Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_F03
(664 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 313 2e-85
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 311 7e-85
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 307 1e-83
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 303 3e-82
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 293 3e-79
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 270 3e-72
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 263 3e-70
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 248 8e-66
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 242 7e-64
sp|P25793|CYSP2_HAECO Cathepsin B-like cysteine proteinase ... 236 4e-62
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 313 bits (803), Expect = 2e-85
Identities = 136/198 (68%), Positives = 158/198 (79%)
Frame = +1
Query: 4 ISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVI 183
+SAED+LTCCG CGDGCNGGFPSGAW++W GLV+GG Y +H+GC+ Y+ P C HHV
Sbjct: 133 VSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVN 192
Query: 184 GPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAA 363
G P CTGE TPKC K C+ GYS +Y EDK +G SSYSV +N++ IM EI NGPVE A
Sbjct: 193 GSRPPCTGEGDTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGA 252
Query: 364 FSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKI 543
FSVY+DF YKSGVYQHVSG ++GGHAI+ILGWGVEN TPYWLV NSWN WGDNG+FKI
Sbjct: 253 FSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKI 312
Query: 544 LRGSDECGIEDEVVAGIP 597
LRG D CGIE E+VAG+P
Sbjct: 313 LRGQDHCGIESEIVAGMP 330
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 311 bits (798), Expect = 7e-85
Identities = 136/199 (68%), Positives = 159/199 (79%)
Frame = +1
Query: 4 ISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVI 183
+SAEDLLTCCG CGDGCNGG+P+ AW++W GLV+GG Y +H+GC+ Y+ P C HHV
Sbjct: 133 VSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVN 192
Query: 184 GPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAA 363
G P CTGE TPKC K C+ GYS TY +DK YG +SYSV ++++ IM EI NGPVE A
Sbjct: 193 GSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGA 252
Query: 364 FSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKI 543
FSVY+DF YKSGVYQHV+G M+GGHAI+ILGWGVEN TPYWLVANSWN WGDNG+FKI
Sbjct: 253 FSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKI 312
Query: 544 LRGSDECGIEDEVVAGIPK 600
LRG D CGIE EVVAGIP+
Sbjct: 313 LRGQDHCGIESEVVAGIPR 331
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 307 bits (787), Expect = 1e-83
Identities = 130/199 (65%), Positives = 157/199 (78%)
Frame = +1
Query: 4 ISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVI 183
+SAEDLLTCCG +CGDGCNGG+PSGAW++W GLV+GG Y +H+GC Y P C HHV
Sbjct: 133 VSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVN 192
Query: 184 GPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAA 363
G P CTGE TPKC K C+AGYS +Y EDK YG +SYSV +++ IM EI NGPVE A
Sbjct: 193 GSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGA 252
Query: 364 FSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKI 543
F+V++DF YKSGVY+H +G ++GGHAI+ILGWG+EN PYWLVANSWN WGDNG+FKI
Sbjct: 253 FTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKI 312
Query: 544 LRGSDECGIEDEVVAGIPK 600
LRG + CGIE E+VAGIP+
Sbjct: 313 LRGENHCGIESEIVAGIPR 331
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 303 bits (776), Expect = 3e-82
Identities = 129/199 (64%), Positives = 156/199 (78%)
Frame = +1
Query: 4 ISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVI 183
+SAEDLLTCCG +CGDGCNGG+PSGAW +W GLV+GG Y +H+GC Y P C HHV
Sbjct: 133 VSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVN 192
Query: 184 GPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAA 363
G P CTGE TP+C K+C+AGYS +Y EDK +G +SYSV ++ + IM EI NGPVE A
Sbjct: 193 GSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGA 252
Query: 364 FSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKI 543
F+V++DF YKSGVY+H +G M+GGHAI+ILGWGVEN PYWL ANSWN WGDNG+FKI
Sbjct: 253 FTVFSDFLTYKSGVYKHEAGDMMGGHAIRILGWGVENGVPYWLAANSWNLDWGDNGFFKI 312
Query: 544 LRGSDECGIEDEVVAGIPK 600
LRG + CGIE E+VAGIP+
Sbjct: 313 LRGENHCGIESEIVAGIPR 331
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 293 bits (750), Expect = 3e-79
Identities = 129/201 (64%), Positives = 151/201 (75%), Gaps = 1/201 (0%)
Frame = +1
Query: 4 ISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVI 183
+SAEDLL+CCGF CG GCNGG+PSGAW YW GLV+GG Y +H+GC+ Y P C HHV
Sbjct: 133 VSAEDLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVN 192
Query: 184 GPYPNCTGEF-PTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEA 360
G P CTGE TP+C + C+ GYS +Y EDK YG +SY V +++ IM EI NGPVE
Sbjct: 193 GSRPPCTGEGGETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEG 252
Query: 361 AFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFK 540
AF VY DF YKSGVYQHVSG +GGHAI+ILGWGVEN TPYWL ANSWN WG G+FK
Sbjct: 253 AFIVYEDFLMYKSGVYQHVSGEQVGGHAIRILGWGVENGTPYWLAANSWNTDWGITGFFK 312
Query: 541 ILRGSDECGIEDEVVAGIPKL 603
