Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_A17
(853 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9NNW7|TRXR2_HUMAN Thioredoxin reductase 2, mitochondria... 240 3e-63
sp|Q9JLT4|TRXR2_MOUSE Thioredoxin reductase 2, mitochondria... 240 4e-63
sp|Q9Z0J5|TRXR2_RAT Thioredoxin reductase 2, mitochondrial ... 239 9e-63
sp|Q9N2I8|TRXR2_BOVIN Thioredoxin reductase 2, mitochondria... 226 8e-59
sp|O89049|TRXR1_RAT Thioredoxin reductase 1, cytoplasmic (T... 219 8e-57
sp|Q9JMH6|TRXR1_MOUSE Thioredoxin reductase 1, cytoplasmic ... 219 8e-57
sp|O62768|TRXR1_BOVIN Thioredoxin reductase 1, cytoplasmic ... 219 8e-57
sp|P91938|TRXR1_DROME Thioredoxin reductase 1, mitochondria... 218 1e-56
sp|Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic ... 216 5e-56
sp|Q9MYY8|TRXR1_PIG Thioredoxin reductase 1, cytoplasmic (T... 216 5e-56
>sp|Q9NNW7|TRXR2_HUMAN Thioredoxin reductase 2, mitochondrial precursor (TR3) (TR-beta)
(Selenoprotein Z) (SelZ)
Length = 524
Score = 240 bits (613), Expect = 3e-63
Identities = 127/247 (51%), Positives = 168/247 (68%), Gaps = 1/247 (0%)
Frame = +3
Query: 51 PIEVIQGDSGKFRVKWKKEKNPGEMSDLFDTVLFAIGRDPCTLDLNLSAAKVSVDPNTKK 230
P V + G+ +V W+ E + FDTVL+AIGR P T LNL A V P+T+K
Sbjct: 281 PSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQK 340
Query: 231 IVSGSKSKSADMEKTSAPNIYAIGDVLQGGVELTPVAIKAGRLLARRLFHKETVHMNYEM 410
I+ S+ E TS P+IYAIGDV++G ELTP+AI AGRLL +RLF + M+Y+
Sbjct: 341 ILVDSR------EATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDN 394
Query: 411 ISTTVFTPLEYACVGMTEEEAFSKLGDKNVEVYHCYFKPLEIVSMGQQPS-CYMKMICDV 587
+ TTVFTPLEY CVG++EEEA ++ G ++VEVYH ++KPLE G+ S CY+KM+C
Sbjct: 395 VPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLR 454
Query: 588 SKSEKVVGLHILGLNAGEILQGFAVAIKQGITHGQLCSTVGIHPTSAEEVVKLHITKRSN 767
+ V+GLH LG NAGE+ QGFA+ IK G ++ Q+ TVGIHPT +EEVVKL I+KRS
Sbjct: 455 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSG 514
Query: 768 IDPHLTG 788
+DP +TG
Sbjct: 515 LDPTVTG 521
>sp|Q9JLT4|TRXR2_MOUSE Thioredoxin reductase 2, mitochondrial precursor (TR3)
Length = 524
Score = 240 bits (612), Expect = 4e-63
Identities = 125/247 (50%), Positives = 168/247 (68%), Gaps = 1/247 (0%)
Frame = +3
Query: 51 PIEVIQGDSGKFRVKWKKEKNPGEMSDLFDTVLFAIGRDPCTLDLNLSAAKVSVDPNTKK 230
P + + + + +V W+ + E + FDTVL+AIGR P T LNL A +S +P +K
Sbjct: 281 PSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPKNQK 340
Query: 231 IVSGSKSKSADMEKTSAPNIYAIGDVLQGGVELTPVAIKAGRLLARRLFHKETVHMNYEM 410
I+ ++ E TS P+IYAIGDV +G ELTP AIKAG+LLA+RLF K + M+Y
Sbjct: 341 IIVDAQ------EATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSN 394
Query: 411 ISTTVFTPLEYACVGMTEEEAFSKLGDKNVEVYHCYFKPLEIVSMGQQPS-CYMKMICDV 587
+ TTVFTPLEY CVG++EEEA + G ++VEVYH Y+KPLE + S CY+KM+C
Sbjct: 395 VPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDASQCYIKMVCMR 454
Query: 588 SKSEKVVGLHILGLNAGEILQGFAVAIKQGITHGQLCSTVGIHPTSAEEVVKLHITKRSN 767
+ V+GLH LG NAGE+ QGFA+ IK G ++ Q+ TVGIHPT +EEVVKLHI+KRS
