Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_F01
(752 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitoc... 397 e-110
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 395 e-110
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 394 e-109
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 374 e-103
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 362 e-100
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 362 e-100
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplas... 362 e-100
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytopl... 360 3e-99
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 352 6e-97
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 331 1e-90
>sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 397 bits (1021), Expect = e-110
Identities = 186/229 (81%), Positives = 204/229 (89%), Gaps = 1/229 (0%)
Frame = +2
Query: 2 MYNTDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDK 181
MYNTDESI GFAHSCFQYA+ KKWPLYMSTKNTILK YDGRFKDIFQEI+D+ YK +FDK
Sbjct: 221 MYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDK 280
Query: 182 LKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGK 361
KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGK
Sbjct: 281 NKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGK 340
Query: 362 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMER 541
TIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ ++E+
Sbjct: 341 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEK 400
Query: 542 ACVDTVDSGKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 685
CV+TV+SG MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 401 VCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 421
Score = 395 bits (1016), Expect = e-110
Identities = 185/229 (80%), Positives = 203/229 (88%), Gaps = 1/229 (0%)
Frame = +2
Query: 2 MYNTDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDK 181
MYNTDESI GFAHSCFQYA+ KKWPLYMSTKNTILK YDGRFKDIFQEI+++ YK +FDK
Sbjct: 190 MYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDK 249
Query: 182 LKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGK 361
KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGK
Sbjct: 250 YKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGK 309
Query: 362 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMER 541
TIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ +E+
Sbjct: 310 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEK 369
Query: 542 ACVDTVDSGKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 685
CV+TV+SG MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 370 VCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 418
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 394 bits (1011), Expect = e-109
Identities = 185/229 (80%), Positives = 202/229 (88%), Gaps = 1/229 (0%)
Frame = +2
Query: 2 MYNTDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDK 181
MYNTDESI GFAHSCFQYA+ KKWPLYMSTKNTILK YDGRFKDIFQ I+++ YK EFDK
Sbjct: 221 MYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDK 280
Query: 182 LKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGK 361
KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGK
Sbjct: 281 HKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGK 340
Query: 362 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMER 541
TIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ +E+
Sbjct: 341 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEK 400
Query: 542 ACVDTVDSGKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 685
CV+TV+SG MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 401 VCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 449
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 523
Score = 374 bits (960), Expect = e-103
Identities = 178/229 (77%), Positives = 196/229 (85%), Gaps = 1/229 (0%)
Frame = +2
Query: 2 MYNTDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDK 181
MYNTDESI GFAHSCFQY++ KKWPLY+STKNTILK YDGRFKDIFQEI+D+ YK +FD+
Sbjct: 293 MYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDR 352
Query: 182 LKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGK 361
KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+A +GSLGLMTSVL+CPDGK
Sbjct: 353 NKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILASRFGSLGLMTSVLVCPDGK 412
Query: 362 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMER 541
TIEAEAAHGTVTRHYREHQKG+PTST IASIFAWTRGLEHRGKLD NQ+LIR+ E+
Sbjct: 413 TIEAEAAHGTVTRHYREHQKGRPTSTKGIASIFAWTRGLEHRGKLDGNQDLIRFAQTREK 472
Query: 542 ACVDTVDSGKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 685
CV TV+ G MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 473 VCVQTVE-GAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 520
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 362 bits (930), Expect = e-100
Identities = 167/228 (73%), Positives = 196/228 (85%)
Frame = +2
Query: 2 MYNTDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDK 181
MYN D+SIE FAHS FQ AL+K WPLY+STKNTILK+YDGRFKDIFQEIYD+QYK++F+
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEA 241
Query: 182 LKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGK 361
KIWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGK
Sbjct: 242 QKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGK 301
Query: 362 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMER 541
