLHAEVSKFKANEQLIVNANAQNRAEILAGQL 180
+ E ++ +L + EL+KR LEE D L E++K +A E + A +
Sbjct: 635 QHEAKIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDAD- 693
Query: 181 DIKSKLDEEFKRQSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYEKVV 360
++K L+ + + E + +Q+ LRD+++EKQ+ +E+KD L + EKL+ DYEK+
Sbjct: 694 EVKKALELQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLK 753
Query: 361 AEGEIKAAKLEGIEKATEKREQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVKKST 540
+E K+ KL+ + E+ EQ++QDLKGLE+TV +ELQTLHNLRKLFVQD++ RVKKS
Sbjct: 754 SEEHEKSTKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSA 813
Query: 541 RGVNXXXXXXXXXXXXXXXXXXNLVQKQKIQFLEMNLEQLTKVHKQLVRDNSDXXXXXXX 720
QKQKI FLE NLEQLTKVHKQLVRDN+D
Sbjct: 814 EMEPEDSGGIHS-------------QKQKISFLENNLEQLTKVHKQLVRDNADLRCELPK 860
Query: 721 XXXXXXSTTERVKALESALKDAKEGAMRDRRRYQHEVDRIKEAVRQRNIARRGNAPQI 894
+T ERVKALE ALK+AKEGAM+D+RRYQ EVDRIKEAVR ++ +R ++ QI
Sbjct: 861 LEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRAHSAQI 918
Score = 30.0 bits (66), Expect = 9.1
Identities = 30/150 (20%), Positives = 70/150 (46%), Gaps = 10/150 (6%)
Frame = +1
Query: 55 QKRKLEEQNDQLHAEVS----KFKANEQLIVNANAQ--NRAEILAGQLDIKSKLDEEFKR 216
+++K EE+ +L+ ++ + QLI Q ++ E+L K+ E
Sbjct: 413 ERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSH 472
Query: 217 ---QSEQYSQQIKELRDKLDEKQRASEEMKDKIHHLSFQNEKLKEDYEKVVAEGEIKAAK 387
+++ ++KE+ L+E ++ ++ S QN+ L ++ + VA ++
Sbjct: 473 LQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESE 532
Query: 388 LEGIEKAT-EKREQARQDLKGLEDTVMKEL 474
L+ +++ + +R++ + L GL MK+L
Sbjct: 533 LQRLQEVSGHQRKRIAEVLNGL----MKDL 558
>sp|P34540|KINH_CAEEL Kinesin heavy chain (Uncoordinated protein 116)
Length = 815
Score = 120 bits (301), Expect = 5e-27
Identities = 107/363 (29%), Positives = 166/363 (45%), Gaps = 73/363 (20%)
Frame = +1
Query: 25 LNNKVDETELQKRKLEEQNDQLHAE---VSKFKANEQLIVNANAQNRAEI---------- 165
L+ K DE + ++LE+ Q+ + + + NE+LI N + + E
Sbjct: 442 LDEKDDEIQKVSQELEKLRQQVLLQEEALGTMRENEELIREENNRFQKEAEDKQQEGKEM 501
Query: 166 ------LAGQLDIKSKLDEEFKRQSEQYSQQIKELRDKLDEKQRAS----EEMKDKIHH- 312
+A LD++ E+ KR+ E + + L D++++ +E KI H
Sbjct: 502 MTALEEIAVNLDVRQAECEKLKRELEVVQEDNQSLEDRMNQATSLLNAHLDECGPKIRHF 561
Query: 313 ---------------LSFQNEKL-----------------------KEDYEKVVAEGEIK 378
++ QN++L KE + E K
Sbjct: 562 KEGIYNVIREFNIADIASQNDQLPDHDLLNHVRIGVSKLFSEYSAAKESSTAAEHDAEAK 621
Query: 379 -AAKLEGIEKATEK--------REQARQDLKGLEDTVMKELQTLHNLRKLFVQDLSNRVK 531
AA + +E + ++QA +++K L D V EL TL NL+K F++ L R +
Sbjct: 622 LAADVARVESGQDAGRMKQLLVKDQAAKEIKPLTDRVNMELTTLKNLKKEFMRVLVARCQ 681
Query: 532 --KSTRGVNXXXXXXXXXXXXXXXXXXNLVQKQKIQFLEMNLEQLTKVHKQLVRDNSDXX 705
+ T G + QKQ+IQFLE NL++LTKVHKQLVRDN+D
Sbjct: 682 ANQDTEGEDSLSGP---------------AQKQRIQFLENNLDKLTKVHKQLVRDNADLR 726
Query: 706 XXXXXXXXXXXSTTERVKALESALKDAKEGAMRDRRRYQHEVDRIKEAVRQRNIARRGNA 885
+R+K LE+AL+D+K+ + +R++YQ EV+RIKEAVRQRN+ RR NA
Sbjct: 727 VELPKMEARLRGREDRIKILETALRDSKQRSQAERKKYQQEVERIKEAVRQRNM-RRMNA 785
Query: 886 PQI 894
PQI
Sbjct: 786 PQI 788
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.310 0.126 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,050,875
Number of Sequences: 369166
Number of extensions: 1119894
Number of successful extensions: 7404
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5637
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6948
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8982382310
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)