Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_A20
(917 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P29774|ETS3_DROME DNA-binding protein D-ETS-3 201 3e-51
sp|Q01414|ERG_LYTVA Transcriptional regulator ERG homolog 194 2e-49
sp|P11308|ERG_HUMAN Transcriptional regulator ERG (Transfor... 193 5e-49
sp|Q90837|ERG_CHICK Transcriptional regulator Erg 193 5e-49
sp|P81270|ERG_MOUSE Transcriptional regulator ERG 193 6e-49
sp|P26323|FLI1_MOUSE Friend leukemia integration 1 transcri... 190 4e-48
sp|Q01543|FLI1_HUMAN Friend leukemia integration 1 transcri... 190 4e-48
sp|P41157|FLI1_XENLA Retroviral integration site protein Fl... 188 2e-47
sp|P29776|ETS6_DROME DNA-binding protein D-ETS-6 168 2e-41
sp|P15036|ETS2_HUMAN C-ets-2 protein 132 1e-30
>sp|P29774|ETS3_DROME DNA-binding protein D-ETS-3
Length = 490
Score = 201 bits (510), Expect = 3e-51
Identities = 118/221 (53%), Positives = 138/221 (62%), Gaps = 8/221 (3%)
Frame = +3
Query: 123 ACSFGGLSSVIFPD-----SSYYTNKSNWMCKQDVGQNPYPYSPLGSCSPCYSLGSTNKS 287
A + GG S ++ S+ + +S +G P+S L P G T+
Sbjct: 249 ASASGGGGSALYSSYKSSWGSHSSTQSQGYSSNALGIKHDPHSQLRQPDPYQMFGPTSSR 308
Query: 288 QTNTNQWRPQGSGQIQLWQFLLELLSDSRNTTFITWEGTNGEFKLIDPDEVARRWGERKS 467
++ GSGQIQLWQFLLELLSDS N + ITWEGTNGEFKL DPDEVARRWGERKS
Sbjct: 309 LASS------GSGQIQLWQFLLELLSDSNNASCITWEGTNGEFKLTDPDEVARRWGERKS 362
Query: 468 KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQPASPTVSGPGASPTSF 647
KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF GLA A QPA+ + PT
Sbjct: 363 KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFQGLAAATQPAA-------SDPT-- 413
Query: 648 EPSIYKYQHDLFNSGVNPFLAPAWQHH---ISAGMSPTNGL 761
YKYQ DLF + P+ HH +S+ MSP +G+
Sbjct: 414 ----YKYQSDLF---MTPY------HHSAKLSSFMSPHHGM 441
>sp|Q01414|ERG_LYTVA Transcriptional regulator ERG homolog
Length = 173
Score = 194 bits (494), Expect = 2e-49
Identities = 95/120 (79%), Positives = 99/120 (82%)
Frame = +3
Query: 321 SGQIQLWQFLLELLSDSRNTTFITWEGTNGEFKLIDPDEVARRWGERKSKPNMNYDKLSR 500
SGQIQLWQFLLELLSDS N ITWEGTNGEFK+ DPDEVARRWGERKSKPNMNYDKLSR
Sbjct: 1 SGQIQLWQFLLELLSDSSNANCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSR 60
Query: 501 ALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQPASPTVSGPGASPTSFEPSIYKYQHDL 680
ALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQP +PS+Y+YQ DL
Sbjct: 61 ALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQPVQA------------DPSMYRYQSDL 108
>sp|P11308|ERG_HUMAN Transcriptional regulator ERG (Transforming protein ERG)
Length = 462
Score = 193 bits (491), Expect = 5e-49
Identities = 99/142 (69%), Positives = 106/142 (74%)
Frame = +3
Query: 255 PCYSLGSTNKSQTNTNQWRPQGSGQIQLWQFLLELLSDSRNTTFITWEGTNGEFKLIDPD 434
P LG T+ N GSGQIQLWQFLLELLSDS N++ ITWEGTNGEFK+ DPD
Sbjct: 275 PYQILGPTSSRLANP------GSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPD 328
