Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_G05
(859 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (En... 106 9e-23
sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor... 105 2e-22
sp|P33435|MMP13_MOUSE Collagenase 3 precursor (Matrix metal... 103 6e-22
sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metal... 102 2e-21
sp|P53690|MMP14_MOUSE Matrix metalloproteinase-14 precursor... 101 2e-21
sp|Q99542|MMP19_HUMAN Matrix metalloproteinase-19 precursor... 101 3e-21
sp|Q9XT90|MMP14_PIG Matrix metalloproteinase-14 precursor (... 101 3e-21
sp|P45452|MMP13_HUMAN Collagenase 3 precursor (Matrix metal... 100 4e-21
sp|O18927|MMP13_HORSE Collagenase 3 precursor (Matrix metal... 100 4e-21
sp|Q10739|MMP14_RAT Matrix metalloproteinase-14 precursor (... 100 5e-21
>sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (Envelysin)
(Sea-urchin-hatching proteinase) [Contains: Hatching
enzyme 18 kDa form]
Length = 587
Score = 106 bits (264), Expect = 9e-23
Identities = 49/89 (55%), Positives = 63/89 (70%)
Frame = +3
Query: 33 GGVLAHAFFPRNGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSNDPNALMAPW 212
GGVLAHAF PRNG+ HFD +E WTEG G NL VAAHE GH++GL+HS +ALM P+
Sbjct: 245 GGVLAHAFLPRNGDAHFDDSETWTEGTRSGTNLFQVAAHEFGHSLGLYHSTVRSALMYPY 304
Query: 213 YGGYISENDFKLPDDDSQGAAFIYGTKNG 299
Y GY+ +F+L +DD G +YG+ +G
Sbjct: 305 YQGYVP--NFRLDNDDIAGIRSLYGSNSG 331
>sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor (MMP-19) (Matrix
metalloproteinase RASI)
Length = 527
Score = 105 bits (261), Expect = 2e-22
Identities = 70/199 (35%), Positives = 95/199 (47%), Gaps = 15/199 (7%)
Frame = +3
Query: 30 PGGVLAHAFFPRNGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSNDPNALMAP 209
PG VLAHA P G++HFD E WTEG G+NLR++AAHE+GHA+GL HS ALMAP
Sbjct: 174 PGKVLAHADIPELGSIHFDKDELWTEGTYQGVNLRIIAAHEVGHALGLGHSRYTQALMAP 233
Query: 210 WYGGYISENDFKLPDDDSQGAAFIYGTKN---------------GKVFVRSNKKREQSAN 344
Y GY + FKL DD G +YG ++ V + +
Sbjct: 234 VYAGY--QPFFKLHPDDVAGIQALYGKRSPETRDEEEETEMLTVSPVTAKPGPMPNPCSG 291
Query: 345 EKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDA 524
E + + + + D ++ VTD F++ A ++ LP L DA
Sbjct: 292 EVDAMVLGPRGKTYAFKGDYVWTVTDSG-------PGPLFQISALWE--GLPGNL---DA 339
Query: 525 LFYDYSGRRFVFFKGNRVF 581
Y RR FFKGN+V+
Sbjct: 340 AVYSPRTRRTHFFKGNKVW 358
>sp|P33435|MMP13_MOUSE Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 472
Score = 103 bits (257), Expect = 6e-22
Identities = 82/238 (34%), Positives = 117/238 (49%), Gaps = 7/238 (2%)
Frame = +3
Query: 6 DPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLF 176
D YP D P G+LAHAF P G+ HFD E WT + G NL +VAAHE+GH++GL
Sbjct: 175 DFYPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFIVAAHELGHSLGLD 232
Query: 177 HSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKEL 356
HS DP ALM P Y Y ++ F LPDDD QG F+YG + + K E+ L
Sbjct: 233 HSKDPGALMFPIY-TYTGKSHFMLPDDDVQGIQFLYGPGDEDPNPKHPKTPEKCDPALSL 291
Query: 357 CNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDALFYD 536
IT++ D + +V + SF +LPN + DA Y+
Sbjct: 292 DAITSLRGETMIFKDRFFWRLHPQQVEAELFLTKSF-------WPELPNHV---DAA-YE 340
Query: 537 YSGRRFVF-FKGNRVFSANGVKLEN---LTISELNVTRPGGFQGRVTAAIVRDKTGKS 698
+ R +F F+G + ++ NG + IS+L + R++AA+ + TGK+