T+EAEAAHGTVTRHYR HQKG+ TSTNPIASIFAW+RGL HR +LDNN EL + +E
Sbjct: 302 TVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALEE 361
Query: 542 ACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 685
C++T+++G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 362 VCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 362 bits (930), Expect = e-100
Identities = 167/228 (73%), Positives = 196/228 (85%)
Frame = +2
Query: 2 MYNTDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDK 181
MYN D+SIE FAHS FQ AL+K WPLY+STKNTILK+YDGRFKDIFQEIYD+QYK++F+
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEA 241
Query: 182 LKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGK 361
KIWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGK
Sbjct: 242 QKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGK 301
Query: 362 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMER 541
T+EAEAAHGTVTRHYR HQKG+ TSTNPIASIFAW+RGL HR +LDNN EL + +E
Sbjct: 302 TVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALEE 361
Query: 542 ACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 685
C++T+++G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 362 VCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 362 bits (928), Expect = e-100
Identities = 167/228 (73%), Positives = 197/228 (86%)
Frame = +2
Query: 2 MYNTDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDK 181
MYN D+SIE FAHS FQ AL+K WPLY+STKNTILK+YDGRFKDIFQEIYD+QYK++F+
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFEA 241
Query: 182 LKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGK 361
KIWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGK
Sbjct: 242 QKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGK 301
Query: 362 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMER 541
T+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAW+RGL HR KLDNN EL + + +E
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALEE 361
Query: 542 ACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 685
C++T+++G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 362 VCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 360 bits (923), Expect = 3e-99
Identities = 167/228 (73%), Positives = 196/228 (85%)
Frame = +2
Query: 2 MYNTDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDK 181
MYN D+SIE FAHS FQ AL+K WPLY+STKNTILK+YDGRFKDIFQEIYD+QYK++F+
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEA 241
Query: 182 LKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGK 361
KIWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGK
Sbjct: 242 QKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGK 301
Query: 362 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMER 541
T+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAWTRGL HR KLDNN+EL + + +E
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEE 361
Query: 542 ACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 685
++T+++G MTKDLAACI GL NVQ + YL T +F+D + EN + KL
Sbjct: 362 VSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKL 409
>sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 352 bits (903), Expect = 6e-97
Identities = 164/228 (71%), Positives = 194/228 (85%)
Frame = +2
Query: 2 MYNTDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDK 181
MYN D+SIE FAHS FQ AL+K WPLY+STKNTILK+YDGRFKDIFQEIYD++YK++F+
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEA 241
Query: 182 LKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGK 361
I YEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGK
Sbjct: 242 QNICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGK 301
Query: 362 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMER 541
T+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAW+RGL HR KLDNN EL + +E
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALED 361
Query: 542 ACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 685
C++T+++G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 362 VCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase)
(IDH) (NADP(+)-specific ICDH) (IDP)
Length = 415
Score = 331 bits (848), Expect = 1e-90
Identities = 154/228 (67%), Positives = 185/228 (81%)
Frame = +2
Query: 2 MYNTDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDK 181
MYNTDES+ FA + A KKWPLY+STKNTILK+YDGRFKDIFQE+Y+ +K+++++
Sbjct: 184 MYNTDESVRSFAEASMNMAYQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKSKYEE 243
Query: 182 LKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGK 361
IWYEHRLIDDM A ALKS GG+VW CKNYDGDVQSD +AQG+GSLGLMTSVL+CPDGK
Sbjct: 244 AGIWYEHRLIDDMAAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGK 303
Query: 362 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMER 541
TIEAEAAHGTVTRHYR HQKG TSTN IASIFAWTRGL HR LDNN+ L+ + +E
Sbjct: 304 TIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNERLLDFTEKLEA 363
Query: 542 ACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 685
AC+ V+SGKMTKDLA IHG K + +HYL T +F+DA+A+ +++L
Sbjct: 364 ACIGAVESGKMTKDLALIIHGSK-LSRDHYLNTEEFIDAVADELKARL 410
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,007,498
Number of Sequences: 369166
Number of extensions: 1932746
Number of successful extensions: 5098
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4936
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5082
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6873311200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)