Query: 435 EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQPASPT 614
EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF G+AQA+QP P
Sbjct: 329 EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPP- 387
Query: 615 VSGPGASPTSFEPSIYKYQHDL 680
E S+YKY DL
Sbjct: 388 -----------ESSLYKYPSDL 398
>sp|Q90837|ERG_CHICK Transcriptional regulator Erg
Length = 478
Score = 193 bits (491), Expect = 5e-49
Identities = 111/208 (53%), Positives = 123/208 (59%), Gaps = 1/208 (0%)
Frame = +3
Query: 60 PSKSIYYYQAMHSMKQEDY-YRACSFGGLSSVIFPDSSYYTNKSNWMCKQDVGQNPYPYS 236
P+ S+Y + D Y +S P S T S+ + Q P
Sbjct: 232 PNTSVYPEATQRITTRPDLPYEQARRSAWTSHSHPTQSKATQPSSSTVPKTEDQRP---- 287
Query: 237 PLGSCSPCYSLGSTNKSQTNTNQWRPQGSGQIQLWQFLLELLSDSRNTTFITWEGTNGEF 416
P LG T+ N GSGQIQLWQFLLELLSDS N+ ITWEGTNGEF
Sbjct: 288 ---QLDPYQILGPTSSRLANP------GSGQIQLWQFLLELLSDSSNSNCITWEGTNGEF 338
Query: 417 KLIDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAM 596
K+ DPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF G+AQA+
Sbjct: 339 KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQAL 398
Query: 597 QPASPTVSGPGASPTSFEPSIYKYQHDL 680
QP P E S+YKY DL
Sbjct: 399 QPHPP------------ESSMYKYPSDL 414
>sp|P81270|ERG_MOUSE Transcriptional regulator ERG
Length = 486
Score = 193 bits (490), Expect = 6e-49
Identities = 99/142 (69%), Positives = 105/142 (73%)
Frame = +3
Query: 255 PCYSLGSTNKSQTNTNQWRPQGSGQIQLWQFLLELLSDSRNTTFITWEGTNGEFKLIDPD 434
P LG T+ N GSGQIQLWQFLLELLSDS N+ ITWEGTNGEFK+ DPD
Sbjct: 299 PYQILGPTSSRLANP------GSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPD 352
Query: 435 EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQPASPT 614
EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF G+AQA+QP P
Sbjct: 353 EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPP- 411
Query: 615 VSGPGASPTSFEPSIYKYQHDL 680
E S+YKY DL
Sbjct: 412 -----------ESSLYKYPSDL 422
>sp|P26323|FLI1_MOUSE Friend leukemia integration 1 transcription factor (Retroviral
integration site protein Fli-1)
Length = 452
Score = 190 bits (483), Expect = 4e-48
Identities = 99/142 (69%), Positives = 106/142 (74%)
Frame = +3
Query: 255 PCYSLGSTNKSQTNTNQWRPQGSGQIQLWQFLLELLSDSRNTTFITWEGTNGEFKLIDPD 434
P LG T+ N GSGQIQLWQFLLELLSDS N + ITWEGTNGEFK+ DPD
Sbjct: 262 PYQILGPTSSRLANP------GSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPD 315
Query: 435 EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQPASPT 614
EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF G+AQA+QP PT
Sbjct: 316 EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQP-HPT 374
Query: 615 VSGPGASPTSFEPSIYKYQHDL 680
E S+YKY D+
Sbjct: 375 -----------ETSMYKYPSDI 385
>sp|Q01543|FLI1_HUMAN Friend leukemia integration 1 transcription factor (Fli-1
proto-oncogene) (ERGB transcription factor)
Length = 452
Score = 190 bits (483), Expect = 4e-48