Sbjct: 341 HPSRDLMFIFRGRKFWALNGYDILEGYPRKISDLGFPKE---VKRLSAAVHFENTGKT 395
>sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 102 bits (253), Expect = 2e-21
Identities = 81/238 (34%), Positives = 116/238 (48%), Gaps = 7/238 (2%)
Frame = +3
Query: 6 DPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLF 176
D YP D P G+LAHAF P G+ HFD E WT + G NL LVAAHE GH++GL
Sbjct: 174 DFYPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFLVAAHEFGHSLGLD 231
Query: 177 HSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKEL 356
HS DP ALM P Y Y ++ F LPDDD QG +YG + + K ++ L
Sbjct: 232 HSKDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSL 290
Query: 357 CNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDALFYD 536
IT++ D + +V + SF +LPN++ DA Y+
Sbjct: 291 DAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSF-------WPELPNRI---DAA-YE 339
Query: 537 YSGRRFVF-FKGNRVFSANGVKLEN---LTISELNVTRPGGFQGRVTAAIVRDKTGKS 698
+ R +F F+G + ++ NG + +SEL R +++AA+ + TGK+
Sbjct: 340 HPARDLIFIFRGKKFWAPNGYDILEGYPQKLSELGFpre---VKKISAAVHFEDTGKT 394
>sp|P53690|MMP14_MOUSE Matrix metalloproteinase-14 precursor (MMP-14) (Membrane-type
matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP) (MMP-X1) (MT-MMP)
Length = 582
Score = 101 bits (252), Expect = 2e-21
Identities = 55/103 (53%), Positives = 70/103 (67%), Gaps = 5/103 (4%)
Frame = +3
Query: 6 DPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKED--GINLRLVAAHEMGHAIG 170
D P D GG LAHA+FP G+ HFDSAE WT ED G ++ LVA HE+GHA+G
Sbjct: 188 DSTPFDG-EGGFLAHAYFPGPNIGGDTHFDSAEPWTVQNEDLNGNDIFLVAVHELGHALG 246
Query: 171 LFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNG 299
L HSNDP+A+M+P+Y +EN F LPDDD +G +YG+K+G
Sbjct: 247 LEHSNDPSAIMSPFYQWMDTEN-FVLPDDDRRGIQQLYGSKSG 288
>sp|Q99542|MMP19_HUMAN Matrix metalloproteinase-19 precursor (MMP-19) (Matrix
metalloproteinase RASI) (MMP-18)
Length = 508
Score = 101 bits (251), Expect = 3e-21
Identities = 73/220 (33%), Positives = 102/220 (46%), Gaps = 16/220 (7%)
Frame = +3
Query: 30 PGGVLAHAFFPRNGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSNDPNALMAP 209
PG VLAHA P G++HFD E WTEG G+NLR++AAHE+GHA+GL HS ALMAP
Sbjct: 173 PGRVLAHADIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAP 232
Query: 210 WYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKRE----------------QSA 341
Y GY FKL DD G +YG K+ + ++ E +
Sbjct: 233 VYEGY--RPHFKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCS 290
Query: 342 NEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSD 521
+E + + + + D ++ V+D FRV A ++ LP L D
Sbjct: 291 SELDAMMLGPRGKTYAFKGDYVWTVSDSG-------PGPLFRVSALWE--GLPGNL---D 338
Query: 522 ALFYDYSGRRFVFFKGNRVFSANGVKLENLTISELNVTRP 641
A Y + FFKG++V+ K+ +LN P
Sbjct: 339 AAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRVEP 378
>sp|Q9XT90|MMP14_PIG Matrix metalloproteinase-14 precursor (MMP-14) (Membrane-type
matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP)
Length = 580
Score = 101 bits (251), Expect = 3e-21
Identities = 55/103 (53%), Positives = 70/103 (67%), Gaps = 5/103 (4%)
Frame = +3
Query: 6 DPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKED--GINLRLVAAHEMGHAIG 170
D P D GG LAHA+FP G+ HFDSAE WT ED G ++ LVA HE+GHA+G
