Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_F08
(449 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransf... 117 9e-27
sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltran... 116 2e-26
sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltran... 114 1e-25
sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltran... 112 3e-25
sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X compo... 106 2e-23
sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltran... 103 1e-22
sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X compo... 103 2e-22
sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltran... 102 4e-22
sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltran... 102 5e-22
sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltran... 100 3e-21
>sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex) (PDC-E2) (70 kDa mitochondrial autoantigen of
primary biliary cirrhosis) (PBC)
Length = 555
Score = 117 bits (294), Expect = 9e-27
Identities = 68/129 (52%), Positives = 81/129 (62%), Gaps = 1/129 (0%)
Frame = +3
Query: 3 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 182
GLITPIVF A L I+S + LA KAR KLQP EF GGTFTISNLGMFGIK F+AI
Sbjct: 428 GLITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAI 487
Query: 183 INSPQAAILAVGAGIPHLAHDPANPSKPKSVTK-MRFTLCADARIIDETSASEFVSRVKS 359
IN PQA ILA+GA L PA+ K V M TL D R++D +++++ K
Sbjct: 488 INPPQACILAIGASEDKLI--PADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKK 545
Query: 360 YLENPSFLL 386
YLE P +L
Sbjct: 546 YLEKPVTML 554
>sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (E2)
(Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2)
Length = 483
Score = 116 bits (291), Expect = 2e-26
Identities = 59/124 (47%), Positives = 80/124 (64%)
Frame = +3
Query: 3 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 182
GLITP++ L LA IS+ + ++ARNNKL+P+E+ GGTFTISNLGMF + +FTAI
Sbjct: 355 GLITPVIRNTHALGLAEISTLAKDYGQRARNNKLKPEEYQGGTFTISNLGMFPVDQFTAI 414
Query: 183 INSPQAAILAVGAGIPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSY 362
IN PQA ILAVG + + D + K M+ TL +D R++D A+ F + +K
Sbjct: 415 INPPQACILAVGTTVDTVVPDSTSEKGFKVAPIMKCTLSSDHRVVDGAMAARFTTALKKI 474
Query: 363 LENP 374
LENP
Sbjct: 475 LENP 478
>sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (Pyruvate
dehydrogenase complex E2 subunit) (PDCE2) (E2)
(Dihydrolipoamide S-acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2) (70 kDa
mitochondrial autoantigen of primary biliary cirrhosis)
(PBC) (M2 antigen complex 70 kDa subunit)
Length = 614
Score = 114 bits (285), Expect = 1e-25
Identities = 65/129 (50%), Positives = 82/129 (63%), Gaps = 1/129 (0%)
Frame = +3
Query: 3 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 182
GLITPIVF A + I++ + LA KAR KLQP EF GGTFTISNLGMFGIK F+AI
Sbjct: 487 GLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAI 546
Query: 183 INSPQAAILAVGAGIPHLAHDPANPSKPKSV-TKMRFTLCADARIIDETSASEFVSRVKS 359
IN PQA ILA+GA L PA+ K V + M TL D R++D +++++ +
Sbjct: 547 INPPQACILAIGASEDKLV--PADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRK 604
Query: 360 YLENPSFLL 386
YLE P +L
Sbjct: 605 YLEKPITML 613
>sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (E2)
(Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2)
Length = 592
Score = 112 bits (281), Expect = 3e-25
Identities = 63/130 (48%), Positives = 85/130 (65%), Gaps = 2/130 (1%)
Frame = +3
Query: 3 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 182
GL TPIV G D L +IS+++ +LAEKA+N KL P EF GTFTISNLGM GIK+F A+
Sbjct: 464 GLFTPIVRGVDMKGLNSISTSVKQLAEKAQNGKLHPSEFESGTFTISNLGMLGIKQFAAV 523
Query: 183 INSPQAAILAVGAG--IPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVK 356
IN PQAAILA+ + L++ P +P ++ T + TL D R+ID +E++ K
Sbjct: 524 INPPQAAILALVPQKLVSFLSNKPDSPY--ETATILSVTLSCDHRVIDGAVGAEWLKSFK 581
Query: 357 SYLENPSFLL 386
Y+ENP L+
Sbjct: 582 DYVENPIKLI 591
>sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (Lipoyl-containing
pyruvate dehydrogenase complex component X) (E3-binding
protein) (E3BP) (proX)
Length = 501
Score = 106 bits (265), Expect = 2e-23
Identities = 56/126 (44%), Positives = 82/126 (65%), Gaps = 2/126 (1%)
Frame = +3
