Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_E14
(709 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 114 2e-25
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 113 4e-25
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 113 6e-25
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 112 7e-25
sp|P55097|CATK_MOUSE Cathepsin K precursor 112 1e-24
sp|O35186|CATK_RAT Cathepsin K precursor 112 1e-24
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 111 2e-24
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 110 3e-24
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 110 3e-24
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 109 6e-24
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 114 bits (286), Expect = 2e-25
Identities = 57/101 (56%), Positives = 67/101 (66%), Gaps = 1/101 (0%)
Frame = +1
Query: 127 ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGI-MKTKPTLEG 303
I+RRLIWE+NLKYI HNLE LG HTY L +N DMTNEE K G+ + +
Sbjct: 44 ISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTNEEVVQKMTGLKVPASHSRSN 103
Query: 304 STYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFLS 426
T P+ G P SVD+R+KGYVTPVKNQ QCGSCW+F S
Sbjct: 104 DTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSS 144
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 113 bits (283), Expect = 4e-25
Identities = 57/101 (56%), Positives = 67/101 (66%), Gaps = 1/101 (0%)
Frame = +1
Query: 127 ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGI-MKTKPTLEG 303
I+RRLIWE+NLKYI HNLE LG HTY L +N DMT+EE K G+ + +
Sbjct: 44 ISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSN 103
Query: 304 STYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFLS 426
T PE G P SVD+R+KGYVTPVKNQ QCGSCW+F S
Sbjct: 104 DTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSS 144
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 113 bits (282), Expect = 6e-25
Identities = 59/132 (44%), Positives = 80/132 (60%)
Frame = +1
Query: 133 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 312
RR IWE+N+K+IQ+HNL +DLG TY+LGLNQF DMT EEFKAKYL M +
Sbjct: 40 RRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGV 99
Query: 313 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFLSYWIIKKANIFRKNNPSNKFLRA 492
N +P +DWR+ GYVT VK+Q CGSCW+F + ++ + KN ++
Sbjct: 100 PYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTME--GQYMKNERTSISFSE 157
Query: 493 TISLNRSGAYGN 528
++ SG +GN
Sbjct: 158 QQLVDCSGPWGN 169
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 112 bits (281), Expect = 7e-25
Identities = 53/110 (48%), Positives = 76/110 (69%)
Frame = +1
Query: 133 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 312
RR +WE+N+K I+ HN EY GKH +++ +N F DMTNEEF+ + +G + + +G +
Sbjct: 48 RRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVF 106
Query: 313 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFLSYWIIKKANIFRK 462
P + LP SVDWR+KGYVTPVKNQ+QCGSCW+F + + + +FRK
Sbjct: 107 REPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGAL-EGQMFRK 154
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 112 bits (280), Expect = 1e-24
Identities = 55/101 (54%), Positives = 67/101 (66%), Gaps = 1/101 (0%)
Frame = +1
Query: 127 ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGI-MKTKPTLEG 303
I+RRLIWE+NLK I HNLE LG HTY L +N DMT+EE K G+ + +
Sbjct: 44 ISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSN 103
Query: 304 STYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFLS 426
T PE G +P S+D+R+KGYVTPVKNQ QCGSCW+F S
Sbjct: 104 DTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSS 144
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 112 bits (280), Expect = 1e-24
Identities = 55/101 (54%), Positives = 67/101 (66%), Gaps = 1/101 (0%)
Frame = +1
Query: 127 ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGI-MKTKPTLEG 303
I+RRLIWE+NLK I HNLE LG HTY L +N DMT+EE K G+ + +
Sbjct: 44 ISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSN 103
Query: 304 STYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFLS 426
T PE G +P S+D+R+KGYVTPVKNQ QCGSCW+F S
Sbjct: 104 DTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSS 144
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 111 bits (277), Expect = 2e-24
Identities = 57/102 (55%), Positives = 69/102 (67%), Gaps = 2/102 (1%)
Frame = +1
Query: 127 ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGS 306
I+RRLIWE+NLK+I HNLE LG HTY L +N DMT+EE K G +K P+ S
Sbjct: 44 ISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTG-LKVPPSRSHS 102
Query: 307 --TYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFLS 426
T P+ G P S+D+R+KGYVTPVKNQ QCGSCW+F S
Sbjct: 103 NDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSS 144
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 110 bits (276), Expect = 3e-24
Identities = 61/150 (40%), Positives = 82/150 (54%), Gaps = 5/150 (3%)
Frame = +1
Query: 133 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 312
RR +WE+N+K I+ HN EY GKH +++ +N F DMTNEEF+ G K +G +
Sbjct: 48 RRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMF 106
Query: 313 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFLSYWIIKKANIFRKNN-----PSN 477
P +P SVDWR+KGYVTPVKNQ QCGSCW+F + + + +FRK
Sbjct: 107 QEP-LFAEIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGAL-EGQMFRKTGKLVSLSEQ 164
Query: 478 KFLRATISLNRSGAYGN*WMWWRVLMDNAF 567
+ + + G G LMDNAF
Sbjct: 165 NLVDCSRAQGNEGCNGG-------LMDNAF 187
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 110 bits (276), Expect = 3e-24
Identities = 57/102 (55%), Positives = 69/102 (67%), Gaps = 2/102 (1%)
Frame = +1
Query: 127 ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGS 306
I+RRLIWE+NLK+I HNLE LG HTY L +N DMT+EE K G +K P+ S
Sbjct: 45 ISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTG-LKVPPSHSRS 103
Query: 307 --TYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFLS 426
T P+ G P S+D+R+KGYVTPVKNQ QCGSCW+F S
Sbjct: 104 NDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSS 145
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 109 bits (273), Expect = 6e-24
Identities = 53/110 (48%), Positives = 72/110 (65%)
Frame = +1
Query: 133 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 312
RR +WE+N+K I+ HN EY GKH++++ +N F DMT+EEF+ G KP +G +
Sbjct: 48 RRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPR-KGKVF 106
Query: 313 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFLSYWIIKKANIFRK 462
P P SVDWR+KGYVTPVKNQ QCGSCW+F + + + +FRK
Sbjct: 107 QEP-LFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGAL-EGQMFRK 154
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,040,186
Number of Sequences: 369166
Number of extensions: 1799242
Number of successful extensions: 3982
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3714
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3860
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6219306880
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)