Identities = 99/141 (70%), Positives = 108/141 (76%), Gaps = 2/141 (1%)
Frame = +3
Query: 255 PCYSLGSTNKSQTNTNQWRPQGSGQIQLWQFLLELLSDSRNTTFITWEGTNGEFKLIDPD 434
P LG T+ N GSGQIQLWQFLLELLSDS N + ITWEGTNGEFK+ DPD
Sbjct: 262 PYQILGPTSSRLANP------GSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPD 315
Query: 435 EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQPASPT 614
EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF G+AQA+QP PT
Sbjct: 316 EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQP-HPT 374
Query: 615 VSGPGASPT--SFEPSIYKYQ 671
S P+ S+ PS + +Q
Sbjct: 375 ESSMYKYPSDISYMPSYHAHQ 395
>sp|P41157|FLI1_XENLA Retroviral integration site protein Fli-1 homolog
Length = 453
Score = 188 bits (477), Expect = 2e-47
Identities = 101/167 (60%), Positives = 113/167 (67%), Gaps = 2/167 (1%)
Frame = +3
Query: 255 PCYSLGSTNKSQTNTNQWRPQGSGQIQLWQFLLELLSDSRNTTFITWEGTNGEFKLIDPD 434
P LG T+ N GSGQIQLWQFLLELLSDS N + ITWEGTNGEFK+ DPD
Sbjct: 263 PYQILGPTSSRLANP------GSGQIQLWQFLLELLSDSSNASCITWEGTNGEFKMTDPD 316
Query: 435 EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQPASPT 614
EVARRWGERKSKPNMNYDKLSRALRYYYDK+IMTKVHGKRYAYKFDF G+AQA+QP PT
Sbjct: 317 EVARRWGERKSKPNMNYDKLSRALRYYYDKSIMTKVHGKRYAYKFDFHGIAQALQP-HPT 375
Query: 615 VSGPGASPTSFE--PSIYKYQHDLFNSGVNPFLAPAWQHHISAGMSP 749
+ P+ F PS + +Q + +P P SP
Sbjct: 376 DTSMYKYPSEFSYMPSYHSHQQKVNFVPSHPSSMPVTSSGFFGATSP 422
>sp|P29776|ETS6_DROME DNA-binding protein D-ETS-6
Length = 475
Score = 168 bits (426), Expect = 2e-41
Identities = 81/96 (84%), Positives = 86/96 (89%), Gaps = 1/96 (1%)
Frame = +3
Query: 315 QGSG-QIQLWQFLLELLSDSRNTTFITWEGTNGEFKLIDPDEVARRWGERKSKPNMNYDK 491
QGSG QIQLWQFLLELL+DS N I+WEG +GEF+LIDPDEVARRWGERK+KPNMNYDK
Sbjct: 249 QGSGGQIQLWQFLLELLADSSNANAISWEGQSGEFRLIDPDEVARRWGERKAKPNMNYDK 308
Query: 492 LSRALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQ 599
LSRALRYYYDKNIMTKVHGKRYAYKFDF GL A Q
Sbjct: 309 LSRALRYYYDKNIMTKVHGKRYAYKFDFHGLMAACQ 344
>sp|P15036|ETS2_HUMAN C-ets-2 protein
Length = 469
Score = 132 bits (333), Expect = 1e-30
Identities = 61/84 (72%), Positives = 68/84 (80%)
Frame = +3
Query: 318 GSGQIQLWQFLLELLSDSRNTTFITWEGTNGEFKLIDPDEVARRWGERKSKPNMNYDKLS 497
GSG IQLWQFLLELLSD +FI+W G EFKL DPDEVARRWG+RK+KP MNY+KLS
Sbjct: 359 GSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLS 418
Query: 498 RALRYYYDKNIMTKVHGKRYAYKF 569
R LRYYYDKNI+ K GKRY Y+F
Sbjct: 419 RGLRYYYDKNIIHKTSGKRYVYRF 442
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,942,120
Number of Sequences: 369166
Number of extensions: 2301130
Number of successful extensions: 6391
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6074
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6361
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9366655350
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)