Query: 3 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 182
GL+TPI+ A + I+ ++ L++KAR+ KL P+E+ GG+F+ISNLGMFGI EFTA+
Sbjct: 372 GLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAV 431
Query: 183 INSPQAAILAVGAGIP--HLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVK 356
IN PQA ILAVG P L D +K + + T+ +D+R++D+ A+ F+ K
Sbjct: 432 INPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFK 491
Query: 357 SYLENP 374
+ LENP
Sbjct: 492 ANLENP 497
>sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 408
Score = 103 bits (258), Expect = 1e-22
Identities = 57/128 (44%), Positives = 79/128 (61%)
Frame = +3
Query: 3 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 182
G++TPIV A+K + +S + L +KA++NKL P EF GG FTISNLGM+GIK F AI
Sbjct: 283 GIVTPIVKDANKKNIIELSREMKTLIKKAKDNKLTPIEFQGGGFTISNLGMYGIKNFNAI 342
Query: 183 INSPQAAILAVGAGIPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSY 362
IN+PQ+ I+ VGA + T M TL AD R+ID ++EF++ K +
Sbjct: 343 INTPQSCIMGVGASTKRAI---VKNDQIIIATIMDVTLSADHRVIDGAVSAEFLASFKRF 399
Query: 363 LENPSFLL 386
+ENP +L
Sbjct: 400 IENPVLML 407
>sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (Lipoyl-containing
pyruvate dehydrogenase complex component X)
Length = 501
Score = 103 bits (257), Expect = 2e-22
Identities = 55/126 (43%), Positives = 80/126 (63%), Gaps = 2/126 (1%)
Frame = +3
Query: 3 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 182
GLITPI+ A + I+ ++ L++KAR+ KL P+E+ GG+F+ISNLGMFGI EF A+
Sbjct: 372 GLITPIIKDAAAKGIQEIADSVKVLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFAAV 431
Query: 183 INSPQAAILAVGAGIP--HLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVK 356
IN PQA ILAVG P L D + + + T+ +D+R++D+ A+ F+ K
Sbjct: 432 INPPQACILAVGRFRPVLKLTEDEEGNPQLQQHQLITVTMSSDSRVVDDELATRFLETFK 491
Query: 357 SYLENP 374
+ LENP
Sbjct: 492 ANLENP 497
>sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 440
Score = 102 bits (254), Expect = 4e-22
Identities = 59/131 (45%), Positives = 82/131 (62%), Gaps = 2/131 (1%)
Frame = +3
Query: 3 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 182
GLITPI+ AD L+A+S + EL +AR +LQPQE+ GGT +ISN+GMFGIK+F A+
Sbjct: 314 GLITPILKQADTKSLSALSVEMKELIARAREGRLQPQEYQGGTSSISNMGMFGIKQFNAV 373
Query: 183 INSPQAAILAVGAG--IPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVK 356
IN PQA+ILA+G+G P + D + ++T D R+ID A+ F+S K
Sbjct: 374 INPPQASILAIGSGERRPWVIDDAITIATVATITG-----SFDHRVIDGADAAAFMSAFK 428
Query: 357 SYLENPSFLLA 389
+E P +LA
Sbjct: 429 HLVEKPLGILA 439
>sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 412
Score = 102 bits (253), Expect = 5e-22
Identities = 55/128 (42%), Positives = 77/128 (60%)
Frame = +3
Query: 3 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 182
GL+TPIV A++ + +S + L +KA++NKL P+EF GG FTISNLGM+GIK F AI
Sbjct: 287 GLVTPIVKNANQKNILELSREMKALIKKAKDNKLTPEEFQGGGFTISNLGMYGIKNFNAI 346
Query: 183 INSPQAAILAVGAGIPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSY 362
IN PQ+ I+ VGA + T M TL AD R++D +EF+ K +
Sbjct: 347 INPPQSCIMGVGASAKRAI---VKNDQITIATIMDVTLSADHRVVDGAVGAEFLVAFKKF 403
Query: 363 LENPSFLL 386
+E+P +L
Sbjct: 404 IESPVLML 411
>sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 447
Score = 99.8 bits (247), Expect = 3e-21
Identities = 52/128 (40%), Positives = 77/128 (60%)
Frame = +3
Query: 3 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 182
GLITPIV A+ L+AIS+ + +L ++A+ KL+P+E+ GGT +SN+GM G+K+F A+
Sbjct: 322 GLITPIVRQAELKSLSAISNEMKDLGKRAKERKLKPEEYQGGTTAVSNMGMMGVKDFAAV 381
Query: 183 INSPQAAILAVGAGIPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSY 362
+N P A ILAVGAG + + M TL D R +D +E ++ K Y
Sbjct: 382 VNPPHATILAVGAGEDRVV---VRNKEMVIANVMTVTLSTDHRCVDGALGAELLAAFKRY 438
Query: 363 LENPSFLL 386
+ENP +L
Sbjct: 439 IENPMGML 446
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,991,415
Number of Sequences: 369166
Number of extensions: 1183489
Number of successful extensions: 3444
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3311
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3410
length of database: 68,354,980
effective HSP length: 100
effective length of database: 49,881,480
effective search space used: 2444192520
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)