ILRG D CGIE E+VAG+P++
Sbjct: 313 ILRGEDHCGIESEIVAGVPRM 333
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 270 bits (689), Expect = 3e-72
Identities = 117/200 (58%), Positives = 146/200 (73%), Gaps = 1/200 (0%)
Frame = +1
Query: 4 ISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVI 183
+SA DL++CC CGDGC GGFP AW YWV G+VTGG H GCQ Y FPKC HH
Sbjct: 143 LSALDLISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTK 201
Query: 184 GPYPNC-TGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEA 360
G YP C T + TP+CK+ CQ GY Y +DK YG SY+V +N++ I ++I+ GPVEA
Sbjct: 202 GKYPACGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEA 261
Query: 361 AFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFK 540
AF VY DF NYKSG+Y+HV+G ++GGHAI+I+GWGVE TPYWL+ANSWN WG+ G F+
Sbjct: 262 AFDVYEDFLNYKSGIYRHVTGSIVGGHAIRIIGWGVEKRTPYWLIANSWNEDWGEKGLFR 321
Query: 541 ILRGSDECGIEDEVVAGIPK 600
++RG DEC IE +VVAG+ K
Sbjct: 322 MVRGRDECSIESDVVAGLIK 341
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 263 bits (672), Expect = 3e-70
Identities = 115/197 (58%), Positives = 144/197 (73%), Gaps = 1/197 (0%)
Frame = +1
Query: 4 ISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVI 183
+SA DLLTCC CG GC GG AW YWV +G+VT H GC+ Y FPKC HH
Sbjct: 142 LSAVDLLTCCE-SCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTK 200
Query: 184 GPYPNCTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEA 360
G YP C + + TP+CK+ CQ Y Y +DK GKSSY+V ++++AI +EI+ GPVEA
Sbjct: 201 GKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEA 260
Query: 361 AFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFK 540
+F+VY DF NYKSG+Y+H++G LGGHAI+I+GWGVEN TPYWL+ANSWN WG+NGYF+
Sbjct: 261 SFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFR 320
Query: 541 ILRGSDECGIEDEVVAG 591
I+RG DEC IE EV+AG
Sbjct: 321 IVRGRDECSIESEVIAG 337
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 248 bits (634), Expect = 8e-66
Identities = 113/205 (55%), Positives = 145/205 (70%), Gaps = 5/205 (2%)
Frame = +1
Query: 4 ISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHV- 180
+SA+DLL+CC CG GCNGG P AW YWV DG+VTG Y A+ GC+ Y FP C HH
Sbjct: 158 LSADDLLSCCK-SCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSK 216
Query: 181 ---IGPYPNCTGEFPTPKCKKACQAGYS-KTYAEDKQYGKSSYSVDSNQQAIMQEILTNG 348
P P+ +PTPKC+K C + Y+ KTY+EDK +G S+Y V + +AI +E++T+G
Sbjct: 217 KTHFDPCPHDL--YPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHG 274
Query: 349 PVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDN 528
P+E AF VY DF NY GVY H G + GGHA+K++GWG+++ PYW VANSWN WG++
Sbjct: 275 PLEIAFEVYEDFLNYDGGVYVHTGGKLGGGHAVKLIGWGIDDGIPYWTVANSWNTDWGED 334
Query: 529 GYFKILRGSDECGIEDEVVAGIPKL 603
G+F+ILRG DECGIE VV GIPKL
Sbjct: 335 GFFRILRGVDECGIESGVVGGIPKL 359
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 242 bits (617), Expect = 7e-64
Identities = 111/206 (53%), Positives = 140/206 (67%), Gaps = 6/206 (2%)
Frame = +1
Query: 4 ISAEDLLTCCG--FRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHH 177
+S+EDLL+CC F CG+GC GG+P AW +WV GLVTGG Y GC+ Y+ C
Sbjct: 135 LSSEDLLSCCTGMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCGET 194
Query: 178 VIG-PYPNCTGEF-PTPKCKKACQA--GYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTN 345
V G +P C + PTPKC +C + Y+ Y +DK +G ++Y+V + I EILTN
Sbjct: 195 VNGVKWPACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTN 254
Query: 346 GPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGD 525
GP+E AF+VY DF Y +GVY H +G LGGHA+KILGWGV+N TPYWLVANSWN WG+
Sbjct: 255 GPIEVAFTVYEDFYQYTTGVYVHTAGASLGGHAVKILGWGVDNGTPYWLVANSWNVAWGE 314
Query: 526 NGYFKILRGSDECGIEDEVVAGIPKL 603
GYF+I+RG +ECGIE VAGIP L
Sbjct: 315 KGYFRIIRGLNECGIEHSAVAGIPDL 340
>sp|P25793|CYSP2_HAECO Cathepsin B-like cysteine proteinase 2 precursor
Length = 342
Score = 236 bits (602), Expect = 4e-62
Identities = 104/198 (52%), Positives = 138/198 (69%), Gaps = 1/198 (0%)
Frame = +1
Query: 4 ISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVI 183
ISA D++TCC +CGDGC GG+P AW Y++ DG+V+GGEY C+ Y C HH
Sbjct: 139 ISATDIMTCCRPQCGDGCEGGWPIEAWKYFIYDGVVSGGEYLTKDVCRPYPIHPCGHHGN 198
Query: 184 GPY-PNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEA 360
Y C G PTP CK+ C+ G K Y DK+YGK +Y V + +AI EIL NGPV A
Sbjct: 199 DTYYGECRGTAPTPPCKRKCRPGVRKMYRIDKRYGKDAYIVKQSVKAIQSEILKNGPVVA 258
Query: 361 AFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFK 540
+F+VY DF +YKSG+Y+H +G + G HA+K++GWG ENNT +WL+ANSW+ WG+ GYF+
Sbjct: 259 SFAVYEDFRHYKSGIYKHTAGELRGYHAVKMIGWGNENNTDFWLIANSWHNDWGEKGYFR 318
Query: 541 ILRGSDECGIEDEVVAGI 594
I+RGS++CGIE + AGI
Sbjct: 319 IVRGSNDCGIEGTIAAGI 336
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,115,008
Number of Sequences: 369166
Number of extensions: 1995285
Number of successful extensions: 6335
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5805
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6216
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5560129980
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)