Sbjct: 186 DSTPFDG-EGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALG 244
Query: 171 LFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNG 299
L HSNDP+A+MAP+Y +EN F LPDDD +G +YG+++G
Sbjct: 245 LEHSNDPSAIMAPFYQWMDTEN-FVLPDDDRRGIQQLYGSESG 286
>sp|P45452|MMP13_HUMAN Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 100 bits (250), Expect = 4e-21
Identities = 79/237 (33%), Positives = 113/237 (47%), Gaps = 6/237 (2%)
Frame = +3
Query: 6 DPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLF 176
D YP D P G+LAHAF P G+ HFD E WT + G NL LVAAHE GH++GL
Sbjct: 174 DFYPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFLVAAHEFGHSLGLD 231
Query: 177 HSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKEL 356
HS DP ALM P Y Y ++ F LPDDD QG +YG + + K ++ L
Sbjct: 232 HSKDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSL 290
Query: 357 CNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDALFYD 536
IT++ D + +V + SF +LPN++ DA +
Sbjct: 291 DAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSF-------WPELPNRI---DAAYEH 340
Query: 537 YSGRRFVFFKGNRVFSANGVKLEN---LTISELNVTRPGGFQGRVTAAIVRDKTGKS 698
S F+G + ++ NG + ISEL + + +++AA+ + TGK+
Sbjct: 341 PSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKE---VKKISAAVHFEDTGKT 394
>sp|O18927|MMP13_HORSE Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 472
Score = 100 bits (250), Expect = 4e-21
Identities = 80/238 (33%), Positives = 116/238 (48%), Gaps = 7/238 (2%)
Frame = +3
Query: 6 DPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLF 176
D YP D P G+LAHAF P G+ HFD E WT + G NL LVAAHE GH++GL
Sbjct: 175 DFYPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFLVAAHEFGHSLGLD 232
Query: 177 HSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKEL 356
HS DP ALM P Y Y ++ F LPDDD QG ++YG + + K ++ L
Sbjct: 233 HSKDPGALMFPIY-TYTGKSHFVLPDDDVQGIQYLYGPGDEDPNPKHPKTPDKCDPSLSL 291
Query: 357 CNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDALFYD 536
IT++ D + V + SF +LPN++ DA Y+
Sbjct: 292 DAITSLRGETMVFKDRFFWRLHPQLVDAELFLTKSF-------WPELPNRI---DAA-YE 340
Query: 537 YSGRRFVF-FKGNRVFSANGVKLEN---LTISELNVTRPGGFQGRVTAAIVRDKTGKS 698
+ + +F F+G + ++ NG + ISEL + +++AA+ + TGK+
Sbjct: 341 HPSKDLIFIFRGRKFWALNGYDILEGYPQKISELGFPKD---VKKISAAVHFEDTGKT 395
>sp|Q10739|MMP14_RAT Matrix metalloproteinase-14 precursor (MMP-14) (Membrane-type
matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP) (MT-MMP)
Length = 582
Score = 100 bits (249), Expect = 5e-21
Identities = 55/103 (53%), Positives = 69/103 (66%), Gaps = 5/103 (4%)
Frame = +3
Query: 6 DPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKED--GINLRLVAAHEMGHAIG 170
D P D GG LAHA+FP G+ HFDSAE WT ED G ++ LVA HE+GHA+G
Sbjct: 188 DSTPFDG-EGGFLAHAYFPGPNIGGDTHFDSAEPWTVQNEDLNGNDIFLVAVHELGHALG 246
Query: 171 LFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNG 299
L HSNDP+ +MAP+Y +EN F LPDDD +G +YG+K+G
Sbjct: 247 LEHSNDPSDIMAPFYQWMDTEN-FVLPDDDRRGIQQLYGSKSG 288
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,507,932
Number of Sequences: 369166
Number of extensions: 1913351
Number of successful extensions: 5769
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5370
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5620
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)