Sbjct: 455 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISKRSG 514
Query: 768 IDPHLTG 788
++P +TG
Sbjct: 515 LEPTVTG 521
>sp|Q9Z0J5|TRXR2_RAT Thioredoxin reductase 2, mitochondrial precursor (TR3)
Length = 526
Score = 239 bits (609), Expect = 9e-63
Identities = 124/239 (51%), Positives = 165/239 (69%), Gaps = 1/239 (0%)
Frame = +3
Query: 75 SGKFRVKWKKEKNPGEMSDLFDTVLFAIGRDPCTLDLNLSAAKVSVDPNTKKIVSGSKSK 254
+ + +V W+ + E FDTVL+AIGR P T +LNL A V+ +P +KI+ ++
Sbjct: 291 TNQLQVTWEDLASGKEDVGTFDTVLWAIGRVPETRNLNLEKAGVNTNPKNQKIIVDAQ-- 348
Query: 255 SADMEKTSAPNIYAIGDVLQGGVELTPVAIKAGRLLARRLFHKETVHMNYEMISTTVFTP 434
E TS P+IYAIGDV +G ELTP AIKAG+LLA+RLF K + MNY + TTVFTP
Sbjct: 349 ----EATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMNYSNVPTTVFTP 404
Query: 435 LEYACVGMTEEEAFSKLGDKNVEVYHCYFKPLEIVSMGQQPS-CYMKMICDVSKSEKVVG 611
LEY CVG++EEEA + G +++EVYH Y+KPLE + S CY+KM+C + V+G
Sbjct: 405 LEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLG 464
Query: 612 LHILGLNAGEILQGFAVAIKQGITHGQLCSTVGIHPTSAEEVVKLHITKRSNIDPHLTG 788
LH LG NAGE+ QGFA+ I+ G ++ Q+ TVGIHPT +EEVVKLHI+KRS +DP +TG
Sbjct: 465 LHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHPTCSEEVVKLHISKRSGLDPTVTG 523
>sp|Q9N2I8|TRXR2_BOVIN Thioredoxin reductase 2, mitochondrial precursor (TR3)
Length = 511
Score = 226 bits (575), Expect = 8e-59
Identities = 122/237 (51%), Positives = 159/237 (67%), Gaps = 1/237 (0%)
Frame = +3
Query: 81 KFRVKWKKEKNPGEMSDLFDTVLFAIGRDPCTLDLNLSAAKVSVDPNTKKIVSGSKSKSA 260
+ RV W + + + FDTVL+AIGR P T LNL A V +P T KI+ ++
Sbjct: 278 QLRVTWVDLTSDRKDAGTFDTVLWAIGRVPETASLNLEKAGVHTNPVTGKILVDAQ---- 333
Query: 261 DMEKTSAPNIYAIGDVLQGGVELTPVAIKAGRLLARRLFHKETVHMNYEMISTTVFTPLE 440
E TS P+IYAIGDV +G ELTP AI AGRLLA+RL + + M+Y + TTVFTPLE
Sbjct: 334 --ETTSVPHIYAIGDVAEGRPELTPTAIMAGRLLAQRLSGRTSDLMDYSSVPTTVFTPLE 391
Query: 441 YACVGMTEEEAFSKLGDKNVEVYHCYFKPLEI-VSMGQQPSCYMKMICDVSKSEKVVGLH 617
Y CVG++EE A ++ G+++VEVYH ++KPLE V CY+KM+C + V+GLH
Sbjct: 392 YGCVGLSEEAAVARHGEEHVEVYHAFYKPLEFTVPQRDASQCYIKMVCLREPPQLVLGLH 451
Query: 618 ILGLNAGEILQGFAVAIKQGITHGQLCSTVGIHPTSAEEVVKLHITKRSNIDPHLTG 788
LG NAGE++QGFA+ IK G ++ QL TVGIHPT AEEV KL I+KRS +DP +TG
Sbjct: 452 FLGPNAGEVIQGFALGIKCGASYQQLMRTVGIHPTCAEEVAKLRISKRSGLDPTVTG 508
>sp|O89049|TRXR1_RAT Thioredoxin reductase 1, cytoplasmic (TR) (TR1) (NADPH-dependent
thioredoxin reductase)
Length = 498
Score = 219 bits (558), Expect = 8e-57
Identities = 116/240 (48%), Positives = 155/240 (64%), Gaps = 1/240 (0%)
Frame = +3
Query: 57 EVIQGDSGKFRVKWKKEKNPGEMSDLFDTVLFAIGRDPCTLDLNLSAAKVSVDPNTKKIV 236
++ G G+ +V K + + D F+TVL A+GRD CT + L V ++ T KI
Sbjct: 258 QIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKI- 316
Query: 237 SGSKSKSADMEKTSAPNIYAIGDVLQGGVELTPVAIKAGRLLARRLFHKETVHMNYEMIS 416
D E+T+ P IYAIGD+L+G +ELTPVAI+AGRLLA+RL+ TV +Y+ +
Sbjct: 317 -----PVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCDYDNVP 371
Query: 417 TTVFTPLEYACVGMTEEEAFSKLGDKNVEVYHCYFKPLE-IVSMGQQPSCYMKMICDVSK 593
TTVFTPLEY C G++EE+A K G++N+EVYH +F PLE V CY K+IC++
Sbjct: 372 TTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKVICNLKD 431
Query: 594 SEKVVGLHILGLNAGEILQGFAVAIKQGITHGQLCSTVGIHPTSAEEVVKLHITKRSNID 773
+E+VVG H+LG NAGE+ QGFA A K G+T QL ST+GIHP AE L +TKRS D
Sbjct: 432 NERVVGFHVLGPNAGEVTQGFAAA-KCGLTKQQLDSTIGIHPVCAEIFTTLSVTKRSGGD 490
>sp|Q9JMH6|TRXR1_MOUSE Thioredoxin reductase 1, cytoplasmic (TR) (TR1)
Length = 499
Score = 219 bits (558), Expect = 8e-57
Identities = 114/240 (47%), Positives = 153/240 (63%), Gaps = 1/240 (0%)
Frame = +3
Query: 57 EVIQGDSGKFRVKWKKEKNPGEMSDLFDTVLFAIGRDPCTLDLNLSAAKVSVDPNTKKIV 236
++ G G+ RV + + + F+TVL A+GRD CT + L V ++ T KI
Sbjct: 258 QIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKI- 316
Query: 237 SGSKSKSADMEKTSAPNIYAIGDVLQGGVELTPVAIKAGRLLARRLFHKETVHMNYEMIS 416
D E+T+ P IYAIGD+L+G +ELTPVAI+AGRLLA+RL+ V +Y+ +
Sbjct: 317 -----PVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCDYDNVP 371
Query: 417 TTVFTPLEYACVGMTEEEAFSKLGDKNVEVYHCYFKPLE-IVSMGQQPSCYMKMICDVSK 593
TTVFTPLEY C G++EE+A K G++N+EVYH +F PLE V CY K+IC++
Sbjct: 372 TTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKIICNLKD 431
Query: 594 SEKVVGLHILGLNAGEILQGFAVAIKQGITHGQLCSTVGIHPTSAEEVVKLHITKRSNID 773
E+VVG H+LG NAGE+ QGFA A+K G+T QL ST+GIHP AE L +TKRS D
Sbjct: 432 DERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSVTKRSGGD 491
>sp|O62768|TRXR1_BOVIN Thioredoxin reductase 1, cytoplasmic (TR) (TR1)
Length = 499
Score = 219 bits (558), Expect = 8e-57
Identities = 118/242 (48%), Positives = 156/242 (64%), Gaps = 4/242 (1%)
Frame = +3
Query: 51 PIEVIQ---GDSGKFRVKWKKEKNPGEMSDLFDTVLFAIGRDPCTLDLNLSAAKVSVDPN 221
PI+V Q G G+ RV K + + ++TVL AIGRD CT + L V ++
Sbjct: 253 PIKVEQIEAGTPGRLRVIAKSTDSDQTIEGEYNTVLLAIGRDACTRKIGLENVGVKINEK 312
Query: 222 TKKIVSGSKSKSADMEKTSAPNIYAIGDVLQGGVELTPVAIKAGRLLARRLFHKETVHMN 401
T KI + E+T+ P IYAIGD+L+G +ELTPVAI+AGRLLA+RL+ TV +
Sbjct: 313 TGKI------PVTEEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 366
Query: 402 YEMISTTVFTPLEYACVGMTEEEAFSKLGDKNVEVYHCYFKPLE-IVSMGQQPSCYMKMI 578
YE + TTVFTPLEY G++EE+A K G++NVEVYH YF PLE + CY K++
Sbjct: 367 YENVPTTVFTPLEYGSCGLSEEKAVEKFGEENVEVYHSYFWPLEWTIPSRDNNKCYAKVV 426
Query: 579 CDVSKSEKVVGLHILGLNAGEILQGFAVAIKQGITHGQLCSTVGIHPTSAEEVVKLHITK 758
C++ +E+VVG H+LG NAGE+ QGFA A+K G+T QL ST+GIHP AE L +TK
Sbjct: 427 CNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHPVCAEVFTTLSVTK 486
Query: 759 RS 764
RS
Sbjct: 487 RS 488
>sp|P91938|TRXR1_DROME Thioredoxin reductase 1, mitochondrial precursor (TrxR-1)
Length = 596
Score = 218 bits (556), Expect = 1e-56
Identities = 115/243 (47%), Positives = 154/243 (63%), Gaps = 1/243 (0%)
Frame = +3
Query: 51 PIEVIQGDSGKFRVKWKKEKNPGEMSDLFDTVLFAIGRDPCTLDLNLSAAKVSVDPNTKK 230
P+ V + D GK VK+K + E D++DTVL+AIGR DLNL PN
Sbjct: 355 PLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNL--------PNAGV 406
Query: 231 IVSGSKSKSADMEKTSAPNIYAIGDVLQGGVELTPVAIKAGRLLARRLFHKETVHMNYEM 410
V K E T+ NIYA+GD++ G ELTPVA+ AGRLLARRL+ T M+Y+
Sbjct: 407 TVQKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKD 466
Query: 411 ISTTVFTPLEYACVGMTEEEAFSKLGDKNVEVYHCYFKPLE-IVSMGQQPSCYMKMICDV 587
++TTVFTPLEYACVG++EE+A + G +EV+H Y+KP E + CY+K + +
Sbjct: 467 VATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAER 526
Query: 588 SKSEKVVGLHILGLNAGEILQGFAVAIKQGITHGQLCSTVGIHPTSAEEVVKLHITKRSN 767
++V GLH +G AGE++QGFA A+K G+T L +TVGIHPT+AEE +L ITKRS
Sbjct: 527 HGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITKRSG 586
Query: 768 IDP 776
+DP
Sbjct: 587 LDP 589
>sp|Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic precursor (TR) (TR1)
Length = 499
Score = 216 bits (551), Expect = 5e-56
Identities = 117/242 (48%), Positives = 154/242 (63%), Gaps = 4/242 (1%)
Frame = +3
Query: 51 PIEVIQ---GDSGKFRVKWKKEKNPGEMSDLFDTVLFAIGRDPCTLDLNLSAAKVSVDPN 221
PI+V Q G G+ RV + + + ++TV+ AIGRD CT + L V ++
Sbjct: 253 PIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEK 312
Query: 222 TKKIVSGSKSKSADMEKTSAPNIYAIGDVLQGGVELTPVAIKAGRLLARRLFHKETVHMN 401
T KI D E+T+ P IYAIGD+L+ VELTPVAI+AGRLLA+RL+ TV +
Sbjct: 313 TGKI------PVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCD 366
Query: 402 YEMISTTVFTPLEYACVGMTEEEAFSKLGDKNVEVYHCYFKPLE-IVSMGQQPSCYMKMI 578
YE + TTVFTPLEY G++EE+A K G++N+EVYH YF PLE + CY K+I
Sbjct: 367 YENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKII 426
Query: 579 CDVSKSEKVVGLHILGLNAGEILQGFAVAIKQGITHGQLCSTVGIHPTSAEEVVKLHITK 758
C+ +E+VVG H+LG NAGE+ QGFA A+K G+T QL ST+GIHP AE L +TK
Sbjct: 427 CNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTK 486
Query: 759 RS 764
RS
Sbjct: 487 RS 488
>sp|Q9MYY8|TRXR1_PIG Thioredoxin reductase 1, cytoplasmic (TR) (TR1)
Length = 499
Score = 216 bits (551), Expect = 5e-56
Identities = 117/242 (48%), Positives = 154/242 (63%), Gaps = 4/242 (1%)
Frame = +3
Query: 51 PIEVIQ---GDSGKFRVKWKKEKNPGEMSDLFDTVLFAIGRDPCTLDLNLSAAKVSVDPN 221
PI+V Q G G+ RV + + + ++TV+ AIGRD CT + L V ++
Sbjct: 253 PIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEK 312
Query: 222 TKKIVSGSKSKSADMEKTSAPNIYAIGDVLQGGVELTPVAIKAGRLLARRLFHKETVHMN 401
T KI D E+T+ P IYAIGD+L+ VELTPVAI+AGRLLA+RL+ TV +
Sbjct: 313 TGKI------PVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCD 366
Query: 402 YEMISTTVFTPLEYACVGMTEEEAFSKLGDKNVEVYHCYFKPLE-IVSMGQQPSCYMKMI 578
YE + TTVFTPLEY G++EE+A K G++N+EVYH YF PLE + CY K+I
Sbjct: 367 YENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKII 426
Query: 579 CDVSKSEKVVGLHILGLNAGEILQGFAVAIKQGITHGQLCSTVGIHPTSAEEVVKLHITK 758
C+ +E+VVG H+LG NAGE+ QGFA A+K G+T QL ST+GIHP AE L +TK
Sbjct: 427 CNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTK 486
Query: 759 RS 764
RS
Sbjct: 487 RS 488
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,260,132
Number of Sequences: 369166
Number of extensions: 2260430
Number of successful extensions: 6160
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5755
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5956
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8390082510
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)